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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Mechanical mechanism of overlying strata breaking and development of fractured zone during close-distance coal seam group mining显示文摘This study mainly investigates the mechanical mechanism of overlying strata breaking and the development of fractured zones during close-distance coal seam group mining in the Gaojialiang coal mine.First,a mechanical model for the second'activation'of broken overlying strata is established,and the related mechanical'activation'conditions are obtained.A recursive formula for calculating the separation distance of overlying strata is deduced.Second,a height determining method for predicting the height of fractured zones during close-distance coal seam group mining is proposed based on two values,namely,the separation distance and ultimate subsidence value of overlying strata.This method is applied to calculate the fractured zone heights in nos.20107 and 20307 mining faces.The calculated results are almost equal to the field observation results.Third,a modified formula for calculating the height of a waterflowing fractured zone is proposed.A comparison of the calculated and observed results shows that the errors are small.The height determining method and modified formula not only build a theoretical foundation for water conservation mining at the Gaojialiang coal mine,but also provide a reference for estimating the height of water-flowing fractured zones in other coal mines with similar conditions. | Jianguo Ning Jun Wang Yunliang Tan Qiang Xu | 2020 | International Journal of Mining Science and Technology2020，30，2： | 19 |
| 3 | Hepatitis B virus reactivation in patients with hepatocellular carcinoma undergoing anti-cancer therapy显示文摘Patients with hepatocellular carcinoma(HCC)often experience hepatic morbidity.Hepatitis B virus(HBV)reactivation is well documented as a serious hepatic morbidity during anti-cancer therapy.Reported rates of HBV reactivation in chronic carriers with HCC undergoing chemotherapy range from 4%-67%.Apart from chemotherapy,HBV reactivation has been increasingly identified in settings of hepatectomy and local ablation therapies.The rates of HBV reactivation vary with different levels of immunosuppression and depend on treatment,viral factors,and patient characteristics.The principal concern relating to reactivation is that a substantial proportion of patients with reactivation suffer from liver dysfunction during therapy,which often leads to disruption of planned,potentially life-prolonging treatments,adversely affecting the patients’final outcome.The first step in the management of HBV reactivation is identification of patients at risk of reactivation by testing for HBV serology prior to commencing anticancer therapy.Although it is a serious complication,HBV reactivation is preventable with prophylactic antiHBV drugs.Multiple publications have shown the benefit of prophylactic or preemptive antiviral therapy in this setting and justified such an approach before the start of therapy.Given the tumors and underlying cirrhosis,long-term use of antivirals with high potency and low risk of resistance is recommended in patients with HCC.This topic review will summarize the epidemiology,pathogenesis,and clinical issues related to HBV reactivation in HCC patients,and will discuss proper management against HBV reactivation during anti-cancer therapy for HCC. | Jeong Won Jang | 2014 | World Journal of Gastroenterology2014，20，24： | 18 |
| 4 | Toward targeting inflammasomes: insights into their regulation and activation显示文摘Inflammasomes are multi-component signaling complexes critical to the initiation of pyroptotic cell death in response to invading pathogens and cellular damage.A number of innate immune receptors have been reported to serve as inflammasome sensors.Activation of these sensors leads to the proteolytic activation of caspase-1,a proinflammatory caspase responsible for the cleavage of proinflammatory cytokines interleukin-1β and interleukin-18 and the effector of pyroptotic cell death,gasdermin D.Though crucial to the innate immune response to