CD10,Bcl-6,CD138,Bcl-2,MUM1在136例弥漫大B细胞淋巴瘤中的表达及预后意义(英文)

查看全文 作　　者：Yan [1]Song;Zhi [1]Cao;Qin [1]Su;Ling [1]Li;Hongtu [1]Zhang;Yuankai [2]Shi;Xun [1]Zhang

机构地区：[1]Department of Pathology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100021, China;[2]Department oF Medical Oncology, Cancer-Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100021, China

出　　处：《The Chinese-German Journal of Clinical Oncology》索引2009年第8卷第10期,共7页

摘　　要：Objective: We evaluated the value of using a panel of GC B-cell (CD10 and Bcl-6) and activation (MUM1, CD138 and Bcl-2) markers by immunohistochemistry to define prognosis in patients with diffuse large B-cell lymphoma (DLBCL). Methods: Two different models (Hans’ and modified Chang’s model) were applied on 136 de novo DLBCL patients. Median follow-up in all patients was 39 months (range 5–80 months). Results: According to Hans’ model, patients with GCB had much better overall survival (5-year OS, 75%) than those with non-GCB (5-year OS, 52%) (Kaplan-Meier survival analysis, P < 0.05, log rank test). According to modified Chang’s model, patients with group 1 had much better overall survival (5-year OS, 78%) than those with group 3 (5-year OS, 44%) while group 2 had no significant value compared with group 1 and group 3 in prognosis (Kaplan-Meier survival analysis, P < 0.05, log-rank test). Using multivariate Cox proportional hazards regression analysis, the international prognostic index scores (IPI), expression of CD138 and the expression pattern of modified Chang’s model were independent prognostic indicators. Conclusion: Our results suggest that the expression patterns of the panel of GCB-cell and activation markers by immunohistochemistry correlate with prognosis of patients with DLBCL and both models can be used well in ordinary work. 关键词：B细胞淋巴瘤弥漫性预后患者价值表达谱免疫组织化学生存分析

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CD10,Bcl-6,CD138,Bcl-2,MUM1在136例弥漫大B细胞淋巴瘤中的表达及预后意义(英文)

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