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| 1 | Combination of propofol and dezocine to improve safety and efficacy of anesthesia for gastroscopy and colonoscopy in adults: A randomized, double-blind, controlled trial显示文摘BACKGROUND Gastroscopy and colonoscopy are important and common endoscopic methods for the diagnosis and treatment of gastrointestinal and colorectal diseases.However,endoscopy is usually associated with adverse reactions such as nervousness,nausea,vomiting,choking cough,and pain.Severe discomfort,such as vomiting,coughing,or body movement,may lead to aggravation of a preexisting condition or even interruption of examination or treatment,especially in some critically ill patients with physiological dysfunction(e.g.,cardiovascular or respiratory disease).The optimal methods for inducing analgesia and sedation in endoscopy are areas of ongoing debate;nevertheless,determining an appropriate regimen of sedation and analgesia is important.AIM To evaluate the effects of propofol combined with dezocine,sufentanil,or fentanyl in painless gastroscopy and colonoscopy.METHODS Four hundred patients were randomly assigned to one of four groups for anesthesia:intravenous dezocine,sufentanil,fentanyl,or saline.Propofol was administered intravenously for induction and maintenance of anesthesia.RESULTS The dosage of propofol in the dezocine group was significantly lower than those in other groups(P<0.01).Bispectral index and Steward score(0-6 points,an unresponsive,immobile patient whose airway requires maintenance to a fully recovered patient)after eye opening in the dezocine group were significantly higher than those in other groups(P<0.01).Awakening time and postoperative pain score(0-10 points,no pain to unbearable pain)in the dezocine group were significantly lower than those in other groups(P<0.01).Mean arterial pressure and pulse oxygen saturation in the dezocine group were significantly more stable at various time points(before dosing,disappearance of eyelash reflex,and wakeup)than those in other groups(P<0.01).The rates of hypopnea,jaw thrust,body movements,and usage of vasoactive drugs in the dezocine group were significantly lower than those in other groups(P<0.01).Additionally,the rates of reflex coughing,nausea,and vomiting were not statistically different between the four groups(P>0.05).CONCLUSION The combination of propofol and dezocine can decrease propofol dosage,reduce the risk for the development of inhibitory effects on the respiratory and cardiovascular systems,increase analgesic effect,decrease body movement,shorten awakening time,and improve awakening quality. | Xue-Ting Li Chao-Qun Ma Si-Hua Qi Li-Min Zhang | 2019 | World Journal of Clinical Cases2019，7，20： | 61 |
| 2 | Clinical study of anesthetization by dezocine combined with propofol for indolent colonoscopy显示文摘AIM: To assess the use of dezocine combined with propofol for the anesthetization of patients undergoing indolent colonoscopy.METHODS: A cross-sectional survey of patients undergoing indolent colonoscopy in the Xinjiang people's Hospital was conducted from April 1 to April 30, 2015. The survey collected patient general information and anesthesia data, including overall medical experience and pain management. Thirty minutes after colonoscopy surgery, samples of venous blood were collected and the biochemical indicators of gastrointestinal function were analyzed. RESULTS: There were 98 female and 62 male respondents. Indolent colonoscopy was found to be more suitable for mid to older-aged patients. The necessary conditions for the diagnosis of digestive diseases were required in 65 of the 73 inpatients. Adverse reactions to the intraoperative process included two cases of body movement and two cases of respiratory depression. Gastrin and vasoactive intestinal peptide levels were slightly increased. However, somatostatin and endothelin levels were slightly decreased. CONCLUSION: This study revealed that dezocine combined with propofol can be successfully used for the anesthetization of indolent colonoscopy patients without pain and should be widely used. | Bin-Bin Xu Xiao-liang Zhao Gui-ping Xu | 2016 | World Journal of Gastroenterology2016，22，24： | 23 |
