Severity of sepsisis is correlated with the elevation of serum high-mobility group box 1 in rats

查看全文 作　　者：HOU Li-[1]chao;QIN Ming-[1]zhe;ZHENG Li-[1]na;LU [1]Yan;WANG [1]Qiang;PENG Dao-[2]rong;YU Xin-[1]ping;XIN Yu-[3]chang;JI Gen-[1]lin;XIONG Li-[1]ze

机构地区：[1]Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China;[2]Center for Clinical Laboratory Medicine of People's LiberationArmy, Department of Clinical Laboratory, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China;[3]Department of Anesthesiology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710038, China

出　　处：《Chinese Medical Journal》索引2009年第4期,共6页

基　　金：This work was supported by the grants from the National Natural Science Foundation of China (No.30471675, No.30672041 and No.30725039); the National Natural Science Foundation of Shaanxi Province (No.2004KI7-GI5) and the National Natural Science Foundation of PLA (No.06G086).We are grateful to Drs. LI Qing and HUI Yan-ping (Department of Pathology, Fourth Military Medical University) for assisting in histopathological analysis; to Dr. SHANG Lei (Department of Health Statistics, Fourth Military Medical University) for his help in the statistics analysis; to Dr. LIU Shan-lu (Department of Microbiology and Immunology, McGill University) for his insightful comments. 摘　　要：背景败血是以特别护理单位的死亡的一个领先的原因。晚煽动性的 cytokine,高活动性的组盒子 1 (HMGB1 ) ,在败血起一个关键作用。在现在的学习,我们在 rats.Methods 在导致lipopolysaccharide 的败血调查了在浆液 HMGB1 层次和器官损害的严厉之间的协会与器官损害的不同的度生产败血的一个动物模型,动物与 lipopolysaccharide 的三不同剂量被对待( 4 , 8 和 16 mg/kg ),并且在控制组的动物与车辆的一样的体积被对待(盐)。浆液 HMGB1 的层次在 lipopolysaccharide ( LPS )或车辆注射以后在 0 , 2 , 4 , 8 , 16 , 24 , 32 和 48 个小时被测量,同时为机关损害的严厉的生物化学、组织病理学说的指示物是 HMGB1 的水平有的 assessed.Results 一积极,与浆液的反常变化的高关联心脏的 troponin ,丙氨酸 aminotransferase , aspartate aminotransferase , creatinine 和血脲氮,以及心,肺,肝和 kidney.Co 关键词：迁移率血清 HMGB1 脂多糖诱导严重脓毒症心肌肌钙蛋白I 重症监护病房炎性细胞因子

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Severity of sepsisis is correlated with the elevation of serum high-mobility group box 1 in rats

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