Urokinase perfusion prevents intrahepatic ischemic-type biliary lesion in donor livers

查看全文 作　　者：Ren Lang Qiang He Zhong-Kui Jin Dong-Dong Han Da-Zhi [1]Chen

机构地区：[1]Department of Hepatobiliary Surgery, BeijingChaoyang Hospital, Capital Medical University, Beijing Centerfor Organ Transplantation, Beijing 100020, China

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第28期,共4页

摘　　要：AIM:To evaluate whether urokinase perfusion of non-heart-beating cadaveric donor livers reduces the incidence of intrahepatic ischemic-type biliary lesions(IITBLs).METHODS:A prospective study was conducted to investigate potential microthrombosis in biliary microcirculation when non-heart-beating cadaveric livers were under warm or cold ischemic conditions.The experimental group included 140 patients who underwent liver transplantation during the period of January 2006 to December 2007, and survived for more than 1 year.The control group included 220 patients who received liver transplantation between July 1999 and December 2005 and survived for more than 1 year.In the experimental group, the arterial system of the donor liver was perfused twice with urokinase during cold perfusion and after trimming of the donor liver.The incidence of IITBLs was compared between the two groups.RESULTS:In the control group, the incidence of IITBLs was 5.9%(13/220 cases) after 3-11 mo of transplantation.In the experimental group, two recipients(1.4%) developed IITBLs at 3 and 6 mo after transplantation, respectively.The difference in the incidence between the two groups was statistically signiflcant(P < 0.05).CONCLUSION:Double perfusion of cadaveric livers from non-heart-beating donors with urokinase mayreduce the incidence of IITBLs. 关键词：肝脏缺血灌注系统尿激酶胆道病变内型肝移植发生率

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Urokinase perfusion prevents intrahepatic ischemic-type biliary lesion in donor livers

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