| 3 | Remimazolam benzenesulfonate anesthesia effectiveness in cardiac surgery patients under general anesthesia显示文摘BACKGROUND Sedation with propofol injections is associated with a risk of addiction,but remimazolam benzenesulfonate is a comparable anesthetic with a short elimination half-life and independence from cell P450 enzyme metabolism.Compared to remimazolam,remimazolam benzenesulfonate has a faster effect,is more quickly metabolized,produces inactive metabolites and has weak drug interactions.Thus,remimazolam benzenesulfonate has good effectiveness and safety for diagnostic and operational sedation.AIM To investigate the clinical value of remimazolam benzenesulfonate in cardiac surgery patients under general anesthesia.METHODS A total of 80 patients who underwent surgery in the Department of Cardiothoracic Surgery from August 2020 to April 2021 were included in the study.Using a random number table,patients were divided into two anesthesia induction groups of 40 patients each:remimazolam(0.3 mg/kg remimazolam benzenesulfonate)and propofol(1.5 mg/kg propofol).Hemodynamic parameters,inflammatory stress response indices,respiratory function indices,perioperative indices and adverse reactions in the two groups were monitored over time for comparison.RESULTS At pre-anesthesia induction,the remimazolam and propofol groups did not differ regarding heart rate,mean arterial pressure,cardiac index or volume per wave index.After endotracheal intubation and when the sternum was cut off,mean arterial pressure and volume per wave index were significantly higher in the remimazolam group than in the propofol group(P<0.05).After endotracheal intubation,the oxygenation index and the respiratory index did not differ between the groups.After endotracheal intubation and when the sternum was cut off,the oxygenation index values were significantly higher in the remimazolam group than in the propofol group(P<0.05).Serum interleukin-6 and tumor necrosis factor-αlevels 12 h after surgery were significantly higher than before surgery in both groups(P<0.05).The observation indices were re-examined 2 h after surgery,and the epinephrine,cortisol and blood glucose levels were significantly higher in the remimazolam group than in the propofol group(P<0.05).The recovery and extubation times were significantly lower in the remimazolam group than in the propofol group(P<0.05);there were significantly fewer adverse reactions in the remimazolam group(10.00%)than in the propofol group(30.00%;P<0.05).CONCLUSION Compared with propofol,remimazolam benzenesulfonate benefited cardiac surgery patients under general anesthesia by reducing hemodynamic fluctuations.Remimazolam benzenesulfonate influenced the surgical stress response and respiratory function,thereby reducing anesthesia-related adverse reactions. | Fang Tang Jian-Min Yi Hong-Yan Gong Zi-Yun Lu Jie Chen Bei Fang Chen Chen Zhi-Yi Liu | 2021 | World Journal of Clinical Cases2021，9，34： | 19 |
| 4 | Safety and efficacy of ciprofol vs.propofol for sedation in intensive care unit patients with mechanical ventilation:a multi-center,open label,randomized,phase 2 trial显示文摘Background:Ciprofol(HSK3486;Haisco Pharmaceutical Group Co.,Ltd.,Chengdu,China),developed as a novel 2,6-disubstituted phenol derivative showed similar tolerability and efficacy characteristics as propofol when applicated as continuous intravenous infusion for 12 h maintenance sedation in a previous phase 1 trial.The phase 2 trial was designed to investigate the safety,efficacy,and pharmacokinetic characteristics of ciprofol for sedation of patients undergoing mechanical ventilation.Methods:In this multicenter,open label,randomized,propofol positive-controlled,phase 2 trial,39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio.The ciprofol infusion was started with a loading infusion of 0.1-0.2 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 0.30 mg·kg^(-1)·h^(-1),which could be adjusted to an infusion rate of 0.06 to 0.80 mg·kg^(-1)·h^(-1),whereas for propofol the loading infusion dose was 0.5-1.0 mg/kg for 0.5-5.0 min,followed by an initial maintenance infusion rate of 1.50 mg·kg^(-1)·h^(-1),which could be adjusted to 0.30-4.00 mg·kg^(-1)·h^(-1)to achieve-2 to+1 Richmond Agitation-Sedation Scale sedation within 6-24 h of drug