共被期刊论文引用了3次
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| 1 | Profile of Dr.Hong-Bing Shen显示文摘Dr.Hong-Bing Shen joined Nanjing Medical University in1981 where he received his college education and earned his Bachelor’s degree in preventive medicine in 1986.He subsequently continued his graduate training and obtained a Master’s degree in epidemiology in 1989. | | 2022 | Science China(Life Sciences)2022，65，1： | 0 |
| 2 | 早期肺鳞状细胞癌和肺腺癌患者立体定向放射治疗后的预后对比显示文摘目的对比分析早期肺鳞状细胞癌(lung squamous cell carcinoma,LUSC)和肺腺癌(lung adenocarcinoma,LUAD)患者立体定向放射治疗(stereotactic body radiation therapy,SBRT)后的预后。方法应用回顾性研究方法。通过收集早期非小细胞肺癌(non small cell lung cancer,NSCLC)患者病历资料对其进行调查。根据患者的组织学类型将其分为LUSC和LUAD两组患者,对比分析两组患者的一般资料和预后状况。结果(1)较之于LUAD组,LUSC组的5年生存率(OS和PFS)均明显偏低,LR(局部复发)率明显偏高,P<0.05。两组的DM(远处转移)率相近,P>0.05。(2)年龄大、男性、肿瘤直径大、组织学类型为LUSC是早期NSCLC患者5年OS的危险因素(P<0.05),HR分别为1.201、2.245、1.378、1.804。HR的95%CI值分别为:1.041~1.386、1.535~3.285、1.090~1.744、1.207~2.696。(3)PS评分高、肿瘤直径大、组织学类型为LUSC是早期NSCLC患者5年PFS的危险因素(P<0.05),HR分别为:1.876、1.205、1.973。HR的95%CI值分别为:1.352~2.602、1.038~1.398、1.258~3.098。(4)肿瘤直径大、组织学类型为LUSC是早期NSCLC患者5年局部复发的危险因素(P<0.05),HR分别为1.273、2.249。HR的95%CI值分别为:1.075~1.506、1.364~3.705。结论SBRT后LUSC患者的OS率和PFS率均低于LUAD患者;LUSC患者的LR风险高于LUAD患者。 | 何志杰 | 2024 | 临床肺科杂志2024，29，2： | 0 |
| 3 | A causal variant rs3769823 in 2q33.1 involved in apoptosis pathway leading to a decreased risk of non-small cell lung cancer显示文摘Objective:Although our previous genome-wide association study(GWAS)has identified chromosome 2q33.1 as a susceptibility locus for non-small cell lung cancer(NSCLC),the causal variants remain unclear.The aims of this study were to identify the causal variants in 2q33.1 and to explore their biological functions in NSCLC.Methods:CCK-8,colony formation,EdU incorporation,Transwell,and quantitative real-time polymerase chain reaction assays were applied to examine variant function.The tumor xenograft model was used to examine variant function in vivo.Caspase-8 activity assays,flow cytometry analysis,and co-immunoprecipitation assays were used to explore the molecular mechanism.Results:The missense variant rs3769823(A>G),which caused the substitution of lysine with arginine at amino acid 14 in caspase-8(caspase-8K14R),was identified as a potential causal candidate in 2q33.1.Compared with the wild type caspase-8(caspase8WT)group,the caspase-8K14R group had higher expression of caspase-8 and cleaved caspase-8.Caspase-8K14R inhibited the proliferation and metastasis of human lung cancer cell lines in vitro.Moreover,caspase-8K14R repressed lung cancer cell growth in vivo.Mechanistically,caspase-8K14R was more sensitive than caspase-8WT to tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)-mediated apoptosis and showed higher binding of caspase-8 and FADD.Conclusions:These results suggested that rs3769823 is the causal variant in chromosome 2q33.1 and is involved in an apoptosis pathway,leading to a decreased risk of NSCLC. | Xu Zhang Na Qin Jingyi Fan Chang Zhang Qi Sun Yayun Gu Meng Zhu Erbao Zhang Juncheng Dai Guangfu Jin Hongxia Ma Zhibin Hu Hongbing Shen | 2022 | Cancer Biology & Medicine2022，19，9： | 0 |
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