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| 1 | Study on the Removal of MIBK from Aqueous Solution by Vacuum Membrane Distillation显示文摘Methyl isobutyl ketone(MIBK) is widely used as extraction agent in hydrometallurgy. As it has a definite solubility in water, so when using MIBK as extraction agent, there will be MIBK in stripping solutions inevitably, which not only pollutes working conditions, but also affects the quality of ultimate product. In order to remove MIBK from aqueous solutions, the means of flat vacuum membrane distillation(VMD) is studied in the paper. The area of the membrane used in the study is 0.02 m 2, the initial volume of feed is 2 L, each experiment was conducted over a time period of 60 120 min. The influences of the factors such as temperature(34.8 55.0 ℃); pressure in the permeate side(10.67 14.67 kPa) and feed flow rate(27.8 69.4 mL/s) were experimentally studied. Increasing the temperature or reducing the pressure in the permeate side results in a faster removal of MIBK; however there is a decrease in removal factor β , increasing the feed flow rate results in a faster removal of MIBK and an increase of removal factor β , especially in the range of lower flow rate. The study indicates that the aim of MIBK removal and recycle from dilute aqueous solutions can be achieved by VMD. | TANG Jian-jun ZHOU Kang-gen ZHANG Qi-xiu LI Qing-gang | 2000 | Journal of Central South University2000，12，4： | 6 |
| 2 | Gram-scale preparation of dialkylideneacetones through Ca(OH)_2-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH显示文摘A synthetic method of dialkylideneacetones has been developed. Compared with known protocols, the method employed catalytic Ca(OH)_2 as the cheap, mild base catalyst and dilute aqueous EtOH(20%, v/v)as the green and safe solvent. The procedure was easily operated: In most cases, the product could be isolated by a simple filtration, and purified by washing with water. This paper provided experimental details of the reactions, which could be applied in gram-scale synthesis and should be a very reliable and practical protocol to prepare these useful compounds in laboratory and at the industrial level. | Hao Zhang Mengting Han Chenggen Yang Lei Yu Qing Xu | 2019 | Chinese Chemical Letters2019，30，1： | 4 |
| 3 | Synthesis of α,β-Unsaturated Ketones using Potassium fluoridealumina Catalyst by Microwave Irradiation显示文摘Microwave irradiation can accelerate the rate of the synthetic reaction of α,β-unsaturated ketones by using KF-Al2O3 as catalyst. The rate enhancement of the reaction is 360-860 fold. | Xiao Hui ZHANG Da Bin GAO Ming GUO Shan Zhen YAN(Department of Chendstry and Chemical Engineering, Dalian University, Dalian 116622) | 1998 | Chinese Chemical Letters1998，9，6： | 4 |
| 4 | 1H nuclear magnetic resonance spectroscopy-basedmetabonomic study in patients with cirrhosis and hepaticencephalopathy显示文摘AIM: To identify plasma metabolites used as biomarkers in order to distinguish cirrhotics from controls and encephalopathics.METHODS: A clinical study involving stable cirrhotic patients with and without overt hepatic encephalopathy was designed. A control group of healthy volunteers was used. Plasma from those patients was analysed using 1H- nuclear magnetic resonance spectroscopy. We used the Carr Purcell Meiboom Gill sequence to process the sample spectra at ambient probe temperature. We used a gated secondary irradiation field for water signal suppression. Samples were calibrated and referenced using the sodium trimethyl silyl propionate peak at 0.00 ppm. For each sample 128 transients(FID's) were acquired into 32 K complex data points over a spectral