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| 1 | Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers显示文摘Prodrug nanoassemblies, which can refrain from large excipients, achieve higher drug loading and control drug release, have been placed as the priority in drug delivery system. Reasoning that glutathione(GSH) and reactive oxygen species(ROS) are highly upgraded in tumor tissues which makes them attractive targets for drug delivery system, we designed and synthetized a novel prodrug which utilized mono thioether bond as a linker to bridge linoleic acid(LA) and docetaxel(DTX). This mono thioether-linked conjugates(DTX-S-LA) could self-assemble into nanoparticles without the aid of much excipients. The mono thioether endowed the nanoparticles redox sensitivity resulting in specific release at the tumor tissue. Our studies demonstrated that the nanoassemblies had uniform particle size, high stability and fast release behavior. DTX-S-LA nanoassemblies outperformed DTX solution in pharmacokinetic profiles for it had longer circulation time and higher area under curve(AUC). Compared with DTX solution, the redox dual-responsive nanoassemblies had comparable cytotoxic activity. Besides, the antitumor efficacy was evaluated in mice bearing 4 T1 xenograft. It turned out this nanoassemblies couldenhance anticancer efficacy by increasing the dose because of higher tolerance. Overall, these results indicated that the redox sensitivity nanoassemblies may have a great potential to cancer therapy. | Meng Li Liwen Zhao Tao Zhang Yue Shu Zhonggui He Yan Ma Dan Liu Yongjun Wang | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 10 |
| 2 | Synthesis of polypeptide bearing 1,4-dithiane pendants for ROS-responsive drug release显示文摘Stimuli-re sponsive polypeptides have been intensively investigated fo r controlled drug release,owing to their favorable biocompatibility and biodegradability.In this work,we designed and synthesized a new kind of polypeptide bearing 1,4-dithiane pendants for reactive oxygen species(ROS)-responsive drug release.The polypeptide-based block copolymer was facilely synthesized by ring-opening polymerization(ROP)of 1,4-dithian-substituted L-glutamate N-carboxyanhydride(DTG-NCA)monomer using an amino-terminated poly(ethylene glycol)methyl ether(mPEG-NH2)as the macro molecular initiator.The resulta nt block copolyme r,mPEG-b-PDTG,could self-assemble into unifo rm micelles in aqueous medium owing to its amphiphilic structure.Then,the H2 O2-triggered oxidation behaviors of the mPEG-b-PDTG micelles were studied by dynamic light scattering(DLS),FT-IR and turbidimetric assay.It was revealed that the oxidation of thioether into sulfoxide in the side chains would result in disassembly of the micelles.Furthermore,the ROS-responsive drug release behavior of the mPEG-b-PDTG micelles was verified by using Nile Red as a model drug.MTT assay also proved that mPEG-b-PDTG was non-toxic in B16 F10 and L929 cells.Therefore,such a new class of oxidation-responsive polypeptide might provide a promising platform for ROS-responsive drug delivery. | Tianhui Zhang Jiuxu Yao Jiamei Tian Mingxiao Deng Xiuli Zhuang Chunsheng Xiao | 2020 | Chinese Chemical Letters2020，31，5： | 2 |
| 3 | The application of sulfur-containing peptides in drug discovery显示文摘In recent decades, peptides as potential drugs were more and more explored with the development of non-oral medicine. There into, sulfur-containing peptide is one of the most popular aspects in peptide drugs due to the introduction of sulfur atoms leading unique properties.The purpose of the present review is to focus on the discovery of various sulfur-containing peptides with particular emphasis on their pharmacological mechanisms. This review is organized according to the structures of the sulfurcontaining peptides. | Jiaoyan Zhao Xuefeng Jiang | 2018 | Chinese Chemical Letters2018，29，7： | 1 |
| 4 | Green Synthesis of Aryl Thioethers through Cu-catalysed C-S Coupling of Thiols and Aryl Boronic Acids in Water显示文摘An efficient, practical, highly selective and environmentally benign method is reported for the synthesis of aryl thioethers via the coupling of thiols with aryl boronic acids in the presence of NaOH and a catalytic amount of CuSO4 at 130 ℃ using water as a green solvent. The products were obtained in moderate to excellent yields;more importantly, the use of toxic ligands and solvents was avoided. A broad range of aryl boronic acids and scalable processes make this methodology valuable and versatile for the synthesis of a broad range of aryl sulfides. | 涂佩华 JIANG Jun XIAO Hongping 李新华 | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，4： | 1 |