infection,dysregulation of inflammasome activation can lead to the development of inflammatory diseases,neurodegeneration,and cancer.Therefore,clinical interest in the modulation of inflammasome activation is swiftly growing.As such,it is imperative to develop a mechanistic understanding of the regulation of these complexes.In this review,we divide the regulation of inflammasome activation into three parts.We discuss the transcriptional regulation of inflammasome components and related proteins,the post-translational mechanisms of inflammasome activation,and advances in the understanding of the structural basis of inflammasome activation. | Shelbi Christgen David E.Place Thirumala-Devi Kanneganti | 2020 | Cell Research2020，30，4： | 17 |
| 5 | Ubiquitination of Rheb governs growth factor-induced mTORC1 activation显示文摘Mechanistic target of rapamycin mTOR complex 1 (mTORC1)plays a key role in the integration of various environmental signals to regulate cell growth and metabolism,mTORC1 is recruited to the lysosome where it is activated by its interaction with GTP-bound Rheb GTPase.However,the regulatory mechanism of Rheb activity remains largely unknown.Here,we show that ubiquitination governs the nucleotide-bound status of Rheb.Lysosome-anchored E3 ligase RNF152 catalyzes Rheb ubiquitination and promotes its binding to the TSC complex.EGF enhances the deubiquitination of Rheb through AKT-dependent USP4 phosphorylation,leading to the release of Rheb from the TSC complex.Functionally,ubiquitination of Rheb is linked to mTORC1-mediated signaling and consequently regulates tumor growth.Thus,we propose a mechanistic model whereby Rheb-mediated mTORC1 activation is dictated by a dynamic opposing act between Rheb ubiquitination and deubiquitination that are catalyzed by RNF152 and USP4 respectively. | Lu Deng Lei Chen Linlin Zhao Yan Xu Xiaoping Peng Xinbo Wang Lin Ding Jiali Jin Hongqi Teng Yanming Wang Weijuan Pan Fei Yu Lujian Liao Li Li Xin Ge Ping Wang | 2019 | Cell Research2019，29，2： | 16 |
| 6 | Effect of activation agents on the surface chemical properties and desulphurization performance of activated carbon显示文摘Flue gas pollution is a serious environmental problem that needs to be solved for the sustainable development of China.The surface chemical properties of carbon have great influence on its desulphurization performance.A series of activated carbons (ACs) were prepared using HNO3,H2O2,NH3·H2O and steam as activation agents with the aim to introduce functional groups to carbon surface in the ACs preparation process.The ACs were physically and chemically characterized by iodine and SO2 adsorption,ultimate analysis,Boehm titration,and temperature-programmed reduction (TPR).Results showed that the iodine number and desulphurization capacity of NH3·H2O activated carbon (AC-NH3) increase with both activation time,and its desulphurization capacity also increases with the concentration of activation agent.However,HNO3 activated carbon (AC-HNO3) and H2O2 activated carbon (AC-H2O2) exhibit more complex behavior.Only their iodine numbers increase monotonously with activation time.Compared with steam activated AC (AC-H2O),the nitrogen content increases 0.232% in AC-NH3 and 0.077% in AC-HNO3.The amount of total basic site on AC-HNO3 is 0.19 mmol·g-1 higher than that on AC-H2O.H2O2 activation introduces an additional 0.08 mmol·g-1 carboxyl groups to AC surface than that introduced by steam activation.The desulphurization capacity of ACs in simulate flue gas desulphurization decreases as follows: AC-NH3 > AC-HNO3 > AC-H2O2 > AC-H2O.This sequence is in accord with the SO2 catalytic oxidation/oxidation ratio in the absence of oxygen and the oxidation property reflected by TPR.In the presence of oxygen,all adsorbed SO2 on ACs can be oxidized into SO3.The desulphurization capacity increases differently according to the activation agents;the desulphurization capacity of AC-NH3 and AC-HNO3 improves by 4.8 times,yet AC-H2O increases only by 2.62 as compared with the desulphurization of corresponding ACs in absence of oxygen. | ZHANG XiangLan,ZHANG Yan,WANG ShuangSheng,ZHANG JingJing & ZHOU Wei School of Chemical and Environmental Engineering,China University of Mining and Technology (Beijing),Beijing 100083,China | 2010 | Science China(Technological Sciences)2010，53，9： | 14 |