width of 6 KHz. 30 degree pulses were applied with an acquisition time of 4.0 s in order to achieve better resolution, followed by a recovery delay of 12 s, to allow for complete relaxation and recovery of the magnetisation. A metabolic profile was created for stable cirrhotic patients without signs of overt hepatic encephalopathy and encephalopathic patients as well as healthy controls. Stepwise discriminant analysis was then used and discriminant factors were created to differentiate between the three groups.RESULTS: Eighteen stabled cirrhotic patients, eighteen patients with overt hepatic encephalopathy and seventeen healthy volunteers were recruited. Patients with cirrhosis had significantly impaired ketone body metabolism, urea synthesis and gluconeogenesis. This was demonstrated by higher concentrations of acetoacetate(0.23 ± 0.02 vs 0.05 ± 0.00, P < 0.01), and b-hydroxybutarate(0.58 ± 0.14 vs 0.08 ± 0.00, P < 0.01), lower concentrations of glutamine(0.44 ± 0.08 vs 0.63 ± 0.03, P < 0.05), histidine(0.16 ± 0.01 vs 0.36 ± 0.04, P < 0.01) and arginine(0.08 ± 0.01 vs 0.14 ± 0.02, P < 0.03) and higher concentrations of glutamate(1.36 ± 0.25 vs 0.58 ± 0.04, P < 0.01), lactate(1.53 ± 0.11 vs 0.42 ± 0.05, P < 0.01), pyruvate(0.11 ± 0.02 vs 0.03 ± 0.00, P < 0.01) threonine(0.39 ± 0.02 vs 0.08 ± 0.01, P < 0.01) and aspartate(0.37 ± 0.03 vs 0.03 ± 0.01). A five metabolite signature by stepwise discriminant analysis could separate between controls and cirrhotic patients with an accuracy of 98%. In patients with encephalopathy we observed further derangement of ketone body metabolism, impaired production of glycerol and myoinositol, reversal of Fischer's ratio and impaired glutamine production as demonstrated by lower b-hydroxybutyrate(0.58 ± 0.14 vs 0.16 ± 0.02, P < 0.0002), higher acetoacetate(0.23 ± 0.02 vs 0.41 ± 0.16, P < 0.05), leucine(0.33 ± 0.02 vs 0.49 ± 0.05, P < 0.005) and isoleucine(0.12 ± 0.02 vs 0.27 ± 0.02, P < 0.0004) and lower glutamine(0.44 ± 0.08 vs 0.36 ± 0.04, P < 0.013), glycerol(0.53 ± 0.03 vs 0.19 ± 0.02, P < 0.000) and myoinositol(0.36 ± 0.04 vs 0.18 ± 0.02, P < 0.010) concentrations. A four metabolite signature by stepwise discriminant analysis could separate between encephalopathic and cirrhotic patients with an accuracy of 87%.CONCLUSION: Patients with cirrhosis and patients with hepatic encephalopathy exhibit distinct metabolic abnormalities and the use of metabonomics can select biomarkers for these diseases. | Konstantinos John Dabos John Andrew Parkinson Ian Howard Sadler John Nicholas Plevris Peter Clive Hayes | 2015 | World Journal of Hepatology2015，7，12： | 3 |
| 5 | Novel synthetic method for ketones from substituted benzimidazolium salts and Grignard reagents显示文摘A new synthetic method of ketones from substituted benzimidazolium salts and Grignard reagents is reported. The influences of the various Grignard reagents on the yield of ketones and the mechanism are discussed. | 史真 顾焕 | 1996 | Science China Chemistry1996，39，6： | 3 |
| 6 | Hepatic adenylate energy charge levels in patients with hepatoma after hepatic artery embolization显示文摘HepaticadenylateenergychargelevelsinpatientswithhepatomaafterhepaticarteryembolizationLILi1,YANLuNan1,CHENXiaoLi1,LUWuShe... | Li, L Yan, LN Chen, XL Lu, WS Xie, XD Wu, YT | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 7 | 过氧化甲乙酮致皮肤及黏膜烧伤伴急性中毒一例显示文摘患儿男,1岁10个月,2013年3月21日不慎误服40%过氧化甲乙酮(methyl ethyl ketone peroxide,MEKP)约15 m L后呕吐,呕吐物(含口腔中未下咽的MEKP)接触下颌部、颈部、前胸部皮肤致烧伤,患儿当即哭闹,伴刺激性呛咳,进而出现呼吸困难。伤后1 h在当地医院立即予气管插管、洗胃、保护胃黏膜、镇静、补液等处理。 | 许志荣 张志 陈宾 刘昌玲 李孝建 赵元元 | 2015 | 中华损伤与修复杂志(电子版)2015，10，5： | 2 |
