Study on the Mechanism of the Rearrangement Reaction of 3-n-Butylphthalide by Deuterium-Labelling

查看全文 作　　者：Bai Ling XU;Zong Ru GUO;Xiao Tian LIANG;Guang Zhong YANG (Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050) 出　　处：《Chinese Chemical Letters》索引1997年第8卷第6期,共4页 摘　　要：By the Grignard reaction of 1, 1-di-deutero-1-bromobutane with phthalaldehydic acid 1’,1’-di-deutero-3-n-butyl phthalide was obtained which underwent a rearrangement reaction using AlCl3 as catalyst in CS2 to give 1-methyl-5-carboxy-3. 4-di-deutero-tetrahydronaphthalene. The mechanism was proposed to be a series of consecutive 1.2-hydride transfers rather than a direct 1,4-hydride 关 键 词：PPM CHD Study on the Mechanism of the Rearrangement Reaction of 3-n-Butylphthalide by Deuterium-Labelling