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| 1 | Epidemiological progresses of hemorhagic fever with renal syndrome in China显示文摘PurposeTosummarizethemajorachievementsofChineseworkontheepidemiologyandpreventionofhemorhagicfeverwithrenalsyndrome(HFRS)inre... | 宋干 | 1999 | Chinese Medical Journal1999，，5： | 35 |
| 2 | Concerned topics of epidural labor analgesia:labor elongation and maternal pyrexia:a systematic review显示文摘Objective:Labor is a complex process and labor pain presents challenges for analgesia.Epidural analgesia(EA)has a well-known analgesic effect and is commonly used during labor.This review summarized frequently encountered and controversial problems surrounding EA during labor,including the labor process and maternal intrapartum fever,to build knowledge in this area.Data sources:We searched for relevant articles published up to 2019 in PubMed using a range of search terms(eg,“labor pain,”“epidural,”“analgesia,”“labor process,”“maternal pyrexia,”“intrapartum fever”).Study selection:The search returned 835 articles,including randomized control trials,retrospective cohort studies,observational studies,and reviews.The articles were screened by title,abstract,and then full-text,with a sample independently screened by two authors.Thirty-eight articles were included in our final analysis;20 articles concerned the labor process and 18 reported on maternal pyrexia during EA.Results:Four classic prospective studies including 14,326 participants compared early and delayed initiation of EA by the incidence of cesarean delivery.Early initiation following an analgesia request was preferred.However,it was controversial whether continuous use of EA in the second stage of labor induced adverse maternal and neonatal outcomes due to changes in analgesic and epidural infusion regimens.There was a high incidence of maternal pyrexia in women receiving EA and women with placental inflammation or histologic chorioamnionitis compared with those receiving systemic opioids.Conclusions:Early EA(cervical dilation≥1 cm)does not increase the risk for cesarean section.Continuous epidural application of low doses of analgesics and programmed intermittent epidural bolus do not prolong second-stage labor duration or impact maternal and neonatal outcomes.The association between EA and maternal pyrexia remains controversial,but pyrexia is more common with EA than without.A non-infectious inflammatory process is an accepted mechanism of epidural-related maternal fever. | Cai-Juan Li Fan Xia Shi-Qin Xu Xiao-Feng Shen | 2020 | Chinese Medical Journal2020，，5： | 35 |
| 3 | 我国肾综合征出血热流行病学研究进展显示文摘 | 石健 | 2007 | 中国人兽共患病学报2007，23，3： | 27 |
| 4 | Structure of the African swine fever virus major capsid protein p72显示文摘Dear Editor,African swine fever(ASF)caused by the African swine fever virus(ASFV)infection is a highly contagious and lethal disease of domestic pigs.Recent spread of the virus to China,1 the biggest pork-consuming country,has caused huge economic loss.So far there is no effective way to prevent the spread of the virus.Vaccine for protection from ASFV infection or effective treatments to cure ASF is urgently needed. | Qi Liu Bingting Ma Nianchao Qian Fan Zhang Xu Tan Jianlin Lei Ye Xiang | 2019 | Cell Research2019，29，11： | 28 |
| 5 | 中国的登革热预防控制任重道远显示文摘 | 罗会明 | 2007 | 华南预防医学2007，33，5： | 23 |
| 6 | 发热伴血小板减少综合征命名、临床分期及分型的建议显示文摘发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)是由新布尼亚病毒引起的一种新发感染性疾病。该病在我国首先报道和命名,其中河南省信阳市疫情较重。 | 袁义美 崔宁 袁春 | 2016 | 中华传染病杂志2016，34，1： | 22 |
