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| 1 | PBPK modeling and simulation in drug research and development显示文摘Physiologically based pharmacokinetic(PBPK) modeling and simulation can be used to predict the pharmacokinetic behavior of drugs in humans using preclinical data.It can also explore the effects of various physiologic parameters such as age,ethnicity,or disease status on human pharmacokinetics,as well as guide dose and dose regiment selection and aid drug–drug interaction risk assessment.PBPK modeling has developed rapidly in the last decade within both the field of academia and the pharmaceutical industry,and has become an integral tool in drug discovery and development.In this mini-review,the concept and methodology of PBPK modeling are briefly introduced.Several case studies were discussed on how PBPK modeling and simulation can be utilized through various stages of drug discovery and development.These case studies are from our own work and the literature for better understanding of the absorption,distribution,metabolism and excretion(ADME) of a drug candidate,and the applications to increase efficiency,reduce the need for animal studies,and perhaps to replace clinical trials.The regulatory acceptance and industrial practices around PBPK modeling and simulation is also discussed. | Xiaomei Zhuang Chuang Lu | 2016 | Acta Pharmaceutica Sinica B2016，6，5： | 21 |
| 2 | Pure quantitative characterization of finite projective special unitary groups显示文摘We prove that each projective special unitary group G can be characterized using; only the set of element orders of G and the order of G. | 曹洪平 施武杰 | 2002 | Science China Mathematics2002，45，6： | 20 |
| 3 | Singular values, quasiconformal maps and the Schottky upper bound显示文摘Some properties and asymptotically sharp bounds are obtained for singular values of Ramanujan’s generalized modular equation, from which infinite_product representations of the Hersch_Pfluger φ distortion function φ K(r) and the Agard η distortion function η K(t) follow. By these results, the explicit quasiconformal Schwarz lemma is improved, several properties are obtained for the Schottky upper bound, and a conjecture on the linear distortion function λ(K) is proved to be true. | 裘松良 | 1998 | Science China Mathematics1998，41，12： | 9 |
| 4 | Special AT-rich sequence-binding protein 1 promotes cell growth and metastasis in colorectal cancer显示文摘AIM: To evaluate the expression of special AT-rich sequence-binding protein 1 (SATB1 ) gene in colorectal cancer and its role in colorectal cancer cell proliferation and invasion.METHODS: Immunohistochemistry was used to detect the protein expression of SATB1 in 30 colorectal cancer (CRC) tissue samples and pair-matched adjacent nontumor samples. Cell growth was investigated after enhancing expression of SATB1. Wound-healing assay and Transwell assay were used to investigate the impact of SATB1 on migratory and invasive abilities of SW480 cells in vitro . Nude mice that received subcutaneous implantation or lateral tail vein were used to study the effects of SATB1 on tumor growth or metastasis in vivo . RESULTS: SATB1 was over-expressed in CRC tissues and CRC cell lines. SATB1 promotes cell proliferation and cell cycle progression in CRC SW480 cells. SATB1 over-expression could promote cell growth in vivo . In addition, SATB1 could significantly raise the ability of cell migration and invasion in vitro and promote the ability of tumor metastasis in vivo . SATB1 could up-regulate matrix metalloproteases 2, 9, cyclin D1 and vimentin, meanwhile SATB1 could down-regulate E-cadherin in CRC. CONCLUSION: SATB1 acts as a potential growth and metastasis promoter in CRC. SATB1 may be useful as a therapeutic target for CRC. | Xue-Feng Fang Zhi-Bo Hou Xin-Zheng Dai Cong Chen Jing Ge Hong Shen Xiao-Feng Li Li-Ke Yu Ying Yuan | 2013 | World Journal of Gastroenterology2013，19，15： | 9 |
| 5 | 水对硅酸盐岩体系部分熔融行为的影响:第二临界端点的重要意义显示文摘水对硅酸盐岩体系的许多物理—化学行为有着非常重大的影响。具体对部分熔融过程来说,水可以显著地降低熔融温度、改变熔体性质、影响微量元素在固—液相之间的分配。近年来,科学家们就大量水对硅酸盐岩体系的部分熔融过程的影响进行了许多的高压实验,他们主要关注第二临界端点对熔融过程的重要作用:第二临界端点的出现极大地改变着部分熔融过程中的基本相关系。本文主要针对这些高压实验研究做一总结,并对未来研究方向做一初步探讨。 | 刘曦 张立飞 HACK C Alistair 郑海飞 胡晓敏 常琳琳 何强 | 2009 | 岩石学报2009，25，12： | 8 |
