Immune mechanisms of Concanavalin A model of autoimmune hepatitis

查看全文 作　　者：Hai-Xia [1]Wang;Man [2]Liu;Shun-Yan [2]Weng;Jing-Jing [2]Li;Chao [2]Xie;Hong-Lin [2]He;Wen [2]Guan;Yun-Sheng [2]Yuan;Jin [3]Gao

机构地区：[1]College of Sciences,Anhui Science and Technology University,Fengyang 233100,Anhui Province,China;[2]Shanghai Municipality Key Laboratory of Veterinary Biotechnology,School of Agriculture and Biology,Shanghai Jiao Tong University,Shanghai 200240,China;[3]Laboratory of Regeneration,School of Pharmacy,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《World Journal of Gastroenterology》索引2012年第18卷第2期,共7页

基　　金：Supported by Program for Excellent Talents of Anhui Province,No.2006JQ1196 摘　　要：As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation.It is considered that lack of good animal AIH models is the main reason for the shortage of a simple and efficient cure.The Concanavalin A (Con A) model is a typical and well established model for investigating T-cell and macrophage dependent liver injury in mice,which closely mimics the pathogenesis mechanisms and pathological changes of patients,and is regarded as the best experimental model for AIH research so far.In this paper we eluci-dated the pathogenic mechanisms of AIH and the evolution of relative animal models.We go on to further focus on Con A-induced liver injury from the point of immunological mechanisms and the change of cytokine levels.Finally,we manifested the clinical significance of the AIH animal models and the challenges they would meet during their future development. 关键词：实验模型自身免疫性刀豆素A 免疫机制肝炎伴刀豆球蛋白A 动物模型发病机制

相关文献

参考文献（66）
引证文献（58）
耦合文献（6）

参考文献(66)

引证文献(58)

耦合文献(6)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Immune mechanisms of Concanavalin A model of autoimmune hepatitis

参考文献(66)

引证文献(58)

耦合文献(6)

用户提示