| 7 | Risk factors for fever and sepsis after percutaneous nephrolithotomy显示文摘Objective:Percutaneous nephrolithotomy(PCNL)is commonly used in the management of large renal stones.Postoperative infections are one of the most common complications of this procedure.The present study is to determine and assess the factors that may increase the risk to develop fever and urinary sepsis after PCNL.Methods:A total of 60 patients(38 males and 22 females)with a mean age of 40.25 years enrolled in this study in Sulaimania Teaching Hospital.Patients had renal stone disease need operation with different socioeconomic status,body mass index and different type and size of stones were included in this study.Patients with preoperative positive urine culture and sensitivity were excluded.Preoperative investigations done for all patients.All Patients received prophylactic antibiotic gentamicin intravenously at the induction of anaesthesia.Renal pelvis urine sample were taken from all patients after puncturing the pelvicalyceal system and send for culture and sensitivity.Patients were monitored closely in the postoperative period for the development of fever and sepsis.Results:Mean duration of the operations was 77.08 min ranged 40e120 min.All patients had postoperative nephrostomy tube.Seventeen(28.33%)patients developed post PCNL fever and the statistically significant factors for post PCNL fever were diabetes mellitus(DM)(p Z 0.001),stone burden(p Z 0.001),number of the stones(p<0.001),degree of hydronephrosis(p Z 0.001),duration of the operation(p<0.001),residual stones(p Z 0.001)and number of tracts(p Z 0.038).Three(5.00%)patients developed post PCNL sepsis,and the statistically significant risk factors for post PCNL sepsis were duration of the operation(p Z 0.013)and intraoperative blood loss,postoperative drop in haemoglobin(HB)level(p Z 0.046).Conclusion:DM,staghorn stones,degree of hydronephrosis,duration of the operation and number of tracts are risk factors for post PCNL fever,while number of stones,intraoperative blood loss,duration of the operation and residual stones are risk factors for post PCNL sepsis. | Aso Omer Rashid Saman Salih Fakhulddin | 2016 | Asian Journal of Urology2016，3，2： | 21 |
| 8 | 蜱传斑点热群立克次体研究进展显示文摘 | 叶晓东 郑寿贵 孙毅 许荣满 | 2008 | 中国人兽共患病学报2008，24，4： | 20 |
| 9 | 汉坦病毒病原学研究进展显示文摘 | 李家亮 李德新 | 2005 | 中华实验和临床病毒学杂志2005，19，2： | 20 |
| 10 | 埃博拉出血热显示文摘埃博拉出血热(Ebola hemorrhagic fever,EHF)1976年首次发生于刚果民主共和国(前扎伊尔)埃博拉河流域,因其引起感染者全身出血症状,故命名为埃博拉出血热。EHF的病原是埃博拉病毒(Ebola virus,EBOV),属于丝状病毒科(Filoviri-dae)丝状病毒属(Filovirus)成员, | 刘阳 马志永 史子学 王水明 王志亮 马玉堃 | 2011 | 中国人兽共患病学报2011，27，11： | 19 |
| 11 | Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury显示文摘AIM: To examine complications associated with the use of therapeutic temperature modulation(mild hypothermia and normothermia) in patients with severe traumatic brain injury(TBI). METHODS: One hundred and fourteen charts were reviewed. Inclusion criteria were: severe TBI with Glasgow Coma Scale(GCS) < 9, intensive care unit(ICU) stay > 24 h and non-penetrating TBI. Patients were divided into two cohorts: the treatment group received therapeutic temperature modulation(TTM) with continuous surface cooling and indwelling bladder temperature probes. The control group received standard treatment with intermittent acetaminophen for fever. Information regarding complications during the time in the ICU was