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| 1 | Biomolecular basis of the role of diabetes mellitus in osteoporosis and bone fractures显示文摘Osteoporosis has become a serious health problem throughout the world which is associated with an increased risk of bone fractures and mortality among the people of middle to old ages.Diabetes is also a major health problem among the people of all age ranges and the sufferers due to this abnormality increasing day by day.The aim of this review is to summarize the possible mechanisms through which diabetes may induce osteoporosis.Diabetes mellitus generally exerts its effect on different parts of the body including bone cells specially the osteoblast and osteoclast,muscles,retina of the eyes,adipose tissue,endocrine system specially parathyroid hormone(PTH) and estrogen,cytokines,nervous system and digestive system.Diabetes negatively regulates osteoblast differentiation and function while positively regulates osteoclast differentiation and function through the regulation of different intermediate factors and thereby decreases bone formation while increases bone resorption.Some factors such as diabetic neuropathy,reactive oxygen species,Vitamin D,PTH have their effects on muscle cells.Diabetes decreases the muscle strength through regulating these factors in various ways and ultimately increases the risk of fall that may cause bone fractures. | Bipradas Roy | 2013 | World Journal of Diabetes2013，4，4： | 41 |
| 2 | Study of the mechanisms of acupuncture and moxibustion treatmentfor ulcerative colitis ratsinview of the gene expression of cytokines显示文摘AIM To observe the effect of acupuncture and moxibustion on the expression of IL 1β and IL 6 mRNA in ulcerative colitis rats. METHODS The SD rat ulcerative colitis model was created by immunological method associated with local stimulation. Colonic mucosa was prepared from human fresh surgical colonic specimens, homogenized by adding appropriate amount of normal saline and centrifuged at 3000*!r/*!min . The supernatant was collected for measurement of protein conentration and then mixed with Freund adjuvant. This antigen fluid was first injected into the plantae of the model group rats, and then into their plantae, dorsa, inguina and abdominal cavities (no Freund adjuvant for the last injection) again on the 10th, 17th, 24th and 31st day. When a certain titer of serum anti colonic antibody was reached, 2% formalin and antigen fluid (no Freund adjuvant) were administered separately by enema. The ulcerative colitis rat model was thus set up. The animals were randomly divided into four groups: model control group (MC, n =8), electro acupuncture group (EA, n =8), herbs partition moxibustion group (HPM 8), normal control group (NC, n =8). HPM: Moxa cones made of refined mugwort floss were placed on the medicinal pad (medicinal pad dispensing: Radix Aconiti praeparata, cortex Cinnamomi, etc ) for Qihai (RN 6) and Tianshu (ST 25, bilateral) and ignited. Two moxa cones were used for each acupoint once a day and 14 times in all. EA: Tianshu (bilateral) and Qihai were stimulated by the intermittent pulse with 2Hz frequency, 4mA intensity for 20 minutes once a day and 14 times in all. After treatment, rats of all four groups were killed