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| 1 | Identification of EGFR kinase domain mutations among lung cancer patients in China:implication for targeted cancer therapy显示文摘Lung cancer is one of the leading causes of death with one of the lowest survival rates. However, a subset of lung cancer patients who are of Asian origin and carry somatic mutations in epidermal growth factor receptor or EGFR have responded remarkable well to two tyrosine kinase inhibitors, gefitinib and erlotinib. While EGFR mutation profiles have been reported from Japan, South Korea, and Taiwan, there is no such report from mainland of China where the largest pool of patients reside. In this report, we identified ten somatic mutations from a total of 41 lung cancer patients in China. Among them, seven mutations were found in 17 adenocarcinomas. In contrast to previous reports, eight of these mutations are deletions in exon 19 and two of these deletions are homozygous. These results suggest that a large portion of Chinese adenocarcinoma patients could benefit from gefitinib or erlotinib. This unique mutation profile provides a rationale to develop the next generation of EGFR inhibitors more suitable for the Chinese population. | BaoMingQIN XiaoCHEN JingDeZHU DuanQingPEI | 2005 | Cell Research2005，15，3： | 66 |
| 2 | 纳豆激酶液体发酵条件的优化显示文摘纳豆激酶是从日本传统食品纳豆中提取出来的一种具有溶血栓功能的酶.笔者从市售纳豆中分离出一株能产纳豆激酶的菌株,并对之进行液体培养,发现在pH7.0,接种量为2%,种龄24h,装液量10mL/100mL,碳源为木糖,浓度为2%,氮源为大豆蛋白胨,浓度为3%的条件下,接种后第四天为产酶高峰期,最高产酶量可达到787.1尿激酶单位/mL发酵液. | 谢秋玲 郭勇 | 1999 | 华南理工大学学报(自然科学版)1999，27，5： | 61 |
| 3 | Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death显示文摘混合的系 kinase 像域的蛋白质(MLKL ) 被识别受体交往下游地工作蛋白质 3 (RIP3 ) 在肿瘤坏死 factor-α(TNF ) 导致了坏死(也叫的 necroptosis ) 。然而, MLKL 怎么工作调停 necroptosis 是未知的。由在 MLKL 大美人房间的 MLKL 功能的宪法,我们证明 MLKL 的 N 终点在 necroptosis 为它的功能被要求。在对待 TNF 的房间的 MLKL 的 oligomerization 为 necroptosis 是必要的,当人工地由使用荷尔蒙绑定领域一起强迫 MLKL (HBD*) 扳机 necroptosis。尤其是,一起强迫 N 终端领域(ND ) 然而并非 MLKL 的 C 终端 kinase 领域引起 necroptosis。进一步的删除分析证明 four-α MLKL (1-130 氨基酸) 的螺旋捆是足够的触发 necroptosis。两 HBD*调停并且 MLKL (ND ) 或 MLKL 的导致 TNF 的建筑群是到血浆膜的类脂化合物椽子的这些建筑群的 tetramers,和 translocation 先于房间死亡。homo-oligomerization 为 MLKL translocation 被要求,为血浆膜地点的信号顺序位于第一和第二 α 的连接; MLKL 的 -helices。MLKL 或 MLKL (ND ) 的血浆膜 translocation 导致钠流入,并且从房间文化媒介的钠的弄空禁止 necroptosis。上述所有现象没在 apoptosis 被看见。因此, MLKL oligomerization 导致 MLKL 的 translocation 到血浆膜,和血浆膜的类脂化合物椽子由自己或经由到增加的另外的蛋白质的 MLKL 复杂行为任何一个钠流入,增加渗透的压力,最后导致膜破裂。 | Xin Chen Wenjuan Li Junming Ren Deli Huang Wan-ting He Yunlong Song Chao Yang Wanyun Li Xinru Zheng PengdaChen Jiahuai Han | 2014 | Cell Research2014，24，1： | 67 |
| 4 | ERK信号通路的信号转导调控机制显示文摘胞外信号调控激酶(ERK)是发现的第1个丝裂原活化蛋白激酶(MAPK),它调控多种重要的细胞生物学过程,包括细胞增殖、分化和凋亡等。ERK信号级联反应能够特异地介导广泛的生物学过程,其机制主要是通过信号的反馈调控,与支架蛋白的相互作用,亚细胞定位的改变,在级联反应的每一个环节存在不同功能的多种组分,细胞内非磷酸酶抑制物和G蛋白等的调控实现的。 | 赵明哲 刘靖华 李玉花 姜勇 | 2009 | 国际病理科学与临床杂志2009，29，1： | 50 |
