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| 1 | Experimental primates and non-human primate(NHP) models of human diseases in China: current status and progress显示文摘Non-human primates(NHPs) are phylogenetically close to humans, with many similarities in terms of physiology, anatomy, immunology, as well as neurology, all of which make them excellent experimental models for biomedical research. Compared with developed countries in America and Europe, China has relatively rich primate resources and has continually aimed to develop NHPs resources. Currently, China is a leading producer and a major supplier of NHPs on the international market. However, there are some deficiencies in feeding and management that have hampered China's growth in NHP research and materials. Nonetheless, China has recently established a number of primate animal models for human diseases and achieved marked scientific progress on infectious diseases, cardiovascular diseases, endocrine diseases, reproductive diseases, neurological diseases, and ophthalmic diseases, etc. Advances in these fields via NHP models will undoubtedly further promote the development of China's life sciences and pharmaceutical industry, and enhance China's position as a leader in NHP research. This review covers the current status of NHPs in China and other areas, highlighting the latest developments in disease models using NHPs, as well as outlining basic problems and proposing effective countermeasures to better utilize NHP resources and further foster NHP research in China. | Xiao-Liang ZHANG Wei PANG Xin-Tian HU Jia-Li LI Yong-Gang YAO Yong-Tang ZHENG | 2014 | Zoological Research2014，35，6： | 16 |
| 2 | Redundant CAMTA Transcription Factors Negatively Regulate the Biosynthesis of Salicylic Acid and N-Hydroxypipecolic Acid by Modulating the Expression of SARD1 and CBP60g显示文摘Two signal molecules, salicylic acid (SA) and N-hydroxypipecolic acid (NHP), play critical roles in plant immunity. The biosynthetic genes of both compounds are positively regulated by master immune-regulating transcription factors SARD1 and CBP60g. However, the relationship between the SA and NHP pathways is unclear. CALMODULIN-BINDING TRANSCRIPTION FACTOR 1 (CAMTA1), CAMTA2, and CAMTA3 are known redundant negative regulators of plant immunity, but the underlying mechanism also remains largely unknown. In this study, through chromatin immunoprecipitation and electrophoretic mobility shift assays, we uncovered that CBP60g is a direct target of CAMTA3, which also negatively regulates the expression of SARD1, presumably via an indirect effect. The autoimmunity of camta3-1 is suppressed by sard1 cbp60g double mutant as well as ald1 and fmo1, two single mutants defective in NHP biosynthesis. Interestingly, a suppressor screen conducted in the camta1/ 2/ 3 triple mutant background yielded various mutants blocking biosynthesis or signaling of either SA or