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| 1 | ceRNA在肿瘤中的研究进展显示文摘竞争性内源RNA(competing endogenous RNA,ceRNA)是一类能与miRNA结合位点(miRNA response element,MRE)结合从而抑制miRISC形成,并能进一步增加相应mRNA的表达来达到RNA间相互沟通及转录后调控基因表达的一类非编码RNA。ceRNA主要包括长链非编码RNA(long non-coding RNA,lncRNA)、环状RNA(circular RNA,circRNA)、假基因、人工合成miRNA抑制剂及病毒miRNA抑制剂等。目前越来越多的研究表明ceRNA在肿瘤的基因调控及肿瘤细胞增殖、凋亡、细胞周期、侵袭和转移等各种生物过程中发挥重要作用。本文从ceRNA分类、调控网络及ceRNA在不同肿瘤中的研究进展作一综述。 | 钱傅燕雯 冯凡 许文林 | 2019 | 现代肿瘤医学2019，27，7： | 10 |
| 2 | lncRNA与miRNA相互调控作用及与心血管疾病的关系显示文摘近期研究表明,有大量基因序列通过ncRNA形式对生命活动进行调控,ncRNA不但参与细胞的增殖、分化和衰老,在癌症、神经退行性疾病和心血管等疾病中亦发挥重要作用。近年来有关miRNA和lncRNA在心血管疾病的病理及治疗方面的作用成为热点,而lncRNA和miRNA之间互相存在一定调控作用,但具体作用机制仍未明确,本文综述了有关lncRNA和miRNA之间相互关系的研究进展、研究方法及其在心血管疾病的作用。 | 廖江铨 刘咏梅 王阶 | 2015 | 临床心血管病杂志2015，31，3： | 9 |
| 3 | ceRNA调控miR-145-5p介导肿瘤发生发展的研究进展显示文摘miR-145-5p是一种微小RNA分子,基因定位于染色体5q32.1,参与恶性肿瘤的发生发展。竞争性内源RNA(competing endogenous RNA,ceRNA)与mRNA竞争结合miRNA结合位点,进而调控miRNA的作用,可能参与调控肿瘤的生物学特性。因此,本文就ceRNA靶向调控miRNA-145-5p与肿瘤的发生发展作一综述。 | 张雨薇 张馨月 白立川 王岩 肖庆桓 | 2020 | 现代肿瘤医学2020，28，10： | 7 |
| 4 | Comprehensive analysis of coding and non-coding RNA transcriptomes related to hypoxic adaptation in Tibetan chickens显示文摘Background:Tibetan chickens,a unique native breed in the Qinghai-Tibet Plateau of China,possess a suite of adaptive features that enable them to tolerate the high-altitude hypoxic environment.Increasing evidence suggests that long non-coding RNAs(lncRNAs)and microRNAs(miRNAs)play roles in the hypoxic adaptation of high-altitude animals,although their exact involvement remains unclear.Results:This study aimed to elucidate the global landscape of mRNAs,lncRNAs,and miRNAs using transcriptome sequencing to construct a regulatory network of competing endogenous RNAs(ceRNAs)and thus provide insights into the hypoxic adaptation of Tibetan chicken embryos.In total,354 differentially expressed genes(DE genes),389 differentially expressed lncRNAs(DE lncRNAs),and 73 differentially expressed miRNAs(DE miRNAs)were identified between Tibetan chickens(TC)and control Chahua chickens(CH).GO and KEGG enrichment analysis revealed that several important DE miRNAs and their target DE lncRNAs and DE genes are involved in angiogenesis(including blood vessel development and blood circulation)and energy metabolism(including glucose,carbohydrate,and lipid metabolism).The ceRNA network was then constructed with the predicted DE gene-DE miRNA-DE lncRNA interactions,which further revealed the regulatory roles of these differentially expressed RNAs during hypoxic adaptation of Tibetan chickens.Conclusions:Analysis of transcriptomic data revealed several key candidate ceRNAs that may play