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| 1 | Aryl hydrocarbon receptor expression in serum,peripheral blood mononuclear cells,and skin lesions of patients with atopic dermatitis and its correlation with disease severity显示文摘Background:The aryl hydrocarbon receptor(AhR)is a ligand-activated transcription factor,which is critically involved in the pathogenesis of a variety of skin diseases.The aim of this study was to detect AhR and its downstream regulators including cytochrome P450(CYP1A1),AhR nuclear translocation(ARNT),and aryl hydrocarbon receptor repressor(AhRR)in serum,peripheral blood mononuclear cells(PBMCs),and skin lesions in patients with atopic dermatitis(AD).Methods:Twenty-nine AD patients defined according to the criteria of Hanifin and Rajka and Chinese criteria of AD were included.Subjects without allergic and chronic diseases were recruited as controls.Patients and controls were selected from the dermatology outpatient clinic of Peking University People’s Hospital from August 1 to December 31 in 2018.Enzyme-linked immunosorbent assay was performed to detect serum AhR level.ThemRNA of AhR,AhRR,ARNT,and CYP1A1 in PBMCs were measured by realtime quantitative polymerase chain reaction.AhR expression in skin lesions was measured by immunohistochemistry.Results:AhR was significantly higher expressed in serum(41.26±4.52 vs.33.73±2.49 pmol/L,t=6.507,P<0.001)and skin lesions(0.191±0.041 vs.0.087±0.017,t=10.036,P<0.001)of AD patients compared with those of controls.The mRNA levels of AhR(1.572±0.392 vs.1.000±0.173,t=6.819,P<0.001),AhRR(2.402±1.716 vs.1.000±0.788,t=3.722,P<0.001),CYP1A1(2.258±1.598 vs.1.000±0.796,t=3.400,P=0.002)in PBMCs of AD patients were higher compared with those of controls.The difference in mRNA levels of ARNT was not statistically significant between the patients and controls(1.383±0.842 vs.1.000±0.586,t=1.653,P=0.105).AhR mRNA levels in PBMCs positively correlated with eczema area and severity index score and serum interleukin-6 levels.Conclusion:AhR and its downstream regulators were highly expressed in serum,PBMCs,and skin of AD patients,which might contribute to the pathogenesis of AD. | Yu-Qing Hu Ping Liu Zhang-Lei Mu Jian-Zhong Zhang | 2020 | Chinese Medical Journal2020，，2： | 6 |
| 2 | Production of aryl oxygen-containing compounds from catalytic pyrolysis of bagasse lignin over LaTixFe1xO3显示文摘A new approach,named production of aryl oxygen-containing compounds from the catalytic pyrolysis of bagasse lignin(BL) over perovskite oxide,was proposed,A series of LaTixFe1-xO3(LTF-x) samples were prepared by the solid state reaction method.The crystal phase and morphology of LTF-x were characterized by XRD and SEM respectively.Catalytic pyrolysis performance of LTF-x was performed by TG-DTG and the distribution patterns of gaseous,liquid and solid products from BL was investigated using a fixed-bed micro-reactor.The optimal reaction conditions were determined:the pyrolysis temperature was 600℃,the mass ratio of mBL:mLTF-0.2 was 3:1,the veloeity of earrier gas was 100 ml·min-1.The gaseous produets were mainly eomposed of CO2,CO,CH4 and CnHm(n=2-4,m=2 n+2 or m=2 n),The main aryl oxygen-containing compounds in liquid products were phenolics,guaiacols,syringols and phenylates,the rest were benzenes,furans,esters and carboxylic acid.The total contents of aryl oxygencontaining compounds were from 62% up to more than 72% under the action of the perovskite.Moreover,the LTF-0.2 sample had nice regenerability. | Haiying Wang Hongjing Han Enhao Sun Yanan Zhang Jinxin Li Yanguang Chen Hua Song Hongzhi Zhao | 2019 | Chinese Journal of Chemical Engineering2019，27，8： | 4 |
