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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | International normalized ratio and Model for End-stage Liver Disease score predict short-term outcome in cirrhotic patients after the resolution of hepatic encephalopathy显示文摘BACKGROUND In patients with cirrhosis,hepatic encephalopathy(HE)indicates a poor prognosis despite the use of artificial liver and liver transplantation,presenting as frequent hospitalizations and increased mortality rate.AIM To determine predictors of early readmission and mid-term mortality in cirrhotic patients discharged after the resolution of HE.METHODS From January to February 2018,213 patients were enrolled in this observational study assessing all the successive patients with cirrhosis discharged from Department of Gastroenterology and Department of Infectious and Liver Diseases,Second Affiliated Hospital of Chongqing Medical University after the resolution of HE.The patients were followed for 6 mo.For each subject,demographic,clinical,and laboratory variables were assessed at the time of diagnosis of HE,during hospital stay,at discharge,and during follow-up.The primary endpoints were incidence of early readmission and mid-term mortality.RESULTS During follow-up,65(31%)patients experienced an early readmission.International normalized ratio(INR)[odds ratio(OR)=2.40;P=0.003)at discharge independently predicted early readmission.The incidence of early readmission was significantly higher in patients with an INR>1.62 at discharge than in those with an INR≤1.62(44%vs 19%;P<0.001).Model for End-stage Liver Disease(MELD)score(OR=1.11;P=0.048)at discharge proved to be an independent predictor of early readmission caused by HE.Hemoglobin(OR=0.97;P=0.005)at discharge proved to be an independent predictor of non-early readmission.During 6 months of follow-up,34(16%)patients died.Artificial liver use(hazard ratio=6.67;P=0.021)during the first hospitalization independently predicted mid-term mortality.CONCLUSION INR could be applied to identify fragile cirrhotic patients,MELD score could be used to predict early relapse of HE,and anemia is a potential target for preventing early readmission. | Xiao-Peng Hu Jian Gao | 2019 | World Journal of Gastroenterology2019，25，26： | 2 |
| 3 | Correlation of human epidermal growth factor receptor protein expression and colorectal cancer显示文摘AIM:To investigate the correlation between human epidermal growth factor receptor(HER-2) protein expression and colorectal cancer(CRC) using a casecontrol study and meta-analysis.METHODS:Tumor tissue specimens from 162 CRC patients were selected for the case group.Fifty cases were randomly selected,and normal CRC tissue at least 10 cm away from the tumor margins of these cases was used to generate the control group.The expression of the HER-2 protein in the 162 CRC tissue samples and the 50 adjacent normal mucosa tissue samples was detected via immunohistochemistry.The experimental data were analyzed using SPSS 18.0software,and R software version 3.1.0 was utilized for further verification.RESULTS:The expression of HER-2 protein in the 162 CRC tissue samples was significantly higher than in the normal tissue specimens.The data showed that the expression of HER-2 in CRC was related to the Dukes' stage,the depth of invasion and lymph node metastasis.The HER-2-positive patients had lower 3-and 5-year OS rates than the HER-2-negative patients,but there was no significant difference.However,there was a statistically significant difference in the 3- and5-year disease-free survival(DFS) rates of HER-2-positive and HER-2-negative patients.The results of the meta-analysis showed that the expression of HER-2in CRC patients was statistically significantly increased over that of healthy people.The 3-year DFS rate in HER-2-positive patients was markedly lower than that in HER-2-negative patients.CONCLUSION:Down-regulation of HER-2 expression might be a dependable strategy for CRC therapy. | Wen-Juan Yang Xing-Jie Shen Xiao-Xia Ma Zhi-Gang Tan Yan Song Yi-Tong Guo Mei Yuan | 2015 | World Journal of Gastroenterology2015，21，28： | 2 |
| 4 | Individual Differences Among Language Learners显示文摘The purpose of the paper is to find out the individual differences among language learners from the following aspects: motivation;personality factors;the role of age in SLA.The author concludes that language learners have a lot of individual differences which are of great importance to their proficiency of language. Teachers should apply different methods to motivate and teach students in order to make them well aquire language. | 李宝宏 姬晓媛 | 2003 | 陕西师范大学学报(哲学社会科学版)2003，32，S2： | 0 |