| 7 | A methylated-DNA-binding complex required for plant development mediates transcriptional activation of promoter methylated genes显示文摘Although the mechanism of DNA methylationmediated gene silencing is extensively studied, relatively little is known about how promoter methylated genes are protected from transcriptional silencing. SUVH1, an Arabidopsis Su(var)3-9 homolog, was previously shown to be required for the expression of a few promoter methylated genes. By chromatin immunoprecipitation combined with sequencing, we demonstrate that SUVH1 binds to methylated genomic loci targeted by RNA-directed DNA methylation. SUVH1 and its homolog SUVH3 function partially redundantly and interact with three DNAJ domain-containing homologs, SDJ1, SDJ2, and SDJ3, thus forming a complex which we named SUVH-SDJ. The SUVH-SDJ complex components are co-localized in a large number of methylated promoters and are required for the expression of a subset of promoter methylated genes. We demonstrate that the SUVHSDJ complex components have transcriptional activation activity. SUVH1 and SUVH3 function synergistically with SDJ1,SDJ2, and SDJ3 and are required for plant viability. This study reveals how the SUVH-SDJ complex protects promoter methylated genes from transcriptional silencing and suggests that the transcriptional activation of promoter methylated genes mediated by the SUVH-SDJ complex may play a critical role in plant growth and development. | Qiang-Qiang Zhao Rong-Nan Lin Lin Li She Chen Xin-Jian He | 2019 | Journal of Integrative Plant Biology2019，61，2： | 14 |
| 8 | Rapid mitogen-activated protein kinase activation by transforming growth factor α in wounded rat intestinal epithelial cells显示文摘RapidmitogenactivatedproteinkinaseactivationbytransforminggrowthfactorαinwoundedratintestinalepithelialcelsMichaelGkee,Michi... | Michael Gke, Michiyuki Kanai, Kathryn Lynch Devaney, and Daniel K. Podolsky Gastrointestinal Unit, Department of Medicine, and Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston, Massa | 1998 | World Journal of Gastroenterology1998，4，3： | 14 |
| 9 | The WRKY transcription factor HpWRKY44 regulates CytP450-like1 expression in red pitaya fruit(Hylocereus polyrhizus)显示文摘Red pitaya(Hylocereus polyrhizus)fruit is a high-value,functional food,containing a high level of betalains.Several genes potentially related to betalain biosynthesis,such as cytochrome P450-like(CytP450-like),have been identified in pitaya fruit,while their transcriptional regulation remains unclear.In this work,the potential involvement of a WRKY transcription factor,HpWRKY44,in regulating CytP450-like1 expression in pitaya fruit was examined.HpWRKY44,a member of the Group 1 WRKY family,contains two conserved WRKY motifs and is localized in the nucleus.HpWRKY44 also exhibits trans-activation ability.Gene expression analysis showed that the expression of HpCytP450-like1 and HpWRKY44 increased steadily during pitaya fruit coloration,which corresponded with the production of elevated betalain levels in the fruit.HpWRKY44 was also demonstrated to directly bind to and activate the HpCytP450-like1 promoter via the recognition of the W-box element present in the promoter.Collectively,our findings indicate that HpWRKY44 transcriptionally activates HpCytP450-like1,which perhaps,at least in part,contributes to betalain biosynthesis in pitaya fruit.The information provided in the current study provides novel insights into the regulatory network associated with betalain biosynthesis during pitaya fruit coloration. | Mei-nv Cheng Zi-juan Huang Qing-zhu Hua Wei Shan Jian-fei Kuang Wang-jin Lu Yong-hua Qin Jian-ye Chen | 2017 | Horticulture Research2017，4，1： | 13 |