| 3 | Influence of calcination temperature for LaTi0.2Fe0.8O3 on catalytic pyrolysis of bagasse lignin显示文摘LaTi(0.2)Fe(0.8)O3(LTF)was prepared by the sol-gel method,and the effects of calcination temperature on the structure and properties were investigated,A new method of preparing aryl oxygen-containing compounds from bagasse lignin(BL)by the catalytic pyrolysis over LTF was proposed.The results show that LTF has cubic crystal phase and porous structure and its optimal calcination temperature is 800℃(LTF-800).In the test for catalytic pyrolysis of BL,with the addition of LTF-800,the yield of liquid product reaches the maximum;the contents of phenolics,guaiacols,syringols,phenylates and furans increase obviously,while those of benzenes,esters and carboxylic acid decrease.The total content of aryl oxygencompounds(including phenolics,guaiacols,syringols and phenylates)in liquid product is more than 74 wt%with the addition of LTF-800,larger than that obtained by single BL pyrolysis(62 wt%).LTF could avoid oxygen-containing functional groups from being excessively destroyed.It has nice regeneration performance by controlled combustion of char even after 5 cycles. | Haiying Wang Hongjing Han Yanan Zhang Jinxin Li Yanguang Chen Hua Song Enhao Sun Hongzhi Zhao Mei Zhang Dandan Yuan | 2019 | Journal of Rare Earths2019，37，8： | 3 |
| 4 | PVP-Supported Palladium-Cadmium Bimetallic Catalyst for the Hydrogen Transfer Dechlorination of Aryl Chlorides显示文摘PVP-supported bimetallic catalyst- PVP-PdCl2-CdCl2, exhibits extremely high catalytic activity for the hydrogen transfer dechlorination of aryl chlorides in neutral environment. The yields of dechlorination products are high under mild reaction conditions and the operation is | Ru Hong KANG Jiang Hua MA Xin Hui LIU Shu Mei HE(Chemistry Department of Flebei Normal University. Shijiazhuang 050016)(Experimental Center of Hebei Normal University. Shijiazhuang 050016) | 1999 | Chinese Chemical Letters1999，10，7： | 3 |
| 5 | Synthesis, Crystal Structure and Catalytic Activity of a Pd-PEPPSI Complex Bearing Bromine Group显示文摘A new Pd-PEPPSI complex(2) with the bromo groups on the para-positions of N-aryl moieties of NHC has been synthesized and characterized by NMR and X-ray single-crystal diffraction. Complex 2 crystallizes in monoclinic, space group P2_1/c with a = 11.8790(8), b = 14.3038(10), c = 15.9905(11) ?, β = 101.291(2)°, V = 2664.4(3) ?3, Z = 4, D_c = 1.722 Mg/m^3, μ = 3.913 mm^(-1), F(000) = 1352, the final R = 0.0682 and wR = 0.1914 for 15113 observed reflections(I > 2σ(I)), R(all data) = 0.0970, w R(all data) = 0.2115, completeness to theta of 25.00 is 100.0% and GOOF = 1.035. Influenced by the electron-withdrawing bromo groups, the Pd-PEPPSI complex(2) showed high catalytic activity for the Suzuki-Miyaura cross-coupling reactions of aryl chlorides and arylboronic acids with a low catalyst loading(0.05 mol%) at room temperature in air. | 李莹 韩方外 徐子扬 王茹 严晨昕 欧尤静 卢倩 刘桂艳 曾永飞 | 2019 | Chinese Journal of Structural Chemistry2019，38，3： | 1 |
| 6 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin promotes migration ability of primary cultured rat astrocytes via aryl hydrocarbon receptor显示文摘Emerging evidence showed that 2,3,7,8-Tetrachlorodibenzo-p-dioxin(TCDD) could induce expression of certain reactivation-associated genes in astrocytes, however, the consequent cellular effects and molecular mechanisms are still unclear. During the process of astrocyte reactivation, migration is a critical cellular event. In the present study, we employed woundhealing assay and Transwell? motility assay to explore the effects of TCDD on cell migration in primary cultured rat cortical astrocytes. We found that upon TCDD treatments at relative low concentrations(10^(-10) and/or 10^(-9) mol/L), the ability of primary astrocytes to migrate horizontally and vertically was promoted. In line with this cellular effect, the