Nuclear factor kappa B: A marker of chemotherapy for human stage Ⅳ gastric carcinoma

查看全文 作　　者：Sheng [1]Ye;You-Ming [2]Long;Jian [3]Rong;Wen-Rui [4]Xie

机构地区：[1]Oncology Department, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China;[2]Clinical College, Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province, China;[3]Jian Rong, Department of Anesthesiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong Province, China;[4]the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510080, Guangdong Province. China

出　　处：《World Journal of Gastroenterology》索引2008年第14卷第30期,共6页

摘　　要：AIM: To detect the nuclear factor kappa B (NF-κB) condition in human stage Ⅳ gastric carcinoma patients and to explore the correlation between NF- κB activation and survival of these patients after chemotherapy. METHODS: Expression of NF-κB-p65 was determined by immunohistochemical analysis. Activity of NF- κB DNA-binding in carcinoma tissue was detected by electrophoretic mobility shift assay. Kaplan-Meier survival analysis was performed to show the relation between NF-κB and progression-free survival (PFS) or overall survival (OS) of the patients. RESULTS: The positive expression rate of NF-κB-p65 in 60 gastric cancer tissue samples was 76.7% (46/60). The expression of NF-κB-p65 was reduced in adjacent carcinoma and normal tissue samples. Electrophoretic mobility shift assay (EMSA) analysis showed a strong activation of NF-κB in cancer tissue samples. A survival difference was found in NF- κB-p65 positive and negative patients. NF-κB-p65 expression was negative in cancer tissue samples (n = 14). PFS was 191.40 ± 59.88 d and 152.93 ± 16.99 d, respectively, in patients with positive NF- κB-p65 expression (n = 46) (P = 0.4028). Thesurvival time of patients with negative and positive NF-κB-p65 expression was 425.16 ± 61.61 d and 418.85 ± 42.98 d, respectively (P = 0.7303). Kaplan-Meier analysis showed no significant difference in PFS or OS. The 46 patient tissue which positive NF- κB-p65 expression was found in the tissue samples from the 46 patients whose PFS and OS were 564.89 ± 75.94 d and s 352.37 ± 41.32 d, respectively (P = 0.0165). CONCLUSION: NF-κB is activated in gastric carcinoma tissue, which is related to the OS after chemotherapy. 关键词：胃癌核因子ΚB 化学疗法生存率

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Nuclear factor kappa B: A marker of chemotherapy for human stage Ⅳ gastric carcinoma

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