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| 1 | Current clinical management of gastrointestinal stromal tumor显示文摘Gastrointestinal stromal tumors(GISTs) are the most common malignant subepithelial lesions(SELs) of the gastrointestinal tract. They originate from the interstitial cells of Cajal located within the muscle layer and are characterized by over-expression of the tyrosine kinase receptor KIT. Pathologically, diagnosis of a GIST relies on morphology and immunohistochemistry [KIT and/or discovered on gastrointestinal stromal tumor 1(DOG1) is generally positive]. The prognosis of this disease is associated with the tumor size and mitotic index. The standard treatment of a GIST without metastasis is surgical resection. A GIST with metastasis is usually only treated by tyrosine kinase inhibitors without radical cure; thus, early diagnosis is the only way to improve its prognosis. However, a GIST is usually detected as a SEL during endoscopy, and many benign and malignant conditions may manifest as SELs. Conventional endoscopic biopsy is difficult for tumors without ulceration. Most SELs have therefore been managed without a histological diagnosis. However, a favorable prognosis of a GIST is associated with early histological diagnosis and R0 resection. Endoscopic ultrasonography(EUS) and EUS-guided fine needle aspiration(EUSFNA) are critical for an accurate diagnosis of SELs. EUSFNA is safe and effective in enabling an early histological diagnosis and adequate treatment. This review outlines the current evidence for the diagnosis and management of GISTs, with an emphasis on early management of small SELs. | Kazuya Akahoshi Masafumi Oya Tadashi Koga Yuki Shiratsuchi | 2018 | World Journal of Gastroenterology2018，24，26： | 70 |
| 2 | Endoscopic ultrasonography for gastric submucosal lesions显示文摘Gastric submucosal tumors(SMTs) are a rather frequent finding,occurring in about 0.36%of routine upper GIendoscopies.Endoscopic ultrasonography(EUS) has emerged as a reliable investigative procedure for evaluation of these lesions.Diagnostic EUS has the ability to differentiate intramural tumors from extraluminal compressions and can also show the layer of origin of gastric SMTs.Tumors can be further characterized by their layer of origin,echo pattern and margin.EUS-risk criteria of their malignant potential are presented,although the emergence of EUS-FNA has opened new indications for transmural tissue diagnosis and expanded the possibilities of EUS in SMTs of the stomach.Tissue diagnosis should address whether the SMT is a Gastrointestinal stromal tumour(GIST) or another tumor type and evaluate the malignant potential of a given GIST.However,there seems to be a lack of data on the optimal strategy in SMTs suspected to be GISTs with a negative EUS-FNA tissue diagnosis.The current management strategies,as well as open questions regarding their treatment are also presented. | Ioannis S Papanikolaou Konstantinos Triantafyllou Anastasia Kourikou Thomas Rsch | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，5： | 44 |
| 3 | 胸部肿瘤经皮穿刺活检中国专家共识显示文摘活检应用于胸部疾病的诊断已有百余年历史。根据取材方法不同,胸部肿瘤活检可分为经支气管镜活检、经皮穿刺活检、经胸腔镜活检和开胸性活检。胸部肿瘤经皮穿刺活检(percutaneous transthoracic needle biopsy,PTNB)是在影像设备引导下完成的活检操作,随着影像技术设备的不断更新,经皮穿刺活检的临床应用范围不断拓展,从最早的病理诊断扩大到组织亚型分类、基因诊断,临床需求日益增多。 | 中国抗癌协会肿瘤介入学专业委员会 中国抗癌协会肿瘤介入学专业委员会青年委员会 | 2018 | 中华医学杂志2018，98，23： | 38 |