| 10 | TREM-1 multimerization is essential for its activation on monocytes and neutrophils显示文摘The triggering receptor expressed on myeloid cells-1(TREM-1)is a receptor expressed on innate immune cells.By promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptors(TLRs),TREM-1 has been characterized as a major player in the pathophysiology of acute and chronic inflammatory diseases,such as septic shock,myocardial infarction,atherosclerosis,and inflammatory bowel diseases.However,the molecular events leading to the activation of TREM-1 in innate immune cells remain unknown.Here,we show that TREM-1 is activated by multimerization and that the levels of intracellular Ca 2+release,reactive oxygen species,and cytokine production correlate with the degree of TREM-1 aggregation.TREM-1 activation on primary human monocytes by LPS required a two-step process consisting of upregulation followed by clustering of TREM-1 at the cell surface,in contrast to primary human neutrophils,where LPS induced a rapid cell membrane reorganization of TREM-1,which confirmed that TREM-1 is regulated differently in primary human neutrophils and monocytes.In addition,we show that the ectodomain of TREM-1 is able to homooligomerize in a concentration-dependent manner,which suggests that the clustering of TREM-1 on the membrane promotes its oligomerization.We further show that the adapter protein DAP12 stabilizes TREM-1 surface expression and multimerization.TREM-1 multimerization at the cell surface is also mediated by its endogenous ligand,a conclusion supported by the ability of the TREM-1 inhibitor LR12 to limit TREM-1 multimerization.These results provide evidence for ligand-induced,receptor-mediated dimerization of TREM-1.Collectively,our findings uncover the mechanisms necessary for TREM-1 activation in monocytes and neutrophils. | Kevin Carrasco Amir Boufenzer Lucie Jolly Helene Le Cordier Guanbo Wang Albert JR Heck Adelheid Cerwenka Emilie Vinolo Alexis Nazabal Alexandre Kriznik Pierre Launay Sebastien Gibot Marc Derive | 2019 | Cellular & Molecular Immunology2019，16，5： | 13 |
| 11 | Kinetics of indium dissolution from marmatite with high indium content in pressure acid leaching显示文摘The kinetics of oxygen pressure acid leaching marmatite with high indium content was studied. The effects of particle size, agitation rate, temperature, H_2SO_4 concentration, and oxygen partial pressure on leaching rate of indium were investigated. The results show that when the agitation rate is above 600 r-min^(-1), its influence on indium leaching rate is insignificant. It is determined that the leaching rates increase with the increase in sulfuric acid concentration, temperature, partial oxygen pressure, and the decrease in particle size. Moreover, the results demonstrate that the process of indium leaching is controlled by interface chemical reaction, with apparent activation energy of 65.7 k J-mol^(-1). The apparent reaction orders of sulfuric acid and oxygen partial pressure are determined to be 0.749 and 1.260, respectively. The leaching reaction process follows shrinking unreacted core model. And finally, the kinetics model equation is established for indium. | Lei Tian Yan Liu Ting-An Zhang Guo-Zhi Lv Shuang Zhou Guo-Quan Zhang | 2017 | Rare Metals2017，36，1： | 11 |
| 12 | Plant immune signaling: Advancing on two frontiers显示文摘Plants have evolved multiple defense strategies to cope with pathogens, among which plant immune signaling that relies on cell-surface localized and intracellular receptors takes fundamental roles. Exciting breakthroughs were made recently on the signaling mechanisms of pattern recognition receptors(PRRs) and intracellular nucleotide-binding site(NBS) and leucine-rich repeat(LRR)domain receptors(NLRs). This review summarizes the current view of PRRs activation, emphasizing the most recent discoveries about PRRs’ dynamic regulation and signaling mechanisms directly leading to downstream molecular events including mitogen-activated protein kinase(MAPK) activation and calcium(Ca2+) burst. Plants also have evolved intracellular NLRs to perceive the presence of specific pathogen effectors and trigger more robust immune responses. We also discuss the current understanding of the mechanisms of NLR activation, which has been greatly advanced by recent breakthroughs including structures of the first full-length plant NLR complex, findings of NLR sensor-helper pairs and novel biochemical activity of Toll/interleukin-1 receptor(TIR) domain. | Wei Wang Baomin Feng Jian-Min Zhou Dingzhong Tang | 2020 | Journal of Integrative Plant Biology2020，62，1： | 11 |