collected as follows: Pneumonia was identified using a combination of clinical and laboratory data. Pulmonary embolism, pneumothorax and deep venous thrombosis were identified based onimaging results. Cardiac arrhythmias and renal failure were extracted from the clinical documentation. acute respiratory distress syndrome and acute lung injury were determined based on chest imaging and arterial blood gas results. A logistic regression was conducted to predict hospital mortality and a multiple regression was used to assess number and type of clinical complications. RESULTS: One hundred and fourteen patients were included in the analysis(mean age = 41.4, SD = 19.1, 93 males), admitted to the Jackson Memorial Hospital Neuroscience ICU and Ryder Trauma Center(mean GCS = 4.67, range 3-9), were identified and included in the analysis. Method of injury included motor vehicle accident(n = 29), motor cycle crash(n = 220), blunt head trauma(n = 212), fall(n = 229), pedestrian hit by car(n = 216), and gunshot wound to the head(n = 27). Ethnicity was primarily Caucasian(n = 260), as well as Hispanic(n = 227) and African American(n = 223); four patients had unknown ethnicity. Patients received either TTM(43) or standard therapy(71). Within the TTM group eight patients were treated with normothermia after TBI and 35 patients were treated with hypothermia. A logistic regression predicting in hospital mortality with age, GCS, and TM demonstrated that GCS(Beta = 0.572, P < 0.01) and age(Beta =-0.029) but not temperature modulation(Beta = 0.797, ns) were significant predictors of in-hospital mortality [χ2(3) = 22.27, P < 0.01] A multiple regression predicting number of complications demonstrated that receiving TTM was the main contributor and was associated with a higher number of pulmonary complications(t =-3.425, P = 0.001). CONCLUSION: Exposure to TTM is associated with an increase in pulmonary complications. These findings support more attention to these complications in studies of TTM in TBI patients. | Kristine H O’Phelan Amedeo Merenda Katherine G Denny Kassandra E Zaila Cynthia Gonzalez | 2015 | World Journal of Critical Care Medicine2015，4，4： | 18 |
| 12 | 登革热发病机制的研究进展显示文摘登革病毒(dengue virus,DENV)可引起登革热(denguefever,DF)、重症的登革出血热(dengue hemorrhagic fever,DHF)和登革休克综合征(dengue shock syndrome,DSS)。每年世界上有1亿人受到DENV感染,近年来,随着旅游业的发展和全球温暖化,DF疫情日益严重,已经成为一个世界性的严重公共卫生问题[1]。 | 黄俊琪 | 2011 | 实用医学杂志2011，27，19： | 18 |
| 13 | Beneficial effects of Houttuynia cordata polysaccharides on “two-hit” acute lung injury and endotoxic fever in rats associated with anti-complementary activities显示文摘Houttuynia cordata Thunb. is a traditional herb used for clearing heat and eliminating toxins,and has also been used for the treatment of severe acute respiratory syndrome(SARS). In vitro, the crude H. cordata polysaccharides(CHCP) exhibited potent anti-complementary activity through both the classical and alternative pathways by acting on components C3 and C4 of the complement system without interfering with the coagulation system. This study was to investigate the preventive effects of CHCP on acute lung injury(ALI) induced by hemorrhagic shock plus lipopolysaccharide(LPS) instillation(two-hit)and LPS-induced fever in rats. CHCP significantly attenuated pulmonary injury in the 'two-hit' ALI model by reducing pulmonary edema and protein exudation in bronchoalveolar lavage fluid(BALF). In addition, it reduced the deposit of complement activation