administration.Results:Of the 39 enrolled patients,36 completed the trial.The median(min,max)of the average time to sedation compliance values for ciprofol and propofol were 60.0(52.6,60.0)min and 60.0(55.2,60.0)min,with median difference of 0.00(95%confidence interval:0.00,0.00).In total,29(74.4%)patients comprising 18(69.2%)in the ciprofol and 11(84.6%)in the propofol group experienced 86 treatment emergent adverse events(TEAEs),the majority being of severity grade 1 or 2.Drug-and sedation-related TEAEs were hypotension(7.7%vs.23.1%,P=0.310)and sinus bradycardia(3.8%vs.7.7%,P=1.000)in the ciprofol and propofol groups,respectively.The plasma concentration-time curves for ciprofol and propofol were similar.Conclusions:ciprofol is comparable to propofol with good tolerance and efficacy for sedation of Chinese intensive care unit patients undergoing mechanical ventilation in the present study setting.Trial registration:ClinicalTrials.gov,NCT04147416. | Yongjun Liu Xiangyou Yu Duming Zhu Jun Zeng Qinhan Lin Bin Zang Chuanxi Chen Ning Liu Xiao Liu Wei Gao Xiangdong Guan | 2022 | Chinese Medical Journal2022，，9： | 19 |
| 5 | Role of combined propofol and sufentanil anesthesia in endoscopic injection sclerotherapy for esophageal varices显示文摘AIM To investigate the efficacy and safety of a combination of sufentanil and propofol injection in patients undergoing endoscopic injection sclerotherapy(EIS) for esophageal varices(EVs). METHODS Patients with severe EVs who underwent EIS with sufentanil and propofol anesthesia between April 2016 and July 2016 at our hospital were reviewed. Although EIS and sequential therapy were performed under endotracheal intubation, we only evaluated the efficacy and safety of anesthesia for the first EIS procedure. Patients were intravenously treated with 0.5-1 μg/kg sufentanil. Anesthesia was induced with 1-2 mg/kg propofol and maintained using 2-5 mg/kg per hour of propofol. Information, regarding age, sex, weight, American Association of Anesthesiologists(ASA) physical status, Child-Turcotte-Pugh(CTP) classification, indications, preanesthetic problems, endoscopic procedure, successful completion of the procedure, anesthesia time, recovery time, and anesthetic agents, was recorded. Adverse events, including hypotension, hypertension, bradycardia, and hypoxia, were also noted.RESULTS Propofol and sufentanil anesthesia was provided in 182 procedures involving 140 men and 42 women aged 56.1± 11.7 years(range, 25-83 years). The patients weighed 71.4 ± 10.7 kg(range, 45-95 kg) and had ASA physical status classifications of Ⅱ(79 patients) or Ⅲ(103 patients). Ninety-five patients had a CTP classification of A and 87 had a CTP classification of B. Intravenous anesthesia was successful in all cases. The mean anesthesia time was 33.1 ± 5.8 min. The mean recovery time was 12.3 ± 3.7 min. Hypotension occurred in two patients(1.1%, 2/182). No patient showed hypertension during the endoscopic therapy procedure. Bradycardia occurred in one patient(0.5%, 1/182), and hypoxia occurred in one patient(0.5%, 1/182). All complications were easily treated with no adverse sequelae. All endoscopic procedures were completed successfully.CONCLUSION The combined use of propofol and sufentanil injection in endotracheal intubation-assisted EIS for EVs is effective and safe. | Yang Yu Sheng-Lin Qi Yong Zhang | 2017 | World Journal of Gastroenterology2017，23，44： | 18 |
| 6 | 成人丙泊酚输注综合征研究进展显示文摘丙泊酚由于其半衰期短,起效快,降低脑耗氧量和降低颅内压的优点在临床上普遍用于各种手术的麻醉诱导和维持,以及重症患者的镇静。丙泊酚输注综合征(propofol infusion sydrome,PRIS)是一种罕见的严重的并发症,表现为大剂量、长时间输注丙泊酚后出现代谢性酸中毒、高脂血症、肝脏脂肪浸润、横纹肌溶解、心律失常和难治性的心力衰竭甚至死亡,应引起临床医师的重视。 | 滕雪 王国年 | 2016 | 临床麻醉学杂志2016，32，4： | 17 |