| 5 | Age is an independent adverse prognostic factor for overall survival in acute myeloid leukemia in Japan显示文摘AIM: To elucidate risk factors for survival of elderly acute myeloid leukemia(AML) patients in a real-world practice by observational study. METHODS: We conducted a population-based study in 213 adult and elderly AML patients(127 males and 86 females) in Kagawa Prefecture, Japan. To construct this cohort, we gathered all data for patients diagnosed with AML at 7 hospitals in Kagawa between 2006 and 2010. The primary end point was overall survival(OS) after AML diagnosis. Unadjusted Kaplan-Meier survival plots were used to determine OS in the overall cohort. Multivariate analysis was used to determine the independent adverse prognostic factors for OS, with the covariates of interest including age, gender, race/ethnicity, CCI, education, median income, metropolitan statistical area size and history of myelodysplastic syndrome.RESULTS: The average population of Kagawa during the study period was 992489, and the incidence of AML was 4.26 per 100000 person-years. A total of 197 patients with non-acute promyelocytic leukemia(non-APL)(119 males and 78 females) were also included. The median age of non-APL patients was 70 years(average 67, range 24-95). The 5-year OS rate was 21.1%. Subsequent analysis by age group showed that the survival rate declined with age; the 5-year OS rates of non-APL patients younger than 64 years, 65-74 years, and older than 75 years were 41.5%, 14.1%, and 8.9%, respectively. Multivariate analysis revealed that unfavorable risk karyotype, older age, poor performance status(PS)(3-4), lack of induction chemotherapy, and antecedent haematological disease were independent prognostic predictors. In the subgroup analysis, we also found that older patients with non-APL had lower complete remission rates and higher early death rates than younger patients, irrespective of PS. However, intensive chemotherapy was a significant predictor for longer survival not only in the patients < 75 years of age, but also in those over 75 with PS 0-2. CONCLUSION: Age would contribute considerable life expectancy to indicate induction chemotherapy with eligible dose of cytotoxic drugs for a favorable case even in advanced elderly. | Hiroaki Ohnishi Osamu Imataki Yasunori Kawachi Makoto Ide Kimihiro Kawakami Masato Waki Hidetaka Takimoto Yasuo Hoshijima Tetsuya Fukumoto Kensuke Matsumoto Fusako Waki Akihito Matsuoka Takamichi Shintani Makiko Uemura Shigeyuki Yokokura Teruhisa Taoka Takuya Matsunaga | 2014 | World Journal of Hematology2014，3，3： | 0 |
| 6 | Survival rate and the determinants of progression from HIV to AIDS and from AIDS to the death in Iran: 1987 to 2016显示文摘Objective: To examine the prognostic factors of progression from HIV to AIDS and AIDS to the death in people living with HIV/AIDS in Iran.Methods: In this registry-based retrospective cohort study, we recruited 28 873 HIV-infected people from 158 Behavioral Diseases Counseling Centers of Iran.Two outcomes of interest included survival rates from HIV diagnosis to AIDS and from AIDS to the death.We used Kaplan-Meier and Cox regression model to investigate survival rate and factors affecting on survival controlling effect of confounding factors.Results: The one, three, five, and ten-year survival rate from HIV to AIDS were 85%, 73%, 61% and 32%, and for AIDS to death were 90%, 81%, 74% and 55%, respectively.Multivariate Cox regression analysis indicated that the risk of progression from AIDS phase toward death in individuals with CD4 less than 200/mm^3, infected with tuberculosis(TB) and not treated by antiretroviral therapy(ART) was 2.17(95% CI: 1.62-2.90), 1.49(95% CI: 1.01-2.20) and 4.88(95% CI: 3.42-6.96) times higher respectively.The risk of progression to AIDS in patients with baseline CD4 less than 200/mm^3 was 2.32(95% CI: 2.14, 2.51) times higher than patients with CD4 > 200/mm^3(P=0.001).On the other hand, tuberculosis increases the risk of death by 49.0%(P=0.04).The hazard ratio of death in patients who did not receive ART was 4.88(95% CI: 3.42, 6.96) times higher than patients who received ART(P<0.001).Conclusion: The early detection of HIV, the screening and treatment of TB and receiving the ART improve the survival of HIV/AIDS patients significantly, and prevent the transmission of HIV to other people. | Mohammad Mirzaei Maryam Farhadian Jalal Poorolajal Parvin Afsar Kazerooni Katayoun Tayeri Younes Mohammadi | 2019 | Asian Pacific Journal of Tropical Medicine2019，12，2： | 0 |