| 5 | 靛玉红对肿瘤细胞抑制作用的研究及相关机制探讨显示文摘[目的]探讨靛玉红对与细胞周期依赖性蛋白激酶(CDK)、Src激酶有关的人类肿瘤细胞生长的抑制作用。[方法]用细胞集落培养方法验证靛玉红对的人白血病细胞株K562、人胃癌细胞株、人淋巴瘤细胞株、人宫颈癌细胞株Heal、人早幼粒白血病细胞株HL-60、人胆囊癌、肝癌、肝门胆管癌细胞株的影响。用四甲基偶氮唑盐(MTT)方法观测靛玉红对K562、胆囊癌、肝门胆管癌细胞株的影响。[结果]靛玉红对这几种肿瘤存在广泛的抑制作用。[结论]靛玉红及其衍生物可能成为有CDK、Src激酶参与的肿瘤的新一代抗肿瘤药物。 | 吴琦玮 葛忠良 高月 张丽 | 2008 | 天津中医药2008，25，1： | 32 |
| 6 | 硒酶及硒化合物生理功能研究的新进展显示文摘硒是动物必需的微量元素 ,硒半胱氨酸是硒蛋白的组份并构成硒酶的活性中心 ,硒蛋白特别是硒酶是硒的主要功能形式。研究发现 ,硒半胱氨酸是参入到蛋白质分子中的第 2 1种氨基酸 ,硒是唯一受基因调控的微量元素。最新研究表明 ,硒及其化合物还具有阻断某些炎症介质的生理活性、抑制蛋白激酶C、激活促分裂原活化蛋白激酶和S6核糖体蛋白激酶、免疫调节及与其它元素和维生素相互作用等多种生理功能 。 | 黄峙 向军俭 郭宝江 | 2001 | 生理科学进展2001，32，4： | 28 |
| 7 | 怀槐的化学成分研究Ⅰ显示文摘怀槐心材有明显的保肝等作用 ,从其乙醇提取物的乙醚萃取部分分得 6个异黄酮类成分 ,经理化性质和光谱分析鉴定为染料木素 (genistein ,Ⅰ )、芒柄花黄素 (formononetin ,Ⅱ )、alfalone(Ⅲ )、雷杜辛 (re tusin ,Ⅳ )、大豆甙元 (daidzein ,Ⅴ )、阿夫罗摩辛 (afrornosin ,Ⅵ ) ,其中化合物Ⅲ和Ⅵ为首次从该植物中分得。 | 黄文哲 段金廒 李正亮 | 2000 | 中国药科大学学报2000，31，1： | 26 |
| 8 | Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line显示文摘曙光 A kinase, serine/threonine 蛋白质 kinase,是潜在的 oncogene。扩大并且在人的肿瘤的几种类型在曙光 A 的表示上被发现了,包括的食道的有鳞的房间癌(ESCC ) 。在表示曙光 A 上的房间对导致 cisplatin 的 apoptosis 更抵抗,这被表明了。然而,调停的分子的机制这些效果仍然保持大部分未知。在这份报告,我们证明在通过在人的 ESCC KYSE150 的 pEGFP-Aurora-A 的稳定的 transfection 的曙光 A 的表示上,房间显著地支持了房间增长并且禁止了 cisplatin- 或紫外导致照耀的 apoptosis。caspase-3 并且 poly 的劈开(自动数据处理核糖) 在在表示房间上的曙光 A 的聚合酶(PARP ) 实质地在 cisplatin 或紫外处理以后被减少。而且,我们发现有 siRNA 的内长的曙光 A kinase 的那 silencing 实质地提高了敏感到导致 cisplatin 或在人的 ESCC EC9706 房间的紫外导致 apoptosis。在平行,在曙光 A 的表示上 potently 起来调整了 Bcl-2 的表示。而且,由废除的 siRNA 的 Bcl-2 击倒 Aurora-A 禁止 apoptosis 上的效果。总起来说,这些数据提供证据在支持房间增长并且禁止 apoptosis 的表示上的那曙光 A,建议是的新奇机制仔细与恶意的显型和 ESCC 房间的反癌症药抵抗有关。 | Xiao Xia Wang Rong Liu Shun Qian Jin Fei Yue Fan Qi Min Zhan | 2006 | Cell Research2006，16，4： | 24 |
| 9 | 放置宫内节育器对子宫内膜血管内皮生长因子及其激酶受体表达及微血管密度变化的影响显示文摘目的 探讨放置固定式带铜宫内节育器 (FCu IUD)和含吲哚美辛FCu IUD(FICu IUD) ,对子宫内膜组织中血管内皮生长因子 (VEGF)及其激酶受体 (KDR)表达以及微血管密度(MVD)变化的影响及意义。方法 采用免疫组化法及原位杂交法 ,检测放置FCu IUD妇女 (10例 ,FCu IUD组 )及放置FICu IUD妇女 (10例 ,FICu IUD组 )放置IUD前后子宫内膜VEGF、VEGFmRNA及KDR的表达 ,并计数子宫内膜MVD。结果 FCu IUD组放置IUD后 ,VEGF及KDR蛋白为 0 5 6 8± 0 0 2 7,0 2 4 4± 0 0 2 2 ,均高于放置IUD前的 0 35 7± 0 0 32 ,0 2 15± 0 0 2 9,放置IUD前后比较 ,差异有显著性 (P <0 0 5 )。FCu IUD组放置IUD前VEGFmRNA表达为 0 35 9± 0 0 2 2 ,低于放置IUD后的 0 4 2 5± 0 0 19,放置IUD前后比较 ,差异有显著性 (P <0 0 5 )。FICu IUD组放置IUD前后VEGF、KDR蛋白及VEGFmRNA表达比较 ,差异无显著性 (P >0 0 5 )。FCu IUD组放置IUD后MVD为 19 8± 4 8,明显高于放置IUD前的 15 4± 2 8,且与VEGF蛋白的表达呈正相关关系 (r=0 84 7,P <0 0 1)。FICu IUD组放置IUD前后MVD比较 ,差异无明显性 (P >0 0 5 )。结论 放置FCu IUD可促进子宫内膜VEGF及KDR的表达 ,FICu IUD可抑制子宫内膜VEGF及KDR的生成。VEGF及KDR可? | 辛志敏 谢青贞 曹路敏 孙莹璞 苏迎春 郭艺红 | 2004 | 中华妇产科杂志2004，39，11： | 21 |
