Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma

查看全文 作　　者：Guo [1,2]Li;Jin [1,2]Gao;Ya-Lan [1]Tao;Bing-Qing [1]Xu;Zi-Wei [1]Tu;Zhi-Gang [1]Liu;Mu-Sheng [1]Zeng;Yun-Fei [1,2]Xia

机构地区：[1]State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China;[2]Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, P. R. China

出　　处：《Chinese Journal of Cancer》索引2012年第31卷第4期,共10页

基　　金：supported by grant from Hi-Tech Research and Development Program of China(No.2006AA02Z4B4) 摘　　要：Serum enzymes that play potential roles in tumor growth have recently been reported to have prognostic relevance in a diverse array of tumors.However,prognosis-related serum enzymes are rarely reported for nasopharyngeal carcinoma(NPC).To clarify whether the level of serum enzymes is linked to the prognosis of NPC,we reviewed the pretreatment data of lactate dehydrogenase(LDH),alkaline phosphatase (ALP),and glutamyl transferase (GGT) in 533 newly diagnosed NPC patients who underwent radical radiotherapy between May 2002 and October 2003 at Sun Yat-sen University Cancer Center.Patients were grouped according to the upper limit of normal values of LDH,ALP,and GGT.The Kaplan-Meier method and log-rank test were used for selecting prognostic factors from clinical characteristics and serum enzymes,and the chi-square test was applied to analyze the relationships of clinical characteristics and serum enzymes.Finally,a Cox proportional hazards model was used to identify the independent prognostic factors.We found that increased levels of LDH had poor effects on both overall survival and distant metastasis-free survival(P=0.009 and 0.035,respectively),and increased pretreatment level of serum ALP had poor effects on both overall survival and local recurrence-free survival(P=0.037 and 0.039,respectively).In multivariate analysis,increased LDH level was identified as an independent prognostic factor for overall survival.Therefore,we conclude that increased pretreatment serum LDH and ALP levels are poor prognostic factors for NPC. 关键词：血清酶 LDH 鼻咽癌 ALP 预后治疗乳酸脱氢酶碱性磷酸酶

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Increased pretreatment levels of serum LDH and ALP as poor prognostic factors for nasopharyngeal carcinoma

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