| 7 | The Research of Difference between Boys and Girls during English Study显示文摘With China's opening up and joining the World Trade Organization,more and more people are learning English.English study is very important for the learners,which involves a lot of factors,among which the learner's own factor is the most direct and main factor.In English teaching,we shouldn’t just pay our attention to the regular teaching principle of teaching stu dents in accordance with their aptitude,and turn a blind eye to the non-intellectual factors of the learners.This thesis analyzes the differences and their reasons,and then puts forward some relevant countermeasures for eliminating the differences in English learning between boys and girls,in the hope of promoting them to make progress together in English study. | 黄翠英 | 2013 | 海外英语2013，，22： | 0 |
| 8 | CASE-CONTROL STUDY FOR HOSPITAL INFECTIONS CAUSED BY GRAM-NEGATIVE BACILLI IN EMERGENCY INTENSIVE CARE UNIT显示文摘Objective To evaluate the potential patient factors associated with hospital infections caused by gram-negative bacilli in Emergency Intensive Care Unit(EICU).Methods A total of 146 patients with hospital infections were investigated.The method of retrospective case-control study and multivariable logistic regression analysis were adopted.Results Univariate analysis revealed relationship among numerous patient factors,and multivariate analysis revealed four factors to be associated independently with hospital infections caused by gram-negative bacilli:mechanical ventilation,corticoid use, length of stay,and coma.Conclusion The comprehensive preventive measures should be taken to deal with the risk factor of hospital infections in EICU. | 伍育旗 余旻 单红卫 钱民 张新黎 吕晓玲 程群霞 杨兴易 | 2013 | Medical Bulletin of Shanghai Jiaotong University2013，25，1： | 0 |
| 9 | A COMPREHENSIVE EVALUATION OF THE ROLE OF INHERITANCE AND ENVIRONMENTAL FACTORS IN PRIMARY LIVER CANCER显示文摘ACOMPREHENSIVEEVALUATIONOFTHEROLEOFINHERITANCEANDENVIRONMENTALFACTORSINPRIMARYLIVERCANCERWangXueliang;XuHuiwen;ChengBing;MenB... | 王学良 徐慧文 程兵 门伯媛 刘蓬勃 | 1994 | Journal of Pharmaceutical Analysis1994，8，1： | 0 |
| 10 | Rac1 activates HIF-1 in laser induced choroidal neovascularization显示文摘AIM:To study the effect of Rac1 on the induction of HIF-1α in choroidal neovascularization(CNV) in mice.· METHODS:One hundred C57BL/6J mice were laser photocoagulated to induce CNV,fifty mice of that were selected randomly for intravitreal injection of Rac1 inhibitor NSC23766 solution(1μL).After laser photocoagulation,fundus fluorescein angiography(FFA) was performed to verify the growth of CNV.Immunohistochemistry and Western blot were used to detect HIF-1α and Rac1 in posterior segment of eye globes.· RESULTS:FFA verified that incidence of CNV was significantly reduced in the eyes with NSC23766 injection comparing with that of eyes without NSC23766 injection(P<0.01).Immunohistochemistry detected that HIF-1α and Rac1 mainly expressed in the new fibrovascular tissue.Western blot showed that HIF-1α and Rac1 was highly increased in tissue explants of retinal pigment epithelium(RPE) and choroid without NSC23766 injection.But for tissue explants of RPE and choroid with NSC23766 injection,both the expressions of HIF-1α and Rac1 were inhibited.· CONCLUSION:Rac1 is crucial to activate HIF-1 regulating the growth of CNV,and its inhibition may have potential therapeutic value. | Peng Zhang, Jian Zhou | 2011 | International Journal of Ophthalmology(English edition)2011，4，1： | 0 |
| 11 | A Numerical Study on Ship Self propulsion Factor显示文摘The scale effect on self propulsion factor is studied numerically in this paper.Model scale and full scale ship computation are conducted as test case.The flow field around ship hull is simulated by solving 3 D RANS equation and two equation turbulence model.The propeller is modeled by force disc and its loading coefficient is investigated by lifting surface method.The comparison between model test and prediction is made. | Qiuxin Gao(China Ship Scientific Research Center, Wuxi 214082,P.R.China) | 1999 | 武汉理工大学学报(交通科学与工程版)1999，24，S1： | 0 |
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