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| 1 | Effect of NF-κB inhibitor PDTC on VEGF and endostatin expression of mice with Lewis lung cancer显示文摘Objective:To investigate the effects of NF-κB inhibitor pyrrolidine dithiocarbamate hydrochloride(PDTC) on vascular endothelial growth factor(VEGF) and endostatin expression in mice with Lewis lung cance;and its mechanism.Methods:Mice survival rate and anti-tumor effects were observed in different concentrations of NF-κB inhibitor PDTC after the Lewis lung cancer mice model was established.VEGF and endostatin expressions were detected by immunohistochemical assay.Results:Lewis lung cancer was be inhibited by 0.5 mg/kg.1.5 mg/kg and 3.0 mg/kg of NF-κB inhibitor PDTC(P<0.05).Microvessel density(MVD) in 0.5 mg/kg.1.5 mg/kg and 3.0 mg/kg NF-κB inhibitor PDTC groups were significantly lower than the control group(P<0.05).Immunohistochemical assay results showed that VEGF and endostatin expressions in the 0.5 mg/kg.1.5 mg/kg and 3.0 mg/kg NF-κB inhibitor PDTC groups were significantly lower than the control group(P<0.05).Western blot results also showed that NF-κB inhibitor PDTC could inhibit VEGF and endostatin expressions in tumor tissues.Conclusions:NF-κB inhibitor PDTC can inhibit tumor formation and reduce tumor angiogenesis in mice with Lewis lung cancer;and its mechanism maybe associated to VEGF and endostatin down-regulation. | Ping Gao Ya-Jie Gao Hong-Lu Liang | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，3： | 18 |
| 2 | Ivorlewis与Sweet手术治疗食管癌的临床评价显示文摘目的:探讨食管癌Ivor lewis和Sweet两种术式的临床应用并评价其效果及心肺保护作用。方法:将食管癌病人临床随机分为两组各60例,分别实行Ivor lewis和Sweet手术,对术中后血流动力学和并发症发生率等项指标进行检测和临床评价。结果:Ivor lewis组SBP,DBP,HR值基本接近正常范围,Sweet组高于此范围,手术并发症发生率Ivor lewis组低于Sweet组(P<0.01)。结论:Ivor lewis术式的血流动力学稳定性优于Sweet组,手术并发症发生率低于Sweet组。Ivor lewis手术有利于心肺功能的保护。 | 周钢 田宝文 朱晓锋 邢宇彤 史宏宇 | 2010 | 黑龙江医药科学2010，33，6： | 17 |
| 3 | Effect of endostar combined with cisplatin on expression of VEGF and Sema3A of Lewis lung cancer rats显示文摘Objective:To evaluate the therapeutic effect of endostar(ED) combined with cisplatin(DDP) on model of C57BL/6 rats,and to further investigate the inhibiting mechanism of endostar from tumor angiogenesis.Methods:Lewis lung cancer cells were inoculated in C57BL/6 mouse,then the mouse were randomized into control group(group A),ED(group B),DDP(group C) and ED/DDP (group D).They were treated according to the plan.And the expressions of VEGF and Sema3A were evaluated by immunhistochemisty.Results:The weight of tumor increased in group A and B.It was decreased in group C and D.The tumor volume was increased in all the 4 groups. The VEGF expression of group D was obviously lower than the other group 3,but the Sema3A expressed of group D was significantly strengthener than the other group 3.The VEGF expression of group B and group D were obviously low