Specific molecular markers in hepatocellular carcinoma

查看全文 作　　者：Yao, Deng-[1]Fu;Dong, Zhi-[2]Zhen;Yao, [3]Min

机构地区：[1]Nantong Univ, Affiliated Hosp, Res Ctr Clin Mol Biol, Nantong 226001, Peoples R China;[2]Nantong Univ, Affiliated Hosp, Dept Diagnost, Nantong 226001, Peoples R China;[3]Nantong Univ, Affiliated Hosp, Dept Lab Med, Nantong 226001, Peoples R China;

出　　处：《Hepatobiliary & Pancreatic Diseases International》索引2007年第6卷第3期,共7页

基　　金：This study was supported by grants from the Key Project of Medical Science from Jiangsu Province (RC2003100);the Project of Medical Science from Department of Health, Jiangsu Province (H200523), China. 摘　　要：BACKGROUND: The carcinogenesis of hepatocellular carcinoma (HCC) is a multi-factorial, multistep and complex process. Its prognosis is poor, and early diagnosis and monitoring metastasis of HCC is of the utmost importance. Circulating diagnostic and prognostic biomarkers could be used in proper postoperative treatment of patients at an early stage of HCC development. This review summarizes recent studies of the specific biomarkers in diagnosis and monitoring metastasis or postoperative recurrence of HCC. DATA SOURCES: An English-language literature search was conducted using MEDLINE (June 1998 to September 2006) on researches of some valuable specific biomarkers in diagnosis and monitoring metastasis or postoperative recurrence of HCC. RESULTS: Hepatoma tissues can synthesize various tumor-related proteins, polypeptides, and isoenzymes, such as alpha-fetoprotein (AFP), hepatoma-specific gamma-glutamyl transpeptidase (HS-GGT), etc, and then secrete into blood. The valuable early diagnostic and prognostic biomarkers could predict the development and metastases of HCC. Recent researches have confirmed that circulating hepatoma-specific AFP subfraction, transforming growth factor (TGF)-β1, HS-GGT, and free insulin-like growth factor (IGF)-Ⅱ may be more specific markers than total AFP level for early diagnosis for HCC. The circulating genetic markers such as AFP-mRNA, TGF-β1-mRNA, IGF-Ⅱ-mRNA, etc from peripheral blood mononuclear cells of HCC patients have been most extensively used in monitoring distal metastasis or postoperative recurrence of HCC. CONCLUSIONS: Hepatoma tissues synthesize and secrete valuable molecular markers into blood. The analyses of circulating hepatoma-specific biomarkers are usefulto early diagnosis of HCC or monitoring metastasis or postoperative recurrence of HCC. 关键词：carcinoma, HEPATOCELLULAR molecular MARKER early diagnosis METASTASIS of tumor POSTOPERATIVE RECURRENCE

相关文献

参考文献（52）
引证文献（61）
耦合文献（368）

参考文献(52)

引证文献(61)

耦合文献(368)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Specific molecular markers in hepatocellular carcinoma

参考文献(52)

引证文献(61)

耦合文献(368)

用户提示