| 10 | 乙烯的生物合成与信号传递显示文摘乙烯是气体植物激素,它在植物的生长发育过程中有很多作用。所以了解乙烯的生物合成及其信号转导是非常重要的。二十年来,通过筛选有异于正常三重反应的突变体,人们发现了乙烯信号转导的粗略轮廓。在拟南芥中,有5个受体蛋白感受乙烯,ETR1、ERS1、ETR2、ERS2、EIN4。它们表现出功能冗余,是乙烯信号的负调控因子,在植物体内以二聚体的形式存在。ETR1的N端与乙烯结合时需要铜离子(Ⅰ)的参与。尽管已经发现ETR1有组氨酸激酶活性,而其它受体有丝氨酸/苏氨酸激酶活性,但受体参与乙烯信号转导的机制还不是很清楚。受体与Raf类蛋白激酶CTR1相互作用,CTR1是乙烯反应的负调控因子。CTR1蛋白失活使EIN2蛋白活化。EIN2的N端是跨膜结构域,与Nramp家族金属离子转运蛋白的跨膜结构域类似。EIN2的C端是一个新的未知结构域,与乙烯信号途径的下游组分相互作用。EIN3位于EIN2的下游,EIN3和EILs诱导ERF1和其它转录因子的表达,这些转录因子依次激活乙烯反应目的基因的表达,表现出乙烯的反应。EIN3受到蛋白酶体介导的蛋白降解途径的调节。由于乙烯是一种多功能的植物激素,其信号途径与其它信号途径有多重的交叉。 | 陈涛 张劲松 | 2006 | 植物学通报2006，23，5： | 20 |
| 11 | Function and regulation of Aurora/Ipllp kinase family in cell division显示文摘During mitosis,the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation,a complex movements orchestrated by mitotic kinases and its effector proteins.Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell.Defects in these processes can lead to aneuploidy or polyploidy.Aurora/Ipllp family, a class of conserved serine/threonine kinases,plays key roles in chromosome segregation and cytokinesis.This article highlights the function and regulation of Aurora/Ipllp family in mitosis and provides potential links between aberrant regulation of Aurora/Ipllp kinases and pathogenesis of human cancer. | YUWENKE ZHENDOU JIEZHANG XUEBIAOYAO | 2003 | Cell Research2003，13，2： | 20 |
| 12 | Alterations in the human epidermal growth factor receptor 2-phosphatidylinositol 3-kinase-v-Akt pathway in gastric cancer显示文摘AIM:To investigate human epidermal growth factor receptor 2(HER2)-phosphatidylinositol 3-kinase(PI3K)-vAkt murine thymoma viral oncogene homolog signaling pathway.METHODS:We analyzed 231 formalin-fixed,paraffinembedded gastric cancer tissue specimens from Japanese patients who had undergone surgical treatment.The patients' age,sex,tumor location,depth of invasion,pathological type,lymph node metastasis,and pathological stage were determined by a review of the medical records.Expression of HER2 was analyzed by immunohistochemistry(IHC) using the HercepTest TM kit.Standard criteria for HER2 positivity(0,1+,2+,and 3+) were used.Tumors that scored 3+ were considered HER2-positive.Expression of phospho Akt(pAkt) was also analyzed by IHC.Tumors were considered pAkt-positive when the percentage of positive tumor cells was 10% or more.PI3K,catalytic,alpha polypeptide(PIK3CA) mutations in exons 1,9 and 20 were analyzed by pyrosequencing.Epstein-Barr virus(EBV) infection was analyzed by in situ hybridization targeting EBV-encoded small RNA(EBER) with an EBER-RNA probe.Microsatellite instability(MSI) was analyzed by polymerase chain reaction using the mononucleotide markers BAT25 and BAT26.RESULTS:HER2 expression levels of 0,1+,2+ and 3+ were found in 167(72%),32(14%),12(5%) and 20(8.7%) samples,respectively.HER2 overexpression(IHC 3+) significantly correlated with intestinal histological type(15/20 vs 98 /205,P = 0.05).PIK3CA mutations were present in 20 cases(8.7%) and significantly correlated with MSI(10/20 vs 9/211,P < 