A new bone repair scaffold combined with chitosan/ hydroxyapatite and sustained releasing icariin

查看全文 作　　者：WU [1]Tao;NAN [2]KaiHui;CHEN [3]JingDi;JIN [1]Dan;JIANG [1]Shan;ZHAO [1]PeiRan;XU [1]JunChang;DU [1]Hao;ZHANG [1]XiaoQiang;LI [1]JianWei;PEI [4]GuoXian

机构地区：[1]Department of Orthopaedics and Traumatology, Nanfang Hospital, Guangzhou 510515, China;[2]The Affiliated Ophthalmology Hospital, Wenzhou Medical College, Wenzhou 325027, China;[3]Key Laboratory of Special Functional Materials, Ministry of Education, South China University of Technology, Guangzhou 510640 China;[4]Department of Orthopaedics, Xijing Hospital, Xi'an 710032, China

出　　处：《Chinese Science Bulletin》索引2009年第54卷第17期,共9页

基　　金：Supported by the National Basic Research Program (Grant No. 2009CB930000);National Natural Science Foundation of China (Grant No. 30700180);Chinese Postdoctoral Science Foundation (Grant No. 20060390206) 摘　　要：Icariin, a plant-derived flavonol glycoside, has been proved as an osteoinductive agent for bone tissue engineering. A new bone repair scaffold was generated by thorough mixing of icariin and chitosan/ hydroxyapatite (icariin-CS/HA) using freeze-drying technigue. Characteristics of morphology, mechanical properties, biocompatibility, drug release behavior and bone repair abilities in vivo were evaluated. The results show that drug loading process of icariin did not affect physical structure of CS/HA composite significantly but decreased mechanical properies of CS/HA composite, which happened with a high dosage; icariin-CS/HA had favorable cell compatibility and promoted osteogenic differentiation of hBMSCs; the controlled release of icariin was satisfactory and the release retained after 90 d in vitro. In addition, icariin-CS/HA scaffolds had favorable osteoconduction and osteoinduction in vivo, and could fill bone defect sites and stimulate newborn bone tissues formation at early stage. On the basis of these data, icariin-CS/HA is believed to be an optical bone repair scaffold for tissue engineering. 关键词：组织工程支架淫羊藿苷羟基磷灰石骨修复壳聚糖缓释复合材料骨组织工程

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A new bone repair scaffold combined with chitosan/ hydroxyapatite and sustained releasing icariin

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