simultaneously. The spleen was separated and the distal colon was dissected. Total tissue RNA was isolated by the guanidinium thiocyanate phenol chloroform extraction method. RT PCR technique was used to study the expression of IL 1β and IL 6 mRNA. RESULTS IL 1β and IL 6 mRNAs were not detected in the spleen and colonic mucosa of the NC rats, whereas they were significantly expressed in that of the MC rats. IL 1β and IL 6 mRNAs were markedly lower in the EA and HPM rats than that in MC rats. There was no significant difference between the levels of IL 1β and IL 6 mRNAs in the EA and HPM rats. The expressions of IL 1β and IL 6 mRNAs were nearly the same in the spleen and colon of all groups. CONCLUSION Acupuncture and moxibustion greatly inhibited the expression of IL 1β and IL 6 mRNA in the experimental ulcerative colitis rats. | Wu HG Zhou LB Pan YY Huang C Chen HP Shi Z Hua XG | 1999 | World Journal of Gastroenterology1999，5，6： | 45 |
| 3 | Cytokines as biochemical markers for knee osteoarthritis显示文摘Osteoarthritis(OA) is a debilitating degenerative joint disease particularly affecting weightbearing joints within the body, principally the hips and knees. Current radiographic techniques are insufficient to show biochemical changes within joint tissue which can occur many years before symptoms become apparent. The need for better diagnostic and prognostic tools is heightened with the prevalence of OA set to increase in aging and obese populations. As inflammation is increasingly beingconsidered an important part of OAs pathophysiology, cytokines are being assessed as possible candidates for biochemical markers. Cytokines, both pro- and antiinflammatory, as well as angiogenic and chemotactic, have in recent years been studied for relevant characteristics. Biochemical markers show promise in determination of the severity of disease in addition to monitoring of the efficacy and safety of disease-modifying OA drugs, with the potential to act as diagnostic and prognostic tools. Currently, the diagnostic power of interleukin(IL)-6 and the relationship to disease burden of IL-1β, IL-15, tumor necrosis factor-α, and vascular endothelial growth factor make these the best candidates for assessment. Grouping appropriate cytokine markers together and assessing them collectively alongside other bone and cartilage degradation products will yield a more statistically powerful tool in research and clinical applications, and additionally aid in distinguishing between OA and a number of other diseases in which cytokines are known to have an involvement. Further large scale studies are needed to assess the validity and efficacy of current biomarkers, and to discover other potential biomarker candidates. | Thomas Mabey Sittisak Honsawek | 2015 | World Journal of Orthopedics2015，6，1： | 38 |