| 4 | 超声引导下甲状腺结节细针穿刺细胞学检查实践指南(2019版)显示文摘细针穿刺抽吸活检术(fine-needle aspiration,FNA)是甲状腺结节在治疗前获取病理诊断的重要手段,穿刺取材的质量和数量直接影响病理诊断结果的敏感性和准确性。当前,高频超声对于甲状腺结节不仅是首选检查方法与初诊手段,更是引导FNA实现微创化病理诊断的可靠技术。甲状腺结节组织结构特征(以超声影像特征加以展现)、穿刺活检器具性能(包括穿刺针具和引导穿刺的超声影像设备)、实施穿刺活检技能水平(包括穿刺操作人员和细胞涂片操作人员)直接影响着甲状腺结节穿刺活检的成败与取材的满意度,是实施高质量甲状腺结节FNA的关键,也是本指南编写组重点关注所在。编写本指南的初衷在于强调重视临床实践经验和操作技能,提倡多维度综合思考,聚焦超声影像特征,选用合适穿刺器具,熟练运用穿刺操作技术,恰当处理穿刺标本。本指南内容仅作为学术界经验交流和借鉴,不作为法律条款,并将根据具体情况适时更新。 | 无 沈理 章建全 周伟 詹维伟 徐辉雄 | 2020 | 中华超声影像学杂志2020，29，5： | 32 |
| 5 | CT引导下经皮肺穿刺对周围型肺部肿块的临床应用价值显示文摘 | 李为春 朱银喜 | 2006 | 临床肺科杂志2006，11，3： | 30 |
| 6 | 超声引导细针穿刺活检技术对TI-RADS4类甲状腺结节良恶性鉴别诊断效能的影响显示文摘目前,超声是临床诊断甲状腺结节主要影像学方法,主要根据甲状腺超声影像报告与数据系统(TI-RADS)结合恶性风险将甲状腺结节进行分类,对其超声描述进行规范化、标准化,其中TI-RADS4类甲状腺结节具有较高恶性风险,临床应尤为重视[1]。超声引导细针穿刺活检(ultrasound-guided fine needle aspiration biopsy,US-FNAB)是临床鉴别甲状腺结节良恶性的主要方法,但不符合经济性原则,且检测过程中可能出现诊断偏差。超声弹性成像(UE)是一种测定病变组织硬度变化信息的影像学检查方式,可为临床确诊肿瘤良恶性提供有效信息。本研究选取我院TI-RADS4类甲状腺结节患者112例(124个结节),旨在明确US-FNAB+UE技术的诊断效能。具体分析如下。 | 白甲顺 | 2020 | 中国药物与临床2020，20，2： | 29 |
| 7 | 2018版甲状腺细针穿刺活检细胞病理学Bethesda报告系统解读显示文摘甲状腺细针穿刺活检(fine needle aspiration,FNA)细胞学检查是术前评估甲状腺结节良恶性、有效减少诊断性手术的重要方法,被各国甲状腺指南推荐作为甲状腺肿瘤术前诊断的重要依据,可有效提高甲状腺手术恶性肿瘤比例至50%。 | 张晓芳 刘志艳 | 2018 | 中华病理学杂志2018，47，9： | 24 |
| 8 | 细针吸取细胞学的进展显示文摘 | 王念黎 | 2006 | 中华病理学杂志2006，35，5： | 21 |
| 9 | Systemic air embolism after transthoracic lung biopsy: A case report and review of literature显示文摘Computed tomography (CT)-guided lung biopsy is a common diagnostic procedure that is associated with various complications, including pneumothorax, hemoptysis and parenchymal hemorrhage. Systemic air embolism is a very rare (0.07%) but potentially lifethreatening complication. We report a fatal case of air embolism to the cerebral and coronary arteries confirmed by head and chest CT, followed by a review of the literature. | Wessam Bou-Assaly Perry Pernicano Ellen Hoeffner | 2010 | World Journal of Radiology2010，2，5： | 20 |
| 10 | 微针疗法基本概念及作用机理显示文摘微针疗法(Micro—needle Treatment),又称微针治疗技术。利用微细针状器械实施皮肤软组织刺激或处理,以期获得治疗或美容作用的医疗技术。可伴有药液或有效成分同步施予或导入,以期增强治疗或美容作用。 | 郑荃 | 2016 | 中国医疗美容2016，6，1： | 19 |
| 11 | 乳腺疾病的影像学引导经皮穿刺组织活检显示文摘 | 刘峰 姜玉新 | 2005 | 中华超声影像学杂志2005，14，6： | 18 |
| 12 | 甲状腺结节大小对超声引导下细针穿刺活检诊断效能的影响显示文摘甲状腺结节是临床的常见病、多发病,5%~15%为恶性[1]。超声引导下细针穿刺活检(ultrasound-guided fine needle aspirationbiopsy,US-FNAB)是目前鉴别良恶性甲状腺结节的最安全有效的方法[2]。然而,US-FNAB的诊断效率受较多因素影响,甲状腺结节大小是否会对穿刺结果造成影响存在一定争议[3]。本组收集不同大小的甲状腺结节行US-FNAB,并与手术切除后病理结果进行对比,分析甲状腺结节大小对US-FNAB诊断效率的影响。 | 谢雨 李杨 杜平杰 左慧 余进洪 | 2020 | 临床超声医学杂志2020，22，4： | 18 |
| 13 | 空芯针穿刺活检在乳腺疾病诊治中应用价值研究进展显示文摘空芯针穿刺活检 ( core needle biopsy, CNB)是乳腺疾病诊断的一种重要手段。CNB自20世纪90年代应用于临床后,因其操作简便、诊断准确性高、创伤小、费用低等特点而受到关注与广泛应用。随着影像引导技术的进步、乳腺癌临床研究的进展以及真空辅助等穿刺设备的改进,CNB正发挥越来越重要的作用。它不仅对乳腺癌的确诊有重要意义,而且为乳腺癌综合治疗方案的选择提供了重要的依据。本文就CNB在乳腺疾病诊治中的应用价值作一综述。 | 孙龙 陈小松 沈坤炜 | 2013 | 中华外科杂志2013，51，6： | 18 |
| 14 | Progress in research of liver surgery in China显示文摘INTRODUCTIONLiver surgery,was started in the late 1950s in Chinaand has developed rapidly in the past 40 years.The study on the diagnosis and treatment of primaryliver cancer in China underwent four stages:①Inthe 1950s,the anatomical study of the liver lay asolid foundation for liver resection.①In | Wu MC Shen F | 2000 | World Journal of Gastroenterology2000，6，6： | 16 |
