Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine

查看全文 作　　者：Sibel [1]Yildirim;Susan Y. [1]Fu;Keith [1]Kim;Hong [2]Zhou;Chang Hun [1]Lee;Ang [2]Li;Sahng Gyoon [1]Kim;Shuang [2]Wang;Jeremy J. [1]Mao

机构地区：[1]Tissue Engineering and Regenerative Medicine Laboratory (TERML), Center for Craniofacial Regeneration, Columbia University Medical Center, New York, NY 10032, USA;[2]Department of Basic Science, Xi'an Jiaotong University School of Stomatology, Xi' an 710049, China

出　　处：《International Journal of Oral Science》索引2011年第3卷第3期,共10页

基　　金：supported by RC2DE020767 from the National Institute of Dental and Craniofacial Research (NIDCR), the National Institutes of Health (NIH) 摘　　要：A tooth is a complex biological organ and consists of multiple tissues including the enamel, dentin, cementum and pulp. Tooth loss is the most common organ failure. Can a tooth be regenerated? Can adult stem cells be orchestrated to regenerate tooth structures such as the enamel, dentin, cementum and dental pulp, or even an entire tooth? If not, what are the therapeutically viable sources of stem cells for tooth regeneration? Do stem cells necessarily need to be taken out of the body, and manipulated ex vivo before they are transplanted for tooth regeneration? How can regenerated teeth be economically competitive with dental implants? Would it be possible to make regenerated teeth affordable by a large segment of the population worldwide? This review article explores existing and visionary approaches that address some of the above-mentioned questions. Tooth regeneration represents a revolution in stomatology as a shift in the paradigm from repair to regeneration: repair is by metal or artificial materials whereas regeneration is by biological restoration. Tooth regeneration is an extension of the concepts in the broad field of regenerative medicine to restore a tissue defect to its original form and function by biological substitutes. 关键词：再生医学牙齿口腔医学干细胞治疗器官功能修复再生组织缺损经济竞争力

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Tooth regeneration: a revolution in stomatology and evolution in regenerative medicine

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