| 5 | Application of L-thiazolidine-4-carboxylic acid monolayer in electrochemical determination of copper(Ⅱ)显示文摘L-Thiazolidine-4-carboxylic acid monolayer was prepared on gold electrodes through the self-assembly approach.Such novel thioether-based monolayer could efficiently preconcentrate Cu2+,which provided a simple,stable and reproducible method for the determination of Cu2+.The modified electrodes were stable enough to be continuously used for one week(more than 30 times regeneration) with lower than 10% decrease in the response.They retained their initial activity for more than one month if used once a day.The calibration curve was linear for Cu2+ from 0.6 to 158.8 μg L?1 with a detection limit of 0.38 μg L?1.The relative standard deviation was 3.2% for a series of six successive measurements.The proposed method was applied in the determination of Cu2+ in mineral water and human hair samples. | CUI Xin1,FU YingZi1,2,LI MiaoSi1,CHEN Min2,HE Xuan1,LIU XiaoHua1 & FENG XiaoMing1 1Key Laboratory of Green Chemistry & Technology,Ministry of Education College of Chemistry,Sichuan University,Chengdu 610064,China 2Key Laboratory of Luminescence and Real-Time Analysis,Ministry of Education College of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715,China | 2010 | Science China Chemistry2010，53，1： | 1 |
| 6 | Synthesis of Novel Cyclic Aryl Ether Thioether Ketone (Sulfone) Oligomers显示文摘Two kinds of macrocyc1ic oligomers containing aromatic sulfide linkages have been synthesized by the solution polycondensation in high yield. The cyclic compounds were characterized by 1H and 13C NMR, by and MALDI -TOF MS. | Ying Hua QI Tian Lu CHEN Hong Yan JIANG Hai Bo LI Ji Ping XU (Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022) | 1998 | Chinese Chemical Letters1998，9，7： | 1 |
| 7 | Synthesis and Adsorption Studies on Magnetic Microbeads of Polythioether-arylamine Resins显示文摘By the suspended condensation reaction of poly(choloromethyl thiirane) with o-tolidine and o-dianisidine respectively, two new microbeads of magnetic chelating resins were synthesized by usingγ-Fe2O3 as magnetic core. Their adsorption properties for Hg(Ⅱ), Cu( Ⅱ ) , Zn( Ⅱ ) , Pb( Ⅱ ) , Au( Ⅲ ) , Pd( Ⅱ ) , Pt (Ⅳ ) and Ag( Ⅰ ) were investigated. The microbeads possess excellent adsorbability for Hg( Ⅱ) and noble metal ions, and predominantly adsorbed Pd( Ⅱ) or Hg(Ⅱ) in the coexistence of Cu ( Ⅱ ), Zn( Ⅱ ) andMg(Ⅱ). The experimental results demonstrate that resin Ⅱ with lower N and S contents has higher adsorption capacities for noble metal ions than resin Ⅰ, which shows the dianisidine group in resin Ⅱ plays an important role in the adsorption , due to the synergistic effects of methoxyl and amino group in adjacent position. | 张超灿 | 2001 | Journal of Wuhan University of Technology(Materials Science)2001，16，3： | 1 |
| 8 | Synthesis of core-shell structured polymers with inserted thioether from a multi-functional scaffold显示文摘The synthesis of a thioether inserted, core-shell structured polymer from the scaffold of hyperbranched polyglycerol (PG) was described. PG was first allyl functionalized, and in the presence of AIBN, the allyl groups further underwent radical addition to thiol compounds, thus thiol functional polyethylene oxide monomether (MPEO) were grafted onto PG. Similarly, 2-mercaptoethy-lammonium chloride was introduced onto PG via thiol addition, and the residual amino groups were further quaternized with decyl bromide, leading to an amphiphilic core-shell structure polymer. | Pu, Hong Ting Zhou, Qing Wan, De Cheng | 2007 | Chinese Chemical Letters2007，18，6： | 0 |
| 9 | Recent advances in directα-C(sp^(3))-H bond functionalization of thioethers显示文摘Thioether skeletons are widely present in drugs,natural products,functional materials,and life science.In the past decade,the selective C–H functionalization of thioethers has been extensively studied to construct novel thioether derivatives.This mini-review systematically introduces the recent advances in the field of the directα-C(sp^(3))-H functionalization of thioethers. | Long Tang Qingyue Hu Ke Yang Mazen Elsaid Chong Liu Haibo Ge | 2022 | Green Synthesis and Catalysis2022，3，3： | 0 |