especially in the 4th-8th days.Pearson correlated analysis showed that the expression VEGF and Sema3A were negatively correlated(r=-0.72, P<0.05).Conclusions:ED combined with DDP could control the tumor growth effectively,and avoid weight loss.ED could reduce VEGF expression,and enhance Sema3A expression.Tumor vessel presents transient normalization.It is easy for DDP perfusion,and to kill tumor cells. | Ping Feng Zhi-Lin Zhang Zhi-Hua Zhang Xiu-Long Zhang Feng Xiang Jian-Hua Tang Bao-Li Xiang | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，1： | 14 |
| 4 | 皂角刺抗肿瘤的初步研究显示文摘目的观察皂角刺水煎液的体内外抗肿瘤作用。方法体内实验:建立小鼠背部皮下移植性实体肿瘤H22荷瘤动物模型,灌胃给药后测定肿瘤体积、质量及免疫器官指数;体外实验:用MTT法测定皂角刺对小鼠lewis肺癌细胞的影响。结果体内实验:在本实验剂量下(0.3mL/g),与模型对照组比较,皂角刺组肿瘤生长减缓,抑瘤率为38.37%,胸腺指数、脾脏指数均增高;体外实验:实验所用浓度的皂角刺水煎液呈剂量依赖性抑制小鼠lewis肺癌细胞生长。结论皂角刺有一定抗肿瘤作用,其机制可能与细胞毒和提高机体免疫作用有关。 | 王莹莹 刘伟杰 杜钢军 | 2014 | 河南大学学报(医学版)2014，33，2： | 12 |
| 5 | Facile synthesis of ultrathin metal-organic framework nanosheets for Lewis acid catalysis显示文摘Ultrathin metalorganic framework (MOF) nanosheets are attracting great interest in catalysis due to their unique and intriguing two-dime nsional (2D) features. Although many progresses have been achieved, it is still highly desirable to develop novel strategies for controllable synthesis of the well-defined ultrathin MOF nanosheets. Herein we report a polyvinylpyrrolidone (PVP)-assisted route to synthesize the ultrathin Ni-MOF nanosheets characteristic of 1.5 nm in thickness, in which PVP is reacted with 2-aminoterephthalic acid (H2BDC-NH2) via formation of C=N bon d, followed by coord inatio n with Ni2+ io ns to form the ultrathi n MOF n anosheets. Impressively, when used in the Kno eve nagel condensation reactions of propane dinitrile with different aldehydes, ultrathin Ni-MOF nanosheets display the significantly enhanced catalytic activity and good stability in respect with the bulk Ni-MOF, mainly owing to the exposed active sites as well as facile mass transfer and diffusion of substrates and products. | Xiaofei Zhang Lin Chang Zhongjie Yang Yanan Shi Chang Long Jianyu Han Binhao Zhang Xueying Qiu Guodong Li Zhiyong Tang | 2019 | Nano Research2019，12，2： | 11 |
| 6 | 病态窦房结综合征显示文摘病态窦房结综合征(sick sinus syndrome,SSS)于1912年Cohn和Lewis首次发现,由Lown于1966年命名。主要是由于窦房结及其邻近组织的器质性病变,引起窦房结起搏功能和窦房结传导障碍,从而产生多种心律失常和临床症状的综合征。过去认为缺血性心脏病、心肌病、风湿性心脏病、心肌炎、高血压性心脏病是最常见的病因,目前认为特发性SSS趋向于主要病因,尤其是在中青年病窦综合征病因中占第一位。 | 孟晓萍 崔建华 费瑜 程泉丽 高丽华 | 2011 | 中国临床医生杂志2011，39，9： | 11 |
