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| 1 | 气候变化国家评估报告(Ⅰ):中国气候变化的历史和未来趋势显示文摘The climate change in China shows a considerable similarity to the global change, though there still exist some significant differences between them. In the context of the global warming, the annual mean surface air temperature in the country as a whole has significantly increased for the past 50 years and 100 years, with the range of temperature increase slightly greater than that in the globe. The change in precipitation trends for the last 50 and 100 years was not significant, but since 1956 it has assumed a weak increasing trend. The frequency and intensity of main extreme weather and climate events have also undergone a significant change. The researches show that the atmospheric CO2 concentration in China has continuously increased and the sum of positive radiative forcings produced by greenhouse gases is probably responsible for the country-wide climate warming for the past 100 years, especially for the past 50 years. The projections of climate change for the 21st century using global and regional climate models indicate that, in the future 20-100 years, the surface air temperature will continue to increase and the annual precipitation also has an increasing trend for most parts of the country. | 丁一汇 任国玉 石广玉 | 2007 | 气候变化研究进展2007，3，z1： | 55 |
| 2 | High-Order Models of Nonlinear and Dispersive Wave in Water of Varying Depth with Arbitrary Sloping Bottom显示文摘High-order models with a dissipative term for nonlinear and dispersive wave in water of va-rying depth with an arbitrary sloping bottom are presented in this article.First,the formal derivations toany high order of μ(=h/λ,depth to deep-water wave length ratio)and ε(=α/h,wave amplitude todepth ratio)for velocity potential,particle velocity vector,pressure and the Boussinesq-type equations forsurface elevation η and horizontal velocity vector U at any given level in water are given.Then,the exactexplicit expressions to the fourth order of μ are derived.Finally,the linear solutions of η,U,C(phase ce-lerity)and C_g(group velocity)for a constant water depth are obtained.Compared with the Airy theory,excellent results can be found even for a water depth as large as the wave legnth.The present high-ordermodels are applicable to nonlinear regular and irregular waves in water of any varying depth(from shal-low to deep)and bottom slope(from mild to steep). | Hong Guangwen Professor, Coastal and Ocean Engineering Research Institute, Hohai University, Nanjing 210024, P. R. China. | 1997 | China Ocean Engineering1997，12，3： | 26 |
| 3 | A projection of future changes in summer precipitation and monsoon in East Asia显示文摘The future potential changes in precipitation and monsoon circulation in the summer in East Asia are projected using the latest generation of coupled climate models under Intergovernmental Panel on Climate Change (IPCC) Special Report on Emission Scenarios (SRES) A1B scenario (a medium emission scenario).The multi-model ensemble means show that during the period of 2010-2099,the summer precipitation in East Asia will increase and experience a prominent change around the 2040s,with a small increase (~1%) before the end of the 2040s and a large increase (~9%) afterward.This kind of two-stage evolution characteristic of precipitation change can be seen most clearly in North China,and then in South China and in the mid and lower Yangtze River Valley.In 2010-2099,the projected precipitation pattern will be dominated by a pattern of 'wet East China' that explains 33.6% of EOF total variance.The corresponded time coefficient will markedly increase after the 2040s,indicating a great contribution from this mode to the enhanced precipitation across all East China.Other precipitation patterns that prevail in the current climate only contribute a small proportion to the total variance,with no prominent liner trend in the future.By the late 21st century,the monsoon circulation will be stronger in East Asia.At low level,this is due to the intensification of southwesterly airflow north of the anticyclone over the western Pacific and the SCS,and at high level,it is caused by the increased northeasterly airflow east of the anticyclone over South Asia.The enhanced monsoon circulation will also experience a two-stage evolution in 2010-2099,with a prominent increase (by ~0.6 m s-1) after the 2040s.The atmospheric water vapor