Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)

查看全文 作　　者：ZHANG [1]Xu;LI [1]Juan;CHEN [1]MinJie;WU [2]Le;ZHANG [2]Chi;ZHANG [1]Jie;ZHOU [3]QunFang;LIANG [1]Yong

机构地区：[1]Key Laboratory of Subtropical Agriculture and Environment, Ministry of Agriculture, Huazhong Agricultural University, Wuhan 430070, China;[2]School of Medicine, Jianghan University, Wuhan 430056, China;[3]State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences, Beifing 100085, China

出　　处：《Chinese Science Bulletin》索引2011年第56卷第15期,共8页

基　　金：supported by the National Natural Science Foundation of China (20890112 and 20907017);the National Basic Research Program of China (2009CB421605);the National High Technology R&D Program of China (2007BAC27B01);State Key Laboratory of Environmental Chemistry and Ecotoxicology (KF2009-05) 摘　　要：Tris-(2,3-dibromopropyl) isocyanurate (TBC) is a heterocyclic brominated flame retardant that was recently detected in the environment in China.TBC is semi-volatile and can accumulate in the lipid of some species,but little is known about its effect on aquatic organisms.We exposed adult zebrafish to 0,0.25,1 and 4mg/L TBC for 28 d and measured the effect on survival,growth,histopathology,hormone levels,enzyme activity,and gene expression.TBC exposure had no effect on survival or growth.We observed significant damage to the liver and gill,including hepatocellular swelling and fatty degeneration in the liver as well as proliferation and edema of epithelial cells in the gills.In addition,exposure to 4mg/L TBC induced proliferation of goblet cells in the intestine of both sexes,acellular areas in the testis,and thinly scattered vitellogenic granules in vitellogenic oocytes.TBC exposure had no effect on the levels of thyroid hormones,testosterone,estradiol,liver superoxide dismutase activity,malondialdehyde content,and brain cholinesterase activity.By contrast,hepatic vitellogenin and cytochrome P4501A gene expression was significantly down-regulated in both male and female zebrafish in response to TBC exposure.Our results suggest that exposure to TBC causes a variety of potential reproductive and endocrine toxic effects. 关键词：溴化阻燃剂异氰脲酸酯毒性作用斑马鱼超氧化物歧化酶活性丙基二溴基因表达

相关文献

参考文献（32）
引证文献（14）
耦合文献（0）

参考文献(32)

引证文献(14)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Toxicity of the brominated flame retardant tris-(2,3-dibromopropyl) isocyanurate in zebrafish (Danio rerio)

参考文献(32)

引证文献(14)

用户提示