| 7 | Antitumor effect of recombinant human endostatin combined with cisplatin on rats with transplanted Lewis lung cancer显示文摘Objective: To observe the antitumor effect and mechanism of recombinant human endostatin(Endostar) injection in tumor combined with intraperitoneal injection of cisplatin on subcutaneous transplanted Lewis lung cancer in rats. Methods: A total of 30 C57 rats were selected, and the monoplast suspension of Lewis lung cancer was injected into the left axilla to prepare the subcutaneous transplanted tumor models in the axilla of right upper limb. The models were randomly divided into Groups A, B, and C. Medication was conducted when the tumor grew to 400 mm3. Group A was the control group without any interventional treatment. Group B was injected with Endostar 5 mg.kg-1.d for 10 d. Group C was given the injection of Endostar 5 mg.kg-1.d combined with intraperitoneal injection of cisplatin 5 mg.kg-1.d for 10 d. All the rats in three groups were executed the day after the 10-d medication and the tumor was taken off for measurement of volume and mass changes and calculation of antitumor rate, after which the vascular endothelial growth factor(VEGF) concentration in rats' plasma was determined by ELISA. The tumor tissues were cut for the preparation of conventional biopsies. After hematoxylin-eosin staining, the pathologic histology was examined to observe the structures of tumor tissues, VEGF score and microvessel density(MVD) in each group. Results: The volume and mass of tumor in Groups B and C were significantly lower than Group A(P < 0.05) while the tumor volume and mass in Group C were significantly lower than Group B(P < 0.05). The antitumor rate in Group C was significantly higher than Group B(P < 0.05), but the tumor VEGF score, MVD and plasma VEGF level in Group C were significantly lower than Groups A and B(P < 0.05). In Group B, the tumor VEGF score, MVD and plasma VEGF level were significantly lower than Group A(P < 0.05). The microscopic image of Group C showed that its number of active tumor cells and the blood capillary around tumor was significantly smaller than that of Groups A and B, and meanwhile atrophy and liquefactive necrosis were seen in local tumor. Conclusions: Endostar injection combined with intraperitoneal injection of cisplatin is effective in reducing tumor VEGF score and MVD of transplanted tumor tissues in rats with Lewis lung cancer to obstruct the nutrient supply of tumor cells and kill tumor cells, so that the inhibition of tumor cell proliferation and metastasis can be achieved with a remarkable effect. | Zhan-Wu Yu Ying-Hua Ju Cheng-Liang Yang Han-Bing Yu Quan Luo Ye-Gang Ma Yong-Yu Liu | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，8： | 10 |
| 8 | 幽门螺杆菌表达LewisB抗原不影响细菌的黏附显示文摘目的 研究幽门螺杆菌 (Hp)表达LewisB抗原对细菌黏附性的可能影响 ,以及Hp的babA2 基因与消化性溃疡的关系。方法 采用体外黏附分析法检测细菌的黏附性 ,聚合酶链反应法(PCR)检测Hp的babA2 基因。结果 (1)在 47例消化性溃疡Hp株中 ,18株为babA2 基因阳性 ;而 31例非溃疡性消化不良Hp株中 ,14株为babA2 阳性 (P =0 .42 7)。 (2 )在表达LewisB抗原的 31株Hp中 ,2 4株细菌黏附阳性 ;而在不表达LewisB抗原的 47株Hp中 ,38株呈细菌黏附阳性 (P =0 .46 3)。结论 (1)Hp的babA2 基因与消化性溃疡的发生无关。 (2 )Hp表达LewisB抗原不影响细菌的黏附 ,从而支持胃上皮LewisB是Hp的受体。 | 唐芙爱 郑鹏远 李振峰 冯常炜 华杰松 段芳龄 | 2001 | 中华消化杂志2001，21，3： | 9 |