content over East Asia will greatly increase (by ~9%) at the end of 21st century.The water vapor transported northward into East China will be intensified and display a prominent increase around the 2040s similar to other examined variables.These indicate that the enhanced precipitation over East Asia is caused by the increases in both monsoon circulation and water vapor,which is greatly different from South Asia.Both the dynamical and thermal dynamic variables will evolve consistently in response to the global warming in East Asia,i.e.,the intensified southwesterly monsoon airflow corresponding to the increased water vapor and southwesterly moisture transport. | Ying Sun YiHui Ding | 2010 | Science China Earth Sciences2010，53，2： | 23 |
| 4 | Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy?显示文摘Perinatal hypoxic-ischemic encephalopathy is a leading cause of neonatal death and disability.Therapeutic hypothermia significantly reduces death and major disability associated with hypoxic-ischemic encephalopathy;however,many infants still experience lifelong disabilities to movement,sensation and cognition.Clinical guidelines,based on strong clinical and preclinical evidence,recommend therapeutic hypothermia should be started within 6 hours of birth and continued for a period of 72 hours,with a target brain temperature of 33.5 ±0.5℃ for infants with moderate to severe hypoxic-ischemic encephalopathy.The clinical guidelines also recommend that infants be re warmed at a rate of 0.5℃ per hour,but this is not based on strong evidence.There are no randomized controlled trials investigating the optimal rate of rewarming after therapeutic hypothermia for infants with hypoxic-ischemic encephalopathy.Preclinical studies of rewarming are conflicting and results were confounded by treatment with sub-optimal durations of hypothermia.In this review,we evaluate the evidence for the optimal start time,duration and depth of hypothermia,and whether the rate of rewarming after treatment affects brain injury and neurological outcomes. | Anthony Davies Guido Wassink Laura Bennet Alistair J.Gunn Joanne O.Davidson | 2019 | Neural Regeneration Research2019，14，10： | 20 |
| 5 | Shift to a low carbon society through energy systems design显示文摘Concern about global warming calls for an advanced approach for designing an energy system to reduce carbon emissions as well as to secure energy security for each country.Conventional energy systems tend to introduce different technologies with high conversion efficiency,leading to a higher average efficiency.Advanced energy systems can be achieved not by an aggregate form of conversion technologies but by an innovative system design itself.The concept of LCS(low carbon society) is a unique approach having multi-dimensional considerations such as social,economic and environmental dimensions.The LCS aims at an extensive restructuring of worldwide energy supply/demand network system by not only replacing the conventional parts with the new ones,but also integrating all the necessary components and designing absolutely different energy networks.As a core tool for the LCS design,energy-economic models are applied to show feasible solutions in future with alternatives such as renewable resources,combined heat and power,and smart grid operations.Models can introduce changes in energy markets,technology learning in capacity,and penetration of innovative technologies,leading to an optimum system configuration under priority settings.The paper describes recent trials of energy models application related to waste-to-energy,clean coal,transportation and rural development.Although the modelling approach is still under investigation,the output clearly shows possible options having variety of technologies and linkages between supply and demand sides.Design of the LCS means an energy systems design with the modelling approach,which gives solution for complex systems,choices among technologies,technology feasibility,R&D targets,and what we need to start. | Toshihiko NAKATA Mikhail RODIONOV Diego SILVA Joni JUPESTA | 2010 | Science China(Technological Sciences)2010，53，1： | 19 |