| 4 | Ankylosing spondylitis: etiology, pathogenesis, and treatments显示文摘Ankylosing spondylitis(AS), a common type of spondyloarthropathy, is a chronic inflammatory autoimmune disease that mainly affects spine joints, causing severe, chronic pain;additionally, in more advanced cases, it can cause spine fusion. Significant progress in its pathophysiology and treatment has been achieved in the last decade. Immune cells and innate cytokines have been suggested to be crucial in the pathogenesis of AS, especially human leukocyte antigen(HLA)?B27 and the interleukin?23/17 axis.However, the pathogenesis of AS remains unclear. The current study reviewed the etiology and pathogenesis of AS, including genome-wide association studies and cytokine pathways. This study also summarized the current pharmaceutical and surgical treatment with a discussion of future potential therapies. | Wei Zhu Xuxia He Kaiyuan Cheng Linjie Zhang Di Chen Xiao Wang Guixing Qiu Xu Cao Xisheng Weng | 2019 | Bone Research2019，7，3： | 30 |
| 5 | 孟鲁司特钠对咳嗽变异性哮喘患者FeNO及炎症因子水平的影响显示文摘目的探讨孟鲁司特钠对咳嗽变异性哮喘(cough variant asthma,CVA)患者呼出气一氧化氮(Fractional exhaled nitric oxide,Fe NO)、肿瘤坏死因子(tumor necrosis factor,TNF-α)、白介素-5(interleukin-5,IL-5)、(Serum amyloid A,SAA)及肺功能的影响。方法 55例CVA患者随机分为对照组29例,观察组26例,两组患者均给予氨溴索片、茶碱缓释片及酮替芬口服;观察组加服孟鲁司特钠片10mg,每晚一次。观察治疗8周后2组患者Fe NO、TNF-α、IL-5、SAA、肺功能(FEV1、PEF、FEV1/FVC)变化。结果治疗8周后,观察组患者Fe NO、TNF-α、IL-5、SAA比对照组均明显下降(P<0.05),观察组FEV1、PEF、FEV1/FVC比对照组明显升高(P<0.05)。结论孟鲁司特钠治疗咳嗽变异性哮喘,炎症因子水平明显降低,肺功能及临床症状显著改善。 | 李桂仙 李立维 李倩 | 2017 | 临床肺科杂志2017，22，11： | 27 |
| 6 | Role of NLRP3 inflammasome in inflammatory bowel diseases显示文摘Inflammasomes are multiprotein intracellular complexes which are responsible for the activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 has been a subject of intensive investigation. NLRP3 is considered to be a sensor of microbial and other danger signals and plays a crucial role in mucosal immune responses, promoting the maturation of proinflammatory cytokines interleukin 1β(IL-1β) and IL-18. NLRP3 inflammasome has been associated with a variety of inflammatory and autoimmune conditions, including inflammatory bowel diseases(IBD). The role of NLRP3 in IBD is not yet fully elucidated as it seems to demonstrate both pathogenic and protective effects. Studies have shown a relationship between genetic variants and mutations in NLRP3 gene with IBD pathogenesis. A complex interaction between the NLRP3 inflammasome and the mucosal immune response has been reported. Activation of the inflammasome is a key function mediated by the innate immune response and in parallel the signaling through IL-1β and IL-18 is implicated in adaptive immunity. Further research is needed to delineate the precise mechanisms of NLRP3 function in regulating immune responses. Targeting NLRP3 inflammasome and its downstream signaling will provide new insights into the development of future therapeutic strategies. | Evanthia Tourkochristou Ioanna Aggeletopoulou Christos Konstantakis Christos Triantos | 2019 | World Journal of Gastroenterology2019，25，33： | 24 |
| 7 | The Change of Interleukin-6 and Tumor Necrosis Factor in Patients with Obstructive Sleep Apnea Syndrome显示文摘The levels of lipopolysaccharide (LPS) induced interleukin 6 (IL 6) and tumor necrosis factor α (TNF α) expression in culture of peripheral blood mononuclear cells (PBMC) and the plasma levels of IL 6 and TNF α in the patients with obstructive sleep apnea syndrome (OSAS) were measured and the relationship between OSAS and IL 6 or TNF α expression studied. Both IL 6 and TNF α were detected by using ELISA in 22 patients with OSAS and 16 normal controls. The levels of LPS induced IL 6 (787.82±151.97 pg/ml) and TNF α (4165.45±1501.43 pg/ml) expression in the supernatant