Identification of TRPM7 channels in human intestinal interstitial cells of Cajal

查看全文 作　　者：Byung Joo [1]Kim;Kyu Joo [2]Park;Hyung Woo [1]Kim;Seok [3]Choi;Jae Yeoul [3]Jun;In Youb [4]Chang;Ju-Hong [5]Jeon;Insuk [5]So;Seon Jeong [6]Kim

机构地区：[1]School of Korean Medicine,Pusan National University;[2]Department of Surgery,College of Medicine,Seoul National University;[3]Department of Physiology,College of Medicine,Chosun University;[4]Department of Anatomy,College of Medicine,Chosun University;[5]Center for Bio-Artif icial Muscle and Department of Physiology,College of Medicine,Seoul National University;[6]Center for Bio-Artifi cial Muscle and Depart-ment of Biomedical Engineering,Hanyang University

出　　处：《World Journal of Gastroenterology》索引2009年第15卷第46期,共6页

基　　金：Supported by The Creative Research Initiative Center for Bio-Artificial Muscle of the Ministry of Education,Science and Technology (MEST) in Korea 摘　　要：AIM:To investigate the characteristics of slow elec-trical waves and the presence of transient receptor potential melastatin-type 7(TRPM7)in the human gas-trointestinal(GI)tract.METHODS:Conventional microelectrode techniques were used to record intracellular electrical responses from human GI smooth muscle tissue.Immunohisto-chemistry was used to identify TRPM7 channels in in-terstitial cells of Cajal(ICCs).RESULTS:The human GI tract generated slow electri-cal waves and had ICCs which functioned as pacemak-er cells.Flufenamic acid,a nonselective cation channel blocker,and 2-APB(2-aminoethoxydiphenyl borate)and La3+,TRPM7 channel blockers,inhibited the slowwaves.Also,TRPM7 channels were expressed in ICCs in human tissue.CONCLUSION:These results suggest that the human GI tract generates slow waves and that TRPM7 chan-nels expressed in the ICCs may be involved in the gen-eration of the slow waves. 关键词：间质细胞胃肠道鉴定国际商会离子通道免疫组化非选择性人体组织

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Identification of TRPM7 channels in human intestinal interstitial cells of Cajal

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