| 6 | MicroRNAs as diagnostic and therapeutic tools for Alzheimer's disease: advances and limitations显示文摘Alzheimer's disease(AD) is the most common age-related, progressive neurodegenerative disease. It is characterized by memory loss and cognitive decline and responsible for most cases of dementia in the elderly. Late-onset or sporadic AD accounts for > 95% of cases, with age at onset > 65 years. Currently there are no drugs or other therapeutic agents available to prevent or delay the progression of AD. The cellular and molecular changes occurring in the brains of individuals with AD include accumulation of β-amyloid peptide and hyperphosphorylated tau protein, decrease of acetylcholine neurotransmitter, inflammation, and oxidative stress. Aggregation of β-amyloid peptide in extracellular plaques and the hyperphosphorylated tau protein in intracellular neurofibrillary tangles are characteristic of AD. A major challenge is identifying molecular biomarkers of the early-stage AD in patients as most studies have been performed with blood or brain tissue samples(postmortem) at late-stage AD. Subjects with mild cognitive impairment almost always have the neuropathologic features of AD with about 50% of mild cognitive impairment patients progressing to AD. They could provide important information about AD pathomechanism and potentially also highlight minimally or noninvasive, easy-to-access biomarkers. MicroRNAs are dysregulated in AD, and may facilitate the early detection of the disease and potentially the continual monitoring of disease progression and allow therapeutic interventions to be evaluated. Four recent reviews have been published of microRNAs in AD, each of which identified areas of weakness or limitations in the reported studies. Importantly, studies in the last three years have shown considerable progress in overcoming some of these limitations and identifying specific microRNAs as biomarkers for AD and mild cognitive impairment. Further large-scale human studies are warranted with less disparity in the study populations, and using an appropriate method to validate the findings. | Bridget Martinez Philip V.Peplow | 2019 | Neural Regeneration Research2019，14，2： | 18 |
| 7 | A Novel 3D Non-Stationary UAV-MIMO Channel Model and Its Statistical Properties显示文摘The wireless communication systems based on Unmanned Aerial Vehicles(UAVs) have found a wide range of applications recently. In this paper, we propose a new three-dimensional(3 D) non-stationary multiple-input multiple-output(MIMO) channel model for the communication links between the UAV and mobile terminal(MT). The new model originates the traditional geometry-based stochastic models(GBSMs) but considers the non-stationary propagation environment due to the rapid movements of the UAV, MT, and clusters. Meanwhile, the upgrade time evolving algorithms of time-variant channel parameters, i.e., the path number based on birth-death processes of clusters, path delays, path powers, and angles of arrival and departure, are developed and optimized. In addition, the statistical properties of proposed GBSM including autocorrelation function(ACF), cross-correlation function(CCF), and Doppler power spectrum density(DPSD) are investigated and analyzed. Simulation results demonstrate that our proposed model provides a good agreement on the statistical properties with the corresponding derived theoretical ones, which indicates its usefulness for the performance evaluation and validation of the UAV based communication systems. | Qiuming Zhu Kaili Jiang Xiaomin Chen Weizhi Zhong Ying Yang | 2018 | China Communications2018，15，12： | 18 |
| 8 | Prediction models of hepatocellular carcinoma development in chronic hepatitis B patients显示文摘Chronic hepatitis B virus(HBV) infection is a major cause of cirrhosis and hepatocellular carcinoma(HCC). Applying the same strategies for antiviral therapy and HCC surveillance to all chronic hepatitis B(CHB) patients would be a burden worldwide. To properly manage CHB patients, it is necessary to identify and classify the risk for HCC development in such patients. Several HCC risk scores based on risk factors such as cirrhosis, age, male gender, and high viral load have been used, and have negative predictive values of ≥ 95%. Most of these have been derived from, and internally validated in, treatment-na?ve Asian CHB patients. Herein, we summarized various HCC prediction models, including IPM(Individual Prediction Model), CU-HCC(Chinese University-HCC), GAG-HCC(Guide with Age, Gender, HBV DNA, Core Promoter Mutations and Cirrhosis-HCC), NGM-HCC(NomogramHCC), REACH-B(Risk Estimation for Hepatocellular Carcinoma in Chronic Hepatitis B), and Page-B score. To develop a noninvasive test of liver fibrosis, we also introduced a new scoring system that uses liver stiffness values from transient elastography, including an LSM(Liver Stiffness Measurement)-based model, LSM-HCC, and mR EACH-B(modified REACH-B). | Hye Won Lee Sang Hoon Ahn | 2016 | World Journal of Gastroenterology2016，22，37： | 16 |