| 6 | The Entropies Evaluation of the High-entropy System and its Determination of Operating Entropy | SONG Hua\|ling\+1,\ ZHAI Cong\|min 2,\ LIU Li\|juan 21.School of management, Hebei University of Technology Cornelis Reiman, Tianjin 300130, China Department of Management, Monash University, Australia 2.School of management, Hebei University of T | 2000 | Systems Science and Systems Engineering2000，10，3： | 8 |
| 7 | 新疆伊宁矿区特殊地质条件液压支架选型研究显示文摘介绍了伊犁4#矿井的概况,针对新疆伊宁矿区伊北煤田巨厚Ⅲ级严重湿陷性表土层、浅埋深、无关键承载层以及'三软'地质条件下厚煤层的开采等特殊地质条件,采用现场地层资料实测和实验室模拟以及类似地质条件下开采情况调研后,对液压支架选型进行了综合分析,并确定了液压支架选型结果,为矿井实现安全高效开采乃至整个矿区煤炭资源大规模开发提供了可靠保障。 | 刘光木 张京超 续文峰 任艳芳 | 2014 | 中国煤炭2014，40，2： | 7 |
| 8 | Special hybrid stress element for stress analyses around circular cutouts in laminated composites显示文摘A 3-dimensional hybrid stress element with a traction-free cylindrical surface based on amodified complementary energy principle has been derived for efficient and accurate analysis of stressconcentration around circular cutouts in thin to thick laminated composites. New expressions of sixstress components are developed by using three stress-functions in cylindrical co-ordinates, so that thehomogeneous equilibrium equations, the interlayer surface transverse-stresses and the traction-freeboundary condition on the cylindrical surface are satisfied exactly, while the interelement traction conti-nuity has been relaxed via the Lagrange multiplier method. Transverse-shear deformation effects areincorporated in each layer with displacement continuity enforced along interlayer surface. Selected ex-amples are used to demonstrate the efficiency and accuracy of the present special element. | 田宗漱 赵奉东 田铮 | 2001 | Science China(Technological Sciences)2001，44，5： | 6 |
| 9 | The first cohomology group of trivial extensions of special biserial algebras显示文摘Given a finite dimensional special biserial algebra A with normed basis we obtain the dimension formulae of the first Hochschild homology groups of A and the vector space Alt(DA). As a consequence, an explicit dimension formula of the first Hochschild cohomology group of trivial extension TA = A × DA in terms of the combinatorics of the quiver and relations is determined. | XU YungeDepartment of Mathematics & Computer Sciences, Hubei University, Wuhan 430062, China | 2004 | Science China Mathematics2004，47，4： | 6 |
| 10 | ACCURACY ANALYSIS OF 12-PARAMETER RECTANGULAR PLATE ELEMENTS WITH GEOMETRIC SYMMETRY显示文摘In this paper, it is proved that the double set parameter rectangular plate elements with geometric symmetry possess a very special convergence property, i.e., the consistency error due to nonconformity is of order O(h2) which is one order higher than that of ACM element and rectangular generalized conforming element proposed by Y. Q. Long, although all these elements have the same asympotical rate of convergence O(h) in the energy norm. This particular property seems to be never seen before for other nonconforming rectangular plate elements. | SHI Dongyang CHEN Shaochun (Department of Mathematics, Zhengzhou University, Zhengzhou 450052, China) | 2000 | Systems Science and Mathematical Sciences2000，13，2： | 6 |
| 11 | Recent developments of InteCAST software and its applications on special castings显示文摘with the development of computer technology, foundry CAE technology has made rapid progress. Commercialsoftware packages of casting process simulation, therefore, have become more and more practical. This paper introducesboth the recent developments and some applications of InteCAST software, a commercial numerical simulation softwarepackage for foundry industry, with more than 120 customers all over the world. The function modules of lnteCAST8.0 andsome new techniques, such as uneven mesh technology for mold filling simulation and numerical mouse technology fordata visualization, were introduced. Several applications on special castings such as investment casting, low pressure diecasting, and high pressure die casting, were given. These applications showed that the software can help engineers tooptimize casting process by forecasting casting defect. | Jianxin ZHOU Ruixiang LIU Liliang CHEN Dunming LIAO | 2005 | China Foundry2005，2，3： | 6 |