0.01).The mutation frequency was high(21%) in T4 cancers and very low(6%) in T2 cancers.Mutations in exons 1,9 and 20 were detected in 5(2%),9(4%) and 7(3%) cases,respectively.Two new types of PIK3CA mutation,R88Q and R108H,were found in exon1.All PIK3CA mutations were heterozygous missense singlebase substitutions,the most common being H1047R(6/20,30%) in exon20.Eighteen cancers(8%) were EBV-positive and this positivity significantly correlated with a diffuse histological type(13/18 vs 93/198,P = 0.04).There were 7 cases of lymphoepithelioma-like carcinomas(LELC) and 6 of those cases were EBV-positive(percent/EBV:6/18,33%;percent/all LELC:6/7,86%).pAkt expression was positive in 119(53%) cases but showed no correlation with clinicopathological characteristics.pAkt expression was significantly correlated with HER2 overexpression(16/20 vs 103/211,P < 0.01) but not with PIK3CA mutations(12/20 vs 107/211,P = 0.37) or EBV infection(8/18 vs 103/211,P = 0.69).The frequency of pAkt expression was higher in cancers with exon20 mutations(100%) than in those with exon1(40%) or exon9(56%) mutations.One case showed both HER2 overexpression and EBV infection and 3 cases showed both PIK3CA mutations and EBV infection.However,no cases showed both PIK3CA mutations and HER2 overexpression.One EBVpositive cancer with PIK3CA mutation(H1047R) was MSI-positive.Three of these 4 cases were positive for pAkt expression.In survival analysis,pAkt expression significantly correlated with a poor prognosis(hazard ratio 1.75;95%CI:1.12-2.80,P = 0.02).CONCLUSION:HER2 expression,PIK3CA mutations and EBV infection in gastric cancer were characterized.pAkt expression significantly correlates with HER2 expression and with a poor prognosis. | Yasutaka Sukawa Hiroyuki Yamamoto Katsuhiko Nosho Hiroaki Kunimoto Hiromu Suzuki Yasushi Adachi Mayumi Nakazawa Takayuki Nobuoka Mariko Kawayama Masashi Mikami Takashi Matsuno Tadashi Hasegawa Koichi Hirata Kohzoh Imai Yasuhisa Shinomura | 2012 | World Journal of Gastroenterology2012，18，45： | 19 |
| 13 | ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer显示文摘 | Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu | 2015 | Cell Research2015，25，5： | 19 |
| 14 | 急重症诊治 第3讲 重症急性胰腺炎治疗要点显示文摘 | 唐承薇 | 2005 | 中国实用内科杂志2005，25，3： | 18 |
| 15 | 铁皮石斛促分裂原活化蛋白激酶基因DoMPK1的克隆及特征分析显示文摘促分裂原活化蛋白激酶(mitogen-activated protein kinase,MAPK)及其级联途径在根瘤、从枝菌根宿主植物共生体系中起重要调控作用。然而,MAPK在兰科菌根共生体系中的作用机制尚不明确。本研究利用RT-PCR、RACE方法,首次从小菇真菌(Mycena sp.)侵染的铁皮石斛根中克隆到一个促分裂原活化蛋白激酶基因,命名为DoMPK1(GenBank注册号JX297594)。DoMPK1基因cDNA全长1 632 bp,编码一条由372个氨基酸组成的肽链,分子量42.61 kD,等电点6.07。DoMPK1蛋白包含MAPK蛋白家族保守的丝氨酸/苏氨酸蛋白激酶催化结构域(39 325)和MAP激酶的保守位点(77-177)。DoMPK1与多种植物MAPK基因高度同源(71%~85%),与单子叶植物MAPK基因亲缘关系较近。DoMPK1为组成型表达,其转录本在石斛根、茎、叶和种子等4种组织中的相对表达量差异不显著。在小菇真菌侵染30天的根中,DoMPK1显著上调,为对照根中的7.91倍,表明DoMPK1可能在小菇真菌铁皮石斛菌根共生早期互作过程中起作用。本研究为进一步解析DoMPK1在小菇真菌铁皮石斛菌根共生中的分子作用奠定基础。 | 张岗 赵明明 宋超 张大为 李标 郭顺星 | 2012 | 药学学报2012，47，12： | 18 |