| 7 | Dose requirement and complications of diluted and undiluted propofol for deep sedation in endoscopic retrograde cholangiopancreatography显示文摘BACKGROUND:In general,the dose requirement and complications of propofol are lower when used in the diluted form than in the undiluted form.The aim of this study was to determine the dose requirement and complications of diluted and undiluted propofol for deep sedation in endoscopic retrograde cholangiopancreatography.METHODS:Eighty-six patients were randomly assigned to either group D (diluted propofol) or U (undiluted propofol).All patients were sedated with 0.02-0.03 mg/kg midazolam (total dose ≤2 mg for age <70 years and 1 mg for age ≥70) and 0.5-1 μg/kg fentanyl (total dose ≤75 μg for age <70 and ≤50 μg for age ≥70).Patients in group U (42) were sedated with standard undiluted propofol (10 mg/mL).Patients in group D (44) were sedated with diluted propofol (5 mg/mL).All patients in both groups were monitored for the depth of sedation using the Narcotrend system.The primary outcome variable was the total dose of propofol used during the procedure.The secondary outcome variables were complications during and immediately after the procedure,and recovery time.RESULTS:All endoscopies were completed successfully.Mean propofol doses per body weight and per body weight per hour in groups D and U were 3.0 mg/kg,6.2 mg/kg per hour and 4.7 mg/kg,8.0 mg/kg per hour,respectively.The mean dose of propofol,expressed as total dose,dose/kg or dose/kg per hour and the recovery time were not significantly different between the two groups.Sedation-related adverse events during and immediately after the procedure were higher in group U (42.9%) than in group D (18.2%) (P=0.013).CONCLUSIONS:Propofol requirement and recovery time in the diluted and undiluted propofol groups were comparable.However,the sedation-related hypotension was significantly lower in the diluted group than the undiluted group. | Somchai Amornyotin Wichit Srikureja Wiyada Chalayonnavin Siriporn Kongphlay | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 15 |
| 8 | 作用于GABA-R的静脉麻醉药(异丙酚与咪唑安定)之间相互作用的研究进展显示文摘目前普遍认为位于突触后膜的配体门控型离子通道可能是全麻药的分子作用位点。其中γ-氨基丁酸型受体(GABAa受体)及其门控Cl^-通道复合物尤显重要。本文扼要概述了异丙酚与苯二氮(艹卓)类在该通道复合物水平的相互作用及其可能机制。 | 夏梦 于布为 | 2003 | 国外医学(麻醉学与复苏分册)2003，24，4： | 15 |
| 9 | Propofol inhibits the adhesion of hepatocellular carcinoma cells by upregulating microRNA-199a and downregulating MMP-9 expression显示文摘BACKGROUND: Propofol is one of the extensively and commonly used intravenous anesthetics and has the ability to influence the proliferation, motility, and invasiveness of many cancer cells. In this study, the effects of propofol on hepatocellular carcinoma cells invasion ability were examined. METHODS: We assessed the invasion ability of HepG2 cells in vitro by determining enzyme activity and protein expression of MMP-9 using gelatin zymography assay and Western blot. The real-time PCR was used to evaluate the effect of propofol on microRNA-199a (miR-199a) expression, and miR-199a-2 precursor to evaluate whether over-expression of miR-199a can affect MMP-9 expression. Finally, the effect of miR-199a on propofol-induced anti-tumor activity using anti-miR-199a was assessed. RESULTS: Propofol significantly elevated the expression of miR-199a and inhibited the invasiveness of HepG2 cells. Propofol also efficiently decreased enzyme activity and protein expression of MMP-9. Moreover, the over-expression of miR-199a decreased MMP-9 protein level. Interestingly, the neutralization of miR-199a by anti-miR-199a antibody reversed the effect of propofol on alleviation of tumor invasiveness and inhibition of MMP-9 activity in HepG2 cells. CONCLUSION: Propofol decreases hepatocellular carcinoma cell invasiveness, which is partly due to the down-regulation of MMP-9 expression by miR-199a. | Jian Zhang Dan Zhang Guo-Qing Wu Zhi-Ying Feng Sheng-Mei Zhu | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 14 |
| 10 | Propofol Attenuates a-Synuclein Aggregation and Neuronal Damage in a Mouse Model of Ischemic Stroke显示文摘a-Synuclein is a soluble monomer abundant in the central nervous system. Aggregates of a-synuclein,consisting of higher-level oligomers and insoluble fibrils,have been observed in many chronic neurological diseases and are implicated in neurotoxicity and neurodegeneration.a-Synuclein has recently been shown to aggregate following acute ischemic stroke, exacerbating neuronal damage.Propofol is an intravenous anesthetic that is commonly used during intravascular embolectomy following acute ischemic stroke. While propofol has demonstrated neuroprotective properties following brain injury, the mechanism of protection in the setting of ischemic stroke is unclear. In this study, propofol administration significantly reduced the neurotoxic aggregation of a-synuclein, decreased the infarct area, and attenuated the neurological deficits after ischemic stroke in a mouse model. We then demonstrated that the propofol-induced reduction of a-synuclein aggregation was associated with increased mammalian target of rapamycin/ribosomal protein S6 kinase beta-1 signaling pathway activity and reduction of the excessive autophagy occurring after acute ischemic stroke. | Yuzhu Wang Dan Tian Changwei Wei Victoria Cui Huan Wang Yanbing Zhu Anshi Wu Yun Yue | 2020 | Neuroscience Bulletin2020，36，3： | 14 |