high-priority roles in the hypoxic adaptation of Tibetan chickens by regulating angiogenesis and energy metabolism.These results provide insights into the molecular mechanisms of hypoxic adaptation regulatory networks from the perspective of coding and non-coding RNAs. | Ying Zhang Woyu Su Bo Zhang Yao Ling Woo Kyun Kim Hao Zhang | 2021 | Journal of Animal Science and Biotechnology2021，12，4： | 6 |
| 5 | LncRNA与miRNA在动脉粥样硬化中互相作用的研究进展显示文摘最近研究发现非编码RNA在生物学过程中参与重要作用,包括细胞的增殖、分化、迁移和肿瘤的发生等,在动脉粥样硬化(AS)中也发挥重要作用。长链非编码RNA(lncRNA)和miRNA之间的互相作用能够更好体现复杂的生物学网络调控,成为治疗疾病的新靶点。而lncRNA和miRNA相互作用的研究在AS中处于初始阶段,具体机制尚不明确。本文综述了在AS中lncRNA和miRNA之间相互作用的研究进展。 | 郑阳 李爽 张寒璐 张毛毛 孙勇 于波 吴健 | 2018 | 心脏杂志2018，30，1： | 5 |
| 6 | Competing endogenous RNAs in lung cancer显示文摘Competing endogenous RNAs(ce RNAs)containing micro RNA response elements can competitively interact with micro RNA via mi RNA response elements,which can combine non-coding RNAs with protein-coding RNAs through complex ce RNA networks.Ce RNAs include non-coding RNAs(long non-coding RNAs,circular RNAs,and transcribed pseudogenes)and protein-coding RNAs(m RNAs).Molecular interactions in ce RNA networks can coordinate many biological processes;however,they may also lead to ce RNA network imbalance and thus contribute to cancer occurrence when disturbed.Recent studies indicate that many dysregulated RNAs derived from lung cancer may function as ce RNAs to regulate multitudinous biological functions for lung cancer,including tumor cell proliferation,apoptosis,growth,invasion,migration,and metastasis.This study therefore reviewed the research progress in the field of non-coding and protein-coding RNAs as ce RNAs in lung cancer,and highlighted validated ce RNAs involved in biological lung cancer functions.Furthermore,the roles of ce RNAs as novel prognostic and diagnostic biomarkers were also discussed.Interpreting the involvement of ce RNAs networks in lung cancer will provide new insight into cancer pathogenesis and treatment strategies. | Meilian Zhao Jianguo Feng Liling Tang | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 7 | 基因表达调控分子circRNAs的研究进展显示文摘环状RNA(circ RNAs)作为一类内源性非编码RNA广泛存在于多种生物细胞中。环状封闭结构、无poly A尾巴是circ RNAs结构上的特征,使其不易被核酸外切酶降解,能够逃脱腺苷酸脱支酶脱帽效应。circ RNAs参与转录或转录后的基因表达调控,尤其是作为mi RNA抑制剂,充当竞争性内源RNA抑制靶标基因的表达。circ RNAs结构上的特异性和调控基因表达的生物学功能,可以在疾病易感性检测、疾病诊断、预后和治疗方面发挥作用。本文就circ RNAs的分类、特征、已知的生物学功能、致病机制及其临床应用作一综述。 | 俞秋嫣 王力 杨忠现 黄恩民 黄远威 罗淦丰 张燕婷 李克 | 2016 | 癌变.畸变.突变2016，28，5： | 5 |
