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| 1 | 大黄素抑制肺癌A549细胞增殖、迁移和侵袭及对SDF1/CXCR4轴信号通路的影响显示文摘目的探讨大黄素对人肺癌A549细胞系增殖、侵袭和迁移能力以及SDF1/CXCR4轴信号通路的影响。方法采用MTT法检测不同浓度大黄素对肺癌A549细胞系的抑制率。通过划痕实验、Transwell小室侵袭实验分别检测大黄素对A549细胞迁移及侵袭能力的影响。荧光定量PCR检测细胞中SDF1和CXCR4基因表达,Western blot法检测A549细胞内SDF1/CXCR4轴信号通路中SDF1和CXCR4等关键蛋白表达水平的变化情况。结果大黄素对肺癌A549细胞的增殖具有抑制作用,呈浓度依赖性。大黄素以浓度依赖的方式抑制A549细胞的增殖、侵袭和迁移。荧光定量PCR检测发现大黄素处理A549细胞中SDF1和CXCR4基因表达降低。Western blot结果提示大黄素可抑制SDF1/CXCR4轴信号通路的SDF1和CXCR4蛋白的表达。结论在一定浓度范围内,大黄素可抑制人非小细胞肺癌A549细胞的增殖、迁移和侵袭,下调分泌蛋白SDF1和CXCR4的表达,其机制可能与抑制SDF1/CXCR4轴信号通路中的SDF1和CXCR4蛋白有关。 | 李剑 童希文 | 2019 | 解剖学研究2019，41，3： | 6 |
| 2 | 高原运动效能降低及防治措施显示文摘高原是一个低压、低氧、低温、高紫外线的特殊环境,人们在高原的运动效能普遍下降,严重影响驻守高原和进入高原人群的生活及身体健康。近年来,高原性缺氧所致损伤与防治引起了广泛关注。研究发现,急进海拔高度越高、运动持续时间越久、进驻越迅速,人的运动效能受到的影响越大。急进高原与长期驻扎高原对人的爆发力、耐力、精细化操作都存在影响。医疗技术的进步使众多预防方法已被用作习服高原环境。然而,体外干预方法成本高、易反弹且效果有限,因此,药物防治显然是更加经济的选择。化学药物通过改善心脏和大脑的缺血缺氧状态,增加肺通气量和动脉血氧合能力以及加速消除运动后不良产物堆积等机制改善高原运动效能;单味中药、中成药和复方制剂等通过促进身体新陈代谢、提高肌肉耐力、增强免疫力等机制提高运动效能。中药在改善高原运动效能损伤方面具有独特的优势和应用前景。 | 李勃深 杨军 王芃 李晓琳 李茂星 张宇轩 | 2023 | 中南大学学报(医学版)2023，48，10： | 0 |
| 3 | Neuroprotective effects of ProBeptigen/CMI-168 on aging-induced cognitive decline and neuroinflammation in mice:a comparison with essence of chicken显示文摘Neuroinflammation and cognitive decline are the key pathological features in aging that bring detrimental impacts upon quality of life.However,there is no effective anti-aging pharmacological therapy thus far.Dietary supplements in particular essence of chicken(EC)has been found to be an effective remedy for alleviating mental stress and improving memory.In addition,a novel hydrolyzed chicken extract,ProBeptigen/CMI-168(PB),showed beneficial effects on cognitive ability.However,the antiaging effect and possible mechanism of PB and EC are still unknown.Here,we investigated the antiaging effects of PB and EC on hippocampus-related cognitive decline and neuroinflammation in aged mice.PB and EC were administered for 16 weeks in 10-month-old mice.Both PB and EC treatments ameliorated age-related deterioration of learning and memory,and attenuated oxidative stress and inflammation in the hippocampus.These results were associated with decreased inflammatory cytokine levels and increased neurotransmitter levels in the hippocampus.The overall effects of improving aging-induced cognitive decline were more robust in PB-treated mice,while EC was effective in decreasing oxidative stress and inflammation.Moreover,alterations in the diversity and composition of the gut microbiota in aged mice were also regulated by both PB and EC,which induced distinguished features in the gut microbiota and their related functions.This study showed that PB exerts neuroprotective effects in aged mice,the mechanism of which might be different from that of EC.Therefore,PB has a potential as dietary supplement for ameliorating cognitive dysfunction and neuroinflammation in elderly individuals. | Yinhua Ni Liyang Ni Lingyan Ma Zhe Wang Yufeng Zhao Luting Hu Liujie Zheng Zhengwei Fu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，4： | 0 |
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