mR NA expression of two promigratory genes, including cell division cycle 42(CDC42) and matrix metalloproteinase 2(MMP2)was induced by TCDD treatment. Dioxin exerts its toxic effects mainly through aryl hydrocarbon receptor(AhR) pathway. So the role of AhR pathway in the pro-migratory effects of TCDD was examined using an AhR antagonist, CH223191. We found that application of CH223191 significantly reversed the pro-migratory effects of TCDD. Interestingly, the basal ability of horizontal migration as well as basal levels of CDC42 and MMP2 expression were dramatically reduced suggesting a possible physiological role of AhR in maintaining the endogenous migration ability of the primary astrocytes. These findings support the notion that dioxin promotes astrocyte reactivation at molecular and cellular levels. | Yangsheng Chen Rui Sha Li Xu Yingjie Xia Yiyun Liu Xuejun Li Heidi Qunhui Xie Naijun Tang Bin Zhao | 2019 | Journal of Environmental Sciences2019，31，2： | 1 |
| 7 | Green Synthesis of Aryl Thioethers through Cu-catalysed C-S Coupling of Thiols and Aryl Boronic Acids in Water显示文摘An efficient, practical, highly selective and environmentally benign method is reported for the synthesis of aryl thioethers via the coupling of thiols with aryl boronic acids in the presence of NaOH and a catalytic amount of CuSO4 at 130 ℃ using water as a green solvent. The products were obtained in moderate to excellent yields;more importantly, the use of toxic ligands and solvents was avoided. A broad range of aryl boronic acids and scalable processes make this methodology valuable and versatile for the synthesis of a broad range of aryl sulfides. | 涂佩华 JIANG Jun XIAO Hongping 李新华 | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，4： | 1 |
| 8 | Replacing“Alkyl”with“Aryl”for inducing accessible channels to closed pores as plateau-dominated sodium-ion battery anode显示文摘Hard carbons are promising anodes for sodium-ion batteries.However,there is still considerable controversy regarding the sodium storage behaviors in hard carbons,which are mainly attributed to the varied precursors,confused pyrolysis mechanism,and different characterization methods.Herein,benefiting from the flexible molecular structure of polymers,a series of hard carbons with carefully tunedmicrostructures are fabricated by adjusting the ratio of aryl and alkyl groups in the epoxy resins.The results of dynamic mechanical analysis,insitu Fourier transform infrared spectra,and synchronous thermal gravimetricinfrared spectrum-gas chromatography/mass spectrometry reveal that replacing the alkyl with aryl groups in the resin can enhance the crosslink density,inhibit the degradation and rearrangement process,and further lead to a more disordered microstructure.In addition,it is suggested that accessible channels provided by sufficiently wide interlayer spacing are necessary for closed pore filling.The optimized anode delivers a high capacity of 375 mAh/g in half cell with an initial Coulombic efficiency of 80.61%,and an energy density of 252 Wh/kg is attained in full cell.Finally,a reliable relationship among precursor-pyrolysis mechanism-structure-performance is established,and the sodium storagemechanism of“adsorption-insertion-pore filling”iswell proved. | Wenlong Shao Qi Cao Siyang Liu Tianpeng Zhang Zihui Song Ce Song Zhihuan Weng Xigao Jian Fangyuan Hu | 2022 | SusMat2022，2，3： | 1 |
| 9 | Synthesis of Novel Cyclic Aryl Ether Thioether Ketone (Sulfone) Oligomers显示文摘Two kinds of macrocyc1ic oligomers containing aromatic sulfide linkages have been synthesized by the solution polycondensation in high yield. The cyclic compounds were characterized by 1H and 13C NMR, by and MALDI -TOF MS. | Ying Hua QI Tian Lu CHEN Hong Yan JIANG Hai Bo LI Ji Ping XU (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022) | 1998 | Chinese Chemical Letters1998，9，7： | 1 |