| 8 | NEW SESQUITERPENES FROM LIGULARIA VEITCHIANA显示文摘Two new eremophilane derivatives and one new nor-sesquiterpene were isolated fromLigularia veitchiana.Their structures were elucidated by spectroscopic methods and 2D-NMR tech-niques and shown to be 1β,10β-epoxy-6β-(2′—semialdehyde acetal hydroxymethylacryloyloxy)-8β-ethoxy-eremophil-7(11)-en-12,8α-olide(1),1β-hydroxy-Δ~6,Δ~9-8-oxo-eremophil-(12)-oic-acid(2)and 1β-hydroxy-Δ~6,Δ~9-8-oxo-11-nor-11-hydroxy-eremophiladiene(3). | Yu ZHAO Zhong Jian JIA Institute of Organic Chemistry,State Key Laboratory of Applied Organic Chemistry at Lanzhou University,Lanzhou 730000. | 1993 | Chinese Chemical Letters1993，4，4： | 2 |
| 9 | STEREOSELECTIVE TOTAL SYNTHESIS OF(±)-4α(H)-EUDESMANE显示文摘The first stereoselective total synthesis of the biomarker(±)-4α(H)-eudesmane 1,starting from(-)-carvone in five steps,has been described. | Xin CHEN Fa Jun NAN Si Chang SHAO Li Yuan MIN Tong Shuang LI Yu Lin LI Key Laboratory of Applied Organic Chemistry and Institute of Organic Chemistry,Lanzhou University,Lanzhou 730000 | 1992 | Chinese Chemical Letters1992，3，12： | 2 |
| 10 | Use of sodium bicarbonate and blood gas monitoring in diabetic ketoacidosis: A review显示文摘Diabetic ketoacidosis(DKA) is a severe and toocommon complication of uncontrolled diabetes mellitus. Acidosis is one of the fundamental disruptions stemming from the disease process, the complications of which are potentially lethal. Hydration and insulin administration have been the cornerstones of DKA therapy; however, adjunctive treatments such as the use of sodium bicarbonate and protocols that include serial monitoring with blood gas analysis have been much more controversial. There is substantial literature available regarding the use of exogenous sodium bicarbonate in mild to moderately severe acidosis; the bulk of the data argue against significant benefit in important clinical outcomes and suggest possible adverse effects with the use of bicarbonate. However, there is scant data to support or refute the role of bicarbonate therapy in very severe acidosis. Arterial blood gas(ABG) assessment is an element of some treatment protocols, including society guidelines, for DKA. We review the evidence supporting these recommendations. In addition, we review the data supporting some less cumbersome tests, including venous blood gas assessment and routine chemistries. It remains unclear that measurement of blood gas pH, via arterial or venous sampling, impacts management of the patient substantially enough to warrant the testing, especially if sodium bicarbonate administration is not being considered. There are special circumstances when serial ABG monitoring and/or sodium bicarbonate infusion are necessary, which we also review. Additional studies are needed to determine the utility of these interventions in patients with severe DKA and pH less than 7.0. | Mit P Patel Ali Ahmed Tharini Gunapalan Sean E Hesselbacher | 2018 | World Journal of Diabetes2018，9，11： | 2 |
| 11 | Cu-Catalyzed Selective Oxy-Cyanoalkylation of Allylamines with Cycloketone Oxime Esters and CO2显示文摘Summaryof main observation and conclusion The radical-initiated carboxylativecyclization of allylamines with CO2represents an efficientand highly promising strategy to afford valuable 2-oxazolidinones.However,the radical precursorsand pathways to generate radicals in such processes are still lim-ited.Herein,we report the firstCu-catalyzed selective oxy-cyanoalkylation of allylamines with cycloketone oxime esters and CO2viaC-C bond cleavage.Many cyanoalkyl-substituted 2-oxazolidinones are obtained in moderate togood yields withhigh regio-and chemo-selectivities.The utility ofthis re-dox-neutral and cyanide-free method is demonstrated with mild conditions,broad substrate scope,good functional group tolerance and easy scalability. | Chuan-Kun Ran He Huang Xing-Hui Li Wei Wang Jian-Heng Ye Si-Shun Yan Bi-Qin Wang Chun Feng Da-Gang Yu | 2020 | Chinese Journal of Chemistry2020，38，1： | 2 |