| 12 | SATB1在胃癌细胞SGC-7901中表达的研究显示文摘目的通过检测胃癌细胞株SGC-7901和胃黏膜上皮细胞GES-1中SATB1 mRNA和蛋白的表达水平,探讨其在胃癌发展和转移中的作用。方法利用荧光定量PCR、RT-PCR检测胃癌细胞株SGC-7901和胃黏膜上皮细胞GES-1中SATB1 mRNA的转录水平表达,通过免疫荧光染色检测SATB1在两种细胞中的表达差异。结果 SATB1 mRNA在SGC-7901中的表达程度显著高于GES-1细胞,免疫荧光染色显示SATB1在胃癌细胞株的胞浆和胞核内均有分布,呈强阳性染色,而在GES-1细胞中无表达。结论 SATB1在胃癌细胞株SGC-7901中mRNA和蛋白水平均呈现高表达,提示SATB1的表达水平可能与胃癌发生发展密切相关,有望成为判断胃癌预后的一个指标。 | 宋桂芹 刘康 白亦光 周玉川 冯刚 | 2014 | 中华全科医学2014，12，1： | 5 |
| 13 | Special AT-rich sequence-binding protein 2 acts as a negative regulator of stemness in colorectal cancer cells显示文摘AIM To find the mechanisms by which special AT-rich sequence-binding protein 2(SATB2) influences colorectal cancer(CRC) metastasis.METHODS Cell growth assay, colony-forming assay, cell adhesion assay and cell migration assay were used to evaluate the biological characteristics of CRC cells with gain or loss of SATB2. Sphere formation assay was used to detect the self-renewal ability of CRC cells. The m RNA expression of stem cell markers in CRC cells with upregulated or downregulated SATB2 expression was detected by quantitative real-time polymerase chain reaction. Chromatin immunoprecipitation(Ch IP) was used to verify the binding loci of SATB2 on genomic sequences of stem cell markers. The Cancer Genome Atlas(TCGA) database and our clinical samples wereanalyzed to find the correlation between SATB2 and some key stem cell markers.RESULTS Downregulation of SATB2 led to an aggressive phenotype in SW480 and DLD-1 cells, which was characterized by increased migration and invasion abilities. Overexpression of SATB2 suppressed the migration and invasion abilities in SW480 and SW620 cells. Using sequential sphere formation assay to detect the selfrenewal abilities of CRC cells, we found more secondary sphere formation but not primary sphere formation in SW480 and DLD-1 cells after SATB2 expression was knocked down. Moreover, most markers for stem cells such as CD133, CD44, AXIN2, MEIS2 and NANOG were increased in cells with SATB2 knockdown and decreased in cells with SATB2 overexpression. Ch IP assay showed that SATB2 bound to regulatory elements of CD133, CD44, MEIS2 and AXIN2 genes. Using TCGA database and our clinical samples, we found that SATB2 was correlated with some key stem cell markers including CD44 and CD24 in clinical tissues of CRC patients.CONCLUSION SATB2 can directly bind to the regulatory elements in the genetic loci of several stem cell markers and consequently inhibit the progression of CRC by negatively regulating stemness of CRC cells. | Ying Li Yu-Hong Liu Yu-Ying Hu Lin Chen Jian-Ming Li | 2016 | World Journal of Gastroenterology2016，22，38： | 5 |
| 14 | 基于人体指纹特征的随机序列发生器显示文摘利用人体指纹特征本身内在的唯一性、不可预测性和外部随机噪声(光照、损伤等)给出了产生随机序列的一类新方法——基于人体指纹特征的随机序列发生器,实现了人体生物特征与密码的结合.使用自相关函数方法和BDS统计检验方法验证了该随机序列优良的线性不相关性和非线性不相关性,得到了完全不可预测的非周期随机序列.通过美国国家标准技术研究院(NIST)推荐的标准随机统计测验FIPS140-1 Tests和NIST Special Publication 800-22 Tests对该随机序列进行了检验.检验结果表明基于人体指纹特征的随机序列发生器是满足密码安全的随机序列发生器,并且实现简单、方便. | 朱和贵 张祥德 杨连平 唐青松 | 2009 | 计算机研究与发展2009，46，11： | 5 |
| 15 | 特殊利益集团如何影响政治过程?——《特殊利益政治学》评价 | 李增刚 | 2004 | 制度经济学研究2004，，2： | 3 |
| 16 | Structure of solvable subgroup of SL(2,C) and integrability of Fuchsian equations on torus T2显示文摘The possible derived lengths and structures of solvable subgroups of SL(2,C) are given in Theorem 1,and the structures of the Riemann surfaces of solutions of the Fuchsian equation on torus with a solvable monodromy group are discussed.Examples in verifying the solvability of monodromy groups for some Fuchsian equations on T2 are given. | 管克英 张绍飞 | 1996 | Science China Mathematics1996，39，5： | 3 |