| 9 | 扶正散结汤拆方配伍中药对Lewis肺癌转移及血管生成影响的研究显示文摘目的:研究扶正散结汤拆方配伍中药对Lewis肺癌荷瘤小鼠肿瘤转移及血管生成机制影响的差异及其协同作用。方法:80只C57小鼠,随机均分为空白组、模型组、顺铂组、扶正组、化痰组、活血组、解毒组、联合组,除空白组外其余小鼠右腋皮下接种Lewis瘤细胞建立肺癌模型,从接种后的第2天开始分别给予相应药物灌胃或腹腔注射,连续14 d后处死,将瘤体剥离常规固定、脱水、包埋切片,免疫组化SP法检测肿瘤组织中VEGF、ES、MMP-2。结果:各给药组肺转移结节数量均低于模型组(P<0.05),以顺铂组和联用组为最少、也最接近,其次依次为扶正组、解毒组和活血组,各组与顺铂组相比,除化痰组外,无显著性差异。顺铂及各配伍组分组均较模型组VEGF、MMP-2表达量降低、ES表达量升高,其中解毒组VEGF表达最低(P<0.05)、联用组ES表达量最高(P<0.05 or P<0.01)、MMP-2表达量最低(P<0.05),而顺铂组不具任何优势。结论:扶正散结汤拆方配伍四法联用具有更好抗肿瘤转移效果,与顺铂相当;在抗肿瘤微血管生成机制方面,各配伍组分作用各有特点,但四法联用具有更优的效果。 | 陈慧彬 陈超 滕鸣健 窦永起 | 2014 | 中华中医药学刊2014，32，12： | 9 |
| 10 | 分层阻滞与交替下传的文氏现象显示文摘 | 楚英杰 | 2005 | 临床心电学杂志2005，14，2： | 9 |
| 11 | 常规吻合器行微创Ivor Lewis中下段食管癌根治术的临床研究显示文摘目的探讨使用常规吻合器胸内吻合在Ivor Lewis式胸腹腔镜联合中、下段食管癌根治术中的可行性、安全性及近期疗效。方法回顾性分析我院2014年6月-2016年4月间20例使用常规吻合器胸内吻合全腔镜Ivor Lewis中、下段食管癌根治术患者的临床资料。结果全组手术顺利,手术时间(270±30)min;淋巴结清扫个数(12±4)枚;手术失血量(150±40)ml;术后胸管拔管时间(7±2)d;术后住院时间(12±2)d。本组1例中转行胸腔镜辅助小切口Ivor Lewis手术,1例出现术后吻合口瘘(经保守治愈),无围手术期死亡、无中转开胸开腹、无其他术后严重并发症。近期随访无死亡。结论通过细节处理,使用常规吻合器行胸内吻合在Ivor Lewis式胸腹腔镜联合中、下段食管癌根治术治疗上是可行的、安全的,能完成所有开放Ivor Lewis手术的步骤,近期疗效满意,远期疗效仍需前瞻性的随机对照临床试验验证。 | 熊剑文 喻东亮 魏益平 张小强 徐建军 宋思蓓 | 2016 | 江西医药2016，51，10： | 9 |
| 12 | H22肝癌与Lewis肺癌荷瘤小鼠证候特征比较研究显示文摘目的比较H22肝癌与Lewis肺癌C57BL/6N荷瘤小鼠证候及其差异。方法分别在雄性C57BL/6N小鼠右腋下接种H22肝癌腹水和Lewis肺癌瘤组织单细胞悬液,并设立正常对照组,采用小鼠四诊工作站平台与方法收集小鼠四诊信息,并进行计量辨证。结果接种第11~21天,Lewis肺癌小鼠肿瘤增长与小鼠死亡速度较H22肝癌小鼠速度快,第21天H22肝癌与Lewis肺癌小鼠存活比例分别为43.75%(7/16)和25.0%(5/20)。H22肝癌与Lewis肺癌荷瘤小鼠均自发形成了常见虚证,其中Lewis肺癌小鼠证候出现早,程度重,发展快。结论H22肝癌与Lewis肺癌C57BL/6N荷瘤小鼠与人类类似,存在着证候的自然发生与演变,可模拟临床肿瘤证候的发生与演变,用于辨证论治的实验研究;而本文所采用的计量化辨证有助于荷瘤小鼠个体化辨证论治,以及疾病和辨证论治客观化、计量化的疗效评价。 | 潘志强 方肇勤 卢文丽 | 2008 | 北京中医药大学学报2008，31，3： | 8 |
| 13 | 全胸腔镜肺叶切除术的现状及争议显示文摘 | 马冬春 | 2010 | 临床肺科杂志2010，15，10： | 8 |
| 14 | Lewis y抗体对α1,2岩藻糖转移酶基因转染后卵巢癌细胞的体外抑制作用显示文摘目的:探讨Lewis y单克隆抗体(mAb)对α1,2岩藻糖转移酶基因转染后高表达Lewis y抗原的卵巢癌细胞系RMG-I-H的体外增殖能力、黏附力以及侵袭力的抑制作用。方法:通过体外细胞增殖实验、细胞黏附实验、细胞体外侵袭实验,以羊抗人IgG抗体处理组或无抗体处理组为对照,检测Lewis y mAb处理前后RMG-I-H细胞增殖能力、黏附力及侵袭力的变化。结果:细胞增殖力与黏附力测定结果表明,实验组与对照组之间有统计学意义(P<0.05),且与对照组相比,第2~7天的生长抑制率分别为5.62%、19.75%、34.96%、46.51%、49.78%和33.33%。不同培养时间(15、30、60min)的黏附抑制率分别为47.59%、58.64%和13.85%。体外细胞侵袭实验显示不同浓度Lewisy抗体处理组与对照组比较均无统计学意义(P>0.05)。结论:抗Lewis y mAb能明显抑制体外RMG-I-H细胞的生长及增殖能力、降低体外培养的RMG-I-H细胞的黏附性,Lewis y抗原与卵巢癌细胞增殖、黏附的生物学行为有关,Lewis y抗体在肿瘤的治疗中显示出潜在的应用价值。 | 李飞飞 林蓓 郝莹莹 刘娟娟 张帆 张淑兰 | 2008 | 细胞与分子免疫学杂志2008，24，3： | 7 |
| 15 | 江西地区汉族人群ABO、Rh、MN、Kidd、Lewis、P血型系统调查显示文摘 | | 2001 | 中国输血杂志2001，14，S1： | 7 |
| 16 | 腹腔镜辅助Ivor Lewis食管癌根治术治疗110例食管癌显示文摘目的总结采用腹腔镜辅助Ivor Lewis手术治疗食管中下段癌的可行性及疗效。方法收集该院2008年3月至2012年5月,110例胸中下段食管癌患者采用腹腔镜游离胃,右胸后外侧切口游离食管,常规淋巴结清扫,同时右胸顶食管胃行机械吻合术。结果 110例患者手术均顺利完成,中转开腹1例,手术时间(201.48±49.57)min,术中出血量(270.52±110.41)mL,淋巴结清扫(25.31±11.45)枚,住院时间(16.87±5.21)d。术后出现并发症17例,除1例肺栓塞死亡外,其余均保守治疗治愈,术后近期随访效果良好。结论腹腔镜辅助Ivor Lewis手术治疗食管癌安全、可行、微创、相对经济,值得推广。 | 李刚 刘衡 谭光忠 | 2013 | 重庆医学2013，42，29： | 7 |