| 10 | Intestinal inflammation and the diet:Is food friend or foe?显示文摘Inflammatory bowel disease(IBD) is a chronic intestinal illness of autoimmune origin affecting millions across the globe. The most common subtypes include ulcerative colitis(UC) and Crohn's disease. While many medical treatments for IBD exist,none come without the risk of significant immunosuppression and in general do not have benign side effect profiles. Surgical intervention exists only as radical resection for medically refractory UC. There exists a dire need for novel treatments that target the inherent pathophysiologic disturbances of IBD,rather than global immune suppression. One avenue of investigation that could provide such an agent is the interaction between certain dietary elements and the aryl hydrocarbon receptor(AHR). The AHR is a cytosolic transcription factor with a rich history in environmental toxicant handling,however,recently a role has emerged for the AHR as a modulator of the gastrointestinal immune system. Studies have come to elucidate these effects to include the enhancement of Th cell subset differentiation,interactions between enteric flora and the luminal wall,and modulation of inflammatory interleukin and cytokine signaling. This review highlights advancements in our understanding of AHR activity in the digestive tract and how this stimulation may be wrought by certain dietary 'micronutriceuticals',namely indole-3-carbinol(I3C) and its derivatives. Greater clarity surrounding these dynamics could lead to a novel diet-derived agonist of the AHR which is not only non-toxic,but also efficacious in the amelioration of clinical IBD. | Bryant W Megna Patrick R Carney Gregory D Kennedy | 2016 | World Journal of Gastrointestinal Surgery2016，8，2： | 1 |
| 11 | Synthesis and Characterization of Aryl Acylguanidines and Their Copper(Ⅱ) Complexes显示文摘A series of eight N-mono-substituted aryl acylguanidines L1~8 were synthesized from the reactions of their parent acylthioureas and respective primary amines, including five R1C(O)N=C(NHR2)2 with balanced arms(denoted as R1–R2–R2: Ph–Ar’–Ar’, L1(1);Ph–Ar’’–Ar’’, L2(2);1-Naph–Ar’–Ar’, L3(3);1-Naph–Ar’’–Ar’’, L4(4);2-Naph–Ar’’–Ar’’, L[5(5);Ar’ = 2,6-Me2C6H3, Ar’’ = 2,6-iPr2C6H3) and three R1C(O)N=C(NHR2)NHR3 with unbalanced arms(denoted as R1–R2–R3: Ph–Ar’–Ph, L6(6);Ph–Ar’ –Ph, L7(7);Ph–Ar’ –Ar’, L8(8)). Treatment of L1~5(1~5) with copper acetate in a molar ratio of 2:1 in dichloromethane led to the formation of homoleptic Cu(Ⅱ) complexes trans-L2n’Cu(9~13), in which the Cu(Ⅱ) center was stabilized by deprotonated ligands Ln’(n = 1~5) in the O,N-bidentate mode. When similar reactions of L6(Ph–Ar’–Ph)(6) and L7(Ph–Ar’’–Ph)(7) that contain unbalanced arms were investigated, the Cu(Ⅱ) products trans-L26’Cu(14) and trans-L27’Cu(15) were formed by deprotonating the bulky amine groups in Ln(-NHAr’ for L6 and-NHAr’’ for L7) rather than the-NHPh group. In sharp contrast, trans-L28’Cu(16) was obtained from two-arm unbalanced L8(Ph–Ar’’–Ar’)(8) not by deprotonating the more bulky-NHAr’’ group but the relatively less bulky-NHAr’ group. In a further exploration, the reaction of 1:1 mixed ligands Ln and Lm with copper acetate was found to give only homoleptic Cu(Ⅱ) complex L2n’Cu instead of the heteroleptic one Ln’CuLm’. The in vitro antibacterial activity of Ln was evaluated against S. aureus, E. coli and C. albicans by determining the minimum inhibitory concentrations(MICs) using Kirby-Bauer test. | 周启 张志娇 王凡凡 韩立 朱成奔 李海普 杨鹰 | 2019 | Chinese Journal of Structural Chemistry2019，38，8： | 1 |
