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| 1 | 基于网络药理学探讨马齿苋治疗溃疡性结肠炎作用机制显示文摘目的:通过网络药理学探索马齿苋治疗溃疡性结肠炎的作用机制。方法:利用TCMSP数据库查找马齿苋活性成分,借助PubChem,PharmMapper数据库预测所选活性成分作用靶点,运用TTD、Omim数据库收集溃疡性结肠炎靶点。通过STRING数据库和Cytoscape软件构建马齿苋活性成分-溃疡性结肠炎共同靶点蛋白互作网络并进行拓扑分析,筛选出马齿苋治疗溃疡性结肠炎的潜在靶点。利用KOBAS数据库、DAVID数据库进行潜在靶点的GO、KEGG富集分析。结果:筛选出马齿苋活性成分9个,马齿苋活性成分与溃疡性结肠炎共同靶点7个;潜在靶点GO富集涉及生物过程117条,细胞组分27种,分子功能31种;潜在靶点KEGG富集包含mTOR信号通路、PI3K-Akt信号通路等。结论:马齿苋治疗溃疡性结肠炎具有多分子、多靶点的特点,可能主要通过调节mTOR信号通路实现其治疗作用。 | 马小兵 杜晓泉 王喜霞 刘力 樊振 李瑞 惠建萍 张耀之 | 2020 | 山东中医杂志2020，39，11： | 3 |
| 2 | Network-pharmacology and molecular docking-based investigation of mechanism of Sophora flavescens on cancer and inflammation显示文摘Objective:In order to explore the systematical regulatory mechanism of Kushen(Sophora flavescens,SF)on inflammation and cancer,we analyzed inter-molecular interactions between herbal ingredients of SF and human inflammation and cancer through network-pharmacology and molecular docking-based approaches.Methods:Firstly,ingredients and potential targets were obtained from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform,GeneCards database,Therapeutic Targets Database and Online Mendelian Inheritance in Man database.Then,protein-protein interaction network and medicine-ingredient-target-disease network were established and analyzed via STRING and Cytoscape.Surflex-dock was performed by SybylX-2.0.Finally,functional enrichment and pathway enrichment were achieved by Gene Ontology database and Kyoto Encyclopedia of Genes and Genomes database.Results:The results showed that 113 components of SF and 53 potential targets were related in the study.SF exerts anti-inflammatory and anti-cancer mechanism through key targets located in nucleus,such as JUN,MYC,RELA,NCOA,PPARG which may trigger the NF-κB pathway,the Bcl-2/Bax pathway and other pathways to effect DNA transcriptional activity.Conclusions:The study predicted the mechanism of SF on cancer and inflammation.According to the results,we suggest that the ingredients of SF effect on DNA bingding and transcription in nuclear receptors-like JUN,MYC,RELA,NCOA,PPARG.the receptors trigger several pathways including NF-κB pathway,the Bcl-2/Bax pathway and others.Eventually,it regulats inflammatory factors and cell proliferation,senescence and apoptosis. | Wenxuan Li Lijuan Deng Yuhe Lei Junshan Liu | 2020 | TMR Modern Herbal Medicine2020，3，4： | 0 |
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