| 16 | 粉防己碱对鼠脑缺血的保护作用显示文摘目的:研究粉防己碱(Tet)对鼠脑缺血的保护作用。方法:采用小鼠断颅和结扎大鼠双侧颈总动脉并人工降压至6.7kPa复制急性脑缺血模型。结果:Tet(15mg·kg-1)可明显延长小鼠断颅后的喘息时间,能明显改善大鼠的脑电活动,可降低脑钙、水含量,降低脑静脉血中乳酸脱氢酶和磷酸肌酸激酶含量。结论:提示Tet对脑缺血有保护作用。 | 祝晓光 顾丽英 陈桂英 田宏 金其泉 | 1997 | 中国药理学通报1997，13，2： | 17 |
| 17 | Functional Insights of Plant GSK3-like Kinases: Multi-Taskers in Diverse Cellular Signal Transduction Pathways显示文摘当 BIN2 代表的植物象 GSK3 一样 kinases 的功能的角色首先在 brassinosteroid 被阐明时,在植物的象 GSK3 一样 kinases 的生理的重要性出现了调整 BR 的信号 transduction 小径。当早研究在理解上更集中了怎么时象 GSK3 一样 kinases 调整 BR 发信号,最近的研究含有象 BR 发信号一样涉及许多细胞的过程的象 GSK3 一样 kinases 的许多新奇底层。植物象 GSK3 一样 kinases 玩在象房间生长,根和有气孔的房间开发,花开发,木部区别,轻反应,和压力回答那样的生理、发展的进程的多样的角色。这里,我们考察在理解植物象 GSK3 一样 kinases 的万用的功能在最近的年里取得的进步。基于在象 GSK3 一样 kinases 和他们的最新识别的底层之间的关系,我们讨论各种各样的细胞的发信号的生理、生物化学的关联在植物由象 GSK3 一样 kinases 调停了。 | Ji-Hyun Youn Tae-Wuk Kim | 2015 | Molecular Plant2015，8，4： | 16 |
| 18 | Polo-like kinase 1 expression is a prognostic factor in human colon cancer显示文摘AIM: To clarify the expression patterns and prognostic implications of the mitotic regulator Polo-like kinase 1(PLK1) in colon cancer.METHODS: Expression of PLK1 was investigated by immunohistochemistry (158 cases) and immunoblotting in tissue of colon adenomas and adenocarcinomas. PLK1expression patterns were correlated with clinicopathological parameters and patient prognosis. In addition, expression of PLK1 was evaluated by immunoblot and PCR in colon carcinoma cell lines, and coexpression of PLK1 with the proliferation marker Ki-67 was investigated.RESULTS: Weak PLK1 expression was observed in normal colon mucosa and adenomas. In contrast, 66.7% of carcinomas showed strong expression of PLK1.Overexpression of PLK1 correlated positively with Dukes stage (P<0.001), tumor stage (P = 0.001) and nodal status (P<0.05). Additionally, PLK1 expression was a prognostic marker in univariate survival analysis (P<0.01) and had independent prognostic significance (RR = 3.3, P = 0.02)in patients with locoregional disease. Expression of PLK1 mRNA and protein was detected in all cell lines investigated. Coexpression of PLK1 and Ki-67 was observed in the majority of colon cancer cells, but a considerable proportion of cells showed PLK1 positivity without Ki-67expression.CONCLUSION: PLK1 is a new prognostic marker for colon carcinoma patients and may be involved in tumorigenesis and progression of colon cancer. Strategies focusing on PLK1 inhibition in vivo might therefore represent a promising new therapeutic approach for this tumor entity. | Wilko Weichert Glen Kristiansen Mathias Schmidt Volker Gekeler Aurelia Noske Silvia Niesporek Manfred Dietel Carsten Denkert | 2005 | World Journal of Gastroenterology2005，11，36： | 16 |
