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| 1 | The enhanced photocatalytic sterilization of MOF-Based nanohybrid for rapid and portable therapy of bacteria-infected open wounds显示文摘Open wounds are prone to infection and difficult to heal,which even threatens the life of patients because bacterial infections can induce other lethal complications without prompt treatment.The commonly used antibiotics treatment for bacterial infections has been reported to cause globally bacterial resistance and even the occurrence of superbacteria.The highly effective and antibiotic-independent therapeutic strategies are urgently needed for treating various kinds of bacteria-infected diseases.In this work,we synthesized an eco-friendly nanohybrid material(ZnDMZ)consisting of a kind of biodegradable metal organic framework(MOF,ZIF-8)combined with Zn-doped MoS_(2)(Zn-MoS_(2))nanosheets,which exhibited great ability to kill bacteria and promote the healing of bacteria-infected wounds under 660 nm light irradiation.The underlying mechanism is that besides the local hyperthermia,the nanohybrid material exhibits enhanced photocatalytic performance than single component in it,i.e.,it can also be excited by 660 nm light to produce more oxygen radical species(ROS)due to the following factors.On one hand,the Zn doping can reduce the work function and the band gap of MoS_(2),which promotes the movement of photoexcited electrons to the surface of the material.On the other hand,the combination between Zn-MoS_(2) and MOF induces the formation of a built-in electric field due to their work function difference,thus accelerating the separation of photoexcited electron-hole pairs.Because of the synergy of photocatalytic effect,photothermal effect and the released Zn ions,the synthesized ZnDMZ possessed a highly effective antibacterial efficacy of 99.9%against Staphylococcus aureus under 660 nm light irradiation for 20 min without cytotoxicity.In vivo tests showed that this nanohybrid material promoted the wound healing due to the released Zn ions.This nanohybrid will be promising for rapid and portable treatment of bacteria-infected open wounds in pathogenic bacteria contaminated environments. | Chaofeng Wang Yue Luo Xiangmei Liu Zhenduo Cui Yufeng Zheng Yanqin Liang Zhaoyang Li Shengli Zhu Jie Lei Xiaobo Feng Shuilin Wu | 2022 | Bioactive Materials2022，7，7： | 3 |
| 2 | 瘢痕组织切除术联合中厚皮肤移植术治疗深度烧伤的效果显示文摘目的:探讨瘢痕组织切除术联合中厚皮肤移植术治疗深度烧伤的效果。方法:选取2018年1月-2021年1月广州市第一人民医院收治的72例深度烧伤患者。根据随机数字表法将其分为观察组与对照组,每组36例。对照组进行常规瘢痕切除治疗,观察组进行瘢痕组织切除术联合中厚皮肤移植术治疗。比较两组术前、术后3个月瘢痕程度,术前、术后7 d炎症因子,术前、术后10 d生长因子。结果:术后3个月,观察组厚度、柔软度、色泽、血管分布评分均明显低于对照组(P<0.05)。术后7 d,观察组白介素-6(IL-6)水平明显低于对照组(P<0.05),白介素-2(IL-2)、干扰素-γ(IFN-γ)水平均明显高于对照组(P<0.05)。术后10 d,观察组血管内皮生长因子(VEGF)、表皮细胞生长因子(EGF)、转化生长因子-β_(1)(TGF-β_(1))水平均明显高于对照组(P<0.05)。结论:瘢痕组织切除术联合中厚皮肤移植术应用于深度烧伤患者治疗中能够对瘢痕程度进行有效缓解,改善炎症因子水平,促进生长因子水平的提高。 | 刘忠考 荣新州 李庆辉 | 2022 | 中外医学研究2022，20，18： | 1 |
| 3 | 梯度空心玻璃微珠诱导的分形自泵水凝胶的制备及其快速吸水性能研究显示文摘通过在水凝胶体系内引入梯度排布的空心玻璃微珠(hollow glass microsphere,HGM),制备了一种具有超高导水效率的分形自泵(fractal self-pumping,FS)水凝胶。在所制备的分形自泵空心玻璃微珠水凝胶(FS-HGM hydrogel)中,水凝胶骨架通过硅烷偶联剂将相邻空心玻璃微珠紧密结合固定,在玻璃微球间形成了逐级变小的亲水分形毛细微通道。结果表明,独特的分形毛细微通道极大地提高了水凝胶的导水性能,在动态接触角实验中表现出超过传统水凝胶约240倍的吸水速率,并且吸水效率随着FS-HGM水凝胶层的增厚有所提升。所制备的快速吸水分形凝胶通过高效移除过量渗出液,加速烫伤伤口愈合,为临床应用中输运生物流体开辟了新途径。 | 兰晋泽 时连鑫 肖五一 张晓斌 王雨哲 王树涛 | 2024 | 现代化工2024，44，1： | 0 |
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