The Toxic Mechanism of High Lethality of Herbicide Butachlor in Marine Flatfish Flounder,Paralichthys olivaceus

查看全文 作　　者：GUO Huarong YIN Licheng ZHANG Shicui FENG [1]Wenrong

机构地区：[1]Department of Marine Biology and Key Laboratory of Marine Genetics and Breeding, Ministry of Education, Ocean University of China, Qingdao 266003, P. R. China

出　　处：《Journal of Ocean University of China》索引2010年第9卷第3期,共8页

基　　金：supported by the National Basic Research Program of China (Grant No 2006CB101805);Undergraduate Innovative Experiment Program of China (Grant Number 091042328) 摘　　要：The toxic mechanism of herbicide butachlor to induce extremely high lethality in marine flatfish flounder,Paralichthys Olivaceus,was analyzed by histopathological examination,antioxidant enzymes activities and ATP content assay.Histopathological examination of gill,liver and kidney of exposed fishes showed that gill was a target organ of butachlor.The butachlor seriously impaired the respiration of gills by a series of lesions such as edema,lifting and detachment of lamellar epithelium,breakdown of pillar cells,and blood congestion.The dysfunction of gill respiration caused suffocation to the exposed flounder with extremely high acute lethality.Antioxidant enzyme activity assay of the in vitro cultured flounder gill(FG) cells exposed to butachlor indicated that butachlor markedly inhibited the antioxidant enzyme activities of Superoxide dismutase(SOD),catalase(CAT) and glutathione peroxidase(GPX).Furthermore,along with the decline of antioxidant enzyme activities,ATP content in the exposed FG cells decreased,too.This infers that the oxidative stress induced by butachlor can inhibit the production of cellular ATP.Similar decrease of ATP content was also observed in the exposed flounder gill tissues.Taken together,as in FG cells,butachlor possibly induced a short supply of ATP in pillar cells by inhibiting the antioxidant enzyme activities and then affecting the contractibility of the pillar cells,which in turn resulted in the blood congestion and suffocation of exposed flounder. 关键词：毒性机制丁草胺比目鱼除草剂牙鲆海洋抗氧化酶活性谷胱甘肽过氧化物酶

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The Toxic Mechanism of High Lethality of Herbicide Butachlor in Marine Flatfish Flounder,Paralichthys olivaceus

参考文献(33)

引证文献(8)

耦合文献(178)

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