Polypeptide dendrimers: Self-assembly and drug delivery

查看全文 作　　者：XU XiangHui LI CaiXia LI HaiPing LIU Rong JIANG Chao WU Yao HE Bin GU [1]ZhongWei

机构地区：[1]National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China

出　　处：《Science China Chemistry》索引2011年第54卷第2期,共8页

基　　金：supported by the National Basic Research Program of China (973 Program,2011CB606206);National High-Tech Research & Development Program of China (863 Program,2007AA021801);National Natural Science Foundation of China (50633020 & 50830105);Sichuan Youth Science & Technology Foundation (07ZQ026-013);Open Fund of Engineering Research Center of Biomass Materials,Ministry of Education (2010LF4002) 摘　　要：Amphiphilic dendritic poly(glutamic acid)-b-polyphenylalanine copolymers were synthesized using generation 3 dendritic poly(glutamic acid) as the macroinitiator in the ring-opening polymerization of NCA-Phe.The block copolymers self-assembled micelles with polyphenylalanine segments as core and dendritic poly(glutamic acid) segments as shell.The biocompatibility of the micelles was studied.The release of the anticancer drug doxorubicin from the micelles was investigated in vitro.The results showed that the sustaining release of the drug could last for 60 h.The micellar drug release system was efficient in inhibiting the proliferation of HepG2 liver cancer cells,75% cancer cells were killed under appropriate in vitro incubation. 关键词：树枝状自组装嵌段共聚物给药多肽药物释放系统抗癌药物细胞增殖

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Polypeptide dendrimers: Self-assembly and drug delivery

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