Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice

查看全文 作　　者：Cuiqing Ma Caihong Li Xiurong Wang Ruihong Zeng Xiaolin Yin Huidong Feng Lin [1]Wei

机构地区：[1]Department of Immunology, Basic Medical College, Hebei Medical University, Shijiazhuang 050017, China

出　　处：《Cellular & Molecular Immunology》索引2009年第6卷第1期,共5页

基　　金：supported by National Natural Science Foundation of China (30771970 and 30872399);Scientific Research Foundation of Health Bureau of Hebei Province (08054). 摘　　要：Group A streptococcus(GAS),an important human pathogen,can cause various kinds of infections including superficial infections and potentially lethal infections,and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA(an Fn-binding protein expressed on the surface of GAS) with that of M protein,the best immunogen of GAS. Assay for immune response showed that FbaA,similar to M protein,could induce protein-specific high IgG titer in BALB/c mice. Furthermore,following GAS challenge,the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. 关键词：A群链球菌 M蛋白免疫力保护率能力浅表性感染特异性IGG 分子免疫学

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Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice

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