| 10 | 基于苯醌结构的新型聚合物电极用于高性能的锂离子电池(英文)显示文摘近年来,设计和合成高性能的锂离子电池用有机化合物电极吸引了许多的关注.很多研究表明基于苯醌和硫醚结构的聚合物可以同时具有高比容量和稳定的循环效率.本研究用一个简单的聚合方法合成了一个新型的梯形聚合物聚(2,3-二噻烯-1,4-二苯醌)(PDB).分析发现此聚合物具有1050 m Ah g-1的初始可逆比容量,并且在循环一百次之后还保留有681 m Ah g-1的比容量和98.4%的库伦比效率.当此聚合物在不同电流下充放电后并且重新设置回小电流时,其比容量还可以恢复到之前小电流充放电时的性能,证明了此聚合物有很好的倍率性能.进一步大电流充放电表明此聚合物可以一直持续1000个循环,再次说明了此聚合物电极的循环稳定性. | 谢健 王子龙 顾培洋 赵毅 徐梽川 张其春 | 2016 | Science China Materials2016，59，1： | 0 |
| 11 | MODIFICATION OF PALLADIUM METALLIC CATALYST WITH POLYMER-ANCHORED THIOETHER LIGANDS显示文摘A well-dispersed metallic palladium catalyst modified by polymer-anchored thioether ligands was used for the hydrogenation of cyclopentadiene to cyclopentene with high activity and selectivity in ambient condition. The evidences to show the modification of catalytic properties by polymer anchored ligands were given. | 刘汉范 毛国平 | 1993 | Chinese Journal of Polymer Science1993，11，4： | 0 |
| 12 | Synthesis,in vitro antibacterial and antifungal evaluation of novel 1,3,4-oxadiazole thioether derivatives bearing the 6-fluoroquinazolinylpiperidinyl moiety显示文摘A series of structurally novel 1,3,4-oxadiazole thioether derivatives(6a-6z) containing a 6-fluoroquinazolinylpiperidinyl moiety were designed and synthesized using pharmacophore hybrid approach,and their structures were fully characterized by ^1H NMR,^(13)C NMR and HRMS spectra.Among them,the structure of compound 6 d was further corroborated via single-crystal X-ray diffraction analysis.In vitro antibacterial bioassays showed that compounds 6 a,6 g,6 u and 6 v possessed EC_(50) values of 30.4,30.6,27.5 and 26.0 μg/mL against phytopathogenic bacterium Xanthomonas oryzae pv.oryzae,respectively,which were significantly superior to that of commercially-available bactericide Bismerthiazol(85.1 μg/mL).Moreover,in vitro antifungal bioassays indicated that seven compounds demonstrated broad-spectrum fungicidal acitivties against six types of phytopathogenic fungi at 50 μg/mL.The present work showed the potential of 1,3,4-oxadiazole thioether derivatives carrying a 6-fluoroquinazolinylpiperidinyl moiety as effective antimicrobial agents for crop protection,deserving further investigations in the future. | Jun Shi Na Luo Muhan Ding Xiaoping Bao | 2020 | Chinese Chemical Letters2020，31，2： | 0 |
| 13 | Upper-rim-modified thioether thiacalix[4]arene used for liquid-liquid extraction of Au(Ⅲ)and Pd(Ⅱ)in hydrochloric acid medium显示文摘Gold(Au)and palladium(Pd)play an increasing role in the production and human life;Therefore,it is of great significance to study their recovery.A 5,11,17,23-tetra-ethylthio-25,26,27,28-tetra-hydroxyl thiacalix[4]arene(TCAET)was synthesized specifically for the capture of Au(Ⅲ)and Pd(Ⅱ)from HCl medium by liquid-liquid extraction.In a 0.1 mol·L^(-1)HCl medium,the transfer of Au(Ⅲ)and Pd(Ⅱ)from the aqueous phase to the organic phase was highly efficient,with a transfer ratio of 100%for Au(Ⅲ)and 98%for Pd(Ⅱ).Furthermore,the extraction equilibrium time for Au(Ⅲ)was just 5 min.Job's method data demonstrated that TCAET formed complexes with Au(Ⅲ)and Pd(Ⅱ)in a ratio of 2:3 and 1:1,respectively,during the extraction process.TCAET showed high selectivity toward Pd(Ⅱ)and Au(Ⅲ)over other competing metal ions.Moreover,both Au(Ⅲ)and Pd(Ⅱ)could be successfully stripped from the loaded organic phases with a 1.0 mol·L^(-1)thiourea in 0.5 mol·L^(-1)HCl and 0.5 mol·L^(-1)thiourea in 0.5 mol·L^(-1)HCl,respectively.Results obtained from five consecutive extraction-stripping cycles showed good reusability of TCAET toward Au(Ⅲ)and Pd(Ⅱ)recovery.The conclusion can provide a certain reference for thiacalixarene in the recovery of precious metal species. | Sheng Wan Rong Xie Jianhong Fan Kewen Tang | 2024 | Chinese Journal of Chemical Engineering2024，66，2： | 0 |
| 14 | INTERACTION OF PLASMA—LIQUID IN AN OXYGEN GLOW DISCHARGE Ⅲ.OXIDATION DESULFURIZATION OF ETHYL—THIOETHER显示文摘A few factors affecting plasma oxidation desulfurization of ethyl-thioether were investigated.Under the typical conditions,the conversion and degree ofdesulfurization of ethyl-thioether can be achieved up to 88% and 79% respectively. | Wan Ying LIU Wei LU Zheng Lan LEI Jin Kun WANG Chengdu Institute of Organic Chemistry,Academia Sinica Chengdu 610015 | 1993 | Chinese Chemical Letters1993，4，10： | 0 |
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