| 9 | From reflux esophagitis to Barrett's esophagus and esophageal adenocarcinoma显示文摘The occurrence of gastroesophageal reflux disease is common in the human population.Almost all cases of esophageal adenocarcinoma are derived from Barrett's esophagus,which is a complication of esophageal adenocarcinoma precancerous lesions.Chronic exposure of the esophagus to gastroduodenal intestinal fluid is an important determinant factor in the development of Barrett's esophagus.The replacement of normal squamous epithelium with specific columnar epithelium in the lower esophagus induced by the chronic exposure to gastroduodenal fluid could lead to intestinal metaplasia,which is closely associated with the development of esophageal adenocarcinoma.However,the exact mechanism of injury is not completely understood.Various animal models of the developmental mechanisms of disease,and theoretical and clinical effects of drug treatment have been widely used in research.Recently,animal models employed in studies on gastroesophageal reflux injury have allowed significant progress.The advantage of using animal models lies in the ability to accurately control the experimental conditions for better evaluation of results.In this article,various modeling methods are reviewed,with discussion of the major findings on the developmental mechanism of Barrett's esophagus,which should help to develop better prevention and treatment strategies for Barrett's esophagus. | Rui-Hua Wang | 2015 | World Journal of Gastroenterology2015，21，17： | 15 |
| 10 | Protective links between vitamin D,inflammatory boweldisease and colon cancer显示文摘Vitamin D deficiency has been associated with a wide range of diseases and multiple forms of cancer including breast, colon, and prostate cancers. Relatively recent work has demonstrated vitamin D to be critical in immune function and therefore important in inflammatory diseases such as inflammatory bowel disease(IBD). Because vitamin D deficiency or insufficiency is increasingly prevalent around the world, with an estimated 30%-50% of children and adults at risk for vitamin D deficiency worldwide, it could have a significant impact on IBD. Epidemiologic studies suggest that low serum vitamin D levels are a risk factor for IBD and colon cancer, and vitamin D supplementation is associated with decreased colitis disease activity and/or alleviated symptoms. Patients diagnosed with IBD have a higher incidence of colorectal cancer than the general population, which supports the notion that inflammation plays a key role in cancer development and underscores the importance of understanding how vitamin D influences inflammation and its cancer-promoting effects. In addition to human epidemiological data, studies utilizing mouse models of colitis have shown that vitamin D is beneficial in preventing or ameliorating inflammation and clinical disease. The precise role of vitamin D on colitis is unknown; however, vitamin D regulates immune cell trafficking and differentiation, gut barrier function and antimicrobial peptide synthesis, all of which may be protective from IBD and colon cancer. Here we focus on effects of vitamin D on inflammation and inflammation-associated colon cancer and discuss the potential use of vitamin D for protection and treatment of IBD and colon cancer. | Stacey Meeker Audrey Seamons Lillian Maggio-Price Jisun Paik | 2016 | World Journal of Gastroenterology2016，22，3： | 15 |
| 11 | Mesenchymal stem cells in the treatment of inflammatory and autoimmune diseases in experimental animal models显示文摘Multipotent mesenchymal stromal cells [also known as mesenchymal stem cells(MSCs)] are currently being studied as a cell-based treatment for inflammatory disorders. Experimental animal models of human immune-mediated diseases have been instrumental in establishing their immunosuppressive properties. In this review, we summarize recent studies examining the effectiveness of MSCs as immunotherapy in several widely-studied animal models, including type 1 diabetes, experimental autoimmune arthritis, experimental autoimmune encephalomyelitis, inflammatory bowel disease, graft-vs-host disease, and systemic lupus erythematosus. In addition, we discuss mechanisms identified by which MSCs mediate immune suppression in specific disease models, and potential sources of functional variability of MSCs between studies. | Matthew W Klinker Cheng-Hong Wei | 2015 | World Journal of Stem Cells2015，7，3： | 14 |