of the culture of PBMC and plasma level of IL 6 (50.67±4.70 pg/ml) and TNF α (299.09±43.57 pg/ml) in the patients with OSAS were significantly higher than those in the normal controls (in the supernatant of the culture of PBMC: 562.69±197.54 pg/ml and 1596.25±403.08 pg/ml respectively; in the plasma: 12.69±2.75 pg/ml and 101.88±21.27 pg/ml respectively). There were significantly positive correlation between the levels of IL 6 and TNF α and the percentage of time of apnea and hyponea, as well as the percentage of time spending at SaO 2 below 90 % in the total sleep time. It was concluded that LPS induced IL 6 and TNF α levels as well as plasma IL 6 and TNF α levels in the patients with OSAS were up regulated, which may be associated with the pathogenesis of OSAS. | 刘辉国 刘瑾 熊盛道 沈关心 张珍祥 徐永健 | 2000 | Journal of Huazhong University of Science and Technology(Medical Sciences)2000，20，3： | 22 |
| 8 | Comprehensive mutation screening for 10 genes in Chinese patients suffering very early onset inflammatory bowel disease显示文摘AIM: To perform sequencing analysis in patients with very early-onset inflammatory bowel disease(VEO-IBD) to determine the genetic basis for VEO-IBD in Chinese pediatric patients.METHODS: A total of 13 Chinese pediatric patients with VEO-IBD were diagnosed from May 2012 and August 2014. The relevant clinical characteristics of these patients were analyzed. Then DNA in the peripheral blood from patients was extracted. Next generation sequencing(NGS) based on an IlluminaMiseq platform was used to analyze the exons in the coding regions of 10 candidate genes: IL-10, IL-10 RA, IL-10 RB, NOD2, FUT2, IL23 R, GPR35, GPR65, TNFSF15, and ADAM30. The Sanger sequencing was used to verify the variations detected in NGS.RESULTS: Out of the 13 pediatric patients, ten were diagnosed with Crohn's disease, and three diagnosed with ulcerative colitis. Mutations in IL-10 RA and IL-10 RB were detected in five patients. There were four patients who had single nucleotide polymorphisms associated with IBD. Two patients had IL-10 RA andFUT2 polymorphisms, and two patients had IL-10 RB and FUT2 polymorphisms. Gene variations were not found in the rest four patients. Children with mutations had lower percentile body weight(1.0% vs 27.5%, P = 0.002) and hemoglobin(87.4 g/L vs 108.5 g/L, P = 0.040) when compared with children without mutations. Although the age of onset was earlier, height was shorter, and the response to treatment was poorer in the mutation group, there was no significant difference in these factors between groups.CONCLUSION: IL-10 RA and IL-10 RB mutations are common in Chinese children with VEO-IBD. Patients with mutations have an earlier disease onset, lower body weight and hemoglobin, and poorer prognosis. | Yuan Xiao Xin-Qiong Wang Yi Yu Yan Guo Xu Xu Ling Gong Tong Zhou Xiao-Qin Li Chun-Di Xu | 2016 | World Journal of Gastroenterology2016，22，24： | 20 |
| 9 | In vitro production of TNFα,IL-6 and sIL-2R in Chinese patients with ulcerative colitis显示文摘InvitroproductionofTNFα,IL6andsIL2RinChinesepatientswithulcerativecolitisXIABing1,GUOHaiJian1,JBACrusius2,DENGChangSheng... | XIA Bing 1, GUO Hai Jian 1, JBA Crusius 2, DENG Chang Sheng 1, SGM Meuwissen 2 and AS Pena 2 | 1998 | World Journal of Gastroenterology1998，4，3： | 18 |