| 12 | Synthesis of some new lignans and the mechanism of intramolecular nonphenolic oxidative coupling of aromatic compounds显示文摘Treatment of cis-1,4-diaryl-2,3-epoxy butane with 2,3-dichloro-5,6-dicyano-1,4-benzo-quinone(DDQ) in trifluoroacetic acid(TFA) gave dibenzocycloheptadienes by pinacol rearrangement and intramolecular oxidative coupling of the aryl groups. Meanwhile, the benzofuran analogues were also formed by the same method. These new lignans have potent CNS inhibitory activities. It has been proven that the method is particularly useful when applied to the substrates in which the ring substituents are electron donating. The structures of these products were identified by the MS, UV, IR, NMR spectra, and elemental and X-ray crystallographic analyses. | 常俊标 谢晶曦 | 2000 | Science China Chemistry2000，43，3： | 0 |
| 13 | MAGNESIUM-NETHAN0L REDUCTION OF 2-(1, 3-DITHIAN-2-YLIDENE)-I-ARYL KETONES:A FACILE ROUTE TO α-ARYL-β-(1,3-DITHANE)ALCOHOLS显示文摘In a facile procedure, 2-(1, 3-dithian-2-ylidene)-l-arylketones 1 vere reduced with magnesium in methanol to give α-aryl-β-(1, 3-dithane) alcohols 2 in good to high yields. | Yu Lan HU Qun LIU De Neng DONG Department oF Chemistry, Northeast Normal University, Changchun 130024 | 1992 | Chinese Chemical Letters1992，3，6： | 0 |
| 14 | Copper-mediated O-arylation of lactols with aryl boronic acids显示文摘An efficient and novel methodology to access phenolic glycosides has been established by using coppermediated coupling reaction of aryl boronic acids with hemiacetals.The reaction takes place normally in the presence of Cu(OAc)_2(1.0 equiv.)and pyridine(2.0 equiv.)at 40℃.This protocol distinguishes itself by wide substrate scope,operational simplicity and giving rise to a myriad of phenolic glycosides in good to excellent yields. | Jing-Jing Sui De-Cai Xiong Xin-Shan Ye | 2019 | Chinese Chemical Letters2019，30，8： | 0 |
| 15 | Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core显示文摘Nav1.7 channels are mainly distributed in the peripheral nervous system.Blockade of Nav1.7 channels with small-molecule inhibitors in humans might provide pain relief without affecting the central nervous system.Based on the facts that many reported Nav1.7-selective inhibitors contain aryl sulfonamide fragments,as well as a tricyclic antidepressant,maprotiline,has been found to inhibit Nav1.7 channels,we designed and synthesized a series of compounds with ethanoanthracene and aryl sulfonamide moieties.Their inhibitory activity on sodium channels were detected with electrophysiological techniques.We found that compound 10o potently inhibited Nav1.7 channels stably expressed in HEK293 cells(IC50=0.64±0.30 nmol/L)and displayed a high Nav1.7/Nav1.5 selectivity.In mouse small-sized dorsal root ganglion neurons,compound 10o(10,100 nmol/L)dose-dependently decreased the sodium currents and dramatically suppressed depolarizing current-elicited neuronal discharge.Preliminary in vivo experiments showed that compound 10o possessed good analgesic activity:in a mouse visceral pain model,administration of compound 10o(30?100 mg/kg,i.p.)effectively and dose-dependently suppressed acetic acid-induced writhing. | Jin-tao Wang Yue-ming Zheng Yue-ting Chen Min Gu Zhao-bing Gao Fa-jun Nan | 2020 | Acta Pharmacologica Sinica2020，41，3： | 0 |
| 16 | Measurement of AhR Ligands in the Tissues of Colon Cancer Patients with XRE Luciferase Reporter显示文摘The Aryl hydrocarbon receptor(AhR)ligands exhibiting modulating activity represents a new class of anticancer agents that can be directed towards several tumors.We have examined AhR expression in human colon cancer and adjacent non-tumor tissue.AhR expression level was about 2-7 times higher in tumor tissue samples than in the adjacent non-tumor samples(in 82%of all the samples).We were unable to find any increase of ABCG2 expression on the level of the transcription,while the expression of MDR2 was increased