| 12 | Animal models of atherosclerosis显示文摘In this mini-review several commonly used animal models of atherosclerosis have been discussed.Among them,emphasis has been made on mice,rabbits,pigs and non-human primates.Although these animal models have played a significant role in our understanding of induction of atherosclerotic lesions,we still lack a reliable animal model for regression of the disease.Researchers have reported several genetically modified and transgenic animal models that replicate human atherosclerosis,however each of current animal models have some limitations.Among these animal models,the apolipoprotein(apo) E-knockout(KO)mice have been used extensively because they develop spontaneous atherosclerosis.Furthermore,atherosclerotic lesions developed in this model depending on experimental design may resemble humans' stable and unstable atherosclerotic lesions.This mouse model of hypercholesterolemia and atherosclerosis has been also used to investigate the impact of oxidative stress and inflammation on atherogenesis.Low density lipoprotein(LDL)-r-KO mice are a model of human familial hypercholesterolemia.However,unlike apo E-KO mice,the LDL-r-KO mice do not develop spontaneous atherosclerosis.Both apo E-KO and LDL-r-KO mice have been employed to generate other relevant mouse models of cardiovascular disease through breeding strategies.In addition to mice,rabbits have been used extensively particularly to understand the mechanisms of cholesterol-induced atherosclerosis.The present review paper details the characteristics of animal models that are used in atherosclerosis research. | Fatemeh Ramezani Kapourchali Gangadaran Surendiran Li Chen Elisabeth Uitz Babak Bahadori Mohammed H Moghadasian | 2014 | World Journal of Clinical Cases2014，2，5： | 14 |
| 13 | Cloning of a gene-edited macaque monkey by somatic cell nuclear transfer显示文摘Cloning of macaque monkeys by somatic cell nucleus transfer(SCNT) allows the generation of monkeys with uniform genetic backgrounds that are useful for the development of non-human primate models of human diseases. Here, we report the feasibility of this approach by SCNT of fibroblasts from a macaque monkey(Macaca fascicularis), in which a core circadian transcription factor BMAL1 was knocked out by clustered regularly interspaced short palindromic repeat/Cas9 gene editing(see accompanying paper).Out of 325 SCNT embryos transferred into 65 surrogate monkeys, we cloned five macaque monkeys with BMAL1 mutations in both alleles without mosaicism, with nuclear genes identical to that of the fibroblast donor monkey. Further peripheral blood m RNA analysis confirmed the complete absence of the wild-type BMAL1 transcript. This study demonstrates that the SCNT approach could be used to generate cloned monkeys from fibroblasts of a young adult monkeys and paves the way for the development of macaque monkey disease models with uniform genetic backgrounds. | Zhen Liu Yijun Cai Zhaodi Liao Yuting Xu Yan Wang Zhanyang Wang Xiaoyu Jiang Yuzhuo Li Yong Lu Yanhong Nie Xiaotong Zhang Chunyang Li Xinyan Bian Mu-ming Poo Hung-Chun Chang Qiang Sun | 2019 | National Science Review2019，6，1： | 14 |
| 14 | Asymptotic normality and strong consistency of maximum quasi-likelihood estimates in generalized linear models显示文摘In a generalized linear model with q × 1 responses, the bounded and fixed (or adaptive) p × q regressors Zi and the general link function, under the most general assumption on the minimum eigenvalue of ∑ni=1 ZiZ'i, the moment condition on responses as weak as possible and the other mild regular conditions, we prove that the maximum quasi-likelihood estimates for the regression parameter vector are asymptotically normal and strongly consistent. | YIN Changming, ZHAO Lincheng & WEI Chengdong School of Mathematics and Information Science, Guangxi University, Manning 530004, China Department of Statistics and Finance, University of Science and Technology of China, Hefei 230026, China Department of Mathematics, Guangxi Teacher College, Manning 530001, China | 2006 | Science China Mathematics2006，49，2： | 13 |