| 15 | Gastrointestinal stromal tumor of the stomach:How to manage?显示文摘Gastrointestinal stromal tumor (GIST) is one of the most common malignant mesenchymal tumors of the stomach. Prognosis of this disease is related to tumor size and mitotic activity and early diagnosis is the only way to improve it.Diagnosis of GIST always requires histological and immunohistochemical confirmation as no imaging modalities can diagnose it conclusively.Endoscopic forceps biopsy results are frequently negative. Endoscopic ultrasound-guided fine needle asp- iration (EUS-FNA) is a technique which allows tissue samples to be obtained with minimal risks and is accurate in the diagnosis of GIST. From the point of view of the endoscopist, aggressive use of EUS-FNA is the only promising way to allow early diagnosis and early treatment of this disease. | Kazuya Akahoshi Masafumi Oya | 2010 | World Journal of Gastrointestinal Endoscopy2010，2，8： | 16 |
| 16 | 超声内镜技术在消化系统疾病诊断中的应用显示文摘超声内镜技术应用于临床已30余载,其在诊断消化系统疾病中应用广泛。近年来,以超声内镜为基础的诊断技术不断发展和完善,超声内镜相关诊断技术主要包括超声内镜弹性成像技术 (endoscopic ultrasound elastography, EUS-EG)、造影增强超声内镜(contrast-enhanced endoscopic ultrasound,CE-EUS)、谐波造影增强超声内镜( contrast harmonicendoscopic ultrasound, CH-EUS)和超声内镜引导下细针穿刺活检术(endoscopic ultrasound guided fine needle aspiration,EUS-FNA)等。 | 孙悦 秘建威 赵东强 | 2018 | 中华超声影像学杂志2018，27，4： | 16 |
| 17 | Bioinspired Adhesive and Antibacterial Microneedles for Versatile Transdermal Drug Delivery显示文摘Microneedles have attracted increasing interest among various medical fields due to their painless,noninvasive,and efficient way of drug delivery.However,practical applications of these microneedles in different epidermal locations and environments are still restricted by their low adhesion and poor antimicrobial activity.Here,inspired by the antibacterial strategy of Paenibacillus polymyxa and adhesion mechanisms of mussel byssi and octopus tentacles,we develop hierarchical microneedles with multifunctional adhesive and antibacterial abilities.With polydopamine hydrogel as the microneedle base and a loop of suctioncup-structured concave chambers encircling each microneedle,the generated microneedles can fit the skin well;keep strong adhesion in dry,moist,and wet environments;and realize self-repair after being split into two parts.Besides,as polymyxin is loaded into both the hydrogel tips and the polydopamine base,the microneedles are endowed with excellent ability to resist common bacteria during storage and usage.We have demonstrated that these microneedles not only showed excellent adhesion when applied to knuckles and ideal antibacterial activity but also performed well in drug-sustained release and treatment for the osteoarthritis rat model.These results indicate that bioinspired multifunctional microneedles will break through the limitation of traditional methods and be ideal candidates for versatile transdermal drug delivery systems. | Xiaoxuan Zhang Guopu Chen Yunru Yu Lingyu Sun Yuanjin Zhao | 2020 | Research2020，，1： | 14 |