| 8 | 胰腺癌特异性差异表达lncRNA相关的ceRNA调控网络的构建显示文摘目的:构建胰腺癌特异性长链非编码RNA(lncRNA)相关的竞争性内源性RNA(ceRNA)调控网络。方法:从TCGA数据库下载178个胰腺癌及4个正常胰腺样本的RNA表达谱数据及相应的临床资料,对比分析差异表达的lncRNA、miRNA和mRNA,基于lncRNA-miRNA在线预测工具miRcode数据库以及miRNA靶基因预测数据库(miRDB、miRTar Base、Target Scan)筛选,构建差异表达lncRNA相关的ceRNA调控网络。针对网络中的关键lncRNA和相应的靶基因进行生存分析。结果:成功构建了胰腺癌特异性lncRNA相关的ceRNA调控网络,该网络包括12个lncRNA,5个miRNA,54个mRNA。KEGG信号通路和GO功能分析结果表明,靶基因主要富集在'TNF signaling pathway''Jak-STAT signaling pathway''Apoptosis multiple species''MAPK signaling pathway'等通路,与'cellular process''biological regulation''regulation of cellular process'等功能关系密切。生存分析结果表明,lncRNA MIR600HR、C9orf139、RP11-796E2.4、AC104809.2,以及靶基因CDHR1、CYFIP2、IL10RA、MAP3K1、SSH2、TSPAN1、VAMP1,与胰腺癌预后关系密切。结论:成功构建了胰腺癌特异性lncRNA相关的ceRNA调控网络,为胰腺癌的诊断、治疗和预后评估提供了潜在靶点。 | 何江洋 李奉喜 黄垂国 牛跃平 | 2018 | 郑州大学学报(医学版)2018，53，4： | 5 |
| 9 | Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus显示文摘Borna disease virus 1(BoDV-1)is neurotropic prototype of Bornaviruses causing neurological diseases and maintaining persistent infection in brain cells of mammalian species.Long non-coding RNA(lncRNA)is transcript of more than 200 nucleotides without proteincoding function regulating various biological processes as proliferation,apoptosis,cell migration and viral infection.However,regulatory of lncRNAs in BoDV-1 infection remains unknown.To identify differential expression profiles and predict functions of lncRNA in BoDV-1 infection,microarray data showed that 3528 lncRNAs and 2661 lncRNAs were differentially expressed in Strain V and Hu-H1 BoDV-infected groups compared with control groups,respectively.Gene Ontology(GO)and pathway analysis suggested that differential lncRNAs may be involved in regulation of metabolic,biological regulation,cellular process,endocytosis,viral infections and cell adhesion processes,cancer in both BoDV-infected strains.ENSMUST00000128469 was found down-regulated in both BoDV-infected groups compared with control groups consistent with microarray(p<0.05).ceRNA analysis indicated possible interaction networks as ENSMUST00000128469/miR-22-5p,miR-206-3p,miR-302b-5p,miR-302c-3p,miR-1a-3p/Igf1.Igf1 was found up-regulated in both BoDV-infected groups compared with control groups(p<0.05).Possible functions of predicted target mRNAs and miRNAs of ENSMUST00000128469 were involved in cell proliferation,transcriptional misregulation and proteoglycan pathways enriched in cancer.lncRNA may be involved in regulation of Hu-H1 inhibited cell proliferation and promoted apoptosis through NF-kB,JNK/MAPK signaling,BCL2 and CDK6/E2F1 pathways different from Strain V.Possible interaction networks as ENSMUST00000128469/miR-22-5p,miR-206-3p,miR-302b-5p,miR-302c-3p,miR-1a-3p/Igf1 may involve in regulation of cell proliferation,apoptosis,and cancer. | Lin Sun Yujie Guo Peng He Xiaoyan Xu Xiong Zhang Haiyang Wang Tian Tang Wei Zhou Ping Xu Peng Xie | 2019 | Genes & Diseases2019，6，2： | 5 |