| 19 | Dynamic expression of extracellular signal-regulated kinase in rat liver tissue during hepatic fibrogenesis显示文摘AIM: To investigate whether extracellular signal-regu- lated kinase 1 (ERK1) is activated and associated with hepatic stellate cell (HSC) proliferation in fibrotic rat liver tissue. METHODS: Rat hepatic fibrosis was induced by bile duct ligation (BDL). Histopathological changes were eval- uated by hematoxylin and eosin staining, and Masson’ s trichrome method. ERK1 mRNA in rat liver tissue was determined by reverse transcription-polymerase chain reaction, while the distribution of ERK1 was assessed by immunohistochemistry. ERK1 protein was detected by Western blotting analysis. The number of activated HSCs was quantified after alpha smooth muscle actin (α-SMA) staining. RESULTS: With the development of hepatic fibrosis, the positive staining cells of α-SMA increased obviously, and mainly resided in the portal ducts. Fiber septa and peri- sinuses were accompanied with proliferating bile ducts. The positive staining areas of the rat livers in model groups 1-4 wk after ligation of common bile duct (12.88% ± 2.63%, 22.65% ± 2.16%, 27.45% ± 1.86%, 35.25% ± 2.34%, respectively) were significantly larger than those in the control group (5.88% ± 1.46%, P < 0.01). With the development of hepatic fibrosis, the positive cells of ERK1 increased a lot, and were mainly distributed in portal ducts, fiber septa around the bile ducts, vas- cular endothelial cells and perisinusoidal cells. Western blotting analysis displayed that the expression of ERK1 and ERK2 protein was up-regulated during the model course, and its level was the highest 4 wk after opera- tion, being 3.9-fold and 7.2-fold higher in fibrotic rat liver than in controls. ERK1 mRNA was expressed in normal rat livers as well, which was up-regulated two days af- ter BDL and reached the highest 4 wk after BDL. The expression of ERK1 was positively correlated with α-SMAexpression (r = 0.958,P < 0.05). | Xiao-Lan Zhang Jin-Ming Liu Chang-Chun Yang Yi-Lin Zheng Li Liu Zhan-Kui Wang Hui-Qing Jiang | 2006 | World Journal of Gastroenterology2006，12，39： | 16 |
| 20 | The IKK-related kinases: from innate immunity to oncogenesis显示文摘在过去的四年,天生的有免疫力的反应的地被 kinase ( IKK )联系了 kinases ,坦克有约束力的 Kinase 1 ( TBK1 )和 IKKi 的 IB 的发现高度影响了,它调整干扰素的活动规章的因素( IRF ) -3/IRF-7 和 NF-B 抄写因素。更最近,激活这些 IKK 相当或相同事物的发信号的小径的另外的必要部件被发现了。这些包括 RNA helicases RIGi 和 MDA5,和作为 CARDIF/MAVS/VISA/IPS-1 知道的下游的 mitochondrial 受动器。除了他们在控制天生的有免疫力的反应的必要功能,最近的研究在房间增长和 oncogenesis 加亮这些 kinases 的一个角色。正规 IKK 很好被认出是连接长期的发炎到癌症的一座桥。新调查结果现在建议 IKK 相关的 kinases TBK1 和 IKKi 也参予影响房间转变和肿瘤前进的发信号的小径。这评论将因此由集中于他们的规定和底层特性在细胞的转变和 oncogenesis 总结并且讨论 TBK1 和 IKKi 的角色。 | Jean-Francois Clément | 2008 | Cell Research2008，18，9： | 16 |
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