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| 1 | 纳米制剂联合微针透皮给药研究进展显示文摘近年来,微针技术因其独特的打开角质层屏障机制被广泛用于经皮给药研究中。纳米技术因其卓越的溶解度高、药物稳定性高、靶向释药及缓控释等性能,在经皮给药领域也受到了广泛的关注。然而,研究者发现上述2种技术也存在明显的缺陷,如微针技术无法提高难溶性药物的溶解度,而纳米制剂的角质层穿透能力较差,从而限制了这2种技术在透皮给药领域的应用价值。目前已有部分学者尝试将纳米制剂与微针联合应用以改善药物理化性质,并实现药物的靶向递送药物、控制药物释放,以此协同增强药物经皮递送效果,促进药物高效应用。因此,本文将简介部分微针及纳米制剂的透皮优势与不足,并总结纳米制剂联合微针的优势、应用及展望。 | 李昊城 卢志扬 淦甜甜 简雯杰 奉建芳 金一 涂亮星 | 2023 | 中国新药杂志2023，32，11： | 1 |
| 2 | Rapidly separable bubble microneedle patch for effective local anesthesia显示文摘In cutaneous cosmetology surgery,local injection or coated anesthetics are generally used to provide analgesia at the treatment site to achieve painless operation.Due to the barrier of corneum,topical cream may cause uncertain dosage and delayed analgesia.Local injection has problems such as pain,infection,and misoperation.Therefore,it is necessary to develop a painless and rapid administration method for local anesthesia.Here,a lidocaine/hyaluronic acid bubble microneedle patch(Lido/HA bMNP)was prepared for rapid drug delivery and efficient analgesia.The bubble structure between microneedles(MNs)and the backing layer allowed the MNs to efficiently penetrate into the skin and remove from the backing layer under shear force to rapidly complete the administration.Drugs were quickly released with the dissolution of HA within 15 s,which immediately played an analgesic effect and lasted for 1 h.Lido/HA bMNP could deliver precise doses to the skin in an extremely short time,which had the advantages of convenient operation,high biosafety,rapid onset of analgesia,and reasonable pain relief time.This patch provided an alternative way for local anesthesia and it was a promising transdermal drug delivery method for the realization of high quality and efficiency“painless medical beauty”. | Yuan Yang Huaqing Chu Yan Zhang Lingling Xu Ruizeng Luo Hui Zheng Tailang Yin Zhou Li | 2022 | Nano Research2022，15，9： | 1 |
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