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| 1 | Functionalization of PEG-PM PC-based polymers for potential theranostic applications显示文摘The synergistic effect of polyethylene glycol(PEG)and poly(2-methacry-loyloxyethyl phosphorytcholine)(PMPC)can effectively reduce the protein absorption,which is beneficial to theranostics.However,PEG-PMPC-based polymers have rarely been used as nanocarriers in the theranostic field due to their limited modifiability and weak interaction with other materials.Herein,a plain method was proposed to endow them with the probable ability of loading small active agents,and the relationship between the structure and the ability of loading hydrophobic agents was explored,thus expanding their applications.Firstly,mPEG-PMPC or 4-arm-PEG-PMPC polymer was synthesized by atom transfer radical polymerization(ATRP)using mPEG-Br or 4-arm-PEG-Br as the macroinitiator.Then a strong hydrophobic segment,poly(butyl methacrylate)(PBMA),was introduced and the ability to load small hydrophobic agents was further explored.The results showed that linear mPEG-PMPC-PBMA could form micelles 50-80 nm in size and load the hydrophobic agent such as Nile red efficiently.In contrast,star-like 4-arm-PEG-PMPC-PBiyiA,a monomolecular micelle(10-20 nm),could hardly load any hydrophobic agent.This work highlights effective strategies for engineering PEG-PMPC-based polymers and may facilitate the further application in numerous fields. | Ning CHEN Sidi LI Xueping LI Lixia LONG Xubo YUAN Xin HOU Jin ZHAO | 2021 | Frontiers of Materials Science2021，15，2： | 0 |
| 2 | 羊肚菌蛋白水解物及其硒化衍生物的细胞保护作用和安全性研究显示文摘该文研究羊肚菌蛋白水解物(morchella protein hydrolysate,MPH)及其硒化衍生物(Se-MPH)的细胞保护作用和安全性。利用H_(2)O_(2)诱导的Caco-2细胞氧化损伤模型研究了MPH和Se-MPH的细胞保护作用。结果显示,MPH和Se-MPH可通过减轻氧化应激和抑制细胞凋亡来保护Caco-2细胞免受氧化损伤,这种保护作用可能主要归因于Nrf2信号通路的激活和凋亡相关蛋白表达的调节。通过细胞毒性试验、红细胞溶血实验、细菌回复突变(bacterial reverse mutation,Ames)试验以及鸡胚绒毛尿囊膜(chick embryo chorioallantoic membrane,CAM)试验研究了MPH和Se-MPH的安全性。结果证实,MPH和Se-MPH没有细胞毒性、溶血活性和致突变潜力,在CAM实验中未观察到明显的血管形态学变化及出血现象。所有这些研究表明,MPH和Se-MPH具有显著的细胞保护作用和良好的安全性,有望作为潜在的营养性、功能性或药物性成分得到开发利用。 | 张强 王梦锦 马玉涵 孙玉军 王松华 | 2021 | 食品与发酵工业2021，47，10： | 0 |
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