| 12 | Relative reactivities of bromine-substituted substrates toward bromophilic attack by a carbanion显示文摘Halophilic attack on carbon-halogen bond by nucleophiles has recently become a sub-ject of interest and intensive study.A wide variety of substrates and nucleophiles has beenexamined.But no quantitative measurements on the reactivities of substrates have ever beenreported.The present work is a first attempt to evaluate the relative reactivities of perfluoro-bromoalkanes(R-Br)and some bromo organic compounds(R-Br)by intermolecular compe-tition kinetics.A large excess of Cl3CCF2CF2Cl(1),a chlorine-containing substrate withconvenient reactivity toward halophilic attack,and R-Br is used to compete for a small amountof the enolate anion of mesityl isopropyl ketone(E-)in dimethyl formamide(DMF)at 20℃in their reactions to form α-chloroisopropyl mesityl ketone(A)and α-bromoisopropylmesityl ketone(B)as products(eq 1) | LI,Xing-Ya JIANG,Xi-Kui ZHANG,Xiao-Jun Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,345 Lingling Lu,Shanghai 200032 | 1992 | Chinese Journal of Chemistry1992，10，2： | 2 |
| 13 | Synthesis and Characterization of Reactive Poly(Aryl Ether Ketone Ketone) Containing Cyclohexene Ring显示文摘A novel heterocyclic poly (aryl ether ketone ketone) (PPEKK) containing cyclohexenering was prepared from 1-methyl-cyclohex-1-ene-4, 5 -diyl-bis(4-chlorophenyl methanone) and 4 (4-hydroxyphenyl)(2H) phthalazin-1-one. The polymer was characterized by FTIR, 1HNMR, DSC,TG and X-ray analysis. | Ying Nan XUAN Xi Gao JIAN Zhi Yong XU(Department of polymer Science, College of Chemical Engineering, Dalian University ofTechnology, Dalian 116012) | 1999 | Chinese Chemical Letters1999，10，12： | 1 |
| 14 | OXIDATION OF ALKYLBENZENES CATALYZED BY IRON( Ⅱ,Ⅲ)-1,10-PHENANTHROLINE AND 2, 2'-BIPYRIDINE COMPLEXES显示文摘Oxidation of alkybenzenes PhCH2R(R=H, CH3, C2H5 and n-C3H7) under 1 atm. of O2 or air catalyzed by iron(Ⅱ, Ⅲ)-2,2’-bipyridine and 1,10-phenanthroline complexes, affords the aryl-substituted ketones and alcohols with the conversion of 15.00%~34.58% containing of 97.60%~99.80% ketones and alcohols. The turnover numbers of these catalysts are over 3500 mol-cat. -1for 3.5 h. | Zi Qiang LEI~* Yun Pu WANG Department of Chemistry, Northwest Normal University, Lanzhou 730070 | 1993 | Chinese Chemical Letters1993，4，1： | 1 |
| 15 | Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease显示文摘AIM To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on wholebody and hepatic fat oxidation of patients with nonalcoholic fatty liver disease(NAFLD).METHODS Participants were randomised into either circuit exercise training(EX;n = 13;3 h/wk without changes in dietary habits),or dietary energy restriction(ER) without changes in structured physical activity(ER;n = 8).Respiratory quotient(RQ) and whole-body fat oxidation rates(Fatox) were determined by indirect calorimetry under basal,insulin-stimulated and exercise conditions.Severity of disease and steatosis was determined by liver histology;hepatic Fatox was estimated from plasma β-hydroxybutyrate co.ncentrations;cardiorespiratory fitness was expressed as VO2 peak.Complete-case analysis was performed(EX:n = 10;ER:n = 6).RESULTS Hepatic steatosis and NAFLD activity score decreased with ER but not with EX.