| 11 | Sedation and analgesia in gastrointestinal endoscopy: What’s new?显示文摘Various types of sedation and analgesia technique have been used during gastrointestinal endoscopy procedures.The best methods for analgesia and sedation during gastrointestinal endoscopy are still debated.Providing an adequate regimen of sedation/analgesia might be considered an art,influencing several aspects of endoscopic procedures: the quality of the examination,the patient’s cooperation and the patient’s and physician’s satisfaction with the sedation.The properties of a model sedative agent for endoscopy would include rapid onset and offset of action,analgesic and anxiolytic effects,ease of titration to desired level of sedation,rapid recovery and an excellent safety prof ile.Therefore there is an impulse for development of new approaches to endoscopic sedation.This article provides an update on the methods of sedation today available and future directions in endoscopic sedation. | Lorella Fanti Pier Alberto Testoni | 2010 | World Journal of Gastroenterology2010，16，20： | 12 |
| 12 | Propofol differentially induces unconsciousness and respiratory depression through distinct interactions between GABAa receptor and GABAergic neuron in corresponding nuclei显示文摘Propofol is the most commonly used intravenous anesthetic worldwide.It can induce loss of consciousness prior to the occurrence of severe respiratory suppression,which is also a pharmacodynamic feature of all general anesthetics.However,the neural mechanisms underlying this natural phenomenon are controversial and highly related to patient safety.In the present study,we demonstrated that the pharmacodynamic effects of propofol(50 and 100 μM)on suppression of consciousness-related excitatory postsynaptic currents in the medial prefrontal cortex(mPFC)and centromedian nucleus of the thalamus(CMT)were lower than those in the kernel respiratory rhythmogenesis nucleus pre-Botzinger complex(PrBo).Furthermore,we unexpectedly found that the GABAa receptor β3 subunit is the key target for propofol's action and that it is mutually and exclusively expressed in GABAergic neurons.It is also more abundant in the mPFC and CMT,but mainly co-localized with GABAergic neurons in the PrBo.As a result,the differentiated expression pattern should mediate more neuron suppression through the activation of GABAergic neurons in the mPFC and CMT at low doses of propofol(50 μM).However,PrBo GABAergic neurons were only activated by propofol at a high dose(100 μM).These results highlight the detailed pharmacodynamic effects of propofol on consciousness-related and respiration-related nuclei and provide the distinct interaction mechanism between the β3 subunit and GABAergic neurons in mediating the suppression of consciousness compared to the inhibition of respiration. | Junli Jiang Yingfu Jiao Po Gao Wen Yin Wei Zhou Yunchun Zhang Yanjun Liu Daxiang Wen Yuan Wang Liang Zhou Tian Yu Weifeng Yu | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 11 |
| 13 | Propofol use in endoscopic retrograde cholangiopancreatography and endoscopic ultrasound显示文摘Compared to standard endoscopy,endoscopic retrograde cholangiopancreatography(ERCP)and endoscopic ultrasound(EUS)are often lengthier and more complex,thus requiring higher doses of sedatives for patient comfort and compliance.The aim of this review is to provide the reader with information regarding the use,safety profile,and merits of propofol for sedation in advanced endoscopic procedures like ERCP and EUS,based on the current literature. | Danny G Cheriyan Michael F Byrne | 2014 | World Journal of Gastroenterology2014，20，18： | 11 |