| 10 | Interleukin-1β is a potential therapeutic target for periodontitis: a narrative review显示文摘Interleukin(IL)-1β, a pro-inflammatory cytokine, was elevated and participates in periodontitis. Not only the link between IL-1β and periodontitis was proved by clinical evidence, but also the increased IL-1β triggers a series of inflammatory reactions and promotes bone resorption. Currently, IL-1β blockage has been therapeutic strategies for autoimmune and autoinflammatory diseases such as rheumatoid arthritis, cryopyrin-associated periodic syndromes, gout and type II diabetes mellitus. It is speculated that IL-1β be a potential therapeutic target for periodontitis. The review focuses on the production, mechanism, present treatments and future potential strategies for IL-1β in periodontitis. | Ran Cheng Zhiwu Wu Mingming Li Meiying Shao Tao Hu | 2020 | International Journal of Oral Science2020，12，1： | 18 |
| 11 | Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophills and regulation by interleukin 10 during intestinal inflammation显示文摘Increasedsecretionofproinflammatorycytokinesbycirculatingpolymorphonuclearneutrophilsandregulationbyinterleukin10duringintes... | S Nikolaus 1, J Bauditz 1, P Gionchetti 2, C Witt 3, H Lochs 1 and S Schreiber 1 1Charité University Hospital, 4th Medical Department, Humboldt University, Berlin, Germany 2Clinica Media I, Policlinico S. Orsola, University of Bolog | 1998 | World Journal of Gastroenterology1998，4，3： | 17 |
| 12 | 莫西沙星治疗耐药肺结核的临床疗效及机制研究显示文摘目的:探讨莫西沙星治疗耐药肺结核的临床疗效及可能机制。方法:选择2013年2月-2015年2月于我院门诊诊治的108例耐药肺结核,参照抽签法分为对照组和观察组,均54例,对照组采用左氧氟沙星治疗,观察组采用莫西沙星治疗,比较两组临床疗效、血清白细胞介素-1(IL-1)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平、CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、TOS、TAS、OSI和副反应的发生情况。结果:观察组治疗有效率高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组血清IL-1,IL-6,TNF-α,TOS及OSI水平显著低于对照组,CD3^+、CD4^+、CD8^+、TAS水平明显高于对照组,差异有统计学意义(P<0.05)。两组副反应发生情况比较差异无统计学意义(P>0.05)。结论:莫西沙星治疗耐药肺结核的临床疗效高,可能与减轻机体炎症反应和氧化应激水平及改善免疫功能有关。 | 王容 周焱 赵川 李毅 杨凤 | 2017 | 现代生物医学进展2017，17，13： | 17 |
| 13 | Clinical evaluation of serum interleukin 10 in patients with acute pancreatitis显示文摘OBJECTIVES: To evaluate the behavior of serum interleukin 10 (IL-10) in patients with acutepancreatitis and to explore the relationship between this cytokine and the severity of the disease.METHODS: In 45 patients with acute pancreatitis, the serum concentrations of IL-10 was determinedon days 1, 2, 3, 4, 5 after admission. Twelve healthy subjects were also studied as controls. Thesesubjects were tested using a commercial ELISA kit. The severity of pancreatitis was determined accordingto APACHE Ⅱ score and Balthazar CT criteria.RESULTS: Healthy subjects had no detectable serum levels of IL-10. In acute pancreatitis patients,the serum IL-10 levels were increased on the first day after the onset of the disease and then progressivelydecreased in the following days. On the first day after the onset of acute pancreatitis, the serum levelsof IL-10 in patients with mild acute pancreatitis were significantly higher than in those with severe acutepancreatitis. In the following days, however, no statistically significant difference was observed betweenthe two groups.CONCLUSIONS: Serum IL-10 concentration reflects the severity of acute