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| 1 | 利用转盘共聚焦显微镜进行快速实验的新方法显示文摘转盘共聚焦显微镜是快速激光共聚焦显微镜的一种,与传统的激光共聚焦显微镜相比具有一些相同点,也有其特有的优势。本文主要介绍转盘共聚焦显微镜的基本原理及如何利用转盘共聚焦显微镜进行快速实验及应用实例,并与传统激光共聚焦显微镜进行比较。转盘共聚焦显微镜具有速度快、灵敏度高、对样品光损伤和光淬灭程度低、操作灵活简单,是随着实验技术发展使用越来越广泛的实验仪器。 | 张彦丽 代亚丽 陈亚兰 靳娇 潘勋 王文娟 | 2019 | 现代生物医学进展2019，19，19： | 3 |
| 2 | Mechanisms of Polycomb group protein function in cancer显示文摘Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-like phenotype characterized by uncontrolled growth.Polycpmb Group(PcG)proteins are members of multiprotein complexes that are highly conserved throughout evolution.Historically,they have been described as essential for maintaining epigenetic cellular memory by locking homeotic genes in a transcriptionally repressed state.What was initially thought to be a.function restricted to a few target genes,subsequently turned out to be of much broader relevance,since the main role of PcG complexes is to:ensure a dynamically choregraphed spatio-temporal regulation of their numerous target genes during development.Their ability to modify chromatin landscapes and refine the expression of master genes controlling major switches in cellular decisions under physiological conditions.is often misregulated in tumors.Surprisingly,their functional implication in the initiation and progression of cancer may be either dependent on Polycomb complexes,or specific for a subunit that acts independently of other PcG members.In this review,we describe how misregulated Polycomb proteins play a pleiotropic role in cancer by altering a broad spectrum of biological processes such as the proliferation-differentiation balance,metabolism and theimmune response,all of which are crucial in tumor progression.We also illustrate how interfering with PcG functions ican provide a powerful strategy to counter tumor progression. | Victoria Parreno Anne-Marie Martinez Giacomo Cavalli | 2022 | Cell Research2022，32，3： | 0 |
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