| 14 | Propofol attenuates TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells by inhibiting Ca^2+/CAMKⅡ/ERK/NF-kB signaling pathway显示文摘Metalloproteinase 9(MMP-9)is able to degrade collagen Ⅳ,an important component of blood-brain barrier(BBB).Expression of MMPs,especially MMP-9,correlates with BBB disruption during central nervous system inflammation.Propofol has been reported to have anti-inflammation effects.In this study,we investigated the effects of propofol on TNF-α-induced MMP-9 expression in human cerebral microvascular endothelial cells(hCMEC/D3 cells)and explored the underlying mechanisms.The hCMEC/D3 cells were treated with propofol(25 pM),followed by TNF-a(25 ng/mL).We showed that TNF-a treatment markedly increased MMP-9 expression and decreased collagen Ⅳ expression in hCMEC/D3 cells,which was blocked by pretreatment with propofol.TNF-ainduced downregulation of collagen Ⅳ was also reversed by MMP-9 knockdown with siRNA.We revealed that TNF-αupregulated MMP-9 expression in hCMEC/D3 cells through activation of Ca^2+/CAMK Ⅱ/ERK/NF-kB signaling pathway;co-treatment with inhibitors of CaMK Ⅱ(KN93),ERK(LY3214996),NF-kB(PDTC)or Ca^2+chelator(BAPTA-AM)abrogated the effect of TNF-αon MMP-9 expression.We further established an in vitro BBB model by co-culturing of hCMEC/D3 cells and human astrocytes for 6 days and measuring frans-endothelial electrical resistance(TEER)to reflect the BBB permeability.TNF-αtreatment markedly decreased TEER value,which was attenuated by pretreatment with propofol(25 mM)or MMP-9 knockdown with siRNA.In conclusion,propofol inhibits TNF-a-induced MMP-9 expression in hCMEC/D3 cells via repressing the Ca^2+/CAMK Ⅱ/ERK/NF-kB signaling pathway.TNF-aimpaired BBB integrity could be reversed by propofol,and propofol attenuates the inhibitory effect of TNF-a on collagen Ⅳ. | Xiao-wei Ding Xia Sun Xue-fang Shen Yan Lu Jia-qiang Wang Zhi-rong Sun Chang-hong Miao Jia-wei Chen | 2019 | Acta Pharmacologica Sinica2019，40，10： | 11 |
| 15 | Sedation and safety of propofol for therapeutic endoscopic retrograde cholangiopancreatography显示文摘Endoscopic retrograde cholangiopancrea tography(ERCP) is the most complex gastrointestinal procedure,which needs patients’ cooperation. The aim of this study was to observe the quality and safey of sedation with propofol in patients undergoing therapeutic ERCP. METHODS:Seventy patients who had undergone therapeutic ERCP were randomly divided into two groups.One group, given intravenously propofol, and the other sedated with routine method, served as the control. Blood pressure, heart rate,oxygen saturation were monitored and cardiorespiratory event was observed. Patient cooperation,performance, recovery time and amnesia served as variables postoperation. RESULTS:Blood pressure elevated in four patients in the propofol group, less than in the control group(P<0.01). Seven patients showed decreased blood pressure after administration of propofol,but none in the control group (P<0.01). Twelve patients in the control group showed mild or significant resistance, but none in the propofol group (P<0.01). The time for performance in the propofol group(P<0.05) was shorter than in the control group. Patient recovery was quicker in the propofol group than in the control group (P<0.01). The degree of amnesia better in the propofol group than in the control group ( P<0.01). The degree of amnesia was also better in the propofol group than in the control group (P<0.01). CONCLUSIONS:Propofol proves to be an excellent sedative for therapeutic ERCP. Being effective and safe, it shows a shorter ERCP duration but quick recovery and better amnesia. It is better than other routine sedatives. | Digestive Department (Chen WX, Lin HJ, Gu Q, Zhong XQ, Yu CH, Li YM and Gu ZY) and Department of Intensive Care Unit (Zhang WF), First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003 , China | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 10 |
