Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats

查看全文 作　　者：Wen-Peng [1]Yuan;Bing [2]Liu;Chang-Heng [1]Liu;Xiao-Jun [1]Wang;Mian-Song [1]Zhang;Xiu-Mei [1]Meng;Xue-Kui [1]Xia

机构地区：[1]Biology Institute of Shandong Academy of Sciences, Jinan 250014, ShandongProvince, China;[2]Chinese Academy of Inspection and Quarantine,Beijing 100025, China

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第11期,共7页

基　　金：Supported by The National Scientific Research Fund of China(2008JK007);the National Key Research and Development Program of China for the Tenth Five-Year Plan,No.2006BAD06A14 摘　　要：AIM:To investigate the antioxidant activity of chitooligosaccharides(COSs)on pancreatic islet cells in diabetic rats induced by streptozotocin. METHODS:The antioxidant effect of COSs on pancreatic islet cells was detected under optical microscopy and with colorimetric assay and gel electrophoresis.The activities of glutathione peroxidase and superoxide dismutase,total antioxidant capacity,and content of malondialdehyde in serum and tissue slices of pancreas were examined after 60 d to determine the effect of COSs in streptozotocin-induced diabetes in rats. RESULTS:COSs can prohibit the apoptosis of pancreatic islet cells.All concentrations of COSs can improve the capability of total antioxidant capacity and activity of superoxide dismutase and decrease the content of malondialdehyde drastically.Morphological investigation in the pancreas showed that COSs have resulted in the reduction of islets,loss of pancreatic cells,and nuclear pyknosis of pancreatic cells. CONCLUSION:COSs possess various biological activities and can be used in the treatment of diabetes mellitus. 关键词：糖尿病大鼠胰岛细胞抗氧化活性壳寡糖超氧化物歧化酶活性谷胱甘肽过氧化物酶总抗氧化能力丙二醛含量

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Antioxidant activity of chito-oligosaccharides on pancreatic islet cells in streptozotocin-induced diabetes in rats

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