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| 1 | Cullin 4B-RING E3 ligase complex in immune cell differentiation and function显示文摘CUL4B,which encodes the scaffold protein in the CRL4B complex,is a commonly mutated gene in X-linked intellectual disability[10,11].In addition to intellectual disability,patients with CUL4B mutations present with an elevated number of monocytes in peripheral blood[10],implying a role for CUL4B in regulating monocytes/macrophages.Monocytes/macrophages are critical players in innate immunity.Hung et al.found that depletion of CUL4B in myeloid cells aggravated lipopolysaccharide(LPS)-induced acute peritonitis[3].They further showed that after LPS stimulation,Cul4b-deficient macrophages secreted more chemokines than control macrophages,which might have accounted for the elevated infiltration of immune cells into the peritoneum[3].Our previous work demonstrated that myeloid-specific Cul4b-knockout mice exhibited reduced survival after LPS injection or Salmonella typhimurium infection compared to control mice[6].In contrast to work from Hung et al.,which showed that Cul4b-deficient macrophages secreted less TNFαand IL-6 after LPS stimulation[3],our works showed that deletion of CUL4B in macrophages increased the production of proinflammatory cytokines and decreased the expression of the anti-inflammatory cytokine IL-10 in response to the activation of Toll-like receptor(TLR).CUL4B regulation of macrophages relies on the ubiquitination activity of the CRL4B complex.The CRL4B complex catalyzes monoubiquitination of H2AK119 at the promoter of Pten,resulting in the repression of Pten transcription and subsequent activation of AKT and AKT-dependent inhibition of GSK3β,which suppresses TLR-triggered proinflammatory responses(Fig.1B)[6]. | Yu Song Shiqi Jin Gongping Sun Yaoqin Gong | 2023 | Cellular & Molecular Immunology2023，20，10： | 0 |
| 2 | CUL4B、TRPM2在胰腺癌组织中的表达和临床意义显示文摘目的探讨胰腺癌组织中E3泛素连接酶Cullin4B(CUL4B)、人瞬时受体电位M2(TRPM2)的表达及临床意义。方法收集2019年3月—2020年3月在西安交通大学医学院附属3201医院接受手术治疗胰腺癌患者86例的癌组织和癌旁组织。采用免疫组织化学检测组织中CUL4B、TRPM2蛋白表达。采用实时荧光定量PCR检测组织中CUL4B、TRPM2 mRNA水平。Spearman秩相关分析CUL4B与TRPM2蛋白表达的关系。Kaplan-Meier曲线分析CUL4B、TRPM2蛋白表达对患者预后的影响。Cox比例风险模型分析胰腺癌预后影响因素。结果胰腺癌组织中CUL4B、TRPM2蛋白阳性率及mRNA基因的相对表达量高于癌旁组织(χ^(2)/t=70.245、60.224、15.741、10.976,P均<0.001)。胰腺癌组织中CUL4B与TRPM2蛋白表达呈显著正相关(r=0.720,P<0.001)。TNM分期ⅡB~Ⅲ期、淋巴结转移胰腺癌中CUL4B、TRPM2蛋白阳性率高于Ⅰ~ⅡA期、无淋巴结转移癌组织(χ^(2)=16.511、14.834,15.576、15.007,P均<0.001)。CUL4B阳性组和阴性组3年总生存率分别为9.68%(6/62)、41.67%(10/24),TRPM2阳性组和阴性组3年总生存率分别为8.33%(5/60)、42.31%(11/26),CUL4B阳性组、TRPM2阳性组患者3年累积生存率低于CUL4B阴性组、TRPM2阴性组患者(Log-Rankχ^(2)/P=9.933/0.002、11.102/0.001)。TNM分期ⅡB~Ⅲ期、淋巴结转移、CUL4B阳性、TRPM2阳性是影响胰腺癌不良预后的独立危险因素[HR(95%CI)=1.781(1.199~2.646),1.962(1.172~3.285),2.482(1.445~4.263),1.733(1.223~2.457)]。结论胰腺癌组织中CUL4B、TRPM2表达升高,两者表达与胰腺癌不良临床病理特征有关,是胰腺癌预后相关肿瘤标志物。 | 马竹芳 庞林元 陈保银 徐菁 | 2024 | 疑难病杂志2024，23，4： | 0 |
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