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| 1 | Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis显示文摘Iron has been shown to trigger oxidative stress by elevating reactive oxygen species (ROS) and to participate in different modes of cell death,such as ferroptosis,apoptosis and necroptosis. However,whether iron-elevated ROS is also linked to pyroptosis has not been reported. Here,we demonstrate that iron-activated ROS can induce pyroptosis via a Tom20-Bax-caspase-GSDME pathway. In melanoma cells,iron enhanced ROS signaling initiated by CCCP,causing the oxidation and oligomerization of the mitochondrial outer membrane protein Tom20. Bax is recruited to mitochondria by oxidized Tom20,which facilitates cytochrome c release to cytosol to activate caspase-3;eventually triggering pyroptotic death by inducing GSDME cleavage. Therefore,ROS acts as a causative factor and Tom20 senses ROS signaling for iron-driven pyroptotic death of melanoma cells. Since iron activates ROS for GSDME-dependent pyroptosis induction and melanoma cells specifically express a high level of GSDME,iron may be a potential candidate for melanoma therapy. Based on the functional mechanism of iron shown above,we further demonstrate that iron supplementation at a dosage used in iron-deficient patients is sufficient to maximize the anti-tumor effect of clinical ROS-inducing drugs to inhibit xenograft tumor growth and metastasis of melanoma cells through GSDME-dependent pyroptosis. Moreover,no obvious side effects are observed in the normal tissues and organs of mice during the combined treatment of clinical drugs and iron. This study not only identifies iron as a sensitizer amplifying ROS signaling to drive pyroptosis,but also implicates a novel iron-based intervention strategy for melanoma therapy. | Bo Zhou Jia-yuan Zhang Xian-shuo Liu Hang-zi Chen Yuan-li Ai Kang Cheng Ru-yue Sun Dawang Zhou Jiahuai Han Qiao Wu | 2018 | Cell Research2018，28，12： | 52 |
| 2 | Artificial senses for characterization of food quality显示文摘Food quality is of primary concern in the food industry and to the consumer. Systems that mimic human senses have been developed and applied to the characterization of food quality. The five primary senses are: vision, hearing, smell, taste and touch. In the characterization of food quality, people assess the samples sensorially and differentiate “good”from “bad”on a continuum. However, the human sensory system is subjective, with mental and physical inconsistencies, and needs time to work. Artificial senses such as machine vision, the electronic ear, electronic nose, electronic tongue, artificial mouth and even artificial the head have been developed that mimic the human senses. These artificial senses are coordinated individually or collectively by a pat- tern recognition technique, typically artificial neural networks, which have been developed based on studies of the mechanism of the human brain. Such a structure has been used to formulate methods for rapid characterization of food quality. This research presents and discusses individual artificial sensing systems. With the concept of multi-sensor data fusion these sensor systems can work collectively in some way. Two such fused systems, artificial mouth and artificial head, are described and discussed. It indicates that each of the individual systems has their own artificially sensing ability to differentiate food samples. It further indicates that with a more complete mimic of human intelligence the fused systems are more powerful than the individual sys- tems in differentiation of food samples. | R.E. Lacey | 2004 | Journal of Bionic Engineering2004，1，3： | 1 |
| 3 | Sensing as Knowing:Medicines,the Senses,and Practical Expertise in Late Imperial China显示文摘The development of the medicinal trade and markets in late imperial China increased anxiety among scholarly physicians about the authenticity of medicines.Even though the market was typically depicted by scholarly physicians as a place full of tricks and deceptions,it was a repertoire where practical knowledge about authentication was created and circulated.The specialized knowledge was mainly transmitted through oral tradition.But in some instances,it was also written down by scholarly physicians or merchants,allowing us to reconstruct the techniques and their underlying rationales.Authentication of medicines mobilized multiple sensory perceptions of the human body,consisting of observing,tasting,smelling,touching,and performing small tests.All these techniques played different roles in the practice of authentication.Even though these sensory techniques seemed like a collection of trivial and practical records without any coherent rationales,an underlying episteme could be detected through a close investigation.Merchants and practitioners in the market did not understand the nature and materiality of medicines by any established theories.Instead,they actively engaged with the tangible form of medicines through the senses and bodily techniques.This sensory form of knowing indicates a type of practical expertise that is distant from the scholarly tradition of materia medica in late imperial China. | LIU Xiaomeng | 2023 | Chinese Medicine and Culture2023，6，1： | 0 |
| 4 | Undiagnosed Medical Causation—Psychosomatic Etiology显示文摘Conscious existence is the product of a neural brain mechanism,which is largely identical with Immanuel Kant’s Oneness Function,a service performed by 200 million neurons in the prefrontal lobe,&makes possible our interior cosmos,the record of our interconnected,or general,experience.Essential for us humans is the well-being of our interior cosmos,or Saint Teresa of Avila’s interior castle,in all interactions with each other&the greater environment.Any disorders of our cosmos are liable to make us fall ill,setting our existence on a path of psychosomatic etiology of a large class of mysterious undiagnosed diseases. | Hermann G.W.Burchard | 2020 | Journal of Philosophy Study2020，10，4： | 0 |
| 5 | Discussion On the Semantics and Culture显示文摘DiscusionOntheSemanticsandCultureWangJianwu(Dept.ofB.C.ofShaanxiInstituteofTechnology)Abstract:Thispaperfocusesonhowsemantics... | Wang Jianwu(Dept.of B.C.of Shaanxi Institute of Technology) | 1997 | 陕西理工学院学报(自然科学版)1997，19，4： | 0 |
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