| 17 | Vibration analysis of a new polymer quartz piezoelectric crystal sensor for detecting characteristic materials of volatility liquidVibration analysis of a new polymer quartz piezoelectric crystal sensor for detecting characteristic materials of volatility liquid显示文摘We present a new polymer quartz piezoelectric crystal sensor that takes a quartz piezoelectric crystal as the basal material and a nanometer nonmetallic polymer thin film as the surface coating based on the principle of quartz crystal microbalance (QCM). The new sensor can be used to detect the characteristic materials of a volatile liquid. A mechanical model of the new sensor was built, whose structure was a thin circle plate composing of polytef/quartz piezoelectric/polytef. The mechanical model had a diameter of 8 mm and a thickness of 170 ~tm. The vibration state of the model was simulated by software ANSYS after the physical parameters and the boundary condition of the new sensor were set. According to the results of experiments, we set up a frequency range from 9.995850 MHz to 9.997225 MHz, 17 kinds of frequencies and modes of vibration were obtained within this range. We found a special frequency fsp of 9.996358 MHz. When the resonant frequency of the new sensor's mechanical model reached the special frequency, a special phenomenon occurred. In this case, the amplitude of the center point O on the mechanical model reached the maximum value. At the same time, the minimum absolute difference between the simulated frequency based on the ANSYS software and the experimental measured stable frequency was reached. The research showed that the design of the new polymer quartz piezoelectric crystal sensor perfectly conforms to the principle of QCM. A special frequency value fsp was found and subsequently became one of the most important parameters in the new sensor design. | 谷宇 李强 许保军 赵囍 | 2014 | Chinese Physics B2014，23，1： | 3 |
| 18 | 基于移动学习模式的独立学院大学英语听说教学改革实践探究——以“VOA Special English”为例显示文摘'微媒体时代'背景下,将移动学习模式引入到独立学院的大学英语教学,可以培养符合时代发展需求的高素质应用型综合人才。学生利用碎片化时间,利用'VOA Special English'手机App进行移动学习最新的新闻英语听力,练习口语表达。该软件的互动性、时效性及纯正规范的发音能激发学生学习兴趣,培养学生自主学习能力,从而提高学生综合听说能力。 | 蒋华 姜丽 朱宇博 | 2019 | 湖北开放职业学院学报2019，32，1： | 3 |
| 19 | Katherine Mansfield: A Special Feminist-By a Close Reading of A Dill Pickle | 何丹丽 | 2011 | 海外英语2011，，8X： | 3 |
| 20 | Special relativity and theory of gravity via maximum symmetry and localization显示文摘Like Euclid,Riemann and Lobachevski geometries are on an almost equal footing,based on the principle of relativity of maximum symmetry proposed by Professor Lu Qikeng and the postulate on invariant universal constants c and R,the de Sitter/anti-de Sitter(dS/AdS)special relativity on dS/AdS-space with radius R can be set up on an almost equal footing with Einstein’s special relativity on the Minkowski-space in the case of R→∞. Thus the dS-space is coin-like:a law of inertia in Beltrami atlas with Beltrami time simultaneity for the principle of relativity on one side,and the proper-time simultaneity and a Robertson-Walker-like dS-space with entropy and an accelerated expanding S3 fitting the cosmological principle on another side. If our universe is asymptotic to the Robertson-Walker-like dS-space of R(?)(3/Λ)1/2,it should be slightly closed in O(A)with entropy bound S(?)3πc3kB/ΛGh.Contrarily,via its asymptotic behavior, it can fix on Beltrami inertial frames without‘an argument in a circle’and acts as the origin of inertia. There is a triality of conformal extensions of three kinds of special relativity and their null physics on the projective boundary of a 5-d AdS-space,a null cone modulo projective equivalence[N](?)p(AdS5). Thus there should be a dS-space on the boundary of S5×AdS5 as a vacuum of supergravity. In the light of Einstein’s‘Galilean regions’,gravity should be based on the localized principle of relativity of full maximum symmetry with a gauge-like dynamics.Thus,this may lead to the theory of gravity of corresponding local symmetry.A simple model of dS-gravity characterized by a dimensionless constant g(?)(AGh/3c3)1/2~10-61shows the features on umbilical manifolds of local dS-invariance. Some gravitational effects out of general relativity may play a role as dark matter. The dark universe and its asymptotic behavior may already indicate that the dS special relativity and dS-gravity be the foundation of large scale physics. | GUO HanYing Institute of Theoretical Physics Chinese Academy of Sciences Beijing 100080 China | 2008 | Science China Mathematics2008，51，4： | 3 |
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