| 15 | Brain stem cells as the cell of origin in glioma显示文摘Glioma incidence rates in the United States are near 20000 new cases per year, with a median survival time of 14.6 mo for high-grade gliomas due to limited therapeutic options. The origins of these tumors and their many subtypes remain a matter of investigation. Evidence from mouse models of glioma and human clinical data have provided clues about the cell types and initiating oncogenic mutations that drive gliomagenesis, a topic we review here. There has been mixed evidence as to whether or not the cells of origin are neural stem cells, progenitor cells or differentiated progeny. Many of the existing murine models target cell populations defined by lineage-specific promoters or employ lineagetracing methods to track the potential cells of origin. Our ability to target specific cell populations will likely increase concurrently with the knowledge gleaned from an understanding of neurogenesis in the adult brain. The cell of origin is one variable in tumorigenesis, as oncogenes or tumor suppressor genes may differentially transform the neuroglial cell types. Knowledge of key driver mutations and susceptible cell types will allow us to understand cancer biology from a developmental standpoint and enable early interventional strategies and biomarker discovery. | Aram S Modrek N Sumru Bayin Dimitris G Placantonakis | 2014 | World Journal of Stem Cells2014，6，1： | 12 |
| 16 | Commonly used animal models of non-alcoholic steatohepatitis显示文摘BACKGROUND:Animal models are an essential tool in non-alcoholic steatohepatitis (NASH) studies. Ideally, such models should reflect the etiology, disease progression, and the established pathology of human NASH. To date, no single animal model displays the range of histopathologic and pathophysiologic features associated with human NASH. The currently available models do not or only partially reflect the real picture of human NASH. In particular, insulin resistance and fibrosing steatohepatitis are rarely reproduced by the currently available models. Consequently, it is necessary to establish NASH models that can best mimic the real etiology, disease progression, and pathogenesis of human NASH. DATA SOURCES:We reviewed the major currently available animal models published in the literature (PubMed) and briefly commented on the pros and cons of these models. RESULT:Three major categories of animal models, genetic, dietary, and combination models, were reviewed and discussed. CONCLUSIONS:Animal models are not only useful in revealing the etiology of NASH, but also are important platforms for the assessment of therapeutic strategies. Currently available models do not reflect the full picture of NASH in patients. Better animal models are needed for a full understanding of human NASH and the development of efficient therapies for this condition. | Fan, Jian-Gao Qiao, Liang | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，3： | 12 |
| 17 | Global change and climate-vegetation classification显示文摘Three phrases of the quantitative study of climate-vegetation classification and their characteristics are presented based on the review of advance in climate-vegetation interaction, a key issue of 'global change and terrestrial ecosystems (GCTE)' which is the core project of International Geosphere-Biosphere Programme (IGBP): (i) characterized by the correlation between natural vegetation types and climate; (? characterized by climatic indices which have obviously been restricted to plant ecophysiology; (iii) characterized by coupling both structure and function of vegetation. Thus, the prospective of climate-vegetation classification for global change study in China was proposed, especially the study coupling climate-vegetation classification models with atmospheric general circulation models (GCMs) was emphasized. | Guangsheng Zhou Yuhui Wang | 2000 | Chinese Science Bulletin2000，45，7： | 12 |