β-hydroxybutyrate concentrations increased significantly in response to ER(0.08 ± 0.02 mmol/L vs 0.12 ± 0.04 mmol/L,P = 0.03) but remained unchanged in response to EX(0.10 ± 0.03 mmol/L vs 0.11 ± 0.07 mmol/L,P = 0.39).Basal RQ decreased(P = 0.05) in response.to EX,while this change was not significant after ER(P = 0.38).VO_(2peak)(P < 0.001) and maximal Fa_(tox) during aerobic exercise(P = 0.03) improved with EX but not with ER(P > 0.05).The increase in β-hydroxybutyrate concentrations was correlated with the reduction in hepatic steatosis(r =-0.56,P = 0.04).CONCLUSION ER and EX lead to specific benefits on fat metabolism of patients with NAFLD.Increased hepatic Fat_(ox) in response to ER could be one mechanism through which the ER group achieved reduction in steatosis. | Ilaria Croci Nuala M Byrne Veronique S Chachay Andrew P Hills Andrew D Clouston Trisha M O'Moore-Sullivan Johannes B Prins Graeme A Macdonald Ingrid J Hickman | 2016 | World Journal of Hepatology2016，8，27： | 1 |
| 16 | Catalytic asymmetric borane reduction of prochiral ketones using chiral camphor-derived mercapto-alcohols显示文摘Easily available D-(+)-camphor-derived chiral mercapto-alcohols 2 and 3 were employed for catalytic asymmetric borane reduction of aromatic ketones. Moderate enantioselectivities with e.e. 20.2-72.1% were obtained with 10 mol% catalyst. Opposite asymmetric induction was achieved when mercapto-alcohols 2 and 3 were used. | 周永贵 侯雪龙 戴立信 | 1998 | Chinese Journal of Chemistry1998，16，3： | 1 |
| 17 | SYNTHESIS OF 3,4-DIPHENYL-1.3,4-DIAZAPHOSPHOLID1N-2-ONE-4-OXIDE BY MANNICH-TYPE REACTION显示文摘Phenylurea reacted with dichlorophenylphosphine and aldehydesor ketones by Mannich-type reaction in anhydrous benzene to give five-mem-bered phosphorous heterocyclic compounds.However.derivatives ofα-ureidoalkylphosphonic acids were obtained as the reaction performedin glacial acetic acid. | Ru Yu CHEN Ke Sheng FENG Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071 | 1992 | Chinese Chemical Letters1992，3，1： | 1 |
| 18 | 非晶态介孔FeAlP催化剂用于合成1,5-苯二氮类化合物(英文)显示文摘A simple and versatile method for the synthesis of 1,5-benzodiazepines from o-phenylenediamine and ketones in the presence of solvents and under solvent-free conditions that used an amorphous mesoporous iron aluminophosphate as catalyst was developed.High yields with excellent selectivity were obtained with a wide variety of ketones under mild reaction conditions.The catalyst had the advantages of ease of preparation,ease of handling,simple recovery,reusability,non toxicity,and being inexpensive. | A.V.VIJAYASANKAR S.DEEPA B.R.VENUGOPAL N.NAGARAJU | 2010 | 催化学报2010，31，11： | 1 |
| 19 | Sampling and determination of carbonyls in stack gas显示文摘Somealdehydesandketonesaretoxicandcarcinogenic.Tothepolutionofaldehydesandketones,agreatatentionhasbeenpaidalovertheworld.The... | Dai Tian you, Wang Qin hui *, Wei Fu sheng China National Environmental Monitoring Center, Beijing 100029, China Tan Pei gong, Liu Jin Qingdao Environmental Monitoring Center, Qingdao 266003, China | 1999 | Journal of Environmental Sciences1999，11，1： | 1 |
| 20 | Solid state reaction of aromatic ketones with heteroaromatics显示文摘The solid state reactions of p-nitroacetophenone,acetyl-ferrocene with indole were catalyzed by anhydrous zinc chloride or aluminum chloride,and gave exclusively the 1:2 condensation products.The solid state condensation of aromatic ketones with l-phenyl-3-methyl-5-pyrazolone was also investigated,and the 1:1 and 2:1 condensation products were obtained.The structures of eleven new products were determined by IR,MS,1H NMR and elemental analysis. | Du, DM Meng, SM Wang, YM Meng, JB Zhou, XZ | 1995 | Chinese Journal of Chemistry1995，13，6： | 1 |
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