pancreatitis. IL-10 is a usefulvariable for early prediction of the prognosis of acute pancreatitis. The low values of serum IL-10 inpatients with severe acute pancreatitis suggests that there may be altered down-regulation of immunesystem response. An enhanced release of IL-10 may be a method for early treatment of acute pancreatitis. | Xi-Chun Han Ying-Chao Zhang Yu Wang Ming-Ku Jia the Department of Surgery Secoad Hospital, Jilin University, Changchun 130041, China | 2003 | Hepatobiliary & Pancreatic Diseases International2003，2，1： | 16 |
| 14 | 右美托咪定对单肺通气患者血清TNF-a、IL-6和IL-10变化的影响显示文摘目的:观察右美托咪定对单肺通气患者血清TNF-α、IL-6和IL-10变化的影响。方法选择择期全麻单肺通气下行开胸手术患者48例,采用随机数字表法分为右美托咪定组(D组)和对照组(C组),各24例。D组麻醉诱导前10 min经静脉输注右美托咪定1滋g/kg,随后以0.5滋g/(kg·h)的速率输注至术毕前30min。C组给予等量0.9%氯化钠溶液。于麻醉诱导前(T0)、单肺通气即刻(T1)、单肺通气30min(T2)、单肺通气90min(T3)、双肺通气后30 min(T4)和术后120min(T5)时间点采用酶联免疫吸附法测定血清TNF-α、IL-6和IL-10浓度,同时观察HR、MAP、SpO2的变化。结果两组患者各时点HR、MAP、SpO2差异均无统计学意义(均P>0.05)。与T0时比较,两组患者T2~T5时血浆TNF- α和IL-6浓度升高(P<0.05),与 C组比较,D组T2~T5时血浆TNF- a和IL-6浓度降低(P<0.05)。与T0时比较,两组患者T3~T5时血浆IL-10浓度升高(P<0.05),两组IL-10浓度的差异无统计学意义(P>0.05)。结论围手术期静脉持续输注右美托咪啶可降低炎性因子TNF-α和IL-6的释放,明显减轻单肺通气患者围术期的炎性反应。 | 罗颖 孙建良 吴艳辉 徐丽慧 丁卫华 | 2014 | 浙江医学2014，36，4： | 15 |
| 15 | Expression of interleukin 1β converting enzyme in 5-FU induced apoptosis in esophageal carcinoma cells显示文摘NTRODUCTIONApoptosisisanimportantphysiologicalformofceldeath.Itisstrictlycontroledbygenes.Ithasbeenshowninexperimentsthatexte... | DENG Li Ying 1, ZHANG Yun Han 2, XU Ping 2, YANG Su Min 1 and YUAN Xue Bin 1 | 1999 | World Journal of Gastroenterology1999，5，1： | 13 |
| 16 | 原发性痛风性关节炎患者白介素-1β的变化及其临床意义显示文摘目的 探讨IL-1β在痛风发病中的作用.方法 采用实时荧光定量聚合酶链反应(RT-qPCR)和酶链免疫吸附实验(ELISA)方法,检测120例痛风性关节炎急性期患者(急性期组)、70例慢性期患者(慢性期组)、80例间歇期患者(间歇期组)和96名健康体检者(正常对照组)的外周血单个核细胞(PBMCs) IL-1β mRNA水平和血浆IL-1β浓度;变量间差异采用方差分析或t检验(校正t检验),变量间相关关系采用Spearman相关分析.结果 各组患者的PBMCs IL-1β mRNA和血浆IL-1β浓度均显著高于正常对照组(均P<0.01);急性期组PBMCs IL-1β mRNA和血浆IL-1β浓度显著高于慢性期和间歇期组(均P<0.01),慢性期组显著高于间歇期组(均P<0.01).患者血浆IL-1β浓度与外周血白细胞计数、中性粒细胞和单核细胞绝对计数、血尿酸、球蛋白、ESR及PBMCs IL-1βmRNA水平均呈显著正相关(均P<0.01),而与载脂蛋白A1呈负相关(P<0.05).结论 血浆IL-1β显著升高在痛风急慢性关节炎炎症机制中发挥着重要作用. | 李玲琴 青玉凤 张全波 周京国 | 2015 | 中华全科医师杂志2015，14，1： | 12 |
| 17 | 降钙素原和白细胞介素-6对急性胰腺炎严重程度及预后的评价显示文摘目的探讨血清降钙素原(PCT)和白细胞介素6(IL-6)与急性胰腺炎(AP)病情严重程度的相关性,以及对AP患者预后的评估价值。方法选取AP患者59例,将其分为轻症AP组38例(MAP组),重症AP组21例(SAP);并根据其预后分为生存组和死亡组,生存组52例,死亡组7例;另选取正常健康体检者51例作为对照组。分别于入院第1、3和7天抽取静脉血检测血清PCT和IL-6水平,同时进行急性生理和慢性健康评分标准Ⅱ(APACHEⅡ)评分。结果与对照组比较,入院第1天MAP组和SAP组血清PCT和IL-6水平均升高(P<0.01),其中SAP组升高更明显(P<0.01);入院第3天时MAP组和SAP组血清PCT和IL-6水平均明显升高达到峰值;经过常规治疗后(入院第7天),两组的PCT和IL-6水平均能下降至正常水平。PCT和IL-6水平与APACHEⅡ评分呈正相关(P<0.05)。结论血清PCT和IL-6水平与AP的发生、发展相关,早期密切观察血清PCT和IL-6水平变化在AP的严重程度和预后评估方面有一定的临床应用价值。 | 王中波 白驹 雷鸣 刘龙标 郑睿东 | 2014 | 国际检验医学杂志2014，35，7： | 12 |
| 18 | IL-10、IL-17在子宫内膜癌中的表达及其与临床病理的关系显示文摘子宫内膜癌(endometrial carcinoma)作为临床常见的妇科恶性肿瘤,多发生于50岁及以上的绝经妇女,并且其发病率有呈逐渐升高的趋势,严重威胁患者的健康和生命质量。关于其发病机制,目前尚无统一结论 ,有研究证实多种细胞因子可能参与了子宫内膜癌的发生及发展过程。 | 欧阳小明 史文静 冀天星 郝卓芳 廖德贵 | 2015 | 中国实验诊断学2015，19，5： | 12 |
