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| 1 | Enhanced treatment for cerebral ischemia-reperfusion injury of puerarin loading liposomes through neutrophils-mediated targeted delivery显示文摘The recovery of blood circulation following cerebral infarction-associated thrombolysis brings new damage to the brain,which is cerebral ischemia-reperfusion injury(CIRI).Inflammation is the main pathological mechanism of CIRI.The inflammatory response triggered by cerebral ischemia-reperfusion provides neutrophils with a special opportunity to facilitate drug delivery to the site of ischemic penumbra through the chemotaxis of inflammatory factors by neutrophils.Puerarin is an isoflavone derivative with a significant neuroprotective effect in vitro.But the blood-brain barrier(BBB)impedes its therapeutic efficacy on CIRI within the brain.Inspired by the pathological process,we have used neutrophils as carriers to enhance the BBB penetration of liposomes loaded with puerarin and improve the concentration of puerarin in the brain parenchyma in this study.These results showed that puerarin-containing liposomes were released in response to inflammatory conditions associated with brain injury to enhance the neuroprotection effect at the ischemic penumbra. | Wei Liu Haowei Lu Xiaoyong Rao Xiang Li Hongdan Lu Feifei Li Yan He Riyue Yu Rongsheng Zhong Yao Zhang Xiaojian Luo Hongliang Xin | 2021 | Nano Research2021，14，12： | 2 |
| 2 | 基于缺血性脑卒中再灌注损伤机制的抗氧化纳米药物研究进展显示文摘在缺血性脑卒中-再灌注过程中,活性氧异常增多引起的脑组织神经元氧化应激是脑缺血-再灌注损伤的最主要病理机制。快速恢复脑组织血流灌注,同时抑制神经元氧化损伤是治疗缺血性脑卒中的有效途径。目前抗氧化类药物存在生物利用率低、作用方式单一及副作用大等缺点,极大限制了其疗效与临床应用。近年来,纳米药物因其尺寸、形貌可控及表面可修饰性等优势,在生物应用中展现出良好的应用前景,有望突破缺血性脑卒中神经保护类药物开发的瓶颈。重点阐明脑缺血-再灌注损伤的机制,综述抗氧化纳米药物的设计合成及其逆转神经元氧化损伤的作用机制与应用,为防治缺血性脑卒中提供新的思路。 | 刘颖 黄冠宁 贺利贞 陈填烽 | 2023 | 药学进展2023，47，10： | 0 |
| 3 | Emerging prospects of protein/peptide-based nanoassemblies for drug delivery and vaccine development显示文摘Proteins have been widely used in the biomedical field because of their well-defined architecture,accurate molecular weight,excellent biocompatibility and biodegradability,and easy-to-functionalization.Inspired by the wisdom of nature,increasing proteins/peptides that possess self-assembling capabilities have been explored and designed to generate nanoassemblies with unique structure and function,including spatially organized conformation,passive and active targeting,stimuli-responsiveness,and high stability.These characteristics make protein/peptide-based nanoassembly an ideal platform for drug delivery and vaccine development.In this review,we focus on recent advances in subsistent protein/peptide-based nanoassemblies,including protein nanocages,virus-like particles,self-assemblable natural proteins,and self-assemblable artificial peptides.The origin and characteristics of various protein/peptide-based assemblies and their applications in drug delivery and vaccine development are summarized.In the end,the prospects and challenges are discussed for the further development of protein/peptide-based nanoassemblies. | Taiyu Liu Lu Li Cheng Cheng Bingfang He Tianyue Jiang | 2022 | Nano Research2022，15，8： | 0 |
| 4 | Silicon-based nanoprobes cross the blood–brain barrier for photothermal therapy of glioblastoma显示文摘Traditional photothermal agents of indocyanine green(ICG)have poor stability,short circulation time,and poor brain permeability due to the blood–brain barrier(BBB),greatly impairing their therapeutic efficacy in glioblastoma(GBM).Herein,we develop a novel kind of SiNPs-based nanoprobes to bypass the BBB for photothermal therapy of GBM.Typically,the SiNPs-based nanoprobes are composed of the particle itself,the BBB-targeting ligand of glucosamine(G),and the therapeutic agent of ICG.We demonstrate that the as-synthesized nanoprobes could cross the BBB through glucose transporter-1(GLUT1)-mediated transcytosis,followed by accumulation at GBM tissues in mice.Compared with free ICG,G-ICG-SiNPs show stronger stability(for example,the fluorescence intensity of G-ICG-SiNPs loaded with the same dose of ICG decays by 34.6%after 25 days of storage,while the fluorescence intensity of ICG decays by 99.5%under the same conditions).Furthermore,the blood circulation time of G-ICG-SiNPs increases by about 17.3-fold compared with their ICG counterparts.After injection of the therapeutic agents into the GBM-bearing mice,GBM-surface temperature rises to 45.3℃in G-ICG-SiNPs group after 5-min 808 nm irradiation but climbs only to 36.1℃in equivalent ICG group under the identical conditions,indicating the superior photothermal effects of GICG-SiNPs in vivo. | Rong Sun Mingzhu Liu Zhaojian Xu Bin Song Yao He Houyu Wang | 2022 | Nano Research2022，15，8： | 0 |
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