products in the lung and improved oxidantantioxidant imbalance. Moreover, CHCP administration inhibited fever in rats, reduced the number of leukocytes and restored serum complement levels. The inhibition on the inappropriate activation of complement system by CHCP may play an important role in its beneficial effects on inflammatory diseases. The anti-complementary polysaccharides are likely to be among the key substances for the heatclearing function of H. cordata. | Yan Lu Yun Jiang Lijun Ling Yunyi Zhang Hong Li Daofeng Chen | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 18 |
| 14 | 基孔肯雅病研究现状和防制对策显示文摘 | 张海林 | 2007 | 中国人兽共患病学报2007，23，6： | 15 |
| 15 | 长期不明原因发热性疾病的临床诊断思维显示文摘发热是临床各科常见的症状和体征,常见于感染性疾病,特别是传染病常常伴有发热,许多传染病以“热”命名。不明原因发热(fever of unknown origin,FUO)是临床各科,特别是感染性疾病科医师经常面临的问题,患者临床表现特异性差,病因诊断是临床常见的难题,而且引起发热的病因繁多,考验临床医师的知识面和耐心和综合分析能力。随着时间的推移,FUO的病因学也在发生变化。近年来,国内外对FUO诊治研究取得一定进展,现作一综述。 | 李刚 李儒贵 谭华炳 | 2014 | 中华实验和临床感染病杂志(电子版)2014，8，1： | 15 |
| 16 | Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality显示文摘Severe fever with thrombocytopenia syndrome (SFTS),an emerging tick-borne infectious disease caused by a novel phlebovirus (SFTS virus, SFTSV), was listed among the top 10 priority infectious diseases by the World Health Organization due to its high fatality of 12%-50% and possibility of pandemic transmission. Currently, effective anti-SFTSV intervention remains unavailable. Here, by screening a library of FDA-approved drugs, we found that benidipine hydrochloride, a calcium channel blocker (CCB), inhibited SFTSV replication in vitro. Benidipine hydrochloride was revealed to inhibit virus infection through impairing virus internalization and genome replication. Further experiments showed that a broad panel of CCBs, including nifedipine, inhibited SFTSV infection. The anti-SFTSV effect of these two CCBs was further an a lyzed in a humanized mouse model in which CCB treatment resulted in reduced viral load and decreased fatality rate. Importantly, by performing a retrospective clinical investigation on a large cohort of 2087 SFTS patients, we revealed that nifedipine administration enhaneed virus clearance, improved clinical recovery, and remarkably reduced the case fatality rate by >5-fold. These findings are highly valuable for developing potential host-oriented therapeutics for SFTS and other lethal acute viral infections known to be inhibited by CCBs in vitro. | Hao Li Lei-Ke Zhang Shu-Fen Li Shao-Fei Zhang Wei-Wei Wan Yu-Lan Zhang Qi-Lin Xin Ke Dai Yuan-Yuan Hu Zhi-Bo Wang Xiang-Tao Zhu Yu-Jie Fang Ning Cui Pan-He Zhang Chun Yuan Qing-Bin Lu Jie-Ying Bai Fei Deng Geng-Fu Xiao Wei Liu Ke Peng | 2019 | Cell Research2019，29，9： | 15 |
| 17 | 非洲猪瘟病毒pMGF505-7R通过抑制IL-1β和Ⅰ型干扰素调控病毒致病力显示文摘非洲猪瘟(African swine fever,ASF)是由非洲猪瘟病毒(African swine fever virus,ASFV)引起的一种急性、高致死性传染病。由于该病毒的致病机制不清楚,而且缺乏商品化的疫苗和特效药物,ASF的防控形势异常严峻。因此,解析ASFV的致病机制是当前迫切需要研究的科学问题。先天免疫是宿主抵抗病原微生物感染的第一道防线,炎症反应和I型干扰素是先天免疫应答的重要成分,ASFV感染如何逃逸宿主的先天免疫系统的监视,其与病毒致病力的关系尚不完全清楚。 | | 2021 | 中国预防兽医学报2021，43，7： | 12 |
| 18 | 登革热的预防与控制显示文摘 | 梁文佳 何剑峰 | 2005 | 华南预防医学2005，31，2： | 11 |
| 19 | 我国亚热带地区登革热流行概况显示文摘 | 吴德仁 谢平 | 2009 | 应用预防医学2009，15，3： | 10 |
| 20 | 发热伴血小板减少综合征12例临床分析显示文摘发热伴血小板减少综合征(severe fever with thrombocytopenia syndrome,SFTS)是由新型布尼亚病毒引起的一种新发传染性疾病口]。目前,有关这一传染病的临床诊断及治疗报道较少,作为山东省疫区之一的地市,本研究分析2010年5月至2011年10月收治的12例典型患者,现报道如下。 | 孙宝霞 路苓 许亮 李俊俊 刘辉辉 刘洋 宋帅 孙延壮 | 2012 | 中华传染病杂志2012，30，8： | 10 |
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