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Study on protecting effects of Baicalin and Octreotide on hepatic injury in rats with severe acute pancreatitis

查看全文 作　　者：Xi-Ping [1]Zhang;Guang-Hua [1]Feng;Wei [1]Zhu;Yang [1]Cai;Qi-Jun [1]Yang;Tong-Fa [1]Ju;Qi [1]xie;Wen-Qin [1]Yuan;Jie [2]Zhang;Zheng [3]Ren 高影响力作者 机构地区：[1]Department of General Surgery, Hangzhou First People's Hospital, Hangzhou 310006, Zhejiang Province, China;[2]First College of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang Province, China;[3]Department of General Surgery, Second Affiliated Hospital Medical College, Zhejiang University, Hangzhou 310003, Zhejiang Province, China高影响力机构 出　　处：《World Journal of Gastroenterology》索引2008年第14卷第42期,共9页高影响力期刊 基　　金：Supported by Technological Foundation Project of Traditional Chinese Medicine Science of Zhejiang province, No. 2003C130 and No. 2004C142;Foundation Project For Medical Science and Technology of Zhejiang province, No. 2003B134;Grave Foundation Project for Technological and Development of Hangzhou, No. 2003123B19;Intensive Foundation Project for Technology of Hangzhou, No. 2004Z006;Foundation Project for Medical Science and Technology of Hangzhou, No. 2003A004;Foundation Project for Technology of Hangzhou, No. 2005224 摘　　要：AIM: To investigate the protective effects and mechanisms of Baicalin and Octreotide on hepatic injury in rats with severe acute pancreatitis (SAP). METHODS: The SAP rat models were prepared and randomly assigned to the model control group, Baicalin treated group, and Octreotide treated group while other healthy rats were assigned to the sham-operated group. Rat mortality, levels of ALT, AST, liver and pancreas pathological changes in all groups were observed at 3, 6 and 12 h after operation. Tissue microarray (TMA) sections of hepatic tissue were prepared to observe expression levels of Bax, Bcl-2 protein and Caspase-3, and changes of apoptotic indexes.RESULTS: Rat survival at 12 h, expression levels of Bax, Caspase-3 protein and apoptotic indexes of liver were all significantly higher in treated groups than in model control group. While the liver and pancreas pathological scores, contents of ALT, AST, and expression levels of Bcl-2 protein were all lower in treated groups than in the model control group. CONCLUSION: Both Baicalin and Octreotide can protect rats with SAP by decreasing the contents of ALT, AST and expression levels of Bcl-2 protein, and improving the expression levels of Bax protein, Caspase-3 protein, and inducing apoptosis. 关 键 词：肝损伤 急性胰腺炎 细胞凋亡 治疗方法
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