NHP, leading to nearly complete suppression of the extreme autoimmunity of camta1/ 2/ 3, suggesting that the SA and NHP pathways can mutually amplify each other. Together, these results reveal that CAMTAs repress the biosynthesis of SA and NHP by modulating the expression of SARD1 and CBP60g, and that the SA and NHP pathways are coordinated to optimize plant immune response. | Tongjun Sun Jianhua Huang Yan Xu Vani Verma Beibei Jing Yulin Sun Alberto Ruiz Orduna Hainan Tian Xingchuan Huang Shitou Xia Laurel Schafer Reinhard Jetter Yuelin Zhang Xin Li | 2020 | Molecular Plant2020，13，1： | 5 |
| 3 | 非人灵长类的自发性肿瘤显示文摘非人灵长类 (nonhumanprimate ,NHP)自发性肿瘤的研究不仅是实验动物学的研究内容 ,而且是动物模型开发和实验肿瘤学的有益源泉 ,也可为实验动物非传染性疾病的控制提供本底数据。NHP的自发肿瘤几乎见于所有的器官系统 ,以消化系统、生殖系统、泌尿系统的肿瘤较多见 ,呼吸系统、心血管系统和神经系统的肿瘤少见。多数NHP的肿瘤流行病学和组织病理特征与人的相近 ,但NHP的肺癌。 | 黄韧 程树军 | 2002 | 中国实验动物学报2002，10，2： | 5 |
| 4 | NHP脱水合成PVP单体两种方法的比较研究显示文摘对羟乙基吡咯烷酮(NHP)脱水的两种不同方法——直接脱水方法与间接脱水方法进行了研究和比较,从研究结果综合考虑各方面因素可以看出,直接脱水方法优于间接脱水方法,是未来PVP单体合成方法的发展趋势。 | 易国斌 崔英德 郭建维 廖列文 | 2000 | 广州化工2000，28，4： | 5 |
| 5 | Biosynthesis and Regulation of Salicylic Acid and N-Hydroxypipecolic Acid in Plant Immunity显示文摘Salicylic acid(SA)has long been known to be essential for basal defense and systemic acquired resistance(SAR).N-Hydroxypipecolic acid(NHP),a recently discovered plant metabolite,also plays a key role in SAR and to a lesser extent in basal resistance.Following pathogen infection,levels of both compounds are dramatically increased.Analysis of SA-or SAR-deficient mutants has uncovered how SA and NHP are biosynthesized.The completion of the SA and NHP biosynthetic pathways in Arabidopsis allowed better understanding of how they are regulated.In this review,we discuss recent progress on SA and NHP biosynthesis and their regulation in plant immunity. | Weijie Huang Yiran Wang Xin Li Yuelin Zhang | 2020 | Molecular Plant2020，13，1： | 5 |
| 6 | N-乙烯基吡咯烷酮的合成显示文摘N-乙烯基吡咯烷酮(NVP)是一种用途广泛的绿色精细化学品,本文介绍了N-乙烯基吡咯烷酮(NVP)的几种主要合成方法,并进行了对比,得到了最佳合成工艺。 | 胡庆华 史铁钧 翟林峰 | 2004 | 化工科技市场2004，27，5： | 4 |
| 7 | 加拿大颁布天然保健品最后法规显示文摘2003年6月18日,加拿大政府创立了一个医药产品新类型——天然保健品(Natural Health Product,NHP),并在政府公报第Ⅱ部分中公布了“天然保健品法规”(简称“NHP法规”),这是自2004年1月开始生效的最后法规。 | 希雨 | 2004 | 国外医药(植物药分册)2004，19，5： | 3 |
| 8 | 人消化系肿瘤染色质非组蛋白电泳图谱分析及免疫原性研究显示文摘从人食管癌、胃癌、直肠癌、肝癌及胎儿肝和从距癌>5cm的癌旁作为对照组织的细胞核中,分别用0.4MNaCl盐提法、苯酚提取法和羟基磷灰石柱层析法提取染色质非组蛋白蛋白质,简称非组蛋白(NHP)进行电泳图谱分析并将不同方法提取的癌NHP作为抗原制备免疫血清做对比免疫组化反应。结果表明①用0.4MNaCl盐提之NHP的质和量更适于作为抗原制备免疫血清和进行免疫组化染色。②以上各种肿瘤NHP与其癌旁NHP之间均有质和量的差异。③不同肿瘤NHP具有组织特异性,然而各种瘤之间也具有相似的共性,即癌NHP之多加带主位于6万d~9万d;多变带区主位于4万d上下处(肝癌NHP之多变带区主位于5万d及8万d);而且肝癌NHP与胎肝NHP有相似处。结果提示癌NHP之多加或加深带可能与癌基因表达的激活有关;而缺如或减弱带可能与载有抗癌基因的染色体区带丢失或基因表达改变有关。 | 陈迪 吴景兰 王一菱 白咸勇 郑乃刚 | 1990 | 河南医科大学学报1990，25，4： | 1 |
