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| 1 | 基于超声波测距技术的盾构盾尾间隙测量系统研制显示文摘盾构施工环境恶劣,为解决人工测量存在安全隐患和采用视觉、激光等间接测量的准确率较低问题,采用超声波传感器设计非接触内嵌式测距模块,研究嵌入式超声波传感器的测距单元、信号处理的采集单元、盾尾间隙测量的显示单元及测量系统工作流程。试验验证和工业性测试结果证明该测量系统精准度较高,满足生产需要,可为K块的选型提供依据,同时为智能调整盾构姿态提供数据支撑,且有助于盾构的管片自动选型和智能纠偏。 | 路亚缇 李光 | 2019 | 隧道建设(中英文)2019，39，S02： | 11 |
| 2 | 基于Labview的视觉盾尾间隙测量系统研究显示文摘盾尾间隙是管片选择的重要依据,间隙过小会造成盾尾与管片发生干扰,降低掘进速度;间隙过大浆液容易将盾尾脂冲破,造成漏浆。为了提高盾尾间隙测量的精准度,确保盾尾间隙变化量在允许范围内,文章研究了一种基于视觉处理的盾尾间隙测量系统,详细说明了整个系统的设计,重点介绍了采集照片后基于Labview的图像处理算法和二维卷积的边缘检测算法,介绍了Labview与PLC的通讯系统及其数据传输。研究结果显示,该测量系统操作方便、精准度较高。 | 路亚缇 徐智良 | 2020 | 现代隧道技术2020，57，1： | 9 |
| 3 | Anti-diabetic vanadyl complexes reduced Alzheimer's disease pathology independent of amyloid plaque deposition显示文摘Association of Alzheimer's disease(AD) with cerebral glucose hypometabolism, likely due to impairments of insulin signaling,has been reported recently, with encouraging results when additional insulin is provided to AD patients. Here, we tested the potential effects of the anti-diabetic vanadium, vanadyl(IV) acetylacetonate(VAC), on AD in vitro and in vivo models. The experimental results showed that VAC at sub-micromolar concentrations improved the viability of neural cells with or without increased β-amyloid(Aβ) burden; and in APP/PS1 transgenic mice, VAC treatment(0.1 mmol kg-1 d-1) preserved cognitive function and attenuated neuron loss, but did not reduce brain Aβ plaques. Further studies revealed that VAC attenuated Aβpathogenesis by(i) activation of the PPARγ-AMPK signal transduction pathway, leading to improved glucose and energy metabolism;(ii) up-regulation of the expression of glucose-regulated protein 75(Grp75), thus suppressing p53-mediated neuronal apoptosis under Aβ-related stresses; and(iii) decreasing toxic soluble Aβ peptides. Overall, our work suggested that vanadyl complexes may have great potential for effective therapeutic treatment of AD. | Yaqiong Dong TessANDra Stewart Yue Zhang Min Shi Chang Tan Xue Li Lan Yuan Aanchal Mehrotra Jing Zhang Xiaoda Yang | 2019 | Science China(Life Sciences)2019，62，1： | 8 |
| 4 | 姜黄素在调节TNF-α介导的大脑炎症反应中的作用显示文摘炎症是人体对外界伤害性刺激的保护性反应,然而,过度炎症能够引起机体伤害性反应,导致慢性疾病。炎症在神经系统疾病的发展过程中起重要作用,细胞因子在很多神经退行性疾病中表达上调,最终引发脑内炎症反应。在脑内细胞因子中,肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)介导了许多疾病的炎症过程,在阿尔茨海默病、帕金森病、多发性硬化症、肌萎缩侧索硬化症等疾病的发展中起重要作用,其功能受转录因子核因子κB(nuclear factor-kappa B,NF-κB)活化的调节。最近有研究表明,姜黄素具有抗炎和抗氧化的特性,能有效抑制炎症反应,因此具有治疗神经炎症疾病的潜力,当前已被尝试用于治疗与大脑相关的各种慢性疾病。本文旨在阐明姜黄素在TNF-α和NF-κB介导的神经炎症反应中的作用,为今后治疗神经炎症相关疾病提供新的思路。 | 董志燕 王得顺 陈磊 | 2019 | 武警后勤学院学报(医学版)2019，0，2： | 2 |
| 5 | The abuse of anesthetic propofol: associated with cognitive impairment显示文摘Propofol (2,6-diisopropylphenol)is a widely used intravenous anesthetic for the fast induction of anesthesia and rapid recovery from general anaesthesia.As a γ-aminobu-tyric acid(GABA)receptor agonist,propofol exerts the anesthetic effects through potentiation of the inhibitory neurotransmitter GABA. | Weili Zhu Wen Zhang Jiali Li Zengbo Ding Yingjie Huang Lin Lu | 2018 | Science China(Life Sciences)2018，61，11： | 2 |
| 6 | 光基因技术调控星形胶质细胞释放ATP和谷氨酸及其对阿尔茨海默病神经元保护机制的研究展望显示文摘阿尔茨海默病是中枢神经系统退行性病变之一,其病理机制主要是各种原因导致的神经元Aβ沉积,包括ATP和谷氨酸不足引起的Aβ沉积。应用光基因技术可以选择性激活表达光敏感通道蛋白的星形胶质细胞,并促其释放ATP和谷氨酸,从而阻断由于ATP和谷氨酸不足引起的Aβ沉积。因此光基因技术有望应用于阿尔茨海默病的治疗,并且避免药物治疗在非选择性及广泛不良反应方面的缺点。 | 柳浦青 何冰冰 陈锋 | 2017 | 中国医药导报2017，14，31： | 1 |
| 7 | Ten years of achievements in biological and medical sciences显示文摘This special issue commemorates the 10th anniversary of Institute of Biomedical Sciences(IBMS),East China Normal University(ECNU).IBMS was established in 2007 by a group of oversea scientists from Harvard Medical School,Yale University,the Texas A&M University,Baylor College of Medicine,the University of Texas MD Anderson Cancer Center,the University of California and the Scripps Research Institute.These scientists were brought together on the initiative of Dr.Mingyao Liu,who was then appointed as the director of IBMS and dean of School of Life Sciences,ECNU.The institute is located on the new | Mingyao Liu Tieliu Shi | 2017 | Science China(Life Sciences)2017，60，2： | 0 |
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