| 10 | Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury显示文摘Circular RNAs(circRNAs)are a class of conserved,endogenous non-coding RNAs that are involved in transcriptional and post-transcriptional gene regulation and are highly enriched in the nervous system.They participate in the survival and differentiation of multiple nerve cells,and may even promote the recovery of neurological function after stroke.However,their role in the inflammatory response after spinal cord injury remains unclear.In the present study,we established a mouse model of T9 spinal cord injury using the modified Allen’s impact method,and identified 16,013 circRNAs and 960 miRNAs that were differentially expressed after spinal cord injury.Of these,the expression levels of circPrkcsh were significantly different between injured and sham-treated mice.We then treated astrocytes with tumor necrosis factor-αin vitro to simulate the inflammatory response after spinal cord injury.Our results revealed an elevated expression of circPrkcsh with a concurrent decrease in miR-488 expression in injured cells.We also found that circPrkcsh regulated the expression of the inflammationrelated gene Ccl2.Furthermore,in tumor necrosis factor-α-treated astrocytes,circPrkcsh knockdown decreased the expression of Ccl2 by upregulating miR-488 expression,and reduced the secretion of inflammatory cytokines in vitro.These findings suggest that differentially expressed circRNAs participate in the inflammatory response after spinal cord injury and act as the regulators of certain microRNAs.Furthermore,circPrkcsh may be used as an miR-488 sponge to regulate Ccl2 expression,which might provide a new potential therapy for SCI.The study was approved by the Animal Ethics Committee of Shandong University of China(approval No.KYLL-20170303)on March 3,2017. | Jia-Nan Chen Yi-Ning Zhang Li-Ge Tian Ying Zhang Xin-Yu Li Bin Ning | 2022 | Neural Regeneration Research2022，17，1： | 4 |
| 11 | TCGA数据库中肝癌相关差异长链非编码RNA筛选和功能预测显示文摘目的通过数据库挖掘寻找肝癌差异长链非编码RNA并预测其调控机制。方法从TCGA数据库中下载374例肝癌样本和50例正常样本lncRNA、miRNA、mRNA的测序数据,筛选出差异基因后构建ceRNA网络关系图,对差异基因进行生存分析。设置差异倍数(fold Change)≥2,P <0. 01。结果在差异基因中发现77个lncRNA与miRNA相关,其中6个(HTR2A-AS1、AC073352. 1、AL359878. 1、AP002478. 1、C2orf48、MYLK-AS1)与肝癌的总生存期相关;并发现了以hsa-mir-424和hsa-mir-519d为关键节点的ceRNA调控网络。结论通过对TCGA肝癌基因数据的分析,筛选了6个lncRNA与肝癌的生存期有关,hsa-mir-424和hsa-mir-519d是重要的ceRNA调控网络节点。 | 孙金旗 马佳康 任凯凯 李南 李雨濛 马军 | 2019 | 胃肠病学和肝病学杂志2019，28，2： | 4 |