| 16 | Propofol induces apoptosis and increases gemcitabine sensitivity in pancreatic cancer cells in vitro by inhibition of nuclear factor-κ B activity显示文摘AIM:To investigate the effect of propofol on human pancreatic cells and the molecular mechanism of propofol action.METHODS:We used the human pancreatic cancer cell line MIAPaCa-2 for in vitro studies measuring growth inhibition and degree of apoptotic cell death induced by propofol alone,gemcitabine alone,or propofol followed by gemcitabine.All experiments were conducted in triplicate and carried out on three or more separate occasions.Data were means of the three or more independent experiments±SE.Statistically significant differences were determined by two-tailed unpaired Student’s t test and defined as P<0.05.RESULTS:Pretreatment of cells with propofol for 24 h followed by gemcitabine resulted in 24%-75% growth inhibition compared with 6%-18%when gemcitabine was used alone.Overall growth inhibition was directly correlated with apoptotic cell death.We also showed that propofol potentiated gemcitabine-induced killing by downregulation of nuclear factor-κB(NF-κB).In contrast,NF-κB was upregulated when pancreatic cancer cells were exposed to gemcitabine alone,suggesting a potential mechanism of acquired chemoresistance.CONCLUSION:Inactivation of the NF-κB signaling pathway by propofol might abrogate gemcitabineinduced activation of NF-κB,resulting in chemosensitization of pancreatic tumors to gemcitabine. | Qi-Hang Du Yan-Bing Xu Meng-Yuan Zhang Peng Yun Chang-Yao He | 2013 | World Journal of Gastroenterology2013，19，33： | 10 |
| 17 | Propofol induces ferroptosis and inhibits malignant phenotypes of gastric cancer cells by regulating miR-125b-5p/STAT3 axis显示文摘BACKGROUND Gastric cancer is a common malignancy with poor prognosis,in which ferroptosis plays a crucial function in its development.Propofol is a widely used anesthetic and has antitumor potential in gastric cancer.However,the effect of propofol on ferroptosis during gastric cancer progression remains unreported.AIM To explore the function of propofol in the regulation of ferroptosis and malignant phenotypes of gastric cancer cells.METHODS MTT assays,colony formation assays,Transwell assays,wound healing assay,analysis of apoptosis,ferroptosis measurement,luciferase reporter gene assay,and quantitative reverse transcription polymerase chain reaction were used in this study.RESULTS Our data showed that propofol was able to inhibit proliferation and induce apoptosis of gastric cancer cells.Meanwhile,propofol markedly repressed the invasion and migration of gastric cancer cells.Importantly,propofol enhanced the erastin-induced inhibition of growth of gastric cancer cells.Consistently,propofol increased the levels of reactive oxygen species,iron,and Fe2+in gastric cancer cells.Moreover,propofol suppressed signal transducer and activator of transcription(STAT)3 expression by upregulating miR-125b-5p and propofol induced ferroptosis by targeting STAT3 in gastric cancer cells.The miR-125b-5p inhibitor or STAT3 overexpression reversed propofol-attenuated malignant phenotypes of gastric cancer cells.CONCLUSION Propofol induced ferroptosis and inhibited malignant phenotypes of gastric cancer cells by regulating the miR-125b-5p/STAT3 axis.Propofol may serve as a potential therapeutic candidate for gastric cancer. | Yi-Ping Liu Zhong-Zhi Qiu Xu-Hui Li En-You Li | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 10 |
| 18 | 性别和年龄对异丙酚-雷米芬太尼靶控输注下意识和疼痛反应消失EC_(50)及BIS值的影响——多中心研究显示文摘Objective To study the effect of gender and ages on predict blood and effect-site EC50 for propofol and remifentanil TCI and bispectral index at loss of consciousness and response to a standard noxious painful stimulus. Methods 405 ASA Ⅰ-Ⅱunpremedicated Chinese patients in 5 medical centers for elective operation were involved. Patients were allocated to 4 groups according to ages (group1: 18 | 徐志鹏 刘芳 岳云 叶铁虎 张炳熙 左明章 徐铭军 郝绒绒 徐原 杨宁 车向明 | 2006 | 国际麻醉学与复苏杂志2006，27，3： | 9 |
| 19 | Effect of propofol and ketamine anesthesia on cognitive function and immune function in young rats显示文摘Objective:To investigate the effects of propofol and ketamine on the cognitive function and immune function in young rats.Method:A total of 80 young rats were randomly divided into four groups:Control group,ketamine group(experimental group A),propofol group(experimental group B),ketamine and propofol group(experimental group Q.All rats had continuous injection for three times,serum IL-2,IL-4 and II.