| 9 | 慢性重型肝炎患者血浆对C3A 细胞增殖功能的影响显示文摘目的观察慢性重型肝炎患者血浆对 C3A 细胞株增殖功能的影响,为研究应用 C3A 细胞株的生物反应器进行生物人工肝支持治疗提供实验依据。方法分别用100%正常人血浆(normal human plasma,NHP)和100%慢性重型肝炎患者血浆(chronic severe hepatitis plasma,CSHP)培养 C3A 细胞,通过四甲基偶氮唑盐法(methyl thiazolyl tetrazolium,MTr)检测细胞活力,光镜下观察 C3A 细胞在100% CSHP 中和在100% NHP 中的状态,扫描电镜观察细胞在100% CSHP 中和在100% NHP 中的生长状态,研究慢性重型肝炎患者血浆对 C3A 细胞增殖的影响。结果①连续5d 检测100% CSHP 培养的 C3A 细胞活力均明显高于100% NHP 组(t 值分别为6.26、4.89、3.55、3.94、6.17,P 值均小于0.01);②姬姆萨染色可见100% CSHP 培养的C3A 细胞生长较密;③48h 电镜下可见2组细胞生长状态均良好,但是100% CSHP 组处于分裂前期细胞数明显多于100%NHP 组,且分裂较活跃。结论 CSHP 对C3A 细胞的增殖有促进作用。 | 陈煜 赵丽莉 王海燕 韩大康 李颖 段钟平 | 2005 | 传染病信息2005，18，2： | 1 |
| 10 | 非人灵长类帕金森模型的研究进展显示文摘帕金森病(Parkinson’s disease,PD),作为全球第二大神经系统退行性疾病,目前已有的治疗手段仍不能从根本上逆转疾病的进程,而治疗手段的发现和评价离不开动物模型的建立,一个可靠、有效的动物模型将有利于PD的发病机制、诊断、治疗方法以及药物筛选的研究。啮齿类动物和非脊椎动物已被广泛用于建立PD模型,但其并不能完全呈现人类PD的行为学和病理特征,而非人灵长类(nonhuman primate,NHP)在生理、解剖结构和免疫等方面与人最为接近,更适合用来探索疾病机理和发现新的治疗方式,因此,本文就帕金森病NHP模型的建立方法进行综述,为帕金森病NHP模型建立提供参考。 | 刘永芳 吴正存 马开利 | 2021 | 中国比较医学杂志2021，31，8： | 1 |
| 11 | 慢性胃炎、胃溃疡患者系统护理干预的应用效果评价显示文摘目的:分析系统护理干预应用于慢性胃炎以及胃溃疡患者中的有效性。方法:择取2016年2月到2018年3月期间接收的慢性胃炎和胃溃疡患者共150例,采用奇偶法形式分为试验组(奇数组,n=75)和对照组(偶数组,n=75)。记录两组干预总有效率,焦虑自评量表以及抑郁自评量表分值,同时记录诺丁汉健康量表评分。结果:试验组总有效率92.00%高于对照组78.67%(P<0.05);SAS以及SDS分值中,护理前两组对比无统计学意义,护理后两组均有所好转,试验组护理后改善分值优于对照组(P<0.05);试验组NHP各项分值高于对照组,两组对比存在差异性(P<0.05)。结论:慢性胃炎和胃溃疡患者行系统护理干预,患者的负性情绪,总有效率均得到改善,同时NHP分值升高,这对于临床研究具有重要作用。 | 杜永宏 | 2020 | 医学食疗与健康2020，18，2： | 1 |
| 12 | Epigenetic regulation of N-hydroxypipecolic acid biosynthesis by the AIPP3-PHD2-CPL2 complex显示文摘N-Hydroxypipecolic acid(NHP)is a signaling molecule crucial for systemic acquired resistance(SAR),a systemic immune response in plants that provides long-lasting and broad-spectrum protection against secondary pathogen infections.To identify negative regulators of NHP biosynthesis,we performed a forward genetic screen to search for mutants with elevated expression of the NHP biosynthesis gene FLAVIN-DEPENDENT MONOOXYGENASE 1(FMO1).Analysis of two constitutive expression of FMO1(cef)and one induced expression of FMO1(ief)mutants revealed that the AIPP3–PHD2–CPL2 protein complex,which is involved in the recognition of the histone modification H3K27me3 and transcriptional repression,contributes to the negative regulation of FMO1 expression and NHP biosynthesis.Our study suggests that epigenetic regulation plays a crucial role in controlling FMO1 expression and NHP levels in plants. | Jiameng Lan Siyu Chen Joana Pico Kevin Ao Shitou Xia Shucai Wang Xin Li Simone D.Castellarin Yuelin Zhang | 2023 | Journal of Integrative Plant Biology2023，65，12： | 0 |
| 13 | 越南完成国家水电规划研究显示文摘水电是越南最重要的自然资源之一,也是最重要的可再生能源。因此,对越南来说,绘制水电资源分布图并评估其现有的和未来的价值意义重大。利用确定的升级程序完成的NHP研究提供了这方面的资料。 | | 2014 | 治黄科技信息2014，，4： | 0 |
| 14 | 人胚肝核基质的电镜观察及蛋白电泳分析显示文摘用2mol/LNacl从人胚肝中提取核基质。对24周龄胚肝细胞核及核基质进行电镜观察,发现其具备细胞核及核基质的基本结构特点。核基质周膜界限完整。可见核孔复合物结构及核仁残骸,有比较清楚的网络状核蛋白基质纤维及颗粒。核基质经牛胰DNase酶解,再经SDS-PAGE分析,表明人胚肝核基质中的非组蛋白(NHP)种类与含量随发育过程而变化。 | 温博贵 裘峻 等 | 1993 | 汕头大学医学院学报1993，，1： | 0 |
| 15 | 一个多媒体教学软件NHP之设计与实现显示文摘本文叙述了一种面向微型计算机的多媒体教学软件的设计与实现,该软件集语音,图形,文字,数据为一体,从视觉,听觉,体觉三方面对学习者进行强化训练,可取得较好的学习效果。 | 唐棠 徐戟 | 1993 | 微型计算机1993，13，5： | 0 |
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