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Inhibitory effects of lidocaine on cerebral vasospasm in a rabbit model of subarachnoid hemorrhage

查看全文 作　　者：Xianqing [1]Shi;Baning [1]Ye;Yuandong [1]Hu;Yuhui [1]Wang;Jianquan [1]Li;Daqing [2]Liao;Jin [2]Liu 高影响力作者 机构地区：[1]Intensive Care Unit, Guizhou Province People's Hospital, Guiyang 550002, Guizhou Province, China;[2]Laboratory of Anaesthesia and Critical Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China高影响力机构 出　　处：《Neural Regeneration Research》索引2010年第5卷第21期,共6页高影响力期刊 基　　金：the Science and Technology Foundation of Guizhou Province, No. J20072118 摘　　要：Following subarachnoid hemorrhage, vasoconstrictor substances, cellular apoptosis, blood coagulation, and vascular cell proliferation affect the onset of cerebral vasospasm. Previous studies from our laboratory have revealed that injection of lidocaine (2 mg) into the cisterna magna reduces cerebral vasospasm and nerve functional impairment in an animal model of subarachnoid hemorrhage. The present study determined the optimal lidocaine dose for vasospasm and brain injury by injecting different doses of lidocaine into the cisterna magna in a rabbit model of subarachnoid hemorrhage. Results showed that endothelin, tumor necrosis factor-α, and interleukin-6 levels significantly increased in plasma, and calcitonin gene-related peptide levels significantly decreased in plasma (P < 0.05). The number of neurons was decreased, the number of cells expressing c-Fos increased in the hippocampus, and cross-sections and diameters of basilar arteries were reduced (P < 0.05). These changes significantly improved following injection of lidocaine (1, 2, 4, and 6 mg) into the cisterna magna. A dose of 6 mg lidocaine into the cisterna magna resulted in optimal effects on cerebral vasospasm and brain injury following subarachnoid hemorrhage. 关 键 词：蛛网膜下腔 利多卡因 动物模型 脑血管 出血 痉挛 抑制作用 降钙素基因相关肽
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