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1Synthesis of L-Hexopyranosyl Fluorides Enabled by Radical Decarboxylative Fluorination: Assembly of a Pentasaccharide Repeating Unit Corresponding to Extracellular Polysaccharide S-88显示文摘L-Hexoses are key components of many biologically relevant natural products and pharmaceuticals.As rare sugars,L-hexoses are not readily obtained from natural sources.Access to L-hexose building blocks from commercially available and inexpensive D-sugars is highly desirable from the viewpoints of organic synthesis and drug discovery.As demonstrated by the convenient preparation of L-glucosyl,L-galactosyl,and L-mannosyl fluorides from readily availableβ-D-C-glucosyl,β-D-C-mannosyl,andβ-D-C-galactosyl derivatives,we describe a novel and efficient approach to the demanding L-glycosyl fluorides.Zhi Qiao Dongwei Li Jingru Gao Zijao Hou Ningjie Yan Ni Song Peng Wang Ming Li 2023Chinese Journal of Chemistry2023,41,22:0
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