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| 1 | Gastric cancer: Epidemiology, risk factors and prevention strategies显示文摘Gastric cancer(GC) is a global health problem, with more than 1 million people newly diagnosed with GC worldwide each year. GC is more prevalent in less developed countries than in more developed countries. About half of all GC cases worldwide occur in East Asia, notably China. Globally, overall incidence rates of GC are declining, which is potentially attributed to a decrease in Helicobacter pylori(H. pylori) infection and the use of refrigeration to preserve foods rather than salt. GC is a multifactorial disease, and its occurrence and development were impacted by environmental and genetic factors. H. pylori infection is the primary risk factor for GC, especially for non-cardia. The prognosis of GC is poor due to stages at the first diagnosis. The 5-year survival rate is less than 10% when patients are diagnosed at an advanced stage, but the rate is as high as 85% if patients are detected at an earlier stage. Endoscopic screening can potentially prevent GC by early diagnosis and early treatment and has been widely adopted in screening programs in East Asian countries, such as Japan and Korea. This review summarizes updated epidemiological aspects, risk factors, and prevention strategies of GC in recent years to help researchers determine the most effective intervention strategies for reducing risk of GC. | Lei Yang Xiangji Ying Shuo Liu Guoqing Lyu Zekuan Xu Xi Zhang Huichao Li Qingyu Li Ning Wang Jiafu Ji | 2020 | Chinese Journal of Cancer Research2020，32，6： | 52 |
| 2 | Development and validation of a questionnaire-based risk scoring system to identify individuals at high risk for gastric cancer in Chinese populations显示文摘Objective:This study aimed to develop and validate a risk scoring system to identify high-risk individuals carrying malignant lesions in stomach for tailored gastric cancer screening.Methods:A gastric cancer risk scoring system(GC-RSS)was developed based on questionnaire-based predictors for gastric cancer derived from systematic literature review.To assess the capability of this system for discrimination,risk scores for 8,214 and 7,235 outpatient subjects accepting endoscopic examination in two endoscopy centers,and 32,630 participants in a community-based cohort in China were calculated to plot receiver operating characteristic curves and generate area under the curve(AUC).To evaluate the performance of GC-RSS,the screening proportion,sensitivity and detection rate ratio compared to universal screening were used under different risk score cutoff values.Results:GC-RSS comprised nine predictors including advanced age,male gender,low body mass index(<18.5 kg/m^(2)),family history of gastric cancer,cigarette smoking,consumption of alcohol,preference for salty food,irregularity of meals and consumption of preserved food.This tool performed well in determining the risk of malignant gastric lesions with AUCs of 0.763,0.706 and 0.696 in three validation sets.When subjects with risk scores≥5 were evaluated with endoscopy,nearly 50%of these endoscopies could be saved with a detection rate of over 1.5 times achieved.When the cutoff was set at 8,only about 10%of subjects with the highest risk would be offered endoscopy,and detection rates for gastric cancer could be increased 2-4 fold compared to universal screening.Conclusions:An effective questionnaire-based GC-RSS was developed and validated.This tool may play an important role in establishing a tailored screening strategy for gastric cancer in China. | Ren Zhou Hongchen Zheng Mengfei Liu Zhen Liu Chuanhai Guo Hongrui Tian Fangfang Liu Ying Liu Yaqi Pan Huanyu Chen Zhe Hu Hong Cai Zhonghu He Yang Ke | 2021 | Chinese Journal of Cancer Research2021，33，6： | 3 |
| 3 | 培元益气汤改善气阴两虚证胃癌相关癌性疲乏及对患者免疫功能的影响显示文摘目的:探讨培元益气汤改善气阴两虚证胃癌的相关癌性疲乏及对患者免疫功能的影响。方法:选取112例气阴两虚证胃癌患者,随机分为观察组和对照组各56例,对照组治疗方案为替吉奥加顺铂化疗,观察组在对照组基础上加以培元益气汤治疗,观察两组患者癌性疲乏及免疫功能指标的变化。结果:治疗21d后,观察组临床疗效为96.43%,对照组为78.57%,两组比较差异有统计学意义(P<0.05)。对照组治疗后简易疲劳量表(BFI)评分低于治疗前,观察组BFI评分低于治疗前(P<0.05);治疗后观察组BFI评分低于对照组(P<0.05)。治疗后观察组CD3^(+)、CD4^(+)表达高于对照组,CD8^(+)表达低于对照组,皮质醇(Cor)水平高于对照组,差异有统计学意义(P<0.05)。治疗后观察组体力状况评分较对照组更高(P<0.05);治疗后两组患者PIPER-疲乏量表评分低于治疗前,差异具有统计学意义(P<0.05);其中观察组PIPER-疲乏量表评分低于对照组(P<0.05)。两组患者治疗后生活质量评分优于治疗前(P<0.05),观察组改善优于对照组(P<0.05)。结论:经培元益气汤治疗后可显著改善气阴两虚证胃癌疲乏疗效,提高患者免疫功能及血清皮质醇水平。 | 孟肖 张新庆 李璐 王艳荣 | 2023 | 陕西中医2023，44，2： | 2 |
| 4 | 胃癌术后患者肺部并发症风险预测logistic回归模型的建立显示文摘目的探讨胃癌患者术后发生肺部并发症风险预警模型建立及相关因素,为临床预防提供参考。方法选取中国人民解放军联勤保障部队第九〇四医院2018年5月至2020年5月胃癌手术后并发肺部并发症的患者60例作为病例组,同期手术后未发生肺部并发症的患者60例作为对照组。采用单因素及多因素logistic回归模型建立肺部并发症风险预警模型系统,分析胃癌患者术后发生肺部并发症风险的相关因素。结果病例组吸烟、开腹手术方式、手术出血量≥300 ml、清扫淋巴结数目≥25个、术前血蛋白<35 g/L、合并慢性阻塞性肺疾病、合并糖尿病、术后发生吻合口瘘比例高于对照组,差异有统计学意义(P<0.05)。logistic回归分析结果显示,吸烟、开腹手术方式、清扫淋巴结数目≥25个、术前血蛋白<35 g/L、合并慢性阻塞性肺疾病、合并糖尿病、术后发生吻合口瘘是胃癌患者手术后发生肺部并发症的独立危险因素(OR>1,P<0.05)。结论通过建立胃癌患者术后肺部并发症风险预警模型,可有效发现相关风险因素,临床可针对风险人群提出针对性的干预措施。 | 王芳 朱晓素 王丽华 | 2023 | 中国医药导报2023，20，5： | 0 |
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