-10 and whole brain IL-I P level,hippocampal neuronal apoptosis level were measured.The cognitive ability in rats was tested by water maze.Results:Water maze test showed on the 1st d,the maze test latency of the control group,the experimental group B and the experimental group C water were decreased gradually;Compared with the control group after 3 days,the latency of the experimental group A,experimental group B and experimental group C were all decreased,the crossing circle times were also reduced.Hippocampal neuron apoptosis were(2.3±1.7)%,(14.7±6.9)%,(4.2±3.3)%,(10.2±4.8r%in control group,experimental group A,experimental group B and experimental group C,respectively.The neurons apoptosis of experimental group A was significantly increased.The serum IL-4 and 1L-10 of the experimental group A,experimental group B and experimental group C after anesthesia were significantly higher than the control group.The whole brain IL-1β of the experimental group A,experimental group B and experimental group C were significantly lower than the control group.Conclusions:Propofol can reduce anesthesia effect of ketamine on the cognitive function and immune function in the young rats. | Yan-Li Cao Wei Zhang Yan-Qun Ai Wen-Xia Zhang Yi Li | 2014 | Asian Pacific Journal of Tropical Medicine2014，7，5： | 8 |
| 20 | Effects of propofol versus urapidil on perioperative hemodynamics and intraocular pressure during anesthesia and extubation in ophthalmic patients显示文摘·AIM:To compare the effect of propofol versus urapidil on hemodynamics and intraocular pressure during anesthesia and extubation for ophthalmic patients.·METHODS:Eighty-two surgical patients (Class:ASA I-￠ò) were randomly assigned to propofol (n =41) and urapidil groups (n =41).Their gender,age,body mass,operation time and dosage of anesthetics had no significant difference between the two groups (P >0.05).The patients of propofol and urapidil groups were given propofol (1.5mg/kg) and urapidil (2.5mg/kg) respectively;and two drugs were all diluted with normal saline to 8mL.Then the drugs were given to patients by slow intravenous injection.After treatment,the patients were conducted immediate suction,tracheal extubation,and then patients wore oxygen masks for 10minutes.By double-blind methods,before the induction medication,at the suction,and 5,10minutes after the extubation,we recorded the systolic and diastolic blood pressure (BP),heart rate (HR),pH,PaO2,PaCO2,SaO2 and intraocular pressure (IOP) respectively.The complete recovery time of the patients with restlessness (on the command they could open eyes and shaking hands) was also recorded during the extubation.The data were analyzed by using a professional SPSS 15.0 statistical software.·RESULTS:The incidence of cough,restlessness and glossocoma was significantly lower in the propofol group than that in the urapidil group after extubation (P <0.05).There were no episodes of hypotension,laryngospasm,or severe respiratory depression.There was no statistical difference in recovery time between two groups (P >0.05).In propofol group,the BP and HR during extubation and thereafter had no significant difference compared with those before induction,while they were significantly lower than those before giving propofol (P <0.05),and had significant difference compared with those in urapidil group (P <0.05).Compared to preinduction,the BP of urapidil group showed no obvious increase during aspiration and extubation.The HR of urapidil group had little changes after being given urapidil,and it was obviously increased compared with that before induction.The stimulation of aspiration and extubation caused less cough and agitation in propofol group than that in urapidil group (P <0.05).The IOP of propofol group showed no obvious increase during extubation compared with that in preinduction,while in the urpidil group,extubation caused IOP significantly increased (P <0.05).The changes in these indicators between the two groups had no significant difference (P >0.05).·CONCLUSION:Compared to urapidil,propofol is superior for preventing the cardiovascular and stress responses and IOP increases during emergence and extubation for the ophthalmic patients.Moreover,it has no effects on patient's recovery.· | Yong-Chong Cheng, Bo-Rong Pan | 2011 | International Journal of Ophthalmology(English edition)2011，4，2： | 8 |
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