| 18 | 'Source-Diagenesis-Accumulation' enrichment and accumulation regularity of marine shale gas in southern China显示文摘After the breakthrough of shale gas exploration and development in the Ordovician Wufeng Formation (Fm.) and Silurian Longmaxi Fm. of Chongqing Jiaoshiba area,Changning-Weiyuan area,etc. in Sichuan basin,a series of discovery and breakthrough were obtained by China Geological Survey in the Cambrian Niutitang Fm. and Sinian Doushantuo Fm. shale of the areas with complicated structure outside Sichuan basin. Based on the understanding of the law of shale gas enrichment in Longmaxi Fm. in the basin,this paper puts forward three elements of the formation and enrichment of shale gas,which are the “Source”,the “Diagenesis ” and the “Accumulation ”,after deeply studying the law shale gas enrichment and accumulation in Sinian-Cambrian reservoir of the complex structure area outside the basin. The “Source”means the sedimentary environment and petrological characteristics of organic shale.The “Diagenesis ”means the basin tectonic subsidence and hydrocarbon generation and expulsion process of organic matter.The “Accumulation” means the tectonic uplift and shale gas preservation. It is proposed that the Sinian-Cambrian and Ordovician-Silurian black shale series in the middle and upper Yangtze region of southern China were both formed in the deep-water shelf environment of rift trough and foreland basin respectively.The dessert intervals were formed in the strong reduction environment under transgressive system tract.The shale lithology belongs to calcium-siliceous and charcoal-siliceous respectively. Based on the summary of structural evolution in Yangtze area,the correlation of structural burial depth with shale diagenesis and the coupling evolution of organic matter with pore structure are discussed. Combining with structural styles,the preservation conditions of shale gas are discussed. Five types of shale gas reservoir control models are further described. Two types of future exploration directions,which are reverse fault syncline and paleo-uplift margin in complex structural area outside the basin,are proposed. | Gang-yi Zhai Yu-fang Wang Zhi Zhou Guo-heng Liu Yu-ru Yang Juan Li | 2018 | China Geology2018，1，3： | 12 |
| 19 | 基于MODELS的工频弧光接地过电压的仿真显示文摘弧光接地过电压是中性点不接地系统中危害最大的过电压之一。目前,关于弧光接地过电压的研究大都采用系统仿真,基于工频熄弧理论,通过控制开关的闭合来模拟电弧的熄灭和重燃,观察弧光接地过电压情况。由于电弧的熄灭和重燃具有强烈的统计特性,电弧不一定是在工频过零时熄灭,也不一定是在电压达到最大值时重燃。因此,按一个工频周期来设定开关的开闭时间模拟弧光接地过电压时,模型不够准确。鉴于这种情况,在对弧光接地过电压产生机理深入研究的基础上,提出了一种新的开关控制方法,采用EMTP中的控制系统暂态分析TACS模块和MODELS模块对开关的控制部分进行处理。运用MODELS模块中特定的MODELS语言编写控制程序,输出一个信号作为TACS开关的输入控制信号,当满足给定电压和电流门槛值时,开关便会相应地闭合及断开。不必按一个工频周期来设定开关的开闭时间,提高了仿真模型的精确性。将其应用于10kV中性点不接地系统及小电阻接地系统的弧光接地过电压的研究,取得了预期效果,具有很好的应用前景。 | 金恩淑 杨明芳 李卫刚 陈韬 | 2009 | 电力系统保护与控制2009，37，13： | 11 |
| 20 | Current humanized mouse models for studying human immunology and HIV-1 immuno-pathogenesis显示文摘A robust animal model for 'hypothesis-testing/mechanistic' research in human immunology and immuno-pathology should meet the following criteria.First,it has well-studied hemato-lymphoid organs and target cells similar to those of humans.Second,the human pathogens establish infection and lead to relevant diseases.Third,it is genetically inbred and can be manipulated via genetic,immunological and pharmacological means.Many human-tropic pathogens such as HIV-1 fail to infect murine cells due to the blocks at multiple steps of their life cycle.The mouse with a reconstituted human immune system and other human target organs is a good candidate.A number of human-mouse chimeric models with human immune cells have been developed in the past 20 years,but most with only limited success due to the selective engraftment of xeno-reactive human T cells in hu-PBL-SCID mice or the lack of significant human immune responses in the SCID-hu Thy/Liv mouse.This review summarizes the current understanding of HIV-1 immuno-pathogenesis in human patients and in SIV-infected primate models.It also reviews the recent progress in the development of humanized mouse models with a functional human immune system,especially the recent progress in the immunodeficient mice that carry a defective gammaC gene.NOD/SCID/gammaC-/(NOG or NSG) or the Rag2-/-/gammaC-/double knockout (DKO) mice,which lack NK as well as T and B cells (NTB-null mice),have been used to reconstitute a functional human immune system in central and peripheral lymphoid organs with human CD34+ HSC.These NTB-hu HSC humanized models have been used to investigate HIV-1 infection,immuno-pathogenesis and therapeutic interventions.Such models,with further improvements,will contribute to study human immunology,human-tropic pathogens as well as human stem cell biology in the tissue development and function in vivo. | MEISSNER Eric | 2010 | Science China(Life Sciences)2010，53，2： | 11 |
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