| 12 | 长链非编码RNA SOX21-AS1调控miR-31-5p/MMP-16轴对胰腺癌细胞活性与增殖的影响显示文摘背景与目的:胰腺癌是一种常见的消化系统恶性肿瘤,也是癌症死亡的常见病因。长链非编码RNA(lncRNA)已在多种恶性肿瘤中被鉴定为调节因子和特异度生物标志物。最新研究表明,lncRNA SOX21-AS1在多种恶性肿瘤的发生、发展中起重要作用。但其在胰腺癌中的作用尚未明确。因此,本研究探讨SOX21-AS1在胰腺癌中的表达及其功能。方法:用qRT-PCR检测SOX21-AS1在20对胰腺癌与邻近癌旁正常组织,以及胰腺癌细胞系(PANC-1、CAPAN2、CFPAC-1、BXPC3、SW1990)与人胰管上皮细胞系(HPDE)中的表达。通过GEPIA数据库分析SOX21-AS1表达与胰腺癌患者预后的关系。采用MTT实验与集落形成实验分析SOX21-AS1沉默后胰腺癌细胞活力与增殖能力的变化。通过DIANA数据库预测SOX21-AS1的靶微小RNA(miRNA)及其下游的靶mRNA,随后进一步通过系列功能实验、双荧光素酶实验、拯救实验以及相关性分析明确它们之间的关系。结果:SOX21-AS1在胰腺癌组织和细胞系中表达均上调,其高表达患者预后差(均P<0.05)。SOX21-AS1沉默后,胰腺癌细胞的活力与增殖能力均明显降低(均P<0.05)。生物信息学分析显示,miR-31-5p与SOX21-AS1及MMP-16 mRNA均存在靶向结合序列,功能实验、荧光素酶实验及挽救实验结果均验证了三者之间的互作关系。此外,相关性分析结果显示,SOX21-AS1的表达与miR-31-5p的表达呈负相关(r^(2)=0.2571,P<0.05),miR-31-5p的表达与MMP-16 mRNA的表达呈负相关(r^(2)=0.3113,P=0.0106)。结论:SOX21-AS1的表达上调与胰腺癌细胞活性、增殖能力增强及胰腺癌患者预后不良相关。机制上,SOX21-AS1可能作为竞争性内源RNA(ceRNA)与miR-31-5p发生竞争性结合,调节MMP-16的表达,从而促进胰腺癌的进展。SOX21-AS1可以作为胰腺癌的潜在预后生物标志物和诊治的靶点。 | 臧龙军 陈东杰 高文哲 黄珲 朱红伟 余枭 | 2022 | 中国普通外科杂志2022，31，3： | 4 |
| 13 | 长链非编码RNA作为ceRNA在胃癌上皮间质转化中的作用研究进展显示文摘胃癌是世界上最常见的恶性肿瘤之一。上皮间质转化(EMT)在胃癌的进展和转移中发挥着关键作用。EMT的调控是一个复杂的网络,转录因子SNAIL/SLUG、TWIST1/2、ZEB1/2在肿瘤EMT的过程中发挥着重要诱导作用,此外EMT的调控还与细胞因子、miRNAs(如miR-200家族)等的参与有关。近些年随着非编码RNA研究的深入,ce RNA网络被发现,其涉及lncRNA、circRNA、miRNA和mRNA等多个RNA分子,可广泛调控肿瘤细胞的增殖和转移,与EMT的关系密切。本文综述了lnc RNA作为ce RNA在胃癌EMT中发挥的作用和分子机制,从而加深对胃癌等恶性肿瘤中ce RNA网络的认识。 | 唐银炳 张鹤腾 张文波 蒋鹏程 | 2022 | 肿瘤防治研究2022，49，4： | 3 |
| 14 | Long noncoding RNA AANCR modulates innate antiviral responses by blocking miR-210-dependent MITA downregulation in teleost fish,Miichthys miiuy显示文摘Viral infection induces the initiation of antiviral effectors and cytokines which are critical mediators of innate antiviral responses.The critical molecular determinants are responsible for triggering an appropriate immune response.Long noncoding RNAs(lncRNAs)have emerged as new gene modulators involved in various biological processes,while how lncRNAs operate in lower vertebrates are still unknown.Here,we discover a long noncoding RNA,termed antiviral-associated long noncoding RNA(AANCR),as a novel regulator for innate antiviral responses in teleost fish.The results indicate that fish MITA plays an essential role in host antiviral responses and inhibition of Siniperca chuatsi rhabdovirus(SCRV)production.miR-210 reduces MITA expression and suppress MITA-mediated antiviral responses,which may help viruses evade host antiviral responses.Further,AANCR functions as a competing endogenous RNA(ceRNA)for miR-210 to control protein abundance of MITA,thereby inhibiting SCRV replication and promoting antiviral responses.Our data not only shed new light on understanding the function role of lncRNA in biological processes in teleost fish,but confirmed the hypothesis that ceRNA networks exist widely in vertebrates. | Qing Chu Tianjun Xu Weiwei Zheng Renjie Chang Lei Zhang | 2021 | Science China(Life Sciences)2021，64，7： | 3 |
