Neuroprotective effects of willed-movement therapy in a rat model of cerebral ischemia/reperfusion

查看全文 作　　者：Deren [1]Hou;Jianfeng [1]Liu;Jinfeng [1]Deng;Zhongyang [1]Hu;Chao [2]Feng;Haixia [1]Zhu

机构地区：[1]Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China;[2]Department of General Surgery, Third Xiangya Hospital Central South University, Changsha 410013, Hunan Province, China

出　　处：《Neural Regeneration Research》索引2011年第6卷第35期,共5页

基　　金：the Science and Technology Projects from Science and Technology Agency,Hunan Province,China,No. 2011FJ3206 摘　　要：The present study established rat models of middle cerebral artery ischemia/reperfusion using the thread method.Rats performed willed-movement(climbing a ladder or wall in a box) when induced by food and water.Results revealed that Longa scores of neurological deficits significantly de-creased in the willed-movement group at 15 days after reperfusion,while expression of glial fibrillary acidic protein,neurotrophic factor-3,and growth-associated protein-43 significantly increased at 7 and 15 days after reperfusion.Results suggested that willed-movement ameliorated neurological deficits by increasing expression of glial fibrillary acidic protein,neurotrophic factor-3,and growth-associated protein-43. 关键词：缺血/再灌注大鼠脑运动保护作用意志模型胶质纤维酸性蛋白神经营养因子3

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Neuroprotective effects of willed-movement therapy in a rat model of cerebral ischemia/reperfusion

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