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| 1 | Whisker of biphasic calcium phosphate ceramics: Osteoimmunomodulatory behaviors显示文摘Immune systems play a critical role in the regulation of bone formation and homeostasis,which arouses a growing interest in the development of biomaterials that can modulate both immune response and osteogenesis.In this study,biphasic calcium phosphate(BCP)ceramics were modified with different whiskered surface,and their effects on macrophage polarization and functional status were investigated.The results showed that compared to BCP-W ceramics with long and solid whiskers,BCPHW ceramics with short and hollow whiskers surface were conducive to protein adsorption and macrophage elongation.Furthermore,BCP-HW ceramics down-regulated the expression of M1 macrophage markers(Il1β,Tnfα,and iNos),promoted the expression of M2 macrophage markers(Il10 and Arg)and growth factors(Tgfβ1 and Bmp2),which might be attributed to the differential integrin expression regulated by different whisker structures.The conditioned medium derived from the supernatant of macrophage/whiskered ceramic co-culture was further used to culture MC3T3-E1 pre-osteoblasts to evaluate the effects of whiskered ceramic-mediated macrophage secretion on osteogenesis in vitro.Compared with BCP-W ones,the secretion pattern induced by BCP-HW ceramics could promote the expression of bone markers in pre-osteoblasts,which might due to the activation of intracellular signaling cascades like BMP/Smad and TGF-β/Smad signaling pathways.A murine intramuscular implantation model suggested that after implantation for 1,2,and 3 weeks,BCP-HW ceramics drove the switch of macrophages to ARG+wound-healing M2 phenotype,while BCP-W ceramics increased the proportion of iNOS+M1 inflammatory macrophages.At 2 months,only BCP-HW could induce ectopic bone formation.Taken together,these results indicated that BCP ceramics with hollow whiskers were capable of creating a proper inflammatory microenvironment to induce bone formation.These whiskered BCP ceramics with good osteo-immunomodulatory capacity hold promise in serving as bone grafts to achieve desired bone repair and regeneration. | Jinjie Wu Cong Feng Menglu Wang Hongfeng Wu Xiangdong Zhu Xiangfeng Li Xuening Chen Xingdong Zhang | 2022 | Nano Research2022，15，10： | 0 |
| 2 | 医用生物陶瓷的功能性生物适配机制及应用显示文摘为了获得满意的临床疗效,优质医用生物陶瓷应该具备怎样的性能一直困扰着广大研究者。自20世纪90年代以来,作者团队致力于研发医用生物陶瓷,从基础科学研究到成果转化,再到临床应用,积累了丰富的研究和应用经验,相继提出了“生物适配”和“精准生物适配”理论。本文围绕“医用生物陶瓷(磷酸钙类材料)的功能性生物适配”这一主题分享本团队的学术研究成果和临床应用经验,从结构适配、降解适配、力学适配、应用适配等四个角度,结合骨科临床应用背景,探讨如何实现其生物适配和设计制造的有效衔接,旨在为医用生物陶瓷的设计、制造、监管和应用提供依据和建议。 | 郑嘉乾 卢霄 鲁亚杰 王迎军 王臻 卢建熙 | 2024 | 无机材料学报2024，39，1： | 0 |
| 3 | 双相磷酸钙构建仿生骨的研究进展显示文摘当先天或后天因素造成的骨缺损超出自愈范围时,需通过植骨填充缺损以促进骨修复。目前临床应用的骨修复材料包括自体骨、同种异体骨及各类人工材料,这些材料各有利弊。其中,双相磷酸钙(BCP)因其与天然骨的无机矿化相组成相似,具有较好的生物相容性和生物活性等优点,成为极具前景的骨组织修复材料。许多研究已证明BCP作为仿生骨的潜力。本文将结合近几年关于BCP的研究做一综述总结分析,为临床应用提供一种新思路。 | 岳莹 文小林 顾靖钏 李全 古浩 张爱国 | 2023 | 中华生物医学工程杂志2023，29，5： | 0 |
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