| 15 | lncRNA作为竞争性内源RNA调控肝癌及中药作用机制研究进展显示文摘针对lncRNA作为ceRNA与miRNA(lncRNA/miRNA/mRNA)相互作用调控肝癌的进展进行综述,包括lncRNA/miRNA/mRNA在肝癌发生发展进程中的功能、机制,lncRNA/miRNA/mRNA调控通路与中药作用机制研究。lncRNA/miRNA/mRNA丰富了肝癌的发生、发展机制,为肝癌诊断及治疗提供新思路。 | 史苗娟 郭鑫昕 商嘉玮 苏式兵 张辉 | 2017 | 上海中医药杂志2017，51，11： | 3 |
| 16 | CeRNA网络介导恶性肿瘤表型调控的机制研究显示文摘竞争性内源RNA(CeRNA)是纵横交错的调控网络,该网络可介导恶性肿瘤细胞表型,包括增殖和抑制、自噬、无限生长、诱导血管生成和血管生成拟态、免疫逃逸等。了解CeRNA介导恶性肿瘤表型调控及其功能,有望为恶性肿瘤提供新的诊断标志物和治疗靶点。 | 张静 黄守国 夏鹰 | 2021 | 国际肿瘤学杂志2021，48，9： | 3 |
| 17 | 骨肉瘤中circRNA-miRNA-mRNA相关调控网络的构建显示文摘[目的]利用GE0数据库中骨肉瘤(osteosarcoma,OS)基因表达谱数据,通过生物信息学方法构建circRNA-miR-NA-mRNA调控网络,探讨OS的发病机制,为OS的后续研究提供依据。[方法]基于GEO数据库筛选出在OS中差异表达的circRNAs,miRNAs和mRNAs。利用StarBase预测circRNA-miRNA的相互作用。通过TargetScan和StarBase预测miRNA耙向的mRNAs。利用Cytoscape中的ClueGO插件进行基因功能和通路富集分析。进一步筛选出circRNA-miRNA-mRNA网络中与OS患者预后相关的mRNAs。[结果]通过R语言进行筛选,与正常骨组织相比,OS组织中共有6个circRNAs和504个mRNAs上调,124个miRNAs下调。对circRNA-miRNA-mRNA调控网络中的基因通过基因功能和通路富集分析发现与多种致癌作用有关,表明其可能在OS的发生发展中发挥重要作用。进一步分析显示FSCN1、MMYO10、NUDT11、SDC4、UBE2V2基因高表达与OS患者预后差显著相关。[结论]circRNA-miRNA-mRNA网络可能为OS发生发展的分子机制提供有价值的数据支持,FSCN1、MMY010、NUDT11、SDC4、UBE2V2可能是OS新的潜在预后生物标志物。 | 王兆强 裴露萍 李刚 | 2021 | 中国矫形外科杂志2021，29，23： | 3 |
| 18 | 基于生物信息学方法的人类GLTP在胰腺腺癌发生发展中的作用及其表观遗传调控机制分析显示文摘通过生物信息学方法分析人类糖脂转运蛋白(GLTP)的基因在肿瘤发生发展中的作用及其表观遗传调控机制。利用UCSC Genome Browser、EMBOSS及GEPIA等在线生物信息学分析工具分析人类GLTP在肿瘤组织中的表达及生存,结果表明人类GLTP在胰腺腺癌(PAAD)组织中的表达水平显著高于癌旁正常组织,提示GLTP很可能参与了PAAD的发生发展。GLTP表达水平与PAAD患者病理分期的分析结果表明,GLTP表达水平在PAAD患者不同病理分期中的差异不显著。甲基化分析结果表明,在PAAD细胞中,人类GLTP的甲基化程度与GLTP的表达水平显著相关。组蛋白修饰分析的结果表明,组蛋白H3K4Me1、H3K27Ac可能通过上调人类GLTP的表达进而影响肿瘤的发生发展进程。内源竞争RNA(ceRNA)调控分析结果表明,人类GLTP与多种microRNA(miRNA)有潜在作用,并且这些miRNA与多种肿瘤及信号通路存在较强的关联性。本研究的结果为进一步研究人类GLTP的功能及其表观遗传调控机制提供了参考。 | 马梅燕 冀慎英 张湘豫 卢梦云 邹先琼 | 2021 | 激光生物学报2021，30，4： | 3 |
| 19 | DLC2在肿瘤中作用及机制的研究进展显示文摘DLC2是新近发现的抑癌基因,在肝癌、乳腺癌、胶质瘤等多种肿瘤中不表达或低表达。DLC2可增强RhoA、Cdc42的GTP酶活性,负性调控Rho蛋白活性及其下游效应分子,并可靶向定位于黏着斑;DLC2还可通过其SAM结构域与蛋白相互作用,促进蛋白泛素化降解;近年来研究发现,DLC2可通过竞争性内源RNA机制与其他转录体相互调控。通过以上3种主要机制,DLC2抑制肿瘤细胞增殖,并促进肿瘤细胞凋亡,阻碍肿瘤细胞转移、侵袭及黏附,削弱肿瘤细胞的干性,增强肿瘤细胞对化疗药物的敏感性。因此,上调DLC2的表达可作为潜在的抗肿瘤策略,用于协同化疗治疗肿瘤。 | 李晓曼 吴媛媛 王爱云 陈文星 陆茵 | 2019 | 中国药理学通报2019，35，7： | 2 |
| 20 | 竞争性内源RNA与肿瘤发生的研究进展显示文摘微小RNA(miRNA)可与信使RNA(mRNA)的3'端非翻译区(3'UTR)互补结合,降低mRNA的稳定性或抑制mRNA的翻译,负性调节靶基因的表达。然而一些mRNAs、假基因、长链非编码RNA(LncRNA)以及环状RNA(circRNA)含有某些miRNA结合位点,可通过miRNA应答元件(MREs)竞争性结合相同的miRNA,解除或减轻miRNA对靶基因的抑制作用,调节靶基因的表达,这种作用机制称为竞争性内源RNA(ceRNA)假说。在肿瘤的发生过程中,mRNAs、假基因转录物、lncRNA、circRNA可作为ceRNA,通过竞争性结合相同的致瘤性或抑瘤性的miRNA,起到抑制或促进肿瘤发生的作用。 | 李艳 沈飞阳 马礼丹 张艳青 | 2015 | 基础医学与临床2015，35，11： | 2 |
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