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| 1 | Development of Virtual Equipment for a Hydraulic Mechanics Experiment显示文摘Laboratory class is very important in the education of hydraulic mechanics. However, it usually requires a high expenditure on equipment purchase and maintenance. Virtual equipment that renders the equipment in a virtual world and provides an interactive interface for users can be an ideal solution to reduce costs. In this research, we focus on developing virtual equipment for a Venturi tube experiment. We em-ployed multiple paper-prototypes to gather user feedback on the preliminary design. Following the final pro-totype, we then implemented the virtual equipment on computers. Interactive functions have been built into the virtual equipment. Users are able to manipulate the equipment and obtain real-time feedback as if they were using actual equipment. The results show that the development of the virtual equipment is technically feasible. | CHAN Ying-Chieh CHEN Ya-Hsin KANG Shih-Chung LEE Tim-Hau | 2008 | Tsinghua Science and Technology2008，13，S1： | 2 |
| 2 | Biomacromolecular nanostructures-based interfacial engineering: from precise assembly to precision biosensing显示文摘Biosensors are a type of important biodevice that integrate biological recognition elements, such as enzyme,antibody and DNA, and physical or chemical transducers, which have revolutionized clinical diagnosis especially under the context of point-of-care tests. Since the performance of a biosensor depends largely on the bio–solid interface, design and engineering of the interface play a pivotal role in developing quality biosensors. Along this line, a number of strategies have been developed to improve the homogeneity of the interface or the precision in regulating the interactions between biomolecules and the interface. Especially,intense efforts have been devoted to controlling the surface chemistry, orientation of immobilization,molecular conformation and packing density of surface-confined biomolecular probes(proteins and nucleic acids). By finely tuning these surface properties, through either gene manipulation or self-assembly, one may reduce the heterogeneity of self-assembled monolayers, increase the accessibility of target molecules and decrease the binding energy barrier to realize high sensitivity and specificity. In this review, we summarize recent progress in interfacial engineering of biosensors with particular focus on the use of protein and DNA nanostructures. These biomacromolecular nanostructures with atomistic precision lead to highly regulated interfacial assemblies at the nanoscale. We further describe the potential use of the high-performance biosensors for precision diagnostics. | Fan Yang Xiaolei Zuo Chunhai Fan Xian-En Zhang | 2018 | National Science Review2018，5，5： | 2 |
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