|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cancer prevention and control: alarming challenges in China显示文摘China is geographically the third largest country in the world and the most populated low-to-middle-income country. Cancer incidence and mortality rates for some cancers in the USA and European countries have steadily decreased over the last decades, whereas the incidence and mortality of certain cancers in China have been increasing at an alarming speed. Rapid industrialization and urbanization in China have been accompanied by incredible changes in lifestyle and environment combined with an aging population. Mortality caused by lung, colorectal and breast cancers has been steadily increasing, whereas cancer mortality from gastric, esophageal and cervical tumors has tended to decrease. Similar to what has occurred in the United States, unhealthy lifestyles in China, including heavy smoking and poor diet combined with pollution, have contributed to increased cancer risk. China is facing many challenges in cancer treatment and prevention for the general population. The major areas that need to be addressed in the control of cancer in China include cancers associated with environmental pollution,tobacco use, occupational carcinogens, infection, excessive alcohol consumption, dietary deficiencies and obesity. In this perspective, we review the problems in each area and suggest ideas for future directions in cancer research and strategies and actions to reduce the incidence of cancer in China. | Ann M.Bode Zigang Dong Hongyang Wang | 2016 | National Science Review2016，3，1： | 22 |
| 2 | Fish sauce and gastric cancer:an ecological study in Fujian Province,China显示文摘AIM To explore the relationship betweenconsumption of fish sauce and the risk of gastriccancer in Fujian Province.METHODS An ecological study was carriedout.A total of 11000 subjects from 55 townshipswere randomly selected from 10 counties withinFujian Province.All subjects were localresidents who had been living in Fujian Provincefor more than 20 years,within the age group of45-74 years.Trained interviewers conductedface-to-face interviews with a standardizedquestionnaire,which covered the frequency andamount of food intake,dietary habit,tobaccoand alcohol consumption and history of chronicgastric diseases.Univariate and multivariateanalyses were performed using Epi-info and SASstatistical packages,respectively.RESULTS A significant correlation betweenmonthly consumption of fish sauce and mortalityof gastric cancer was found.Pearson’scoefficient of correlation was statisticallysignificant with r=0.7356 for males,r=0.5246for females(P<0.01).In the multivariateanalysis,consumption of fish sauce still showedan association with the risk of gastric cancer.No significant positive correlation betweenesophagus cancer,liver cancer,colon cancerand consumption of fish sauce were observed.CONCLUSION Long-term intake of fish saucemay be related to high mortality of gastriccancer.Consumption of fish sauce might be oneof important and unique etiologic factors ofgastric cancer in Fujian Province.Furtherstudies are needed to confirm this ecologicalstudy. | Lin Cai Shun Zhang Yu Wei Min Ye Ying Nan Yi | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
| 3 | Gastrin,somatostatin,and experimental disturbance of the gastrointestinal tract in rats显示文摘INTRODUCTIONThe field of gastrointestinal hormones has expanded at a dizzying rate[1-4].Gastrointestinal hormones as regulatory peptides that appear to be major components of bodily integration and have important regulatory actions on physioligical function of the gastrointestinal tract .The successful isolation of some gastrointestinal hormones and the development of sensitive methods for their detection have led to the unexpected finding that they also exist in the brain . | Yong Li Yao~1 Bo Xu~2 Wan Dai Zhang~1 Yu Gang Song~1 ~1Institute of Gastrointestinal Diseases,Nanfang Hospital,First Military Medical University,Guangzhou 510515,Guangdong Province,China ~2Department of Orthopedics Nanfang Hospital,First Military Medical University,Guangzhou 510515,Guangdong Province,ChinaYong Li Yao graduated from First Military Mcdical University with a master degree in 1998.She now works in the Institute of Gastrointestinal Diseases,Nanfang Hospital as a doctoral candidate majoring gastrointestinal diseases and gastrointestinal hormones,she has published 8 papers. | 2001 | World Journal of Gastroenterology2001，7，3： | 12 |
| 4 | Study on environmental etiology of high incidence areas of liver cancer in China显示文摘INTRODUCTIONChina is a country with a high incidence of liver cancer insome areas.Liver cancer has a wide distribution andthreatens human health seriously.A rough estimationshows that out of a population of 1.2×10~8 in liver | Hoteyi S. Mohamed Ismael | 2000 | World Journal of Gastroenterology2000，6，4： | 11 |
| 5 | Chemopreventive effect of oltipraz on AFB_1-induced hepatocarcinogenesis in tree shrew model显示文摘INTRODUCTIONHepatocellular carcinoma (HCC) is one of themajor cancers in the world with a mortality of morethan 250 000 cases yearly.More than 137 000 casesof HCC were diagnosed each year in China,whichacount approximately for more than 40 percent ofthe total number in the world.HCC has become thesecond major cause of death for cancer in | TW Kensler BD Roebuck | 2000 | World Journal of Gastroenterology2000，6，5： | 5 |