in half of the tumors compared to the levels of expression in normal adjacent tissue.We have used FICZ as a potent high affinity ligand of the AhR to calibrate the reporter cell line HEK293TAhR-luc as a potent high affinity ligand of the AhR.The concentration of xenobiotic response element(XRE)ligands is higher,than in the blood of healthy people in 86%of the patients.The proposed test system will allow the use of the AhR ligand level as an additional diagnostic marker in the treatment of colon cancer. | Bystriakova Margarita Koshkin Sergei Tolkunova Elena | 2019 | Journal of Oncology Research2019，1，1： | 0 |
| 17 | 硅胶功能化的N-丙哌嗪固载钯纳米粒子作为有效的多相催化剂用于氰化反应(英文)显示文摘An efficient heterogeneous Pd catalytic system has been developed, based on immobilization of Pd nanoparticles (PNPs) on a silica-bonded N-propylpiperazine (SBNPP) substrate. The SBNPP substrate effectively stabilizes the PNPs and improves their stability against aggregation. The catalytic activity of this catalyst was investigated in the cyanation of aryl halides with K4[Fe(CN)6 ] as the cyanide source. The catalyst could be recycled several times without appreciable loss of catalytic activity. | Khodabakhsh NIKNAM Abdollah DERIS Farhad PANAHI | 2013 | 催化学报2013，34，4： | 0 |
| 18 | Ring-opening polymerization of 2,2-dimethyltrimethylene carbonate using rare earth aryl oxides substituted by alkyl groups显示文摘Single component rare earth aryl oxides substituted by various alkyl groups [Ln(OAr)3] such as methyl,isopropyl,and tertbutyl have been developed to initiate the ring-opening polymerization of 2,2-dimethyltrimethylene carbonate(DTC).The catalytic activity of rare earth aryl oxides,characteristics of the ring-opening polymerization as well as the polymerization kinetics and mechanism were intensively examined.The experimental results turn out that the catalytic activity of Ln(OAr)3 changes in good concordance with variation of ligands' structure and number of alkyl groups on benzene ring.The greater the ability of electron-donation of alkyl groups,the greater the catalytic activity.Moreover,the greater the number of substituted alkyls on benzene ring,the greater the catalytic activity.The results show that rare earth tris(2,4,6-tri-tert-butylphenolate)s [Ln(OTTBP)3](Catalyst 1) exhibit rather great activity in all lanthanide aryl oxides.Investigations of the polymerization mechanism by 1H NMR spectroscopy revealed that the DTC monomer inserted into the growing chains with acyloxygen bond cleavage. | Zhang, Li Fang Wang, Yan Wang, Pei Shen, Li Juan | 2010 | Science China Chemistry2010，53，3： | 0 |
| 19 | Synthesis of Aryl Hydrazines via Cul/BMPO Catalyzed Cross-Coupling ofAryl Halides with Hydrazine Hydrate in Water显示文摘The N,N'-bis(2,6-dimethylphenyl)oxalamide was discovered as a powerful ligand for Cu-catalyzed cross-coupling of aryl halides with hydra-zine hydrate, leading to the formation of a variety of aryl hydrazines at 80℃ in water under the assistance of K3PO4 and 4 mil% cetyltrimethylammoniumbromide from aryl bromides and aryl iodides. Good to excellent yields were observed in most cases. | Siripuram Vijay Kumar Dawei Ma | 2018 | Chinese Journal of Chemistry2018，36，11： | 0 |
| 20 | A Novel Condensation Reaction of Alkyl Aryl Ketone with Ethyl Ortho-Formate under Microwave Irradiation显示文摘Under microwave tridiahon, boron trifluoride has been found to mediate a novel condensahon reachon of alkyl aryl ketone with ethyl ortho-formate to give a series of new condensation products (5,6,7,8 ). Their trictures were determined by IR, 1H-/13C-NMR, MS spectra, and the crystal smicture of 8 was further defined by X-ray diffraction. | Yu, JH Hu, YL Yang, SY Yin, YQ Cai, LP | 1998 | Chinese Chemical Letters1998，9，1： | 0 |
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