| 13 | Carbon materials from melamine sponges for supercapacitors and lithium battery electrode materials: A review显示文摘With the increasing energy demand together with the deteriorating environment and decreasing fossil fuel resources,the development of highly efficient energy conversion and storage devices is one of the key challenges of both fundamental and applied research in energy technology.Melamine sponges(MS)with low density,high nitrogen content,and high porosity have been used to design and obtain three‐dimensional porous carbon electrode materials.More importantly,they are inexpensive,environment‐friendly,and easy to synthesize.There have been many reports on the modification of carbonized MS and MS‐based composites for supercapacitor and lithium battery electrode materials.In this paper,recent studies on the fabrication of electrode materials using MS as raw materials have been mainly reviewed,including carbonation,doping activation,and composite modification of MS,and expectations for the development of porous carbon materials for energy storage as a reference with excellent performance,environment‐friendliness,and long life. | Yanying Shi Guijing Liu Rencheng Jin Hui Xu Qingyao Wang Shanmin Gao | 2019 | Carbon Energy2019，1，2： | 11 |
| 14 | Synergistic effect between ceria and tungsten oxide on WO_3-CeO_2-TiO_2 catalysts for NH_3-SCR reaction | Lei Chen Duan Weng Zhichun Si Xiaodong Wu | 2012 | Progress in Natural Science:Materials International2012，22，4： | 11 |
| 15 | Treg/Th17 cell balance and phytohaemagglutinin activation of T lymphocytes in peripheral blood of systemic sclerosis patients显示文摘AIM To investigate T-cell activation, the percentage of peripheral T regulatory cells(Tregs), Th17 cells and the circulating cytokine profile in systemic sclerosis(SSc).METHODS We enrolled a total of 24 SSc patients and 16 healthy controls in the study and divided the patients as having diffuse cutaneous SSc(dc SSc, n = 13) or limited cutaneous SSc(lc SSc, n = 11). We performed a further subdivision of the patients regarding the stage of the disease-early, intermediate or late. Peripheral venous blood samples were collected from all subjects. We performed flow cytometric analysis of the activationcapacity of T-lymphocytes upon stimulation with PHA-M and of the percentage of peripheral Tregs and Th17 cells in both patients and healthy controls. We used ELISA to quantitate serum levels of human interleukin(IL)-6, IL-10, tissue growth factor-β1(TGF-β1), and IL-17 A.RESULTS We identified a decreased percentage of CD3+CD69+ cells in PHA-stimulated samples from SSc patients in comparison with healthy controls(13.35% ± 2.90% vs 37.03% ± 2.33%, P < 0.001). However, we did not establish a correlation between the down-regulated CD3+CD69+ cells and the clinical subset, nor regarding the stage of the disease. The activated CD4+CD25+ peripheral lymphocytes were represented in decreased percentage in patients when compared to controls(6.30% ± 0.68% vs 9.36% ± 1.08%, P = 0.016). Regarding the forms of the disease, dc SSc patients demonstrated lower frequency of CD4+CD25+ T cells against healthy subjects(5.95% ± 0.89% vs 9.36% ± 1.08%, P = 0.025). With regard to Th17 cells, our patients demonstrated increased percentage in comparison with controls(18.13% ± 1.55% vs 13.73% ± 1.21%, P = 0.031). We detected up-regulated Th17 cells within the lc SSc subset against controls(20.46% ± 2.41% vs 13.73% ± 1.21%, P = 0.025), nevertheless no difference was found between dc SSc and lc SSc patients. Flow cytometric analysis revealed an increased percentage of CD4+CD25-Foxp3+ in dc SSc patients compared to controls(10.94% ± 1.65% vs 6.88% ± 0.91, P = 0.032). Regarding the peripheral cytokine profile, we detected raised levels of IL-6 [2.10(1.05-4.60) pg/m L vs 0.00 pg/m L, P < 0.001], TGF-β1(19.94 ± 3.35 ng/m L vs 10.03 ± 2.25 ng/m L, P = 0.02), IL-10(2.83 ± 0.44 pg/m L vs 0.68 ± 0.51 pg/m L, P = 0.008), and IL-17 A [6.30(2.50-15.60) pg/m L vs 0(0.00-0.05) pg/m L, P < 0.001] in patients when compared to healthy controls. Furthermore, we found increased circulating