| 18 | Endoscopic incisional therapy for benign esophageal strictures: Technique and results显示文摘Benign esophageal strictures refractory to the conventional balloon or bougie dilatation may be subjected to various adjunctive modes of therapy, one of them being endoscopic incisional therapy(EIT). A proper delineation of the stricture anatomy is a prerequisite. A host of electrocautery and mechanical devices may be used, the most common being the use of needle knife, either standard or insulated tip. The technique entails radial incision and cutting off of the stenotic rim. Adjunctive therapies, to prevent re-stenosis, such as balloon dilatation, oral or intralesional steroids or argon plasma coagulation can be used. The common strictures where EIT has been successfully used are Schatzki's rings(SR) and anastomotic strictures(AS). Short segment strictures(< 1 cm) have been found to have the best outcome. When compared with routine balloon dilatation, EIT has equivalent results in treatment na?ve cases but better long term outcome in refractory cases. Anecdotal reports of its use in other types of strictures have been noted. Post procedure complications of EIT are mild and comparable to dilatation therapy. As of the current evidence, incisional therapy can be used for management of refractory AS and SR with relatively short stenosis(< 1 cm) with good safety profile and acceptable long term patency. | Jayanta Samanta Narendra Dhaka Saroj Kant Sinha Rakesh Kochhar | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 14 |
| 19 | Precut sphincterotomy:A reliable salvage for difficult biliary cannulation显示文摘Even experienced endoscopists have 90% success in achieving deep biliary cannulation with standard methods. Biliary cannulation may become difficult in 10%-15% of patients with biliary obstruction and pre- cut (access) sphincterotomy is frequently chosen as a rescue treatment in these cases. Generally, precut sphincterotomy ensures a rate of 90%-100% success- ful deep biliary cannulation. The precut technique has been performed as either a fistulotomy with a needle knife sphincterotome or as a transpapillary septotomy with a standard sphincterotome. Both methods have similar efficacy and complication rates when adminis- tered to the proper patient. Although precut sphincter- otomy ensures over 90% success of biliary cannula- tion, it has been characterized as an independent risk factor for pancreatitis. The complications of the precut technique are not limited to pancreatitis. Two more important ones, bleeding and perforation, are also re- ported in some publications as being observed more commonly than during standard sphincterotomy. It is also reported that precut sphincterotomy increases morbidity when performed in patients without dilata- tion of their biliary tract. Nevertheless, precut sphinc- terotomy is a good alternative as a rescue method in the setting of a failed standard cannulation method. This paper discusses the technical details, timing, ef- ficacy and potential complications of precut sphincter- otomy. | Ulku Saritas Yucel Ustundag Ferda Harmandar | 2013 | World Journal of Gastroenterology2013，19，1： | 13 |
| 20 | LOW AND HIGH FREQUENCY ELECTROCU-PUNCTURE STIMULATIONS RELEASE (Met^5)ENKEPHALIN AND DYNORPHIN A IN RAT SPINAL CORD显示文摘It has been known in the clinical practice that the therapeutic effect of acupuncture varies widely in different individuals, although the acupuncturist is using the same acupoint and the same mode of needle manipulation. In addition, the effect of | 费宏 谢国玺 韩济生 | 1987 | Chinese Science Bulletin1987，32，21： | 13 |
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