| 6 | Historical review of the causes of cancer显示文摘In the early 1900 s, numerous seminal publications reported that high rates of cancer occurred in certain occupations. During this period, work with infectious agents produced only meager results which seemed irrelevant to humans. Then in the 1980 s ground breaking evidence began to emerge that a variety of viruses also cause cancer in humans. There is now sufficient evidence of carcinogenicity in humans for human T-cell lymphotrophic virus, human immunodeficiency virus, hepatitis B virus, hepatitis C virus, human papillomavirus, Epstein-Barr virus, and human herpes virus 8 according to the International Agency for Research on Cancer(IARC). Many other causes of cancer have also been identified by the IARC, which include: Sunlight, tobacco, pharmaceuticals, hormones, alcohol, parasites, fungi, bacteria, salted fish, wood dust, and herbs. The World Cancer Research Fund and the American Institute for Cancer Research have determined additional causes of cancer, which include beta carotene, red meat, processed meats, low fibre diets, not breast feeding, obesity, increased adult height and sedentary lifestyles. In brief, a historical review of the discoveries of the causes of human cancer is presented with extended discussions of the difficulties encountered in identifying viral causes of cancer. | Clarke Brian Blackadar | 2016 | World Journal of Clinical Oncology2016，7，1： | 2 |
| 7 | 在 hepatocellular 癌的化学致癌物和基因变化的相互作用显示文摘In the etiology of hepatocellular carcinoma (HCC), in addition to hepatitis B virus and hepatitis C virus infections, chemical carcinogens also play important roles. For example, aflatoxin B 1 (AFB 1 ) epoxide reacts with guanine in DNA and can lead to genetic changes. In HCC, the tumor suppressor gene p53 codon 249 mutation is associated with AFB 1 exposure and mutations in the K -ras oncogene are related to vinyl chloride exposure. Numerous genetic alterations accumulate during the process of hepatocarcinogenesis. Chemical carcinogen DNA-adduct formation is the basis for these genetic changes and also a molecular marker which reflects exposure level and biological effects. Metabolism of chemical carcinogens, including their activation and detoxification, also plays a key role in chemical hepatocarcinogenesis. Cytochrome p450 enzymes, N -acetyltransferases and glutathione S -transferases are involved in activating and detoxifying chemical carcinogens. These enzymes are polymorphic and genetic variation influences biological response to chemical carcinogens. This genetic variation has been postulated to influence the variability in risk for HCC observed both within and across populations. Ongoing studies seek to fully understand the mechanisms by which genetic variation in response to chemical carcinogens impacts on HCC risk. | Yu-Jing Zhang | 2010 | World Journal of Hepatology2010，2，3： | 1 |
| 8 | Food components and diet habits:chief factors of cancer development显示文摘Food is a vital need for everyone.Today,there is food for all,but the world still suffers from under-and over-nutrition and risk of cancer development and chronic diseases can follow both cases.Worldwide,cancer is a leading cause of mortality after cardiovascular disease;it is considered the second reason for death globally.Role of nutritional habits,the quality of food,the consumption of canned foods,genetically modified fruits and vegetables and exposed food to certain pesticides and carcinogens agents,and unhealthy lifestyle behaviours such as smoking,alcohol,obesity,and fast-foods consumption may be at risk to the development of some cancers.In recent decades,researchers have carried out attention in this field to improve the quality of life and to limit nutrition problems.Thus,this study aims to summarize current evidence on the relationship between nutritional factors and cancer expansion,how nutrition can be a heal and a source of fatal illness leading to death.In detail,this review will highlight the influence of specific foodstuffs on the threat of cancer incidence and recurrence by providing some examples of most carcinogenic compounds. | Rihab Ksouri | 2019 | Food Quality and Safety2019，3，4： | 0 |
| 9 | CHEMICAL“CARCINOGENS”,AS MODULATORS OF INTER-CELLULAR COMMUNICATION,ARE MITOGENS,NOT MUTAGENS.显示文摘Although mutations clearly play a role in themulti-stage process of carcinogenesis,a challengewll be made to the paradigm that most chemical'carcinogens' act via mutagenic activity('carcinogens as mutagens').Control ofproliferation and differentiation within andbetween tissues is mediated by | James E.Trosko | 1991 | 癌变.畸变.突变1991，3，S1： | 0 |
| 10 | Concept of chemoprevention in colorectal cancer显示文摘Colorectal cancer remains a significant cause of morbidity and mortality throughout the world.The incidence of colorectal cancer is nearly four-fold higher in more-developed as compared with less-developed regions of the world.At present an early detection of colorectal cancer remains a crucial step in determining the therapeutic outcomes.Screening programmes have been introduced in an effort to detect colorectal cancer at an early stage or at a precancerous colonic polyp stage.These programmes should be used by the health professionals as an opportunity to educate the public regarding the use of chemoprevention in colorectal cancer,which is the main focus of this review and an attractive concept needing further evaluation. | Colm O'Morain Asghar Qasim | 2009 | World Journal of Gastrointestinal Oncology2009，1，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员