IL-10, TGF-β, IL-6 and IL-17 A in the lc SSc subset vs control subjects, as it follows: IL-10(3.32 ± 0.59 pg/m L vs 0.68 ± 0.51 pg/m L, P = 0.003), TGF-β1(22.82 ± 4.99 ng/m L vs 10.03 ± 2.25 ng/m L, P = 0.031), IL-6 [2.08(1.51-4.69) pg/m L vs 0.00 pg/m L, P < 0.001], and IL-17 A [14.50(8.55-41.65) pg/m L vs 0.00(0.00-0.05) pg/m L, P < 0.001]. Furthermore, circulating IL-17 A was higher in lc SSc as opposed to dc SSc subset(31.99 ± 13.29 pg/m L vs 7.14 ± 3.01 pg/m L, P = 0.008). Within the dc SSc subset, raised levels of IL-17 A and IL-6 were detected vs healthy controls: IL-17 A [2.60(0.45-9.80) pg/m L vs 0.00(0.00-0.05) pg/m L, P < 0.001], IL-6 [2.80(1.03-7.23) pg/m L vs 0.00 pg/m L, P < 0.001]. Regarding the stages of the disease, TGF-β1 serum levels were increased in early stage against late stage, independently from the SSc phenotype(30.03 ± 4.59 ng/m L vs 13.08 ± 4.50 ng/m L, P = 0.017).CONCLUSION It is likely that the altered percentage of Th17 and CD4+CD25-Fox P3+ cells along with the peripheral cytokine profile in patients with SSc may play a key role in the pathogenesis of the disease. | Ekaterina Krasimirova Tsvetelina Velikova Ekaterina Ivanova-Todorova Kalina Tumangelova-Yuzeir Desislava Kalinova Vladimira Boyadzhieva Nikolay Stoilov Tsvetelina Yoneva Rasho Rashkov Dobroslav Kyurkchiev | 2017 | World Journal of Experimental Medicine2017，7，3： | 10 |
| 16 | Microglial activation after ischaemic stroke显示文摘Ischaemic stroke can induce rapid activation of microglia.As the resident immune cells of the central nervous system,microglial activation is believed to play a central role in neuroinflammation and pathological progression of ischaemic tissue.The activation of microglia after ischaemia involves several stereotypical events including morphological transformation,proliferation and polarisation.Studies using confocal or two-photon imaging techniques have revealed that the degree of microglial activation is correlated with the degree of ischaemia.Activated microglia display diverse polarisation phenotypes.It remains largely unclear regarding whether activated microglia are beneficial or detrimental to poststroke recovery.This mini-review focuses on the morphological and functional aspects of microglial activation,with particular attention to progress in two-photon imaging studies. | Shengxiang Zhang | 2019 | Stroke & Vascular Neurology2019，4，2： | 10 |
| 17 | Molecular mechanisms of triggering,amplifying and targeting RANK signaling in osteoclasts显示文摘Osteoclast differentiation depends on receptor activator of nuclear factor-κB(RANK) signaling,which can be divided into triggering,amplifying and targeting phases based on how active the master regulator nuclear factor of activated T-cells cytoplasmic 1(NFATc1) is. The triggering phase is characterized by immediateearly RANK signaling induced by RANK ligand(RANKL) stimulation mediated by three adaptor proteins,tumor necrosis factor receptor-associated factor 6,Grb-2-associated binder-2 and phospholipase C(PLC)γ2,leading to activation of IκB kinase,mitogen-activated protein kinases and the transcription factors nuclear factor(NF)-κB and activator protein-1(AP-1). Mice lacking NF-κB p50/p52 or the AP-1 subunit c-Fos(encoded by Fos) exhibit severe osteopetrosis due to a differentiation block in the osteoclast lineage. The amplification phase occurs about 24 h later in a RANKLinduced osteoclastogenic culture when Ca2+ oscillation starts and the transcription factor NFATc1 is abundantly produced. In addition to Ca2+ oscillation-dependent nuclear translocation and transcriptional auto-induction of NFATc1,a Ca2+ oscillation-independent,osteoblastdependent mechanism stabilizes NFATc1 protein in dif-ferentiating osteoclasts. Osteoclast precursors lacking PLCγ2,inositol-1,4,5-trisphosphate receptors,regulator of G-protein signaling 10,or NFATc1 show an impaired transition from the triggering to amplifying phases. The final targeting phase is mediated by activation of numerous NFATc1 target genes responsible for cell-cell fusion and regulation of bone-resorptive function. This review focuses on molecular mechanisms for each of the three phases of RANK signaling during osteoclast differentiation. | Yukiko Kuroda Koichi Matsuo | 2012 | World Journal of Orthopedics2012，3，11： | 10 |