| 17 | 天南星抗肿瘤的初步研究显示文摘目的观察天南星的抗肿瘤作用。方法体内实验:建立小鼠H22肝癌皮下移植模型,灌胃给予天南星粉,2次/d,监测小鼠体质量,检测肿瘤体积、质量以及免疫器官指数,评价天南星对肿瘤生长的影响;体外实验:采用MTT法测定天南星水煎液对lewis肺癌细胞生长的影响。结果体内试验:在本实验剂量下(100g/L),与对照组比较,天南星灌胃可使肿瘤生长减慢,抑瘤率为34.7%,给药期间不影响小鼠生长状态,胸腺指数和肝脏指数略微降低,脾脏指数升高;体外实验:天南星水煎液在实验剂量下对lewis肺癌细胞生长无影响。结论天南星有抗肿瘤作用,其抗肿瘤作用不是直接细胞毒作用。 | 戚笑笑 李红 杜钢军 | 2014 | 河南大学学报(医学版)2014，33，2： | 7 |
| 18 | 环磷酰胺和顺铂对内皮细胞增殖和lewis肺癌血管生成的影响显示文摘 | 周彩存 康健 粟波 倪健 易祥华 | 2003 | 中华结核和呼吸杂志2003，26，4： | 7 |
| 19 | 机器人微创Ivor Lewis食管癌根治术的应用显示文摘目的探究机器人辅助Ivor Lewis食管癌根治术的应用和疗效。方法回顾性分析2015年5月至2018年4月期间于上海交通大学医学院附属瑞金医院胸外科接受达芬奇机器人辅助Ivor Lewis食管癌根治术的70例中下段食管癌患者的临床资料,男54例、女16例,平均年龄(62.0±7.6)岁。其中40例采用机器人辅助吻合器胃食管胸内吻合术,30例采用机器人胃食管手工双层吻合。结果全组患者平均手术时间(308.7±60.6)min,平均出血量(190.0±95.1)ml,2例(2.9%)患者中转开胸手术。全组患者未发生院内及术后30 d内死亡。术后并发症发生率34.3%,其中吻合口瘘发生率8.6%。术后中位住院时间9.0(Interquartile Range,IQR,5.0)d。肿瘤平均大小为(3.2±1.5)cm,手术R0切除率为100.0%,总淋巴结平均清扫个数(19.3±8.7)枚。结论机器人辅助Ivor Lewis术安全可行,可获得满意的短期临床疗效。 | 张亚杰 韩宇 项捷 李鹤成 | 2018 | 中国胸心血管外科临床杂志2018，25，9： | 7 |
| 20 | Prospective postsurgical capsule endoscopy in patients with Crohn's disease显示文摘AIM: To clarify the usefulness of postsurgical capsule endoscopy(CE) in the diagnosis of recurrent small bowel lesions of Crohn's disease(CD). METHODS: This prospective study included 19 patients who underwent ileocolectomy or partial ileal resection for CD. CE was performed 2-3 wk after surgery to check for the presence/absence and severity of lesions remaining in the small bowel, and for any recurrence at the anastomosed area. CE was repeated 6-8 mo after surgery and the findings were compared with those obtained shortly after surgery. The Lewis score (LS) was used to evaluate any inflammatory changes of the small bowel. RESULTS: One patient was excluded from analysis because of insufficient endoscopy data at the initial CE. The total LS shortly after surgery was 428.3 on average(median, 174; range, 8-4264), and was ≥ 135(active stage) in 78%(14 of 18) of the patients. When the remaining unresected small bowel was divided into 3 equal portions according to the transition time(proximal, middle, and distal tertiles), the mean LS was 286.6, 83.0, and 146.7, respectively, without any significant difference. Ulcerous lesions in the anastomosed area were observed in 83% of all patients. In 38% of the 13 patients who could undergo CE again after 6-8 mo, the total LS was higher by ≥ 100 than that recorded shortly after surgery, thus indicating a diagnosis of endoscopic progressive recurrence. CONCLUSION: Our pilot study suggests that CE can be used to objectively evaluate the postoperative recurrence of small bowel lesions after surgery for CD. | Tomoaki Kono Nobuyuki Hida Koji Nogami Masaki Iimuro Yoshio Ohda Yoko Yokoyama Koji Kamikozuru Katsuyuki Tozawa Mikio Kawai Tomohiro Ogawa Kazutoshi Hori Hiroki Ikeuchi Hiroto Miwa Shiro Nakamura Takayuki Matsumoto | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 7 |
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