| 19 | Recombinant adenovirus vector Ad-hIL-10 protects grafts from cold ischemia-reperfusion injury following orthotopic liver transplantation in rats显示文摘BACKGROUND:Interleukin 10(IL-10),a Th2 type cytokine,modulates inflammatory responses by inhibiting the production of proinflammatory cytokines.This study was designed to investigate the protective effects of adenovirus- mediated human IL-10(Ad-hIL-10)gene transfer on protecting grafts from cold ischemia-reperfusion injury following orthotopic liver transplantation in rats. METHODS:Adenoviruses encoding hIL-10 orβ-galactosidase (Ad-lacZ)were injected via the superior mesenteric vein into prospective donor animals.The donor liver was harvested 48 hours after transduction,and stored for 12 hours at 4℃ in lactated Ringer's solution prior to transplantation.The rats were divided into saline,Ad-lacZ,and Ad-hIL-10 groups.Liver function test,histopathological examination,reverse transcriptase-polymerase chain reaction(RT-PCR),and Western blotting were performed at 24 hours after transplantation in the three groups. RESULTS:Liver function(ALT and AST)was significantly improved,and the Suzuki score was significantly decreased in the Ad-hIL-10 group.The levels of hepatic TNF-α,MIP-2,ICAM-1 mRNA,and NF-κB protein in the Ad-hIL-10 group were significantly decreased.The expression of hIL-10 mRNA was detected by RT-PCR in Ad-hIL-10-treated grafts but not in controls treated with saline or Ad-lacZ. CONCLUSIONS:Donor pretreatment with Ad-hIL-10 down- regulates the expression of proinflammatory cytokines TNF-α,MIP-2,and ICAM-1 mRNA.hIL-10 protects against hepatic cold ischemia-reperfusion injury,at least in part,by suppressing NF-κB activation and subsequent expression of proinflammatory mediators. | Si, Zhong-Zhou Li, Jie-Qun Qi, Hai-Zhi He, Zhi-Jun Hu, Wei Li, Yi-Ning | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，2： | 11 |
| 20 | New roles of osteoblasts involved in osteoclast differentiation显示文摘Bone-resorbing osteoclasts are formed from a monocyte/macrophage lineage under the strict control o bone-forming osteoblasts. So far,macrophage colonystimulating factor(M-CSF),receptor activator o nuclear factor-κB ligand(RANKL),and osteoprotegerin(OPG) produced by osteoblasts play major roles in the regulation of osteoclast differentiation. Recent studies have shown that osteoblasts regulate osteoclastogenesis through several mechanisms independent o M-CSF,RANKL,and OPG production. Identification o osteoclast-committed precursors in vivo demonstrated that osteoblasts are involved in the distribution o osteoclast precursors in bone. Interleukin 34(IL-34)a novel ligand for c-Fms,plays a pivotal role in maintaining the splenic reservoir of osteoclast-committed precursors in M-CSF deficient mice. IL-34 is also able to act as a substitute for osteoblast-producing M-CSF in osteoclastogenesis. Wnt5 a,produced by osteoblasts,enhances osteoclast differentiation by upregulating RANK expression through activation of the noncanonical Wnt pathway. Semaphorin 3A produced by osteoblasts inhibits RANKL-induced osteoclast differentiation through the suppression of immunoreceptortyrosine-based activation motif signals. Thus,recent findings show that osteoclast differentiation is tightly regulated by osteoblasts through several different mechanisms. These newly identified molecules are expected to be promising targets of therapeutic agents in bone-related diseases. | Teruhito Yamashita Naoyuki Takahashi Nobuyuki Udagawa | 2012 | World Journal of Orthopedics2012，3，11： | 11 |
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