| 18 | Fluoxetine is Neuroprotective in Early Brain Injury via its Antiinflammatory and Anti-apoptotic Effects in a Rat Experimental Subarachnoid Hemorrhage Model显示文摘Fluoxetine, an anti-depressant drug, has recently been shown to provide neuroprotection in central nervous system injury, but its roles in subarachnoid hemorrhage(SAH) remain unclear. In this study, we aimed to evaluate whether fluoxetine attenuates early brain injury(EBI) after SAH. We demonstrated that intraperitoneal injection of fluoxetine(10 mg/kg per day) significantly attenuated brain edema and blood-brain barrier(BBB) disruption, microglial activation, and neuronal apoptosis in EBI after experimental SAH, as evidenced by the reduction of brain water content and Evans blue dye extravasation, prevention of disruption of the tight junction proteins zonula occludens-1, claudin-5, and occludin, a decrease of cells staining positive for Iba-1, ED-1, and TUNEL and a decline in IL-1 b, IL-6, TNF-a, MDA, 3-nitrotyrosine, and 8-OHDG levels. Moreover, fluoxetine significantly improved the neurological deficits of EBI and long-term sensorimotor behavioral deficits following SAH in a rat model. These results indicated that fluoxetine has a neuroprotective effect after experimental SAH. | Hui-Min Hu Bin Li Xiao-Dong Wang Yun-Shan Guo Hua Hui Hai-Ping Zhang Biao Wang Da-Geng Huang Ding-Jun Hao | 2018 | Neuroscience Bulletin2018，34，6： | 10 |
| 19 | Biomass-derived Porous Carbon Materials for Supercapacitor Electrodes:A Review显示文摘The development of renewable,cost-efficient,and environmentally friendly electrode materials with excellent performance is urgently needed for improving supercapacitors(SCs).Recently,biomass-derived porous carbons(BPCs)have received increasing attention due to their excellent physical and chemical properties,widespread availability,and low production cost.In this review,the progress in preparing BPCs and the properties of prepared BPCs are presented and discussed.In addition,the applications of BPCs as electrode materials for supercapacitors are also summarized.More importantly,the pore structure and surface properties of BPCs are all determining factors to improve electrochemical performance.Moreover,a high energy density and power density can be pursued by using composites based on BPCs as electrode materials,of which combining transition metallic oxide with BPCs is one of the most attractive selections.Therefore,rational design of BPCs with respect to the supercapacitor's performance should be conducted in the future. | Huimei Wang Zhong Liu Lanfeng Hui Lan Ma | 2020 | Paper And Biomaterials2020，5，2： | 10 |
| 20 | Behaviour of layered sandstone under Brazilian test conditions:Layer orientation and shape effects显示文摘The experimental study in this paper focuses on the effects of the layer orientation and sample shape on failure strength and fracture pattern of samples tested under Brazilian test conditions(i.e.diametrical loading of cylindrical discs)for one particular layered sandstone which is from Modave in the south of Belgium.The variations of the strength in combination with the failure patterns are examined as a function of the inclination angle between the layer plane and the loading direction.The experimental,results clearly show that the induced fracture patterns are a combination of tensile and/or shear fractures.In shape effect experiments the layer thickness and the number of layer boundaries are investigated.Different blocks of Modave sandstone are used to prepare samples.The layer thickness is different among the various blocks,but the layer thickness in each studied rock block can be considered to be constant;hence,the number of layer boundaries changes according to the sample diameter for samples of the same block.The experimental study shows that the layer thickness plays a more important role than the number of layer boundaries per sample. | Abbass Tavallali André Vervoort | 2013 | Journal of Rock Mechanics and Geotechnical Engineering2013，5，5： | 9 |
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